Article
Biochemistry & Molecular Biology
Roopa Siddaiah, Christiana N. Oji-Mmuo, Deborah T. Montes, Nathalie Fuentes, Debra Spear, Ann Donnelly, Patricia Silveyra
Summary: Bronchopulmonary dysplasia (BPD) is a chronic lung disease that develops in neonates as a consequence of preterm birth and inflammation. The study identified certain miRNAs in tracheal aspirates of preterm infants with severe BPD, suggesting their potential as biomarkers for disease severity in infants with BPD.
Review
Pediatrics
Amelie Stritzke, Vineet Bhandari, Abhay Lodha
Summary: The use of iNO in premature infants is controversial, with no significant impact on survival or other morbidities based on substantial evidence. Most scientific organizations do not recommend iNO use in preterm infants, except in unique clinical circumstances.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Article
Obstetrics & Gynecology
Sophia Baig, Pragnya Das, Niharika Podaralla, Alan Evangelista, Ishminder Kaur, Vineet Bhandari
Summary: This study found a correlation between the presence of polymorphonuclear cells and microbial growth with the levels of proinflammatory cytokines in the tracheal aspirates of ventilated preterm infants. Higher cell counts and presence of microbial growth were associated with increased levels of proinflammatory cytokines IL-10, IL-1 beta, and TNF-alpha in the tracheal aspirates.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Article
Medicine, Research & Experimental
Jordana Grazziela A. Coelho dos Reis, Geovane Marques Ferreira, Alice Aparecida Lourenco, Agata Lopes Ribeiro, Camila Pacheco da Silveira Martins da Mata, Patricia de Melo Oliveira, Daisymara Priscila de Almeida Marques, Linziane Lopes Ferreira, Felipe Alves Clarindo, Murillo Ferreira da Silva, Heitor Portella Povoas Filho, Nilson Roberto Ribeiro Oliveira, Maisah Meyhr D'Carmo Sodre, Sandra Rocha Gadelha, George Rego Albuquerque, Bianca Mendes Maciel, Ana Paula Melo Mariano, Mylene de Melo Silva, Renato Fontana, Lauro Juliano Marin, Renata Santiago Alberto Carlos, Amanda Teixeira Sampaio Lopes, Fabricio Barbosa Ferreira, Uener Ribeiro dos Santos, Iris Terezinha Santos de Santana, Hllytchaikra Ferraz Fehlberg, Rachel Passos Rezende, Joao Carlos T. Dias, Eduardo Gross, Gisele Assis Castro Goulart, Marie Gabriele Santiago, Ana Paula Motta Lavigne de Lemos, Aline O. da Conceicao, Carla Cristina Romano, Luciana Debortoli de Carvalho, Olindo Assis Martins Filho, Claudio Almeida Quadros, David L. Morris, Sarah J. Valle
Summary: This study evaluated the mucolytic and anti-inflammatory effects of BromAc (R) in tracheal aspirate samples from critically ill COVID-19 patients. The results showed that BromAc (R) had a significant mucolytic effect and reduced the action of cytokine storm, indicating its potential as a pharmacological treatment for COVID-19.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pediatrics
Liina Suvari, Otto M. Helve, M. Anneli Kari, L. Ursula Turpeinen, P. Anniina Palojarvi, Markus J. Leskinen, Sture Andersson, A. Cecilia Janer
Summary: The study found that infants with RDS had significantly lower umbilical cord blood GC concentrations, which were correlated with oxygen supplementation. Within the first 2 hours after birth, the expression of α-ENaC, α1, and β1Na,K-ATPase was correlated with cord blood betamethasone and total GC concentrations. Overall, enhancing lung liquid absorption through increased expression of sodium transporters may contribute to the beneficial effects of antenatal GCs on the lungs.
PEDIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Wes Onland, Martin Offringa, Anton van Kaam
Summary: Bronchopulmonary dysplasia (BPD), a common complication of prematurity, can be treated with systemic corticosteroids but may have adverse neurodevelopmental effects. This study evaluated the benefits and harms of inhaled corticosteroids as an alternative treatment for preterm infants at risk of developing BPD. The evidence regarding the effectiveness of inhaled corticosteroids on mortality and BPD at 36 weeks' postmenstrual age is uncertain. More research is needed to establish the potential benefits and harms of this treatment.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Multidisciplinary Sciences
Jordan T. Russell, J. Lauren Ruoss, Diomel de la Cruz, Nan Li, Catalina Bazacliu, Laura Patton, Kelley Lobean McKinley, Timothy J. Garrett, Richard A. Polin, Eric W. Triplett, Josef Neu
Summary: The use of antibiotics in neonates can affect the gut microbiome diversity, while different types of nutrition shape the early infant gut microbiome. The study discovered an association between Veillonella and the neurotransmitter gamma-aminobutyric acid (GABA).
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Camilla Rigotti, Emanuela Zannin, Chiara Veneroni, Maria Luisa Ventura, Raffaele L. Dellaca
Summary: This study aims to explore the short-term repeatability of forced oscillation technique (FOT) measurement of lung function, assess the lung function response to bronchodilators (BDs) by FOT, and prove that only some very preterm infants manifest a change in lung mechanics in response to BD. The results suggest a threshold for assessing BD responsiveness by FOT in preterm infants and propose the potential use of FOT in evaluating and personalizing BD treatment.
JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Joseph M. Collaco, Sharon A. McGrath-Morrow, Megan Griffiths, Raul Chavez-Valdez, Charlamaine Parkinson, Jie Zhu, Frances J. Northington, Ernest M. Graham, Allen D. Everett
Summary: Lower plasma levels of VEGF during the first week of life are associated with the diagnosis of RDS in preterm infants. Preterm infants with higher levels of IL-6 and IL-8 during the first week of life are also more likely to be diagnosed with BPD.
JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Rachel Mullaly, Naomi McCallion, Afif El-Khuffash
Summary: This systematic literature review examines the effect of inhaled nitric oxide (iNO) on preterm neonates with preterm prelabour rupture of membranes (PPROM) and early hypoxaemic respiratory failure (HRF). The findings suggest that iNO can improve oxygenation when standard care fails, but it may also increase mortality and morbidity, possibly due to the high prevalence of pulmonary hypertension in this cohort.
Article
Pediatrics
Siamak M. Yazdi, Ekta U. Patel, Colby D. Richardson, K. Thomas Hardy, John E. Baatz, Jennifer K. Mulligan, Rita M. Ryan
Summary: This study demonstrates that dexamethasone treatment significantly reduces the severity of bronchopulmonary dysplasia (BPD) in preterm infants by decreasing respiratory severity score (RSS), CD4+IL-6+ cells, CD8+IL-6+ cells, CXCR3+IL-6+ cells, and CXCR3+IL-2+ cells, as well as total IFN-gamma in TA. Additionally, the study found a significant correlation between RSS and CD4+IL-6+ cells in TA.
Article
Biochemistry & Molecular Biology
Samuel J. Gentle, Khandaker A. Ahmed, Nengjun Yi, Casey D. Morrow, Namasivayam Ambalavanan, Charitharth Lal, Rakesh P. Patel
Summary: The study found that nitrate reductase activity in the oral cavity peaked at 29 weeks' post menstrual age, and infants who developed bronchopulmonary dysplasia (BPD) had significantly lower nitrate reductase activity at this time. The oral microbiota and nitrate reductase activity may play a role in the development of BPD in extremely preterm infants.
Article
Nutrition & Dietetics
Alicja Kolodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka
Summary: A study was conducted to assess the effectiveness of monitored vitamin D supplementation in preterm infants. Results showed that a higher percentage of infants in the monitored group had safe vitamin D levels, while potential vitamin D toxicity was observed in the standard treatment group. Therefore, vitamin D intake should be between 800-1000 IU and monitored to avoid overdose.
Article
Pediatrics
Belal Alshaikh, Jumana Samara, Shirin Moossavi, Tahsin Ferdous, Amuchou Soraisham, Deonne Dersch-Mills, Marie-Claire Arrieta, Harish Amin
Summary: This study found that the use of probiotics in extremely low-birth-weight infants can shorten the time to achieve full enteral feeds and reduce the incidence of cow's milk protein intolerance symptoms.
