Ceramide and Regulation of Vascular Tone

Bioactive Lipids and Redox Signaling: Molecular Mechanism and Disease Pathogenesis

(2018) Pin-Lan Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Regulation of Staphylococcus aureus Infection of Macrophages by CD44, Reactive Oxygen Species, and Acid Sphingomyelinase

(2018) Cao Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Plasma Ceramides

(2018) Jeffrey W. Meeusen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Could Ceramides Become the New Cholesterol?

(2018) Scott A. Summers   Cell Metabolism

Circulating Sphingolipids, Insulin, HOMA-IR, and HOMA-B: The Strong Heart Family Study

(2018) Rozenn N. Lemaitre et al.   DIABETES

Strong Heart, Low Ceramides

(2018) William L. Holland et al.   DIABETES

Role of sphingolipids in senescence: implication in aging and age-related diseases

(2018) Magali Trayssac et al.   JOURNAL OF CLINICAL INVESTIGATION

Manifestations and mechanisms of myocardial lipotoxicity in obesity

(2018) A. C. Sletten et al.   JOURNAL OF INTERNAL MEDICINE

The Ceramide Ratio: A Predictor of Cardiometabolic Risk

(2018) Trevor S. Tippetts et al.   JOURNAL OF LIPID RESEARCH

Plasma concentrations of molecular lipid species predict long-term clinical outcome in coronary artery disease patients

(2018) Sharda S. Anroedh et al.   JOURNAL OF LIPID RESEARCH

Novel mechanisms regulating endothelial barrier function in the pulmonary microcirculation

(2018) Szandor Simmons et al.   JOURNAL OF PHYSIOLOGY-LONDON

Association between plasma ceramides and inducible myocardial ischemia in patients with established or suspected coronary artery disease undergoing myocardial perfusion scintigraphy

(2018) Alessandro Mantovani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acid ceramidase deficiency: Farber disease and SMA-PME

(2018) Fabian P. S. Yu et al.   Orphanet Journal of Rare Diseases

Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia

(2018) Esther van Mastrigt et al.   PLoS One

Ceramide Metabolism Balance, a Multifaceted Factor in Critical Steps of Breast Cancer Development

(2018) Victor García-González et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration

(2018) Henryk Jęśko et al.   MOLECULAR NEUROBIOLOGY

Sphingolipids and Innate Immunity: A New Approach to Infection in the Post-Antibiotic Era?

(2018) Jennifer E. Baker et al.   Surgical Infections

The Role of Sphingolipids on Innate Immunity to Intestinal Salmonella Infection

(2017) Fu-Chen Huang   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ceramides and depression: A systematic review

(2017) Adam Dinoff et al.   JOURNAL OF AFFECTIVE DISORDERS

Fenretinide differentially modulates the levels of long- and very long-chain ceramides by downregulating Cers5 enzyme: evidence from bench to bedside

(2017) Dušan Garić et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Ceramide enhances COX-2 expression and VSMC contractile hyperreactivity via ER stress signal activation

(2017) Huina Zhang et al.   VASCULAR PHARMACOLOGY

Dietary and Endogenous Sphingolipid Metabolism in Chronic Inflammation

(2017) et al.   Nutrients

Plasma Dihydroceramides Are Diabetes Susceptibility Biomarker Candidates in Mice and Humans

(2017) Leonore Wigger et al.   Cell Reports

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

(2017) Eleanor Wheeler et al.   PLOS MEDICINE

Brain Ceramide Metabolism in the Control of Energy Balance

(2017) Céline Cruciani-Guglielmacci et al.   Frontiers in Physiology

Endothelial NLRP3 inflammasome activation and arterial neointima formation associated with acid sphingomyelinase during hypercholesterolemia

(2017) Saisudha Koka et al.   Redox Biology

Inflammatory Mediators in Tracheal Aspirates of Preterm Infants Participating in a Randomized Trial of Inhaled Nitric Oxide

(2017) Mandy Laube et al.   PLoS One

Ceramide Signaling and Metabolism in Pathophysiological States of the Lung

(2016) Irina Petrache et al.   Annual Review of Physiology

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 CohortHighlights

(2016) Aki S. Havulinna et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Acid ceramidase and the treatment of ceramide diseases: The expanding role of enzyme replacement therapy

(2016) Edward H. Schuchman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fatty Acid Metabolic Defects and Right Ventricular Lipotoxicity in Human Pulmonary Arterial HypertensionClinical Perspective

(2016) Evan L. Brittain et al.   CIRCULATION

Plasma Lipidomic Profiles Improve on Traditional Risk Factors for the Prediction of Cardiovascular Events in Type 2 Diabetes MellitusClinical Perspective

