State of play and clinical prospects of antibody gene transfer

Recombinant Adeno-Associated Viral Integration and Genotoxicity: Insights from Animal Models

(2017) Randy J. Chandler et al.   HUMAN GENE THERAPY

Treatment of Human B-Cell Lymphomas Using Minicircle DNA Vector Expressing Anti-CD3/CD20 in a Mouse Model

(2017) Xiaojuan Pang et al.   HUMAN GENE THERAPY

AAV9 delivered bispecific nanobody attenuates amyloid burden in the gelsolin amyloidosis mouse model

(2017) Adriaan Verhelle et al.   HUMAN MOLECULAR GENETICS

Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention

(2017) Jacqueline M. Brady et al.   IMMUNOLOGICAL REVIEWS

Cancer immunotherapy — immune checkpoint blockade and associated endocrinopathies

(2017) David J. Byun et al.   Nature Reviews Endocrinology

Biopharmaceuticals

(2017) Ann Gils et al.   THERAPEUTIC DRUG MONITORING

Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge

(2017) Norbert Pardi et al.   Nature Communications

Advances in Non-Viral DNA Vectors for Gene Therapy

(2017) Cinnamon Hardee et al.   Genes

Adenoviral Expression of a Bispecific VHH-Based Neutralizing Agent That Targets Protective Antigen Provides Prophylactic Protection from Anthrax in Mice

(2016) Mahtab Moayeri et al.   Clinical and Vaccine Immunology

Adeno-Associated Virus Serotype 9-Expressed ZMapp in Mice Confers Protection Against Systemic and Airway-Acquired Ebola Virus Infection

(2016) Maria P. Limberis et al.   JOURNAL OF INFECTIOUS DISEASES

Rapid and Long-Term Immunity Elicited by DNA-Encoded Antibody Prophylaxis and DNA Vaccination Against Chikungunya Virus

(2016) Karuppiah Muthumani et al.   JOURNAL OF INFECTIOUS DISEASES

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice

(2016) Wencheng Liu et al.   JOURNAL OF NEUROSCIENCE

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Oncolytic Adenovirus Expressing Monoclonal Antibody Trastuzumab for Treatment of HER2-Positive Cancer

(2016) I. Liikanen et al.   MOLECULAR CANCER THERAPEUTICS

401. In Vivo Expression of Plasmid Encoded IgG for PD-1 or LAG3 by Synthetic DNA as a New Tool for Cancer Immunotherapy

(2016) Kar Muthumani et al.   MOLECULAR THERAPY

Host Anti-antibody Responses Following Adeno-associated Virus–mediated Delivery of Antibodies Against HIV and SIV in Rhesus Monkeys

(2016) José M Martinez-Navio et al.   MOLECULAR THERAPY

Broadly Neutralizing Antibodies for HIV-1 Prevention or Immunotherapy

(2016) Marina Caskey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antibody Approaches To Treat Brain Diseases

(2016) Vera Neves et al.   TRENDS IN BIOTECHNOLOGY

Intravenous adenovirus expressing a multi-specific, single-domain antibody neutralizing TcdA and TcdB protects mice fromClostridium difficileinfection

(2016) Zhiyong Yang et al.   Pathogens and Disease

Advances in Therapeutic Fc Engineering – Modulation of IgG-Associated Effector Functions and Serum Half-life

(2016) Abhishek Saxena et al.   Frontiers in Immunology

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

(2016) Patricia Kleinpeter et al.   OncoImmunology

Promise and problems associated with the use of recombinant AAV for the delivery of anti-HIV antibodies

(2016) Sebastian P Fuchs et al.   Molecular Therapy-Methods & Clinical Development

Perspectives on Cost and Value in Cancer Care

(2016) Leonard B. Saltz   JAMA Oncology

Recombinant AAV Vectors for Enhanced Expression of Authentic IgG

(2016) Sebastian P. Fuchs et al.   PLoS One

A Dual Target-directed Agent against Interleukin-6 Receptor and Tumor Necrosis Factor α ameliorates experimental arthritis

(2016) Youngkyun Kim et al.   Scientific Reports

Towards effective non-viral gene delivery vector

(2015) Michaela Šimčíková et al.   Biotechnology & Genetic Engineering Reviews

The use of combinations of monoclonal antibodies in clinical oncology

(2015) Linda M. Henricks et al.   CANCER TREATMENT REVIEWS

Vectored antibody gene delivery mediates long-term contraception

(2015) Juan Li et al.   CURRENT BIOLOGY

The Skeletal Muscle Environment and Its Role in Immunity and Tolerance to AAV Vector-Mediated Gene Transfer

