Article
Biochemistry & Molecular Biology
Liujun Jiang, Xiaolei Sun, Jiacheng Deng, Yanhua Hu, Qingbo Xu
Summary: Significant progress has been made in understanding the nature and functions of vascular stem cells, particularly in cardiovascular research. Recent studies using genetic lineage tracing mouse models have shed light on the behaviors of these cells during physiological angiogenesis and in vascular diseases. Further research using new techniques is crucial to fully elucidate the role of vascular stem cells in development and diseases.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Biochemistry & Molecular Biology
Girish Jayant, Stephen Kuperberg, Kaumudi Somnay, Raj Wadgaonkar
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by scarring and fibrotic transformation of the lung, leading to respiratory function loss and often death. Increased vascular permeability has been identified as a contributing factor to fibrogenesis. Sphingolipids, particularly the sphingosine-1-phosphate (S1P) axis, play a critical role in cell signaling pathways affecting vascular endothelial integrity. This review focuses on the role of sphingolipids in IPF pathogenesis and explores the potential of S1P modulators as therapeutic targets for IPF.
Review
Physiology
Simone Regina Potje, Tiago Dal-Cin Paula, Michele Paulo, Lusiane Maria Bendhack
Summary: This review summarizes the role of endothelial glycocalyx and caveolae in vascular homeostasis, with a focus on their association with impaired nitric oxide production and reactive oxygen species generation, which may contribute to the development of cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Hematology
Pascal Yazbeck, Xavier Cullere, Paul Bennett, Vijay Yajnik, Huan Wang, Kenji Kawada, Vanessa M. Davis, Asit Parikh, Andrew Kuo, Vijayashree Mysore, Timothy Hla, David S. Milstone, Tanya N. Mayadas
Summary: The study reveals that DOCK4, an atypical Rho family GTPase GEF, plays a critical role in lung vascular barrier function by regulating AJs. DOCK4 deficiency leads to lung hemorrhage, increased microvascular permeability, and impaired response to S1P-induced permeability changes. Additionally, S1P may act as a potential upstream regulator of DOCK4 activity.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Chao Ye, Fen Zheng, Nan Wu, Guo-qing Zhu, Xiu-zhen Li
Summary: Vascular remodeling plays a crucial role in the development of various vascular diseases and is closely associated with the release of extracellular vesicles (EVs). EVs impact vascular remodeling by affecting oxidative stress, inflammation, calcification, and lipid plaque formation. Therefore, EVs have the potential to be used as biomarkers for diagnosis and prognosis, as well as therapeutic targets for vascular remodeling and cardiovascular diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Pharmacology & Pharmacy
Shigang Lin, Ruoran Lin, Hongkun Zhang, Qingbo Xu, Yangyan He
Summary: This review focuses on the functional changes of peripheral arterial cells and the mechanisms of PAD pathogenesis. It summarizes the progress of current clinical treatment and potential therapeutic methods for PAD, and provides insights for future perspectives.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Bryce R. Evans, Anais Yerly, Emiel P. C. van der Vorst, Iris Baumgartner, Sarah Maike Bernhard, Marc Schindewolf, Yvonne Doering
Summary: Atherosclerotic vascular disease is the most common cause of ischemia, myocardial infarction, and stroke. The structure and function of the arterial vessel wall, consisting of the adventitia, media, and intima, determine vascular function. Vascular smooth muscle cells and endothelial cells are key in shaping the vascular wall and maintaining proper function. Atherosclerosis, initiated by endothelial dysfunction, leads to pathological alterations known as vascular remodeling, ultimately causing insufficient vascular function and cardiovascular events.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alberto Canfran-Duque, Noemi Rotllan, Xinbo Zhang, Irene Andres-Blasco, Bonne M. Thompson, Jonathan Sun, Nathan L. Price, Marta Fernandez-Fuertes, Joseph W. Fowler, Diego Gomez-Coronado, William C. Sessa, Chiara Giannarelli, Robert J. Schneider, George Tellides, Jeffrey G. McDonald, Carlos Fernandez-Hernando, Yajaira Suarez
Summary: The accumulation of 25-hydroxycholesterol (25-HC) in human coronary atherosclerotic lesions accelerates atherosclerosis progression and promotes plaque instability through autocrine and paracrine actions. Macrophage-derived 25-HC intensifies the inflammatory response of lipid-loaded macrophages and inhibits smooth muscle cell migration within the plaque. These effects are independent of 25-HC-mediated modulation of transcriptional activity.
Review
Pharmacology & Pharmacy
Belay Tesfamariam
Summary: Vascular scaffold implantation causes injury to the intimal layer and disrupts the regenerated endothelial monolayer, leading to compromised barrier integrity and increased permeability. Mechanical stretching of the vascular wall triggers RhoA/Rho kinase-mediated contractility, resulting in destabilization of adherens junctions and endothelial barrier dysfunction. This review highlights the involvement of Rho GTPases in the disruption of endothelial barrier integrity following vascular scaffold implantation and the potential of targeting downstream Rho-associated protein kinases to restore endothelial barrier integrity and stability.
DRUG DISCOVERY TODAY
(2023)
Review
Hematology
Eric Engelbrecht, Calum A. MacRae, Timothy Hla
Summary: Membrane phospholipid metabolism produces lysophospholipids, which act as ligands for G-protein-coupled receptors influencing various biological processes. Lysophosphatidic acid and S1P are particularly significant in vascular development and cardiovascular diseases, with potential connections to the Wnt pathway. These findings highlight the importance of lysophospholipid signaling in cardiovascular disease and the potential for novel therapeutic strategies.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lan-Lan Bu, Huan-Huan Yuan, Ling-Li Xie, Min-Hua Guo, Duan-Fang Liao, Xi-Long Zheng
Summary: This review examines the molecular mechanisms and functional alterations associated with endothelial cell senescence and death in different stages of atherosclerosis, highlighting the various factors and forms of cell death involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
Bingyang Lu, Xiao Han, Ansha Zhao, Dan Luo, Manfred F. Maitz, Haohao Wang, Ping Yang, Nan Huang
Summary: Coronary atherosclerosis lesions exhibit a low-pH chronic inflammatory response. A novel method using pH-responsive self-assembling films with hydrogen sulfide (H2S) releasing aspirin derivative ACS14 as drug has been developed to regulate drug release adjusted to the lesion's microenvironment, promoting self-healing capacity of blood vessels. Experimentation showed promising results for treating cardiovascular diseases.
BIOACTIVE MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Vijaya Karoor, Derek Strassheim, Timothy Sullivan, Alexander Verin, Nagavedi S. Umapathy, Edward C. Dempsey, Daniel N. Frank, Kurt R. Stenmark, Evgenia Gerasimovskaya
Summary: Butyrate shows protective effects in a rat model of hypoxic pulmonary hypertension by preventing pulmonary vascular remodeling and increased permeability, reducing right ventricular hypertrophy, and increasing histone H3 acetylation. Additionally, it modulates cytokine profiles in lung tissue and upregulates tight junctional proteins in endothelial cells, suggesting its potential as a complementary treatment for PH and other cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
William Durante, Ghazaleh Behnammanesh, Kelly J. Peyton
Summary: SGLT2 inhibitors improve cardiovascular outcomes in patients with diabetes through various mechanisms such as increasing nitric oxide bioavailability, regulating endothelial cell function, and exerting antioxidant and anti-inflammatory effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lucia Serrano Diaz Del Campo, Raquel Rodrigues-Diez, Mercedes Salaices, Ana M. Briones, Ana B. Garcia-Redondo
Summary: Vascular remodeling is a typical feature of vascular diseases, and inflammation plays a key role in regulating this process. Specialized pro-resolving mediators (SPMs) can modulate the function of vascular cells and protect against the development of vascular remodeling in cardiovascular diseases such as atherosclerosis, aneurysms, and restenosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