(2016) Zahir H. Alshehry et al.   CIRCULATION

Lipid Use and Misuse by the Heart

(2016) P. Christian Schulze et al.   CIRCULATION RESEARCH

Thirty Years of Saying NO

(2016) Paul M. Vanhoutte et al.   CIRCULATION RESEARCH

Ceramide and Sphingosine-1-Phosphate in Cell Death Pathways : Relevance to the Pathogenesis of Alzheimer';s Disease

(2016) Sankha Shubhra Chakrabarti et al.   Current Alzheimer Research

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol

(2016) Reijo Laaksonen et al.   EUROPEAN HEART JOURNAL

Lipidomic analysis of epidermal lipids: a tool to predict progression of inflammatory skin disease in humans

(2016) Shan Li et al.   Expert Review of Proteomics

The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL

(2016) Caroline Camaré et al.   FREE RADICAL BIOLOGY AND MEDICINE

Vascular sphingolipids in physiological and pathological adaptation

(2016) Yao-Ming Chang   Frontiers in Bioscience-Landmark

Implication of sphingosin-1-phosphate in cardiovascular regulation

(2016) Ningjun Li   Frontiers in Bioscience-Landmark

The role of epidermal sphingolipids in dermatologic diseases

(2016) Sonia Borodzicz et al.   Lipids in Health and Disease

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Sphingolipids in Congenital Diaphragmatic Hernia; Results from an International Multicenter Study

(2016) Kitty G. Snoek et al.   PLoS One

Molecular mechanism of lipid-induced cardiac insulin resistance and contractile dysfunction

(2016) Yilin Liu et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Role of acid sphingomyelinase and IL-6 as mediators of endotoxin-induced pulmonary vascular dysfunction

(2016) Rachele Pandolfi et al.   THORAX

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls

(2016) Simon Lea et al.   International Journal of Chronic Obstructive Pulmonary Disease

Sphingosine-1-Phosphate is Involved in the Occlusive Arteriopathy of Pulmonary Arterial Hypertension

(2016) Salina Gairhe et al.   Pulmonary Circulation

Plasma Sphingolipids Associated with Chronic Obstructive Pulmonary Disease Phenotypes

(2015) Russell P. Bowler et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Early Pulmonary Vascular Disease in Preterm Infants at Risk for Bronchopulmonary Dysplasia

(2015) Peter M. Mourani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies

(2015) Augusto C. Montezano et al.   CANADIAN JOURNAL OF CARDIOLOGY

Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo

(2015) Leena P. Bharath et al.   DIABETES

Role of sphingomyelinases in neurological disorders

(2015) Wei-Yi Ong et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Sphingolipids in cardiovascular diseases and metabolic disorders

(2015) Sonia Borodzicz et al.   Lipids in Health and Disease

CFTR and sphingolipids mediate hypoxic pulmonary vasoconstriction

(2015) Christoph Tabeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Three plasma metabolite signatures for diagnosing high altitude pulmonary edema

(2015) Li Guo et al.   Scientific Reports

A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung

(2015) Yidan D. Zhao et al.   PLoS One

The Sphingosine Kinase 1/Sphingosine-1-Phosphate Pathway in Pulmonary Arterial Hypertension

(2014) Jiwang Chen et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Hypertension in Cystic Fibrosis with Advanced Lung Disease

(2014) Don Hayes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sphingolipids in Lung Growth and Repair

(2014) Jeroen Tibboel et al.   CHEST

Ceramide Changes the Mediator of Flow-Induced Vasodilation From Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation

(2014) Julie K. Freed et al.   CIRCULATION RESEARCH

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Loss of Cystic Fibrosis Transmembrane Conductance Regulator Impairs Lung Endothelial Cell Barrier Function and Increases Susceptibility to Microvascular Damage from Cigarette Smoke

(2014) Mary Beth Brown et al.   Pulmonary Circulation

A Comprehensive Review on Metabolic Syndrome

(2014) Jaspinder Kaur   Cardiology Research and Practice

Ceramide Mediates Acute Oxygen Sensing in Vascular Tissues

(2013) Laura Moreno et al.   ANTIOXIDANTS & REDOX SIGNALING

A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1

(2013) Christel Cinq-Frais et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Ceramides in the Pathophysiology of the Anterior Segment of the Eye

(2013) Alexandra Robciuc et al.   CURRENT EYE RESEARCH

Sequestosome1/p62: A regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowth

(2013) Tetsuro Ishii et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin andPCSK9Deficiency

(2013) Kirill Tarasov et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Review: Novel insights into the regulation of vascular tone by sphingosine 1-phosphate

(2013) D. Kerage et al.   PLACENTA

Lipotoxicity contributes to endothelial dysfunction: A focus on the contribution from ceramide