(2015) Florence Boisgerault et al.   CURRENT GENE THERAPY

Engineering humoral immunity as prophylaxis or therapy

(2015) Cailin E Deal et al.   CURRENT OPINION IN IMMUNOLOGY

In situproduction of therapeutic monoclonal antibodies

(2015) Todd J Suscovich et al.   Expert Review of Vaccines

Scancell’s vaccine SCIB1 could help to prevent recurrence of melanoma

(2015) Richard Goodfellow   Immunotherapy

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

(2015) Norbert Pardi et al.   JOURNAL OF CONTROLLED RELEASE

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

(2015) Kevin O. Saunders et al.   JOURNAL OF VIROLOGY

Cancer-fighting viruses win approval

(2015) Heidi Ledford   NATURE

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

(2015) Matthew R. Gardner et al.   NATURE

$1-million price tag set for Glybera gene therapy

(2015) Chris Morrison   NATURE BIOTECHNOLOGY

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

Preclinical Testing Oncolytic Vaccinia Virus Strain GLV-5b451 Expressing an Anti-VEGF Single-Chain Antibody for Canine Cancer Therapy

(2015) Marion Adelfinger et al.   Viruses-Basel

Protection against dengue disease by synthetic nucleic acid antibody prophylaxis/immunotherapy

(2015) Seleeke Flingai et al.   Scientific Reports

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

(2015) Sebastian P. Fuchs et al.   PLoS Pathogens

Expression of anti-VEGF antibody together with anti-EGFR or anti-FAP enhances tumor regression as a result of vaccinia virotherapy

(2015) Ting Huang et al.   Molecular Therapy-Oncolytics

Long-term in vivo expression of trastuzumab following intramuscular electrotransfer of the encoding DNA in mice

(2015) Kevin Hollevoet et al.   Journal for ImmunoTherapy of Cancer

A novel vaccinia virus with dual oncolytic and anti-angiogenic therapeutic effects against triple-negative breast cancer

(2014) Sepideh Gholami et al.   BREAST CANCER RESEARCH AND TREATMENT

Tumor-specific oncolytic adenoviruses expressing granulocyte macrophage colony-stimulating factor or anti-CTLA4 antibody for the treatment of cancers

(2014) T Du et al.   CANCER GENE THERAPY

Adeno-Associated Virus 9-Mediated Airway Expression of Antibody Protects Old and Immunodeficient Mice against Influenza Virus

(2014) Virginie S. Adam et al.   Clinical and Vaccine Immunology

Immunomodulatory Antibody Therapy of Cancer: The Closer, the Better

(2014) R. S. Dronca et al.   CLINICAL CANCER RESEARCH

General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination

(2014) Aline Baldo et al.   CURRENT GENE THERAPY

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

AAV-mediated persistent bevacizumab therapy suppresses tumor growth of ovarian cancer

(2014) Yi Xie et al.   GYNECOLOGIC ONCOLOGY

The therapeutic monoclonal antibody market

(2014) Dawn M Ecker et al.   mAbs

Catalytic Immunoglobulin Gene Delivery in a Mouse Model of Alzheimer’s Disease: Prophylactic and Therapeutic Applications

(2014) Jinghong Kou et al.   MOLECULAR NEUROBIOLOGY

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

(2014) Christine E Engeland et al.   MOLECULAR THERAPY

Adeno-associated Virus–mediated Delivery of a Recombinant Single-chain Antibody Against Misfolded Superoxide Dismutase for Treatment of Amyotrophic Lateral Sclerosis

(2014) Priyanka Patel et al.   MOLECULAR THERAPY

Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission

(2014) Alejandro B Balazs et al.   NATURE MEDICINE

The immune checkpoint inhibitors: where are we now?

