ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

Immune cell trafficking across the barriers of the central nervous system in multiple sclerosis and stroke

(2016) Melissa A. Lopes Pinheiro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dendritic cells as therapeutic targets in neuroinflammation

(2016) Felix Lüssi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Postarrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro

(2016) Henriette Rudolph et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Therapeutic depletion of monocyte-derived cells protects from long-term axonal loss in experimental autoimmune encephalomyelitis

(2016) Monica A. Moreno et al.   JOURNAL OF NEUROIMMUNOLOGY

Human T-Lymphotropic Virus Type 1-Induced Overexpression of Activated Leukocyte Cell Adhesion Molecule (ALCAM) Facilitates Trafficking of Infected Lymphocytes through the Blood-Brain Barrier

(2016) Céline Curis et al.   JOURNAL OF VIROLOGY

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

(2016) Marie-Theres Weil et al.   Cell Reports

Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation

(2015) Catherine Larochelle et al.   ANNALS OF NEUROLOGY

Netrin 1 regulates blood–brain barrier function and neuroinflammation

(2015) Cornelia Podjaski et al.   BRAIN

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The dynamic blood-brain barrier

(2015) James Keaney et al.   FEBS Journal

PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE

(2014) Karthik Sathiyanadan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

JAM-A and ALCAM are therapeutic targets to inhibit diapedesis across the BBB of CD14+ CD16+ monocytes in HIV-infected individuals

(2014) Dionna W. Williams et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

(2014) Romeo Cecchelli et al.   PLoS One

The Oral Commensal Streptococcus mitis Shows a Mixed Memory Th Cell Signature That Is Similar to and Cross-Reactive with Streptococcus pneumoniae

(2014) Stian André Engen et al.   PLoS One

Fingolimod in relapsing multiple sclerosis: An integrated analysis of safety findings

(2014) Ludwig Kappos et al.   Multiple Sclerosis and Related Disorders

Ninjurin1 Deficiency Attenuates Susceptibility of Experimental Autoimmune Encephalomyelitis in Mice

(2013) Bum Ju Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier

(2013) R. Gorina et al.   JOURNAL OF IMMUNOLOGY

ALCAM — Novel multiple sclerosis locus interfering with HLA-DRB1*1501

(2013) Marta Wagner et al.   JOURNAL OF NEUROIMMUNOLOGY

Mechanisms of HIV Entry into the CNS: Increased Sensitivity of HIV Infected CD14+CD16+ Monocytes to CCL2 and Key Roles of CCR2, JAM-A, and ALCAM in Diapedesis

(2013) Dionna W. Williams et al.   PLoS One

Natalizumab Therapy for Multiple Sclerosis

(2013) Jens Kuhle et al.   SEMINARS IN NEUROLOGY

Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

(2013) Hongxia Duan et al.   Scientific Reports

Going Against the Tide – How Encephalitogenic T Cells Breach the Blood-Brain Barrier

(2012) Ruth Lyck et al.   JOURNAL OF VASCULAR RESEARCH

Role of ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions

(2011) Igal Ifergan et al.   ANNALS OF NEUROLOGY

The CD6 Multiple Sclerosis Susceptibility Allele Is Associated with Alterations in CD4+ T Cell Proliferation

(2011) D. M. Kofler et al.   JOURNAL OF IMMUNOLOGY

Cocaine Hijacks  1 Receptor to Initiate Induction of Activated Leukocyte Cell Adhesion Molecule: Implication for Increased Monocyte Adhesion and Migration in the CNS

(2011) H. Yao et al.   JOURNAL OF NEUROSCIENCE

Improved Survival, Vascular Differentiation and Wound Healing Potential of Stem Cells Co-Cultured with Endothelial Cells

(2011) Dora C. S. Pedroso et al.   PLoS One

The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

(2011) J. I. Alvarez et al.   SCIENCE

Settings and mechanisms for trans-cellular diapedesis

(2010) Peter et al.   Frontiers in Bioscience-Landmark

Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation

(2010) Oliver Steiner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Knocking at the brain’s door: intravital two-photon imaging of autoreactive T cell interactions with CNS structures

(2010) Naoto Kawakami et al.   Seminars in Immunopathology

CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system

(2009) Alexander Mildner et al.   BRAIN

EAE: An immunologist's magic eye

(2009) Gurumoorthy Krishnamoorthy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

(2009) C. V. Carman   JOURNAL OF CELL SCIENCE

Culture-Induced Changes in Blood—Brain Barrier Transcriptome: Implications for Amino-Acid Transporters in vivo

(2009) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

(2009) Caroline Coisne et al.   JOURNAL OF IMMUNOLOGY

ALCAM Regulates Mediolateral Retinotopic Mapping in the Superior Colliculus

(2009) M. Buhusi et al.   JOURNAL OF NEUROSCIENCE

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci

(2009) Philip L De Jager et al.   NATURE GENETICS