Neuroimmune Response in Ischemic Preconditioning

Protective features of peripheral monocytes/macrophages in stroke

(2016) Michael Gliem et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astrocytic GAP43 Induced by the TLR4/NF- B/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and Neurotoxicity

(2016) C.-C. Hung et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

Focal cerebral ischemic tolerance and change in blood-brain barrier permeability after repetitive pure oxygen exposure preconditioning in a rodent model

(2016) Xi Wang et al.   JOURNAL OF NEUROSURGERY

Beyond neurovascular coupling, role of astrocytes in the regulation of vascular tone

(2016) J.A. Filosa et al.   NEUROSCIENCE

Astrocytes in neuroprotection and neurodegeneration: The role of connexin43 and pannexin1

(2016) M. Freitas-Andrade et al.   NEUROSCIENCE

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis

(2015) Reza Khorooshi et al.   ACTA NEUROPATHOLOGICA

Roles of microglia in brain development, tissue maintenance and repair

(2015) Mackenzie A. Michell-Robinson et al.   BRAIN

Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

(2015) Patrick Ejlerskov et al.   CELL

Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after hypoxia-ischemia

(2015) Takashi Umekawa et al.   GLIA

Macrophage-derived osteopontin induces reactive astrocyte polarization and promotes re-establishment of the blood brain barrier after ischemic stroke

(2015) Michael Gliem et al.   GLIA

Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge

(2015) Diana M. Norden et al.   GLIA

A critical review of mechanisms regulating remote preconditioning-induced brain protection

(2015) Robert Meller et al.   JOURNAL OF APPLIED PHYSIOLOGY

IgM-Dependent Phagocytosis in Microglia Is Mediated by Complement Receptor 3, Not Fc /  Receptor

(2015) J. R. Weinstein et al.   JOURNAL OF IMMUNOLOGY

Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia

(2015) Ana R. Inácio et al.   Journal of Neuroinflammation

Ischemic Preconditioning in White Matter: Magnitude and Mechanism

(2015) Margaret A. Hamner et al.   JOURNAL OF NEUROSCIENCE

Ischemia preconditioning protects astrocytes from ischemic injury through 14-3-3γ

(2015) Ying Pang et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons

(2015) M.P. Helley et al.   NEUROSCIENCE

Hypoxic preconditioning and cell death from oxygen/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons

(2015) P.E. Bickler et al.   NEUROSCIENCE

Brain Vascular Pericytes Following Ischemia Have Multipotential Stem Cell Activity to Differentiate Into Neural and Vascular Lineage Cells

(2015) Takayuki Nakagomi et al.   STEM CELLS

A MultiCenter Pilot Randomized Controlled Trial of Remote Ischemic Preconditioning in Major Vascular Surgery

(2015) D. A. Healy et al.   Vascular and Endovascular Surgery

Matched Cohort Analysis of the Effects of Limb Remote Ischemic Conditioning in Patients with Aneurysmal Subarachnoid Hemorrhage

(2015) Azim N. Laiwalla et al.   Translational Stroke Research

Mechanisms and Functional Significance of Stroke-Induced Neurogenesis

(2015) Quentin Marlier et al.   Frontiers in Neuroscience

Rational modulation of the innate immune system for neuroprotection in ischemic stroke

(2015) Diana Amantea et al.   Frontiers in Neuroscience

Interferon regulatory factor 7 participates in the M1-like microglial polarization switch

(2014) Tatsuhide Tanaka et al.   GLIA

TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation

(2014) Diana M. Norden et al.   GLIA

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

(2014) Zhiwei Tang et al.   Journal of Neuroinflammation

Phase I Clinical Trial for the Feasibility and Safety of Remote Ischemic Conditioning for Aneurysmal Subarachnoid Hemorrhage

(2014) Nestor R. Gonzalez et al.   NEUROSURGERY

Modifications in Rat Plasma Proteome after Remote Ischemic Preconditioning (RIPC) Stimulus: Identification by a SELDI-TOF-MS Approach

(2014) Pierre Hibert et al.   PLoS One

Astrocytic Toll-Like Receptor 3 Is Associated with Ischemic Preconditioning- Induced Protection against Brain Ischemia in Rodents

(2014) Lin-na Pan et al.   PLoS One

Reprogramming the Response to Stroke by Preconditioning

(2014) Susan L. Stevens et al.   STROKE

Post-ischemic inflammation regulates neural damage and protection

(2014) Takashi Shichita et al.   Frontiers in Cellular Neuroscience

Molecular and Cellular Immune Responses to Ischemic Brain Injury

(2014) Hilary A. Seifert et al.   Translational Stroke Research

Immune mechanisms in cerebral ischemic tolerance

(2014) Lidia Garcia-Bonilla et al.   Frontiers in Neuroscience

Biphasic Mechanisms of Neurovascular Unit Injury and Protection in CNS Diseases

(2013) Takakuni Maki et al.   CNS & Neurological Disorders-Drug Targets

Interferons in the central nervous system: A few instruments play many tunes

(2013) Trevor Owens et al.   GLIA

CX3CR1 deficiency induces an early protective inflammatory environment in ischemic mice

(2013) Stefano Fumagalli et al.   GLIA

Toll-like receptor 3 activation modulates hippocampal network excitability, via glial production of interferon-β

(2013) Derek A. Costello et al.   HIPPOCAMPUS

The p53 Transcription Factor Modulates Microglia Behavior through MicroRNA-Dependent Regulation of c-Maf

(2013) W. Su et al.   JOURNAL OF IMMUNOLOGY

Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning

(2013) Hussein Kalakech et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification of a unique TGF-β–dependent molecular and functional signature in microglia

(2013) Oleg Butovsky et al.   NATURE NEUROSCIENCE

Microglia: Multiple roles in surveillance, circuit shaping, and response to injury

(2013) E. E. Benarroch   NEUROLOGY

Apolipoprotein A-I Is a Potential Mediator of Remote Ischemic Preconditioning

(2013) Pierre Hibert et al.   PLoS One

Simvastatin Attenuates Stroke-induced Splenic Atrophy and Lung Susceptibility to Spontaneous Bacterial Infection in Mice

(2013) Rong Jin et al.   STROKE

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

Pathobiology of injury after stroke: the neurovascular unit and beyond

(2012) Ulrich Dirnagl   Annals of the New York Academy of Sciences

TLR9 Bone Marrow Chimeric Mice Define a Role for Cerebral TNF in Neuroprotection Induced by CpG Preconditioning

(2012) Amy EB Packard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

How type I interferons shape myeloid cell function in CNS autoimmunity

(2012) S. M. Brendecke et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Activation of immune responses to brain antigens after stroke

(2012) Kyra J. Becker   JOURNAL OF NEUROCHEMISTRY

Novel therapeutic strategies targeting innate immune responses and early inflammation after stroke

(2012) Takashi Shichita et al.   JOURNAL OF NEUROCHEMISTRY

Poly-ICLC preconditioning protects the blood-brain barrier against ischemic injuryin vitrothrough type I interferon signaling

(2012) Raffaella Gesuete et al.   JOURNAL OF NEUROCHEMISTRY

The spleen contributes to stroke induced neurodegeneration through interferon gamma signaling

(2012) Hilary A. Seifert et al.   METABOLIC BRAIN DISEASE

The Chronic Protective Effects of Limb Remote Preconditioning and the Underlying Mechanisms Involved in Inflammatory Factors in Rat Stroke

(2012) Dingtai Wei et al.   PLoS One

Secondary Intracerebral Hemorrhage Due to Early Initiation of Oral Anticoagulation After Ischemic Stroke