PEDIATRIC RESEARCH
(2022)
Article
Pediatrics
Katinka P. Bach, Carl A. Kuschel, Nicola Patterson, Hana Skwish, Sabine Huth, Hui Hui Phua, Frank H. Bloomfield
Summary: This study found that lower bias gas flow in ventilated extremely preterm infants did not alter tracheal aspirate cytokine concentrations, but the lower incidence of necrotizing enterocolitis and mortality warrants further investigation.
Article
Acoustics
Martin Poryo, Anika Zimmer, Amr Hamza, Stefan Wagenpfeil, Michael Zemlin, Martina Geipel, Guenther Loeffler, Sascha Meyer, Erol Tutdibi
ULTRASCHALL IN DER MEDIZIN
(2022)
Letter
Pediatrics
Anna-Veera Seppanen, Elizabeth S. Draper, Stavros Petrou, Henrique Barros, Lazaros Andronis, Sung Wook Kim, Rolf F. Maier, Pernille Pedersen, Janusz Gadzinowski, Jo Lebeer, Ulrika Aden, Liis Toome, Arno F. J. van Heijst, Marina Cuttini, Jennifer Zeitlin
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2022)
Correction
Pediatrics
Martin Poryo, Steffi Hess, Lilly Stock, Sarah Ruffing, Michael Zemlin, Sascha Meyer
KLINISCHE PADIATRIE
(2022)
Editorial Material
Pediatrics
Martin Poryo, Lilly Stock, Sarah Ruffing, Michael Zemlin, Sascha Meyer
KLINISCHE PADIATRIE
(2023)
Article
Environmental Sciences
Noura Zayat, Patrick Truffert, Elodie Drumez, Alain Duhamel, Julien Labreuche, Michael Zemlin, David Milligan, Rolf F. Maier, Pierre-Henri Jarreau, Heloise Torchin, Jennifer Zeitlin, Alexandra Nuytten
Summary: This study suggests that postnatal steroids (PNS) may be associated with an increased risk of gross motor impairment in preterm infants, regardless of their risk of bronchopulmonary dysplasia (BPD). However, there is an increased risk of cognitive anomalies for patients treated with dexa/betamethasone that is no longer observed with hydrocortisone.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Mandy Laube, Ulrich H. Thome
Summary: This article discusses sex-specific differences in alveolar epithelial functions, with a focus on preterm infants and respiratory disorders associated with premature birth. It provides an overview of fetal lung development and the challenges faced during the transition to air breathing. The article also explores potential sex-specific causes of pulmonary complications and highlights the importance of understanding steroidogenic enzymes' expression during fetal lung development. Additionally, it reviews the knowledge about sex-specific aspects of lung growth and maturation, with a special emphasis on alveolar epithelial Na+ transport and the observed sex differences in this process.
Article
Pediatrics
Justine Hussong, Eva Mohler, Anna Kuhn, Markus Wenning, Thomas Gehrke, Holger Burckhart, Ulf Richter, Alexandra Nonnenmacher, Michael Zemlin, Thomas Lucke, Folke Brinkmann, Tobias Rothoeft, Thorsten Lehr
Summary: Evaluations after the third wave of COVID-19 in Germany showed that adolescents who chose to receive a vaccination experienced improved mental health and higher health-related quality of life. Compared to evaluations after the first and second waves, adolescents reported higher quality of life and fewer mental health problems. This may be attributed to their adaptation to the changes brought by the pandemic, as well as the relaxation of restrictions and the prospect of vaccination.
Article
Pediatrics
Masood Abu-Halima, Felix Sebastian Oberhoffer, Viktoria Wagner, Mohamed Abd El Rahman, Anna-Maria Jung, Michael Zemlin, Tilman R. Rohrer, Eckart Meese, Hashim Abdul-Khaliq
Summary: This study found that the abundance levels of circulating miR-126-3p and miR-126-5p were significantly higher in Turner Syndrome (TS) patients compared to healthy volunteers (HVs). Within the TS cohort, a lower abundance level of miR-126-3p and miR-126-5p was associated with significantly higher aortic stiffness.
