Article
Food Science & Technology
Mengcong Li, Shuhui Liu, Lei Tan, Yan Luo, Zhangshan Gao, Jiwen Liu, Yuting Wu, Wentao Fan, Sarah DeSaeger, Suquan Song
Summary: This study found that FB1 contamination has a toxic effect on the intestine and disrupts its barrier function. FB1 also leads to excessive production of cytokines, further damaging the intestinal immune barrier. By inhibiting the expression of CerS2, FB1 induces endoplasmic reticulum stress, resulting in the destruction of the intestinal barrier. However, this damage can be restored by overexpression of CerS2 or the use of an ER stress inhibitor.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Neurosciences
Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Ahmed Elsherbini, Liping Zhang, Priyanka Tripathi, Haiyan Qin, Emily Roush, Stefka D. Spassieva, Mariana Nikolova-Karakashian, Timothy S. McClintock, Erhard Bieberich
Summary: Deficiency of nSMase2 improves memory in adult mice and prevents oxidative stress-induced elevation of ceramide and secretion of exosomes by astrocytes that suppress neuronal function.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Lin Che, Zi-Li Wu, Lian-Yun Huang, Jia-Shen Wu, Ze-Bang Du, Jin-Xian Lin, Yan-Hua Su, Xiao-Xuan Chen, Zhong-Ning Lin, Yu-Chun Lin
Summary: The study elucidates the mechanism by which cadmium pollutants affect vascular health, highlighting the importance of regulating the expression of the COX-2 gene in patients with cardiovascular diseases to mitigate the adverse effects caused by cadmium exposure.
BIOCHEMICAL PHARMACOLOGY
(2021)
Editorial Material
Cell Biology
Yoon Mee Yang, Ekihiro Seki
Summary: The study shows that intracellular ER stress can be transmitted to neighboring hepatocytes through connexin 43, leading to exacerbated ER stress and promoting hepatosteatosis and insulin resistance.
Article
Immunology
Kexin Liu, Wenrui Zhen, Dongying Bai, Haiqiu Tan, Xianglong He, Yuqian Li, Yanhao Liu, Yi Zhang, Koichi Ito, Bingkun Zhang, Yanbo Ma
Summary: This study found that immune stress leads to growth inhibition in broilers, and growth inhibition can be reversed by inhibiting COX-2 activity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Wenrun Cai, Xugang Sun, Fanjie Jin, Di Xiao, Hui Li, Huizhi Sun, Yifei Wang, Yang Lu, Jing Liu, Chongbiao Huang, Xiuchao Wang, Song Gao, Hongwei Wang, Chuntao Gao, Tiansuo Zhao, Jihui Hao
Summary: CAFs in PDAC promote tumor angiogenesis through MEndoT, with their phenotypic transition being regulated by the PERK-eIF2 alpha-ERK1/2 axis. Pharmacological inhibition of PERK may limit the transition of CAFs, suggesting they could be therapeutic targets for improving PDAC prognosis.
Article
Cell Biology
Hang Zhu, Maoxiang Zhao, Yundai Chen, Dandan Li
Summary: Overexpression of Bag5 can reverse catecholamine-induced endothelial cell damage by inhibiting ER stress, attenuating oxidative stress, and repressing inflammation to promote cell survival. Pathway analysis showed that the MAPK-ERK pathway controls Bag5 expression, suggesting a potential mechanism for catecholamine-induced endothelial cell damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Xiaolin Zhang, Ziwei Yang, Ting Pan, Xubing Long, Qinqin Sun, Pei-Hui Wang, Xiaojuan Li, Ersheng Kuang
Summary: This study reveals the sequential induction of reticulophagy, ER stress, and acute inflammatory responses during SARS-CoV-2 infection, implying the therapeutic potential of reticulophagy and ER stress-related drugs for COVID-19.
Article
Cardiac & Cardiovascular Systems
Yuxuan Guo, Yangpo Cao, Blake D. Jardin, Xiaoran Zhang, Pingzhu Zhou, Silvia Guatimosim, Junsen Lin, Zhan Chen, Yueyang Zhang, Neil Mazumdar, Fujian Lu, Qing Ma, Yao-Wei Lu, Mingming Zhao, Da-Zhi Wang, Erdan Dong, William T. Pu
Summary: The aim of this study is to investigate the role of RYR2 in cardiomyocyte maturation. The researchers used genetic editing techniques to knockout RYR2 and found that its depletion led to structural and transcriptional defects in cardiomyocytes, along with activation of ER stress pathways. The defects in RYR2-depleted cardiomyocytes were partially rescued by an ER stress alleviator.
CARDIOVASCULAR RESEARCH
(2023)
Article
Plant Sciences
Jiaqi Sun, Weina Wang, Huanquan Zheng
Summary: This study reveals the involvement of RHD3 in the ER-phagy process under ER stress and the hyposensitivity of the rhd3 mutant to ER and salt stress. The increased association of RHD3 with ATG8e-marked autophagosomes and its breakdown under ER stress are demonstrated. The physical interaction between RHD3 and ATG8 is also enhanced under ER stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Editorial Material
Cell Biology
Baiying Li, Liwen Jiang
Summary: The regulation of autophagy in plants is still poorly understood, but recent research has identified the role of ufmylation components in maintaining ER homeostasis under salt stress. The expression of Ufm1-conjugating enzyme and Ufm1 protein increases in response to salt stress, indicating their involvement in regulating reticulophagy in plants.
Article
Endocrinology & Metabolism
Sheng-Chiang Su, Yi-Jen Hung, Fu-Huang Lin, Chang-Hsun Hsieh, Chieh-Hua Lu, Chu-Yen Chien, Ying-Chen Chen, Peng-Fei Li, Feng-Chih Kuo, Jhih-Syuan Liu, Nain-Feng Chu, Chien-Hsing Lee
Summary: This study found that serum level of the endoplasmic reticulum (ER) chaperone, protein disulfide isomerase family A, member 4 (PDIA4), is associated with type 2 diabetes mellitus (T2DM), insulin sensitivity, and obesity. Higher serum PDIA4 concentration is significantly associated with an increased risk of T2DM. These findings provide new insights into the relationship between ER stress, T2DM, and metabolic dysfunction, and suggest that PDIA4 may be a potential therapeutic target for T2DM.
ACTA DIABETOLOGICA
(2022)
Article
Biochemistry & Molecular Biology
Eloisa Aparecida Vilas-Boas, Lisa Nalbach, Emmanuel Ampofo, Camila Ferraz Lucena, Lea Naudet, Fernanda Ortis, Angelo Rafael Carpinelli, Bruce Morgan, Leticia Prates Roma
Summary: Modern lifestyles, lack of physical activity, poor nutrition, and high levels of saturated free fatty acids in obese individuals contribute to the increasing prevalence of obesity and type 2 diabetes. The study suggests that transient NOX2-dependent H2O2 production may be a key factor in early palmitate-induced lipotoxic effects.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marina Fuertes-Agudo, Maria Luque-Tevar, Carme Cucarella, Paloma Martin-Sanz, Marta Casado
Summary: Oxidative stress and inflammation are important factors in the development of liver diseases. NRF2 plays a crucial role in protecting against oxidative damage by regulating the expression of cytoprotective genes. COX-2, in addition to its role in inflammation, has a beneficial effect in reducing inflammation and oxidative stress in liver diseases, and it works together with NRF2 to provide a hepatoprotective effect.
Article
Oncology
Chien-Chih Chiu, Yen-Chun Chen, Yung-Ding Bow, Jeff Yi-Fu Chen, Wangta Liu, Jau-Ling Huang, En-De Shu, Yen-Ni Teng, Chang-Yi Wu, Wen-Tsan Chang
Summary: Chemotherapy is the main treatment for advanced or unresectable hepatocellular carcinoma (HCC), but chemoresistance is a significant challenge. Exogenous ceramide has anticancer effects, but recent studies have shown ceramide resistance. diTFPP is a novel compound that can increase the sensitivity of HCC cells to ceramide treatment. This study clarifies the mechanism by which diTFPP enhances the response to C-2-ceramide-induced stresses, providing insights into ceramide resistance and aiding in the development of adjuvants for ceramide-based cancer therapeutics.
Article
Water Resources
Shengnan Chen, Zuosinan Chen, Hang Xu, Zhe Kong, Zhibin Xu, Qingquan Liu, Pingsheng Liu, Zhiqiang Zhang
Summary: Urban trees and forests provide multiple ecosystem services for urban dwellers. This study monitored the sap flow of a Chinese pine plantation in a semi-arid urban environment and found that soil moisture played an important role in stand transpiration. The study also revealed the sensitivity of leaf stomata to vapor pressure deficit and solar radiation, and the reduction of canopy conductance under soil water stress.