(2014) Rachel M. Webster   NATURE REVIEWS DRUG DISCOVERY

mRNA-based therapeutics — developing a new class of drugs

(2014) Ugur Sahin et al.   NATURE REVIEWS DRUG DISCOVERY

Prolonged Prophylactic Protection from Botulism with a Single Adenovirus Treatment Promoting Serum Expression of a VHH-Based Antitoxin Protein

(2014) Jean Mukherjee et al.   PLoS One

Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice

(2014) C. Deal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broadly neutralizing antibodies abrogate established hepatitis C virus infection

(2014) Y. P. de Jong et al.   Science Translational Medicine

Adeno-associated virus delivery of broadly neutralizing antibodies

(2014) Bruce C. Schnepp et al.   Current Opinion in HIV and AIDS

A New Strategy to Deliver Synthetic Protein Drugs: Self-reproducible Biologics Using Minicircles

(2014) Hyoju Yi et al.   Scientific Reports

Self in vivo production of a synthetic biological drug CTLA4Ig using a minicircle vector

(2014) Yeri Alice Rim et al.   Scientific Reports

Pre-existing immunity against Ad vectors

(2014) Hugues Fausther-Bovendo et al.   Human Vaccines & Immunotherapeutics

Gene therapy and DNA delivery systems

(2013) D. Ibraheem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Treatment of malignant effusion by oncolytic virotherapy in an experimental subcutaneous xenograft model of lung cancer

(2013) Stephanie Weibel et al.   Journal of Translational Medicine

Broad protection against influenza infection by vectored immunoprophylaxis in mice

(2013) Alejandro B Balazs et al.   NATURE BIOTECHNOLOGY

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

(2013) J. A. Horwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adeno-associated virus (AAV) vectors in gene therapy: immune challenges and strategies to circumvent them

(2013) Sangeetha Hareendran et al.   REVIEWS IN MEDICAL VIROLOGY

Intranasal Antibody Gene Transfer in Mice and Ferrets Elicits Broad Protection Against Pandemic Influenza

(2013) M. P. Limberis et al.   Science Translational Medicine

Pre-existing Anti–Adeno-Associated Virus Antibodies as a Challenge in AAV Gene Therapy

(2013) Vedell Louis Jeune et al.   Human Gene Therapy Methods

Optimized and enhanced DNA plasmid vector based in vivo construction of a neutralizing anti-HIV-1 envelope glycoprotein Fab

(2013) Kar Muthumani et al.   Human Vaccines & Immunotherapeutics

Tolerability of intramuscular and intradermal delivery by CELLECTRA®adaptive constant current electroporation device in healthy volunteers

(2013) Malissa C Diehl et al.   Human Vaccines & Immunotherapeutics

Passive immunization with a recombinant adenovirus expressing an HA (H5)-specific single-domain antibody protects mice from lethal influenza infection

(2012) Irina L. Tutykhina et al.   ANTIVIRAL RESEARCH

Factor IX expression in skeletal muscle of a severe hemophilia B patient 10 years after AAV-mediated gene transfer

(2012) G. Buchlis et al.   BLOOD

AAVrh.10-Mediated Expression of an Anti-Cocaine Antibody Mediates Persistent Passive Immunization That Suppresses Cocaine-Induced Behavior

(2012) Jonathan B. Rosenberg et al.   HUMAN GENE THERAPY

Overview of Routes of IgG Administration

(2012) Troy R. Torgerson   JOURNAL OF CLINICAL IMMUNOLOGY

Muscle-Directed Anti-Aβ Single-Chain Antibody Delivery via AAV1 Reduces Cerebral Aβ Load in an Alzheimer’s Disease Mouse Model

(2012) Junling Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Performance of High Quality Minicircle DNA for In Vitro and In Vivo Gene Transfer

(2012) Dennis Kobelt et al.   MOLECULAR BIOTECHNOLOGY

First gene therapy approved

(2012) Nuala Moran   NATURE BIOTECHNOLOGY

Human Anti-CCR4 Minibody Gene Transfer for the Treatment of Cutaneous T-Cell Lymphoma

(2012) Thomas Han et al.   PLoS One

Virotherapy of Canine Tumors with Oncolytic Vaccinia Virus GLV-1h109 Expressing an Anti-VEGF Single-Chain Antibody

(2012) Sandeep S. Patil et al.   PLoS One

Brain delivery of AAV9 expressing an anti-PrP monovalent antibody delays prion disease in mice

(2012) Fabio Moda et al.   Prion

AAV-Directed Persistent Expression of a Gene Encoding Anti-Nicotine Antibody for Smoking Cessation

(2012) M. J. Hicks et al.   Science Translational Medicine

Monoclonal antibodies: magic bullets with a hefty price tag

(2012) A. F. Shaughnessy   BMJ-British Medical Journal

Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells

(2011) Sarah L. Davies et al.   BIOTECHNOLOGY PROGRESS

Adeno-associated virus-mediated anti-DR5 chimeric antibody expression suppresses human tumor growth in nude mice

