Current state and recent advances in biopharmaceutical production in Escherichia coli, yeasts and mammalian cells

High-throughput methods for miniaturization and automation of monoclonal antibody purification processes

(2012) Katrin Treier et al.   BIOTECHNOLOGY PROGRESS

Metabolic engineering of recombinant protein secretion by Saccharomyces cerevisiae

(2012) Jin Hou et al.   FEMS YEAST RESEARCH

The need for innovation in biomanufacturing

(2012) Uwe Gottschalk et al.   NATURE BIOTECHNOLOGY

A Multi-Omics Analysis of Recombinant Protein Production in Hek293 Cells

(2012) Stefanie Dietmair et al.   PLoS One

Systems biotechnology of animal cells: the road to prediction

(2012) Nuno Carinhas et al.   TRENDS IN BIOTECHNOLOGY

Mammalian cell protein expression for biopharmaceutical production

(2011) Jianwei Zhu   BIOTECHNOLOGY ADVANCES

Rational engineering of Escherichia coli strains for plasmid biopharmaceutical manufacturing

(2011) Geisa A. L. Gonçalves et al.   Biotechnology Journal

Mammalian cells as biopharmaceutical production hosts in the age of omics

(2011) Stefanie Dietmair et al.   Biotechnology Journal

Engineering of Therapeutic Proteins Production in Escherichia coli

(2011) Mariusz Kamionka   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Unraveling the Chinese hamster ovary cell line transcriptome by next-generation sequencing

(2011) Jennifer Becker et al.   JOURNAL OF BIOTECHNOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

'Pharmers' hope for first plant drug harvest

(2011) Alisa Opar   NATURE REVIEWS DRUG DISCOVERY

Engineering of protein secretion in yeast: strategies and impact on protein production

(2010) Alimjan Idiris et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Disposable bioreactors: the current state-of-the-art and recommended applications in biotechnology

(2010) Regine Eibl et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Gene amplification and vector engineering to achieve rapid and high-level therapeutic protein production using the Dhfr-based CHO cell selection system

(2010) Jonathan J. Cacciatore et al.   BIOTECHNOLOGY ADVANCES

Generation of stable cell lines by site-specific integration of transgenes into engineered Chinese hamster ovary strains using an FLP-FRT system

(2010) Hong Zhou et al.   JOURNAL OF BIOTECHNOLOGY

Bioprocess Control in Microscale: Scalable Fermentations in Disposable and User-Friendly Microfluidic Systems

(2010) Matthias Funke et al.   Microbial Cell Factories

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Towards revealing the structure of bacterial inclusion bodies

(2010) Lei Wang   Prion

Application of microbioreactors in fermentation process development: a review

(2009) Daniel Schäpper et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhanced protein secretion from multiprotease-deficient fission yeast by modification of its vacuolar protein sorting pathway

(2009) Alimjan Idiris et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

RNA interference technology to improve recombinant protein production in Chinese hamster ovary cells

(2009) Suh-Chin Wu   BIOTECHNOLOGY ADVANCES

The production of biopharmaceuticals in plant systems

(2009) Saskia R. Karg et al.   BIOTECHNOLOGY ADVANCES

Extracellular recombinant protein production from Escherichia coli

(2009) Ye Ni et al.   BIOTECHNOLOGY LETTERS

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Design Parameters to Control Synthetic Gene Expression in Escherichia coli

(2009) Mark Welch et al.   PLoS One

Modulation of Chaperone Gene Expression in Mutagenized Saccharomyces cerevisiae Strains Developed for Recombinant Human Albumin Production Results in Increased Production of Multiple Heterologous Proteins

(2008) T. Payne et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

(2008) Lei Wang et al.   PLOS BIOLOGY

Sec- and Tat-mediated protein secretion across the bacterial cytoplasmic membrane—Distinct translocases and mechanisms

(2007) Paolo Natale et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of Low Culture Temperature on Specific Productivity and Transcription Level of Anti-4-1BB Antibody in Recombinant Chinese Hamster Ovary Cells

(2003) Sung Kwan Yoon et al.   BIOTECHNOLOGY PROGRESS