HYDROLOGICAL PROCESSES
(2022)
Article
Materials Science, Biomaterials
Peiming Liu, Tianyi Bao, Lian Sun, Zeyi Wang, Jin Sun, Wan Peng, Donglin Gan, Guoyong Yin, Pingsheng Liu, Wei-Bing Zhang, Jian Shen
Summary: The study introduces a novel mineralized PLGA/PSBMA scaffold as a carrier for rhBMP-2 with high efficiency sustained release leading to successful healing of critical-sized bone defects in rats at an ultralow dosage. This finding suggests promising potential for bone defect repair utilizing the mineralized scaffold.
BIOMATERIALS SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Haiyang Liu, Junfeng Du, Shanshan Chao, Shuoguo Li, Huiyun Cai, Hongjie Zhang, Gang Chen, Pingsheng Liu, Pengcheng Bu
Summary: This study reveals that Fusobacterium nucleatum promotes self-renewal of colorectal cancer stem-like cells (CCSCs) and acquisition of CCSC features in non-CCSCs by manipulating cellular lipid accumulation. F. nucleatum decreases lipid accumulation in CCSCs by enhancing fatty acid oxidation, while increasing lipid accumulation in non-CCSCs by promoting fatty acid formation. Lipid droplets play a crucial role in this process, facilitating the degradation of the cell fate regulator Numb and activating Notch signaling, leading to the gain of stem-like cell features.
Article
Gastroenterology & Hepatology
Kang Xie, Yangli Liu, Xixia Li, Hong Zhang, Shuyan Zhang, Ho Yi Mak, Pingsheng Liu
Summary: Dietary and symbiotic bacteria have a significant impact on metazoan lipid metabolism, but the mechanisms by which bacteria influence lipid storage in their host are still unknown. This study used Caenorhabditis elegans as a model organism to investigate the interaction between gut microbiota and the host. The results showed that feeding C. elegans with Stenotrophomonas maltophilia (S. maltophilia) bacteria retarded growth and promoted excessive neutral lipid storage. Gene expression analysis revealed a lipogenic response induced by dietary S. maltophilia. Furthermore, it was observed that excess neutral lipid was stored in expanded lipid droplets due to enhanced endoplasmic reticulum (ER)-lipid droplet interactions. The study also identified a gene mutation in C. elegans that conferred resistance to S. maltophilia. This work provides a new model for understanding how microbes regulate metazoan physiology.
Article
Chemistry, Physical
Tianyi Bao, Zheng Zhou, Peng Gao, Xiaohan Dong, Jian Chen, Shujie Zhao, Pingsheng Liu, Guoyong Yin
Summary: This study designed a multilayer polyelectrolyte coating that can promote the integration of metallic implants with bone and possess antibacterial properties. Stable coatings were constructed on titanium alloy substrates using a layer-by-layer technology, allowing for the sustained release of bone morphogenetic protein 2 and promotion of cell differentiation. Additionally, the polycationic component in the coating significantly improved the antibacterial properties of the titanium alloy surface.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Jin Sun, Wan Peng, Birong Fan, Donglin Gan, Li Li, Pingsheng Liu, Jian Shen
Summary: Photodynamic inactivation (PDI) is a promising approach to combat multi-drug resistance. However, the short half-life of O-1(2) and the photobleaching of the photosensitizer (PS) limit its efficiency. Researchers have developed a ROS conversion strategy that converts O-1(2) to hydrogen peroxide (H2O2), leading to an extended half-life of ROS and reduced photobleaching. This reinforced photodynamic model system improves antibacterial efficiency and accelerates wound healing.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Letter
Cell Biology
Kai Zhang, Chang Zhou, Zemin Li, Xuehan Li, Ziyun Zhou, Linjia Cheng, Ahmed Hammad Mirza, Yumeng Shi, Bingbing Chen, Mengwei Zhang, Liujuan Cui, Congyan Zhang, Taotao Wei, Xuelin Zhang, Shuyan Zhang, Pingsheng Liu
Article
Environmental Sciences
Xiaoye Li, Yixuan Tang, Pingsheng Liu, Zhengrong Cheng
Summary: This paper aims to fill the gap in existing research on the internal causes of inter-regional differences in carbon emission efficiency. By accurately measuring China's dynamic carbon emission efficiency of industrial energy, the study found that the efficiency is increasing and overall energy efficiency is at a high level. Long-term gaps are mainly attributed to regional differences and transvariation intensity. The study also highlights the importance of efficiency change and technological change in improving carbon emission efficiency.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Food Science & Technology
Bingbing Chen, Yumeng Shi, Kai Zhang, Yanzhong Chang, Pengcheng Fu, Pingsheng Liu, Shuyan Zhang
Summary: Increased consumption of high-fat low-fiber foods is associated with the development of metabolic syndromes. Fermentable dietary fiber, such as inulin, can alleviate metabolic abnormalities. This study systematically investigated the effect of inulin on mice with metabolic disorders induced by short-term and long-term high-fat feeding. The results showed that inulin reduced body weight, improved glucose intolerance, and alleviated hepatic steatosis in both groups of mice, suggesting a potential mechanism mediated through the modulation of gut microbiota.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Biochemical Research Methods
Linjia Cheng, Yilu Xu, Kangling Zhu, Bin Liang, Shuyan Zhang, Pingsheng Liu
Summary: In this study, a generally applicable method for preparing high-quality protein samples from animal tissues and achieving near 100% recovery of proteins was established. The method overcomes issues such as protein degradation and modification during sample preparation and assay interference. The protein content is represented by equal wet tissue mass, providing a better means to present the expression level of a protein in various tissues. High-quality protein samples from almost all tissues can be prepared.
PROTEOMICS CLINICAL APPLICATIONS
(2023)
Article
Materials Science, Biomaterials
Yaning Dong, Youxin Li, Birong Fan, Wan Peng, Weijian Qian, Xiaoxue Ji, Donglin Gan, Pingsheng Liu
Summary: A new type of quaternized lignin-functionalized poly(hexamethylene biguanide) hydrochloride (QL-PHMB-PAM) hydrogel was developed as a multifunctional dressing material for infected wound repair. This hydrogel exhibited strong adhesiveness and antioxidative properties, and showed high efficiency and long-term antibacterial activity against pathogens such as Staphylococcus aureus and Escherichia coli. In vivo experiments demonstrated that this hydrogel accelerated the healing of infected wounds by promoting blood vessel and hair follicle reconstruction, making it a promising alternative wound dressing material.
BIOMATERIALS SCIENCE
(2023)
Article
Engineering, Biomedical
Peiming Liu, Jin Sun, Wan Peng, Yahui Gu, Xiaoxue Ji, Zhi Su, Pingsheng Liu, Jian Shen
Summary: Good's buffers have been widely used in cell/organ culture as biocompatible pH stabilizers. However, the emergence of adverse effects such as cellular uptake, autophagic activation, and cytotoxicity under light exposure raises concerns over its biocompatibility. Riboflavin in the cell culture medium produces reactive oxygen species (ROS) under light exposure, causing severe toxicity and disruption of normal cell functions. Zwitterionic betaines have been identified as a new generation of biocompatible pH buffers that do not exhibit these adverse effects.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Wan Peng, Birong Fan, Youxin Li, Yaning Dong, Weijian Qian, Xiaoxue Ji, Donglin Gan, Pingsheng Liu, Jian Shen
Summary: This study presents a layer-by-layer strategy for the construction of a dual-functional coating on silicone rubber substrates, which possesses both antifouling and bactericidal properties. The optimal copolymer composition of 70% SBMA and 30% NHSMA exhibited a highly efficient overall antibacterial property with near 100% antibacterial ratio without compromising cellular viability. This strategy can be applied to various silicone rubber-based biomedical devices requiring antibacterial surfaces.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Xiaohan Dong, Wan Peng, Jin Sun, Youxin Li, Birong Fan, Yaning Dong, Donglin Gan, Weibing Zhang, Pingsheng Liu, Jian Shen
Summary: Zwitterionic phosphorylcholine-based polymers have dual functionality in inhibiting biofilm formation and inducing re-mineralization of damaged dental tissues. The copolymers exhibit high affinity to dentine substrates and efficiently inhibit protein adsorption and bacterial adhesion. Furthermore, they promote robust re-mineralization of dentine surfaces and tubules, making them a promising candidate for treating dental hypersensitivity and related diseases.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Materials Science, Biomaterials
Zhuangzhang Ma, Jin Sun, Xiaohan Dong, Donglin Gan, Wan Peng, Youxin Li, Weijian Qian, Pingsheng Liu, Jian Shen
Summary: In this study, a general strategy was reported to address bacterial-associated infection, blood coagulation, and tissue adhesion on polyurethane substrates. Well-defined block polymers were constructed on the substrates and showed significant anti-fouling and anti-attachment properties against protein, bacteria, platelets, and cells. The coating also improved the lubricating property of the substrates without compromising their mechanical performance.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
