Going Against the Tide – How Encephalitogenic T Cells Breach the Blood-Brain Barrier

Mechanisms of Leukocyte Transendothelial Migration

(2011) William A. Muller   Annual Review of Pathology-Mechanisms of Disease

Chemokine triggered integrin activation and actin remodeling events guiding lymphocyte migration across vascular barriers

(2011) Ronen Alon et al.   EXPERIMENTAL CELL RESEARCH

Th17 lymphocytes traffic to the central nervous system independently of α4 integrin expression during EAE

(2011) Veit Rothhammer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Loss of  4 Integrin Expression Differentially Affects the Homing of Th1 and Th17 Cells

(2011) S. Glatigny et al.   JOURNAL OF IMMUNOLOGY

Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots

(2011) Ziv Shulman et al.   NATURE IMMUNOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The blood–brain barrier, chemokines and multiple sclerosis

(2010) David W. Holman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Settings and mechanisms for trans-cellular diapedesis

(2010) Peter et al.   Frontiers in Bioscience-Landmark

Endothelial Heparan Sulfate Controls Chemokine Presentation in Recruitment of Lymphocytes and Dendritic Cells to Lymph Nodes

(2010) Xingfeng Bao et al.   IMMUNITY

Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation

(2010) Oliver Steiner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

 4 1 Integrin Mediates the Recruitment of Immature Dendritic Cells across the Blood-Brain Barrier during Experimental Autoimmune Encephalomyelitis

(2010) P. Jain et al.   JOURNAL OF IMMUNOLOGY

LFA-1 and Mac-1 Define Characteristically Different Intralumenal Crawling and Emigration Patterns for Monocytes and Neutrophils In Situ

(2010) R. Sumagin et al.   JOURNAL OF IMMUNOLOGY

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

PSGL-1 is dispensible for the development of active experimental autoimmune encephalomyelitis in SJL/J mice

(2010) Ruben Bill et al.   JOURNAL OF NEUROIMMUNOLOGY

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration

(2009) A. Gerard et al.   BLOOD

Lymphocyte Crawling and Transendothelial Migration Require Chemokine Triggering of High-Affinity LFA-1 Integrin

(2009) Ziv Shulman et al.   IMMUNITY

Mechanisms for transcellular diapedesis: probing and pathfinding by `invadosome-like protrusions'

(2009) C. V. Carman   JOURNAL OF CELL SCIENCE

Culture-Induced Changes in Blood—Brain Barrier Transcriptome: Implications for Amino-Acid Transporters in vivo

(2009) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Transcellular migration of leukocytes is mediated by the endothelial lateral border recycling compartment

(2009) Zahra Mamdouh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Vav1 Is Essential for Mechanotactic Crawling and Migration of Neutrophils out of the Inflamed Microvasculature

(2009) M. Phillipson et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

(2009) Caroline Coisne et al.   JOURNAL OF IMMUNOLOGY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

(2009) Andrea Reboldi et al.   NATURE IMMUNOLOGY

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

β1integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity

(2009) Martina Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The blood–brain and the blood–cerebrospinal fluid barriers: function and dysfunction

(2009) Britta Engelhardt et al.   Seminars in Immunopathology

Trans-cellular migration: cell–cell contacts get intimate

(2008) Christopher V Carman et al.   CURRENT OPINION IN CELL BIOLOGY

Cells on the run: shear-regulated integrin activation in leukocyte rolling and arrest on endothelial cells

(2008) Ronen Alon et al.   CURRENT OPINION IN CELL BIOLOGY

Leukocyte transmigration requires kinesin-mediated microtubule-dependent membrane trafficking from the lateral border recycling compartment

(2008) Zahra Mamdouh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Filopodia: molecular architecture and cellular functions

(2008) Pieta K. Mattila et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms of leukocyte migration across the blood–retina barrier

(2008) Isabel J. Crane et al.   Seminars in Immunopathology