(2013) J. David Symons et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Novel sphingosine-containing analogues selectively inhibit sphingosine kinase (SK) isozymes, induce SK1 proteasomal degradation and reduce DNA synthesis in human pulmonary arterial smooth muscle cells

(2013) Hoe-Sup Byun et al.   MedChemComm

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

The control of the balance between ceramide and sphingosine-1-phosphate by sphingosine kinase: Oxidative stress and the seesaw of cell survival and death

(2012) James R. Van Brocklyn et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY

Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex

(2012) Q.-J. Zhang et al.   DIABETES

Hypoxic Pulmonary Vasoconstriction

(2012) J. T. Sylvester et al.   PHYSIOLOGICAL REVIEWS

Ceramide Expression and Cell Homeostasis in Chronic Obstructive Pulmonary Disease

(2012) Maria C. Scarpa et al.   RESPIRATION

Sphingolipids, Lipotoxic Cardiomyopathy, and Cardiac Failure

(2012) Tae-Sik Park et al.   Heart Failure Clinics

Ceramide inhibits Kv currents and contributes to TP-receptor-induced vasoconstriction in rat and human pulmonary arteries

(2011) Javier Moral-Sanz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides

(2011) Kelly S. Schweitzer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Genetics of the ceramide/sphingosine-1-phosphate rheostat in blood pressure regulation and hypertension

(2011) Mogens Fenger et al.   BMC GENETICS

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Ceramide Is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease

(2010) Malcolm Brodlie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pulmonary Vascular Dysfunction Is Associated with Poor Outcomes in Patients with Acute Lung Injury

(2010) Todd M. Bull et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Neutral Sphingomyelinase 2

(2010) Simone Filosto et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Redox Regulation of Protein Kinases as a Modulator of Vascular Function

(2010) Greg A. Knock et al.   ANTIOXIDANTS & REDOX SIGNALING

Vascular Barrier Regulation by PAF, Ceramide, Caveolae, and NO - an Intricate Signaling Network with Discrepant Effects in the Pulmonary and Systemic Vasculature

(2010) Wolfgang M. Kuebler et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ceramide in Redox Signaling and Cardiovascular Diseases

(2010) Xiang Li et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pulmonary Hypertension in COPD: Epidemiology, Significance, and Management

(2010) Omar A. Minai et al.   CHEST

Oxidative Stress and Hypertension: Current Concepts

(2010) Ana M. Briones et al.   CURRENT HYPERTENSION REPORTS

Protective effects of imipramine in murine endotoxin-induced acute lung injury

(2010) Jin Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Membrane raft redox signalosomes in endothelial cells

(2010) Chun Zhang et al.   FREE RADICAL RESEARCH

Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction

(2010) Giovanna Frazziano et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Reactive oxygen species signaling in pulmonary vascular smooth muscle

(2010) Francisco Perez-Vizcaino et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Maturation of O2 sensing and signaling in the chicken ductus arteriosus

(2009) Angel L. Cogolludo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Sphingosine-1-phosphate and modulation of vascular tone

(2009) Junsuke Igarashi et al.   CARDIOVASCULAR RESEARCH

Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells

(2009) Gregory B. Waypa et al.   CIRCULATION RESEARCH

Platelet-activating factor reduces endothelial nitric oxide production: role of acid sphingomyelinase

(2009) Y. Yang et al.   EUROPEAN RESPIRATORY JOURNAL

Cellular localization of mitochondria contributes to Kv channel-mediated regulation of cellular excitability in pulmonary but not mesenteric circulation

(2008) Amy L. Firth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Improved Pulmonary Function by Acid Sphingomyelinase Inhibition in a Newborn Piglet Lavage Model

(2008) Philipp von Bismarck et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Sphingolipids in the Lungs

(2008) Stefan Uhlig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

(2008) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Activation of neutral sphingomyelinase is involved in acute hypoxic pulmonary vasoconstriction

(2008) A. Cogolludo et al.   CARDIOVASCULAR RESEARCH

The sphingolipid salvage pathway in ceramide metabolism and signaling

(2008) Kazuyuki Kitatani et al.   CELLULAR SIGNALLING

Sphingosine-1-Phosphate in the Regulation of Vascular Tone

(2008) Bodo Levkau   CIRCULATION RESEARCH

Targeting sphingosine-1-phosphate signalling for cardioprotection

(2008) Simon Kennedy et al.   CURRENT OPINION IN PHARMACOLOGY

Hypoxia activates NADPH oxidase to increase [ROS]i and [Ca2+]i through the mitochondrial ROS-PKCɛ signaling axis in pulmonary artery smooth muscle cells

(2008) R RATHORE et al.   FREE RADICAL BIOLOGY AND MEDICINE

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical Role of Lipid Raft Redox Signaling Platforms in Endostatin-Induced Coronary Endothelial Dysfunction

(2007) Si Jin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY