A Biochemical Approach to Understand the Pathogenesis of Advanced Pulmonary Arterial Hypertension: Metabolomic Profiles of Arginine, Sphingosine-1-Phosphate, and Heme of Human Lung

Elevation of Plasma Cell-Free Hemoglobin in Pulmonary Arterial Hypertension

(2014) Evan L. Brittain et al.   CHEST

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Metabolomic Heterogeneity of Pulmonary Arterial Hypertension

(2014) Yidan Zhao et al.   PLoS One

Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimer’s disease pathogenesis

(2014) Timothy A Couttas et al.   Acta Neuropathologica Communications

Sphingolipid Modulation: A Strategy for Cancer Therapy

(2012) Antonio Delgado et al.   Anti-Cancer Agents in Medicinal Chemistry

Comprehensive Mass Spectrometric Mapping of the Hydroxylated Amino Acid residues of the α1(V) Collagen Chain

(2012) Chenxi Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perturbation of sphingolipid metabolism induces endoplasmic reticulum stress-mediated mitochondrial apoptosis in budding yeast

(2012) Kentaro Kajiwara et al.   MOLECULAR MICROBIOLOGY

Metabolomic Analysis of Bone Morphogenetic Protein Receptor Type 2 Mutations in Human Pulmonary Endothelium Reveals Widespread Metabolic Reprogramming

(2012) Joshua P. Fessel et al.   Pulmonary Circulation

Targeting Energetic Metabolism

(2011) Rubin M. Tuder et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dysregulation of sphingolipid metabolism in cancer

(2011) Lindsay K. Ryland et al.   CANCER BIOLOGY & THERAPY

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling

(2010) B. S. Zuckerbraun et al.   CARDIOVASCULAR RESEARCH

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era

(2010) Marc Humbert et al.   CIRCULATION

Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension

(2010) G. Sutendra et al.   Science Translational Medicine

Bilirubin as a prognostic marker in patients with pulmonary arterial hypertension

(2010) Yasuko Takeda et al.   BMC Pulmonary Medicine

Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration

(2009) You-Yang Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Sickle cell disease vasculopathy: A state of nitric oxide resistance

(2008) Katherine C. Wood et al.   FREE RADICAL BIOLOGY AND MEDICINE