NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

(2010) Md. Hasan Zaki et al.   IMMUNITY

Control of Intestinal Homeostasis, Colitis, and Colitis-Associated Colorectal Cancer by the Inflammatory Caspases

(2010) Jeremy Dupaul-Chicoine et al.   IMMUNITY

The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer

(2010) Irving C. Allen et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combined Polymorphisms in Genes Encoding the Inflammasome Components NALP3 and CARD8 Confer Susceptibility to Crohn's Disease in Swedish Men

(2009) Ida Schoultz et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency

(2009) Daniel K. Podolsky et al.   GASTROENTEROLOGY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Pure Hemozoin Is Inflammatory In Vivo and Activates the NALP3 Inflammasome via Release of Uric Acid

(2009) J. W. Griffith et al.   JOURNAL OF IMMUNOLOGY

Fecal β-Defensin-2 in Children With Inflammatory Bowel Diseases

(2009) Nathalie Kapel et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Dysregulation of Human β-Defensin-2 Protein in Inflammatory Bowel Disease

(2009) Marian C. Aldhous et al.   PLoS One

Nod2 is required for the regulation of commensal microbiota in the intestine

(2009) T. Petnicki-Ocwieja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced  -defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease

(2008) L A Simms et al.   GUT

Phagocyte dysfunction and inflammatory bowel disease

(2008) Farooq Z. Rahman et al.   INFLAMMATORY BOWEL DISEASES

NOD2/CARD15 genotype influences MDP-induced cytokine release and basal IL-12p40 levels in primary isolated peripheral blood monocytes

(2008) Vanessa Beynon et al.   INFLAMMATORY BOWEL DISEASES

Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohnʼs disease

(2008) Ben Willing et al.   INFLAMMATORY BOWEL DISEASES

Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

(2008) Alexandra-Chloé Villani et al.   NATURE GENETICS

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface

(2008) S. Vaishnava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE