Alarmins: Feel the Stress

The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

(2016) Daniel Okin et al.   CELL

Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis

(2016) Atsuko Murota et al.   CYTOKINE

IL-33 ameliorates Alzheimer’s disease-like pathology and cognitive decline

(2016) Amy K. Y. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erratum: Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

(2016) Idan Cohen et al.   Scientific Reports

NADPH oxidase controls neutrophilic response to sterile inflammation in mice by regulating the IL-1 /G-CSF axis

(2015) J. Bagaitkar et al.   BLOOD

Stress sounds the alarmin: The role of the danger-associated molecular pattern HMGB1 in stress-induced neuroinflammatory priming

(2015) Matthew G. Frank et al.   BRAIN BEHAVIOR AND IMMUNITY

Cytokine and growth factor profiling in patients with the metabolic syndrome

(2015) Seyed Reza Mirhafez et al.   BRITISH JOURNAL OF NUTRITION

Cigarette Smoke Silences Innate Lymphoid Cell Function and Facilitates an Exacerbated Type I Interleukin-33-Dependent Response to Infection

(2015) Jennifer Kearley et al.   IMMUNITY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

N-linked glycosylation plays a crucial role in the secretion of HMGB1

(2015) Young Hun Kim et al.   JOURNAL OF CELL SCIENCE

HMGB1 in the pathogenesis of ultraviolet-induced ocular surface inflammation

(2015) S J Han et al.   Cell Death & Disease

Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation

(2015) E. Suzanne Cohen et al.   Nature Communications

Anti-HMGB1 antibody reduces weight gain in mice fed a high-fat diet

(2015) V N Montes et al.   Nutrition & Diabetes

Oxidative stress-mediated HMGB1 biology

(2015) Yan Yu et al.   Frontiers in Physiology

Deacetylation-mediated interaction of SIRT1-HMGB1 improves survival in a mouse model of endotoxemia

(2015) Jung Seok Hwang et al.   Scientific Reports

Interleukin 16 expression changes in association with ovarian malignant transformation

(2014) Aparna Yellapa et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

High Mobility Group Box 1 Protein Is Methylated and Transported to Cytoplasm in Clear Cell Renal Cell Carcinoma

(2014) Fei Wu et al.   Asian Pacific Journal of Cancer Prevention

Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in β-cells

(2014) R Guzmán-Ruiz et al.   INTERNATIONAL JOURNAL OF OBESITY

Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation

(2014) Juliana Bessa et al.   JOURNAL OF AUTOIMMUNITY

PARP-1 Mediates LPS-Induced HMGB1 Release by Macrophages through Regulation of HMGB1 Acetylation

(2014) Zhiyong Yang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-1α neutralisation in patients with cancer

(2014) Charles Anthony Dinarello   LANCET ONCOLOGY

MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study

(2014) David S Hong et al.   LANCET ONCOLOGY

Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma

(2014) Tobias Bald et al.   NATURE

Central domain of IL-33 is cleaved by mast cell proteases for potent activation of group-2 innate lymphoid cells

(2014) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine Secretion in Macrophages: SNAREs, Rabs, and Membrane Trafficking

(2014) Rachael Zoe Murray et al.   Frontiers in Immunology

Oxidative post-translational modifications and their involvement in the pathogenesis of autoimmune diseases

(2014) Brent J. Ryan et al.   Redox Biology

Ultraviolet light exposure stimulates HMGB1 release by keratinocytes

(2013) Kelly E. Johnson et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

DNA Damage Triggers a Chronic Autoinflammatory Response, Leading to Fat Depletion in NER Progeria

(2013) Ismene Karakasilioti et al.   Cell Metabolism

TLR4 is essential for dendritic cell activation and anti-tumor T-cell response enhancement by DAMPs released from chemically stressed cancer cells

(2013) Hongliang Fang et al.   Cellular & Molecular Immunology

Inflammation triggers high mobility group box 1 (HMGB1) secretion in adipose tissue, a potential link to obesity

(2013) Manoj Kumar Gunasekaran et al.   CYTOKINE

High-mobility group protein B1: a new biomarker of metabolic syndrome in obese children

(2013) Teresa Arrigo et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

(2013) Yue Zheng et al.   IMMUNITY

Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

(2013) Donald A. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Cellular Processes by Interleukin-16 in Homeostasis and Cancer

(2013) Jillian Richmond et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

Mechanisms of Sterile Inflammation

(2013) Anna Rubartelli et al.   Frontiers in Immunology

Redox-control of the alarmin, Interleukin-1α

(2013) Donald A. McCarthy et al.   Redox Biology

High mobility group box-1 is phosphorylated by protein kinase C zeta and secreted in colon cancer cells

(2012) Hanna Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting IL-1 in depression

(2012) Michael Maes et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Post-Translational Modification of Human Heat Shock Factors and Their Functions: A Recent Update by Proteomic Approach

(2012) Yan-Ming Xu et al.   JOURNAL OF PROTEOME RESEARCH

Oxidation of HMGB1 Causes Attenuation of Its Pro-Inflammatory Activity and Occurs during Liver Ischemia and Reperfusion

(2012) Anding Liu et al.   PLoS One

IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G

(2012) E. Lefrancais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

(2012) Peleg Rider et al.   Frontiers in Immunology

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

Role of IL-1  and the Nlrp3/caspase-1/IL-1  axis in cigarette smoke-induced pulmonary inflammation and COPD

(2011) N. S. Pauwels et al.   EUROPEAN RESPIRATORY JOURNAL

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

(2011) Domagoj Vucic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

(2011) Fernando M. Botelho et al.   PLoS One

Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice

(2011) Jae-Young Um et al.   PLoS One

Regulation of the DNA Damage Response to DSBs by Post-Translational Modifications

(2010) C. Oberle et al.   CURRENT GENOMICS

IL-1  Modulates Neutrophil Recruitment in Chronic Inflammation Induced by Hydrocarbon Oil

(2010) P. Y. Lee et al.   JOURNAL OF IMMUNOLOGY

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of posttranslational modifications in the assembly of stress granules

(2010) Takbum Ohn et al.   Wiley Interdisciplinary Reviews-RNA

Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis

(2009) Vilma Urbonaviciute et al.   AUTOIMMUNITY

Nuclear retention of IL-1α by necrotic cells: A mechanism to dampen sterile inflammation

(2009) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

Tyrosine sulfation: an increasingly recognised post-translational modification of secreted proteins

(2009) Martin J. Stone et al.   New Biotechnology

Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A–H2B acidic pocket

(2008) Lucie Roussel et al.   EMBO REPORTS

ROS Eliminate Danger

(2008) Marcus E. Peter   IMMUNITY

Induction of Immunological Tolerance by Apoptotic Cells Requires Caspase-Dependent Oxidation of High-Mobility Group Box-1 Protein

(2008) Hirotaka Kazama et al.   IMMUNITY

Oral Presentations

(2008)   PEDIATRIC DIABETES

The IL-1-Like Cytokine IL-33 Is Constitutively Expressed in the Nucleus of Endothelial Cells and Epithelial Cells In Vivo: A Novel ‘Alarmin’?

(2008) Christine Moussion et al.   PLoS One

Post-translational modification of proteins during intermittent hypoxia

(2008) Ganesh K. Kumar et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

High-mobility group box protein 1 (HMGB1): an alarmin mediating the pathogenesis of rheumatic disease

(2008) David S Pisetsky et al.   ARTHRITIS RESEARCH & THERAPY

Ozone Exposure of Macrophages Induces an Alveolar Epithelial Chemokine Response through IL-1α

(2007) Rizwan Manzer et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY