N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

Published 2015 View Full Article

Authors

Keywords

mRNA, Modified RNA, Nucleobase modifications, Antiviral innate immunity, Toll-like receptor, Gene therapy

Journal

JOURNAL OF CONTROLLED RELEASE

Volume 217, Issue -, Pages 337-344

Publisher

Elsevier BV

Online

2015-09-03

DOI

10.1016/j.jconrel.2015.08.051

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