Article
Biochemistry & Molecular Biology
Mandy Laube, Ulrich H. Thome
Summary: Albumin enhances epithelial Na+ transport and barrier integrity by activating the PI3K/AKT/SGK1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pediatrics
Elisabeth Kaiser, Regine Stutz, Sybelle Goedicke-Fritz, Michelle Bous, Michael Zemlin, Christian Adams
Summary: Premature infants are exposed to high sound levels, especially during non-invasive ventilation, with sound pressure levels increasing particularly in the non-physiological high-frequency range. An optimized design of the incubator can further reduce continuous sound exposure.
KLINISCHE PADIATRIE
(2023)
Article
Clinical Neurology
Raquel Costa, Adrien M. Aubert, Anna-Veera Seppanen, Ulrika Aden, Iemke Sarrechia, Michael Zemlin, Marina Cuttini, Mairi Mannamaa, Veronique Pierrat, Arno van Heijst, Henrique Barros, Jennifer Zeitlin, Samantha Johnson
Summary: This study aimed to assess the accuracy of parent-reported gross motor impairment (GMI) at age 2 in predicting significant movement difficulties at age 5 in extremely preterm children. The results showed that parent reports of GMI at age 2 accurately classified movement difficulties at age 5 in most children. However, there were some cases where children with movement difficulties at age 5 were not identified at age 2.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Acoustics
Paula Freundt, Nasenien Nourkami-Tutdibi, Erol Tutdibi, Paul Janzing, Thomas von Ostrowski, Martin Langer, Michael Zemlin, Johannes Steinhard
Summary: This study aimed to analyze the feasibility of using a high-end simulator with a randomly moving fetus for structured ultrasound simulation training (SIM-UT) in teaching second-trimester ultrasound screening. The results showed that novices significantly improved their ultrasound skills after 8 hours of training, reaching the level of physicians. After 12 hours of SIM-UT, the trial group performed faster than the physician group and obtained standard planes close to expert level.
ULTRASCHALL IN DER MEDIZIN
(2023)
Article
Nutrition & Dietetics
Cosima Zemlin, Laura Altmayer, Caroline Stuhlert, Julia Theresa Schleicher, Carolin Woermann, Marina Lang, Laura-Sophie Scherer, Ida Clara Thul, Lisanne Sophie Spenner, Jana Alisa Simon, Alina Wind, Elisabeth Kaiser, Regine Weber, Sybelle Goedicke-Fritz, Gudrun Wagenpfeil, Michael Zemlin, Erich-Franz Solomayer, Joerg Reichrath, Carolin Mueller
Summary: This study aimed to analyze serum 25-hydroxyvitamin D (25(OH)D) levels in newly diagnosed breast cancer patients and its association with prognostic and lifestyle factors. The results showed a common deficiency of vitamin D in breast cancer patients, but did not support the hypothesis that vitamin D deficiency may be a main prognostic factor for breast cancer.
Article
Biochemistry & Molecular Biology
Michelle Bous, Charline Schmitt, Muriel Charlotte Hans, Regine Weber, Nasenien Nourkami-Tutdibi, Sebastian Tenbruck, Bashar Haj Hamoud, Gudrun Wagenpfeil, Elisabeth Kaiser, Erich-Franz Solomayer, Michael Zemlin, Sybelle Goedicke-Fritz
Summary: The sex of the newborn may affect the lymphocyte subpopulations in cord blood, with higher frequencies of B cell counts in male newborns and higher counts of certain T cell subpopulations in female newborns. This indicates that sex may have a significant impact on the developing immune system, emphasizing the need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Obstetrics & Gynecology
Paul Janzing, Nasenien Nourkami-Tutdibi, Erol Tutdibi, Paula Freundt, Thomas von Ostrowski, Martin Langer, Michael Zemlin, Johannes Steinhard
Summary: The purpose of this study was to analyze the learning curves of ultrasound novices in fetal echocardiography during structured simulation-based ultrasound training (SIM-UT). The results showed that the students consistently improved their ultrasound performance during the 6-week training program. After 6 weeks, they were able to reach the same skill level as the expert group in acquiring the AHA/ISUOG fetal echocardiography standard planes. SIM-UT is highly effective for learning fetal echocardiography.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)