(2012) Michael Gliem et al.   STROKE

Toll-Like Receptor 7 Preconditioning Induces Robust Neuroprotection Against Stroke by a Novel Type I Interferon-Mediated Mechanism

(2012) Philberta Y. Leung et al.   STROKE

Proof of Concept: Pharmacological Preconditioning with a Toll-like Receptor Agonist Protects against Cerebrovascular Injury in a Primate Model of Stroke

(2011) Frances Rena Bahjat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interferon regulatory factor-7 modulates experimental autoimmune encephalomyelitis in mice

(2011) Mohammad Salem et al.   Journal of Neuroinflammation

Interferon regulatory factor 3 plays an anti-inflammatory role in microglia by activating the PI3K/Akt pathway

(2011) Leonid Tarassishin et al.   Journal of Neuroinflammation

Lateral fluid percussion injury of the brain induces CCL20 inflammatory chemokine expression in rats

(2011) Mahasweta Das et al.   Journal of Neuroinflammation

Multiple Preconditioning Paradigms Converge on Interferon Regulatory Factor-Dependent Signaling to Promote Tolerance to Ischemic Brain Injury

(2011) S. L. Stevens et al.   JOURNAL OF NEUROSCIENCE

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Preconditioning induces sustained neuroprotection by downregulation of adenosine 5′-monophosphate-activated protein kinase

(2011) V.R. Venna et al.   NEUROSCIENCE

Can Genes Modify Stroke Outcome and By What Mechanisms?

(2011) Roger P. Simon et al.   STROKE

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

(2010) Kazuhide Hayakawa et al.   Annals of the New York Academy of Sciences

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice

(2010) Kazuhide Hayakawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Injury-Induced Type I IFN Signaling Regulates Inflammatory Responses in the Central Nervous System

(2010) R. Khorooshi et al.   JOURNAL OF IMMUNOLOGY

TLR ligands induce synergistic interferon-β and interferon-λ1 gene expression in human monocyte-derived dendritic cells

(2010) Sanna M. Mäkelä et al.   MOLECULAR IMMUNOLOGY

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

(2010) Takashi Satoh et al.   NATURE IMMUNOLOGY

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Astrocyte function and role in motor neuron disease: A future therapeutic target?

(2009) Daniel Blackburn et al.   GLIA

Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning

(2009) Jesús M. Pradillo et al.   JOURNAL OF NEUROCHEMISTRY

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use

(2009) Ulrich Dirnagl et al.   LANCET NEUROLOGY

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

(2009) F. K. Swirski et al.   SCIENCE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Hypoxic preconditioning up-regulates glucose transport activity and glucose transporter (GLUT1 and GLUT3) gene expression after acute anoxic exposure in the cultured rat hippocampal neurons and astrocytes

(2008) Shun Yu et al.   BRAIN RESEARCH

Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein

(2008) Xinhua Zhan et al.   BRAIN RESEARCH

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

(2008) Marco Prinz et al.   IMMUNITY

Proliferating Progenitor Cells: A Required Cellular Element for Induction of Ischemic Tolerance in the Brain

(2008) Samaneh Maysami et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Microglia-Mediated Neurotoxicity in a New Model of the Stroke Penumbra

(2008) V. Kaushal et al.   JOURNAL OF NEUROSCIENCE

The spleen contributes to stroke‐induced neurodegeneration

(2008) Craig T. Ajmo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning

(2008) C. Ren et al.   NEUROSCIENCE

Inflammation and the neurovascular unit in the setting of focal cerebral ischemia

(2008) G.J. del Zoppo   NEUROSCIENCE

Delayed Tolerance With Repetitive Transient Focal Ischemic Preconditioning in the Mouse

(2008) Jian Zhang et al.   STROKE

Inflammation and the Emerging Role of the Toll-Like Receptor System in Acute Brain Ischemia

(2008) B. J. Marsh et al.   STROKE

Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases

(2007) B MARSH et al.   CURRENT OPINION IN PHARMACOLOGY