mRNA as novel technology for passive immunotherapy

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

(2018) Norbert Pardi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a

(2018) Daniel S. Roseman et al.   MOLECULAR THERAPY

Targeted mRNA Therapy for Ornithine Transcarbamylase Deficiency

(2018) Mary G. Prieve et al.   MOLECULAR THERAPY

A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates

(2018) Staci Sabnis et al.   MOLECULAR THERAPY

Optimization of mRNA untranslated regions for improved expression of therapeutic mRNA

(2018) Kirtika H. Asrani et al.   RNA Biology

mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice

(2018) Susan Liu-Chen et al.   Scientific Reports

A cell-penetrating whole molecule antibody targeting intracellular HBx suppresses hepatitis B virus via TRIM21-dependent pathway

(2018) Jun-Fang Zhang et al.   Theranostics

Trans -acting translational regulatory RNA binding proteins

(2018) Robert F. Harvey et al.   Wiley Interdisciplinary Reviews-RNA

Biocompatible, Purified VEGF-A mRNA Improves Cardiac Function after Intracardiac Injection 1 Week Post-myocardial Infarction in Swine

(2018) Leif Carlsson et al.   Molecular Therapy-Methods & Clinical Development

Exploring Cytotoxic mRNAs as a Novel Class of Anti-cancer Biotherapeutics

(2018) Kristin Hirschberger et al.   Molecular Therapy-Methods & Clinical Development

Bezlotoxumab (Zinplava) for Prevention of Recurrent Clostridium Difficile Infection

(2017)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

State of play and clinical prospects of antibody gene transfer

(2017) Kevin Hollevoet et al.   Journal of Translational Medicine

Chemical and structural effects of base modifications in messenger RNA

(2017) Emily M. Harcourt et al.   NATURE

Elimination of large tumors in mice by mRNA-encoded bispecific antibodies

(2017) Christiane R Stadler et al.   NATURE MEDICINE

Codon optimality, bias and usage in translation and mRNA decay

(2017) Gavin Hanson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Systemic delivery of factor IX messenger RNA for protein replacement therapy

(2017) Suvasini Ramaswamy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia

(2017) Ding An et al.   Cell Reports

Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

(2017) Andreas H. Laustsen et al.   PLoS Neglected Tropical Diseases

Novel T cells with improved in vivo anti-tumor activity generated by RNA electroporation

(2017) Xiaojun Liu et al.   Protein & Cell

Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer

(2017) Julia Tchou et al.   Cancer Immunology Research

Fundamentals and Methods for T- and B-Cell Epitope Prediction

(2017) Jose L. Sanchez-Trincado et al.   Journal of Immunology Research

Translation of Angiotensin-Converting Enzyme 2 upon Liver- and Lung-Targeted Delivery of Optimized Chemically Modified mRNA

(2017) Eva Schrom et al.   Molecular Therapy-Nucleic Acids

Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats

(2016) Elizabeth R. Balmayor et al.   BIOMATERIALS

Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo

(2016) Kevin J. Kauffman et al.   BIOMATERIALS

Optimizing T-cell receptor gene therapy for hematologic malignancies

(2016) Emma C. Morris et al.   BLOOD

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

(2016) F DeRosa et al.   GENE THERAPY

Structure, activity and uptake mechanism of siRNA-lipid nanoparticles with an asymmetric ionizable lipid

(2016) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

CD19 CAR–T cells of defined CD4+:CD8+ composition in adult B cell ALL patients

(2016) Cameron J. Turtle et al.   JOURNAL OF CLINICAL INVESTIGATION

Messenger RNA-based therapeutics for brain diseases: An animal study for augmenting clearance of beta-amyloid by intracerebral administration of neprilysin mRNA loaded in polyplex nanomicelles

(2016) Chin-Yu Lin et al.   JOURNAL OF CONTROLLED RELEASE

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Systematic screening of soluble expression of antibody fragments in the cytoplasm of E. coli

(2016) Anna Gaciarz et al.   Microbial Cell Factories

Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome

(2016) Xiaoyu Li et al.   Nature Chemical Biology

Chimeric antigen receptor-modified T cells for the treatment of solid tumors: Defining the challenges and next steps

(2016) Gregory L. Beatty et al.   PHARMACOLOGY & THERAPEUTICS

A novel intracellular antibody against the E6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models

(2016) Carla Amici et al.   Oncotarget

Intrathecal delivery of frataxin mRNA encapsulated in lipid nanoparticles to dorsal root ganglia as a potential therapeutic for Friedreich’s ataxia

(2016) Joseph F. Nabhan et al.   Scientific Reports

Post-exposure Treatment with Anti-rabies VHH and Vaccine Significantly Improves Protection of Mice from Lethal Rabies Infection

(2016) Sanne Terryn et al.   PLoS Neglected Tropical Diseases

Chimeric Antigen Receptors Modified T-Cells for Cancer Therapy

(2016) Hanren Dai et al.   JNCI-Journal of the National Cancer Institute

Clinical use of blinatumomab for B-cell acute lymphoblastic leukemia in adults

(2016) Mojtaba Akhtari et al.   Therapeutics and Clinical Risk Management

Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies

(2016) Sebastian P Fuchs et al.   Molecular Therapy-Methods & Clinical Development

Immunological quality and performance of tumor vessel-targeting CAR-T cells prepared by mRNA-EP for clinical research

(2016) Kanako Inoo et al.   Molecular Therapy-Oncolytics

Phenotypic lentivirus screens to identify functional single domain antibodies

(2016) Florian I. Schmidt et al.   Nature Microbiology

Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

(2015) Zeguo Zhao et al.   CANCER CELL

T-Cell Therapy: Options for Infectious Diseases: Table 1.

(2015) Shreemanta K. Parida et al.   CLINICAL INFECTIOUS DISEASES

In situproduction of therapeutic monoclonal antibodies

(2015) Todd J Suscovich et al.   Expert Review of Vaccines

A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2′O-Methylated Self RNA

(2015) Christine Schuberth-Wagner et al.   IMMUNITY

Treatment of neurological disorders by introducing mRNA in vivo using polyplex nanomicelles

(2015) Miyuki Baba et al.   JOURNAL OF CONTROLLED RELEASE

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Blinatumomab: a bispecific T cell engager (BiTE) antibody against CD19/CD3 for refractory acute lymphoid leukemia

(2015) Jingjing Wu et al.   Journal of Hematology & Oncology

Chimeric Antigen Receptor– and TCR-Modified T Cells Enter Main Street and Wall Street

(2015) David M. Barrett et al.   JOURNAL OF IMMUNOLOGY

Antibody Glycosylation and Its Impact on the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies and Fc-Fusion Proteins

(2015) Liming Liu   JOURNAL OF PHARMACEUTICAL SCIENCES

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

(2015) Kevin O. Saunders et al.   JOURNAL OF VIROLOGY

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

(2015) Daniel W Lee et al.   LANCET

Alternative molecular formats and therapeutic applications for bispecific antibodies

(2015) Christoph Spiess et al.   MOLECULAR IMMUNOLOGY

Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals

(2015) Andreas Thess et al.   MOLECULAR THERAPY

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

(2015) Azita J Mahiny et al.   NATURE BIOTECHNOLOGY

Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome

(2015) Xiaoyu Li et al.   Nature Chemical Biology

Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

(2015) Jean-Charles Nault et al.   NATURE GENETICS

Generation of knock-in primary human T cells using Cas9 ribonucleoproteins

(2015) Kathrin Schumann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adoptive cell transfer as personalized immunotherapy for human cancer

(2015) S. A. Rosenberg et al.   SCIENCE

Screening of mRNA Chemical Modification to Maximize Protein Expression with Reduced Immunogenicity

(2015) Satoshi Uchida et al.   Pharmaceutics

Pharmacokinetics and Immunogenicity of Broadly Neutralizing HIV Monoclonal Antibodies in Macaques

(2015) Yvonne Rosenberg et al.   PLoS One

Current concepts in the diagnosis and management of cytokine release syndrome

(2014) D. W. Lee et al.   BLOOD

A GMP-compliant protocol to expand and transfect cancer patient T cells with mRNA encoding a tumor-specific chimeric antigen receptor

(2014) Christian Krug et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination

(2014) Aline Baldo et al.   CURRENT GENE THERAPY

TALEN-mediated editing of endogenous T-cell receptors facilitates efficient reprogramming of T lymphocytes by lentiviral gene transfer

(2014) B Berdien et al.   GENE THERAPY

Going viral: chimeric antigen receptor T-cell therapy for hematological malignancies

(2014) Saar Gill et al.   IMMUNOLOGICAL REVIEWS

Current advances in T-cell-based cancer immunotherapy

(2014) Mingjun Wang et al.   Immunotherapy

   T Cell Receptor Transfer to    T Cells Generates Functional Effector Cells without Mixed TCR Dimers In Vivo

(2014) L. T. van der Veken et al.   JOURNAL OF IMMUNOLOGY

Single-Domain Antibodies Targeting Neuraminidase Protect against an H5N1 Influenza Virus Challenge

(2014) F. M. Cardoso et al.   JOURNAL OF VIROLOGY

Phase III safety study of rituximab administered as a 90-minute infusion in patients with previously untreated diffuse large B-cell and follicular lymphoma

(2014) Shaker Dakhil et al.   LEUKEMIA & LYMPHOMA

Delivery of antibodies to the cytosol

(2014) Andrea LJ Marschall et al.   mAbs

Complement activation-related pseudoallergy: A stress reaction in blood triggered by nanomedicines and biologicals

(2014) Janos Szebeni   MOLECULAR IMMUNOLOGY

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

Bispecific antibodies rise again

(2014) Ken Garber   NATURE REVIEWS DRUG DISCOVERY

Chimeric Antigen Receptor T Cells for Sustained Remissions in Leukemia

(2014) Shannon L. Maude et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

(2014) Jean Mukherjee et al.   PLoS One

Protective Effect of Different Anti-Rabies Virus VHH Constructs against Rabies Disease in Mice

(2014) Sanne Terryn et al.   PLoS One

Pre-existing immunity against Ad vectors

(2014) Hugues Fausther-Bovendo et al.   Human Vaccines & Immunotherapeutics

High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells

(2013) Volker Jäger et al.   BMC BIOTECHNOLOGY

Targeting and killing of glioblastoma with activated T cells armed with bispecific antibodies

(2013) Ian M Zitron et al.   BMC CANCER

Subcutaneous administration of rituximab (MabThera) and trastuzumab (Herceptin) using hyaluronidase

(2013) O Shpilberg et al.   BRITISH JOURNAL OF CANCER

Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology

(2013) Michael Kalos et al.   IMMUNITY

Single-Chain Fragment Variable Passive Immunotherapies for Neurodegenerative Diseases

(2013) Liang Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

B-lymphocyte lineage cells and the respiratory system

(2013) Atsushi Kato et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Modified Foxp3 mRNA protects against asthma through an IL-10–dependent mechanism

(2013) Lauren E. Mays et al.   JOURNAL OF CLINICAL INVESTIGATION

Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

(2013) Aleš Berlec et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Treatment of Metastatic Renal Cell Carcinoma With CAIX CAR-engineered T cells: Clinical Evaluation and Management of On-target Toxicity

(2013) Cor HJ Lamers et al.   MOLECULAR THERAPY

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

(2013) Lior Zangi et al.   NATURE BIOTECHNOLOGY

Broad protection against influenza infection by vectored immunoprophylaxis in mice

(2013) Alejandro B Balazs et al.   NATURE BIOTECHNOLOGY

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Inhibition of translation by IFIT family members is determined by their ability to interact selectively with the 5'-terminal regions of cap0-, cap1- and 5'ppp- mRNAs

(2013) P. Kumar et al.   NUCLEIC ACIDS RESEARCH

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

(2013) Satoshi Uchida et al.   PLoS One

Monoclonal antibodies for prophylactic and therapeutic use against viral infections

(2013) Leonard Both et al.   VACCINE

The Basic Principles of Chimeric Antigen Receptor Design

(2013) Michel Sadelain et al.   Cancer Discovery

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Mesothelin-Specific Chimeric Antigen Receptor mRNA-Engineered T Cells Induce Antitumor Activity in Solid Malignancies

(2013) G. L. Beatty et al.   Cancer Immunology Research

T Cells Expressing Chimeric Antigen Receptors Can Cause Anaphylaxis in Humans

(2013) M. V. Maus et al.   Cancer Immunology Research

Expression of Recombinant Antibodies

(2013) André Frenzel et al.   Frontiers in Immunology

Bispecific Antibodies and Trispecific Immunocytokines for Targeting the Immune System Against Cancer

(2012) Philippe Fournier et al.   BIODRUGS

Chimeric antigen receptors for T cell immunotherapy: current understanding and future directions

(2012) Kevin J. Curran et al.   JOURNAL OF GENE MEDICINE

Passive immunity in the prevention of rabies

(2012) Leonard Both et al.   LANCET INFECTIOUS DISEASES

Dual targeting strategies with bispecific antibodies

(2012) Roland Kontermann   mAbs

Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin

(2012) Katalin Karikó et al.   MOLECULAR THERAPY

Systemic Delivery of Modified mRNA Encoding Herpes Simplex Virus 1 Thymidine Kinase for Targeted Cancer Gene Therapy

(2012) Yuhua Wang et al.   MOLECULAR THERAPY

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice

(2012) Florian Klein et al.   NATURE

Redirecting T Cells to Ewing's Sarcoma Family of Tumors by a Chimeric NKG2D Receptor Expressed by Lentiviral Transduction or mRNA Transfection

(2012) Manfred Lehner et al.   PLoS One

Systemic administration of a bispecific antibody targeting EGFRvIII successfully treats intracerebral glioma

(2012) B. D. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

(2011) J. N. Kochenderfer et al.   BLOOD

Treatment of Advanced Leukemia in Mice with mRNA Engineered T Cells

(2011) David M. Barrett et al.   HUMAN GENE THERAPY

Tumor Regression in Patients With Metastatic Synovial Cell Sarcoma and Melanoma Using Genetically Engineered Lymphocytes Reactive With NY-ESO-1

(2011) Paul F. Robbins et al.   JOURNAL OF CLINICAL ONCOLOGY

Targeted Therapy With the T-Cell–Engaging Antibody Blinatumomab of Chemotherapy-Refractory Minimal Residual Disease in B-Lineage Acute Lymphoblastic Leukemia Patients Results in High Response Rate and Prolonged Leukemia-Free Survival

(2011) Max S. Topp et al.   JOURNAL OF CLINICAL ONCOLOGY

Nanobodies With In Vitro Neutralizing Activity Protect Mice Against H5N1 Influenza Virus Infection

(2011) Lorena Itatí Ibañez et al.   JOURNAL OF INFECTIOUS DISEASES

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

(2011) Michael S D Kormann et al.   NATURE BIOTECHNOLOGY

State-of-the-art gene-based therapies: the road ahead

(2011) Mark A. Kay   NATURE REVIEWS GENETICS

Transmigration of beta amyloid specific heavy chain antibody fragments across the in vitro blood–brain barrier

(2011) K.S. Rutgers et al.   NEUROSCIENCE

Generating the optimal mRNA for therapy: HPLC purification eliminates immune activation and improves translation of nucleoside-modified, protein-encoding mRNA

(2011) Katalin Karikó et al.   NUCLEIC ACIDS RESEARCH

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

(2011) B. R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Llama-Derived Single Domain Antibodies to Build Multivalent, Superpotent and Broadened Neutralizing Anti-Viral Molecules

(2011) Anna Hultberg et al.   PLoS One

Comparison of IRES and F2A-Based Locus-Specific Multicistronic Expression in Stable Mouse Lines

(2011) Hsiao Yun Chan et al.   PLoS One

A Neutralizing Human Monoclonal Antibody Protects African Green Monkeys from Hendra Virus Challenge

(2011) K. N. Bossart et al.   Science Translational Medicine

Contributions of humoral and cellular immunity to vaccine-induced protection in humans

(2011) Ian J. Amanna et al.   VIROLOGY

Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies

(2010) Diane R. Mould et al.   BIODRUGS

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

(2010) Y. Zhao et al.   CANCER RESEARCH

RIG-I Detects Viral Genomic RNA during Negative-Strand RNA Virus Infection

(2010) Jan Rehwinkel et al.   CELL

Correlates of Protection Induced by Vaccination

(2010) S. A. Plotkin   Clinical and Vaccine Immunology

Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies

(2010) Ron J. Keizer et al.   CLINICAL PHARMACOKINETICS

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

(2010) A N Kuhn et al.   GENE THERAPY

Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

(2010) H. H. von Horsten et al.   GLYCOBIOLOGY

Case Report of a Serious Adverse Event Following the Administration of T Cells Transduced With a Chimeric Antigen Receptor Recognizing ERBB2

(2010) Richard A Morgan et al.   MOLECULAR THERAPY

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

(2010) Maria R Parkhurst et al.   MOLECULAR THERAPY

Enhanced antibody half-life improves in vivo activity

(2010) Jonathan Zalevsky et al.   NATURE BIOTECHNOLOGY

Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation

(2010) Bart R. Anderson et al.   NUCLEIC ACIDS RESEARCH

Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

(2009) Ayman El-Sayed et al.   AAPS Journal

Challenges in monoclonal antibody-based therapies

(2009) Haritha Samaranayake et al.   ANNALS OF MEDICINE

Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom

(2009) Rahma Ben Abderrazek et al.   BIOCHEMICAL JOURNAL

Strategies to Extend Plasma Half-Lives of Recombinant Antibodies

(2009) Roland E. Kontermann   BIODRUGS

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

(2009) L. A. Johnson et al.   BLOOD

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer

(2009) K Birkholz et al.   GENE THERAPY

Adeno-Associated Virus-Mediated Gene Transfer to Nonhuman Primate Liver Can Elicit Destructive Transgene-Specific T Cell Responses

(2009) Guangping Gao et al.   HUMAN GENE THERAPY

Preventing and exploiting the oncogenic potential of integrating gene vectors

(2009) Ute Modlich et al.   JOURNAL OF CLINICAL INVESTIGATION

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Endosomes: A legitimate platform for the signaling train

(2009) J. E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal antibody-based therapies for microbial diseases

(2009) Carolyn Saylor et al.   VACCINE

Adoptive immunotherapy using human peripheral blood lymphocytes transferred with RNA encoding Her-2/neu-specific chimeric immune receptor in ovarian cancer xenograft model

(2008) S H Yoon et al.   CANCER GENE THERAPY

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Human respiratory syncytial virus and other viral infections in infants receiving palivizumab

(2008) Guy Boivin et al.   JOURNAL OF CLINICAL VIROLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY

Quantitative Effect of Suboptimal Codon Usage on Translational Efficiency of mRNA Encoding HIV-1 gag in Intact T Cells

(2008) Kholiswa C. Ngumbela et al.   PLoS One

Treatment of Argentine hemorrhagic fever

(2007) Delia A. Enria et al.   ANTIVIRAL RESEARCH

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

(2007) Thomas Tiller et al.   JOURNAL OF IMMUNOLOGICAL METHODS