(2011) Fujia Lv et al.   CANCER LETTERS

Engineering human cells for in vivo secretion of antibody and non-antibody therapeutic proteins

(2011) David Sánchez-Martín et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeted cancer immunotherapy with oncolytic adenovirus coding for a fully human monoclonal antibody specific for CTLA-4

(2011) J D Dias et al.   GENE THERAPY

Persistent Suppression of Ocular Neovascularization with Intravitreal Administration of AAVrh.10 Coding for Bevacizumab

(2011) Yanxiong Mao et al.   HUMAN GENE THERAPY

Calcium Electrotransfer for Termination of Transgene Expression in Muscle

(2011) Pernille Hojman et al.   HUMAN GENE THERAPY

New Generation of Plasmid Backbones Devoid of Antibiotic Resistance Marker for Gene Therapy Trials

(2011) Gaëlle Vandermeulen et al.   MOLECULAR THERAPY

2A Peptide-based, Lentivirus-mediated Anti-death Receptor 5 Chimeric Antibody Expression Prevents Tumor Growth in Nude Mice

(2011) Meng Li et al.   MOLECULAR THERAPY

Antibody-based protection against HIV infection by vectored immunoprophylaxis

(2011) Alejandro B. Balazs et al.   NATURE

Affinity maturation of an anti-V antigen IgG expressed in situ through adenovirus gene delivery confers enhanced protection against Yersinia pestis challenge

(2010) T J Van Blarcom et al.   GENE THERAPY

AAVrh.10-mediated genetic delivery of bevacizumab to the pleura to provide local anti-VEGF to suppress growth of metastatic lung tumors

(2010) M Watanabe et al.   GENE THERAPY

Transgene expression in mononuclear muscle cells not infiltrating inflammatory cells following intramuscular plasmid gene electrotransfer

(2010) Jarupa Ratanamart et al.   JOURNAL OF GENE MEDICINE

Early or Late-Stage Anti-N-Terminal Huntingtin Intrabody Gene Therapy Reduces Pathological Features in B6.HDR6/1 Mice

(2010) Abigail Snyder-Keller et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Industrialization of mAb production technology: The bioprocessing industry at a crossroads

(2010) Brian Kelley   mAbs

Aβ-directed Single-chain Antibody Delivery Via a Serotype-1 AAV Vector Improves Learning Behavior and Pathology in Alzheimer's Disease Mice

(2010) Deborah A Ryan et al.   MOLECULAR THERAPY

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Biosafety of DNA vaccines: New generation of DNA vectors and current knowledge on the fate of plasmids after injection

(2010) Florence Faurez et al.   VACCINE

Genetic Delivery of Bevacizumab to Suppress Vascular Endothelial Growth Factor-Induced High-Permeability Pulmonary Edema

(2009) Masaki Watanabe et al.   HUMAN GENE THERAPY

Adenovirus-Mediated Delivery of an Anti-V Antigen Monoclonal Antibody Protects Mice against a Lethal Yersinia pestis Challenge

(2009) C. Sofer-Podesta et al.   INFECTION AND IMMUNITY

Intrabody Gene Therapy Ameliorates Motor, Cognitive, and Neuropathological Symptoms in Multiple Mouse Models of Huntington's Disease

(2009) A. L. Southwell et al.   JOURNAL OF NEUROSCIENCE

Generating Differentially Targeted Amyloid-β Specific Intrabodies as a Passive Vaccination Strategy for Alzheimer's Disease

(2009) Kelly L Sudol et al.   MOLECULAR THERAPY

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

(2009) Ou Cao et al.   MOLECULAR THERAPY

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

(2009) Philip R Johnson et al.   NATURE MEDICINE

Anti-VEGF single-chain antibody GLAF-1 encoded by oncolytic vaccinia virus significantly enhances antitumor therapy

(2009) A. Frentzen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin

(2009) Y. Shimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growth inhibition of an established A431 xenograft tumor by a full-length anti-EGFR antibody following gene delivery by AAV

(2008) D T Ho et al.   CANCER GENE THERAPY

"Active" Cancer Immunotherapy by Anti-Met Antibody Gene Transfer

(2008) E. Vigna et al.   CANCER RESEARCH

Gene Delivery of the Murine Equivalent of Bevacizumab (Avastin), an Anti-Vascular Endothelial Growth Factor Monoclonal Antibody, to Suppress Growth of Human Tumors in Immunodeficient Mice

(2008) Masaki Watanabe et al.   HUMAN GENE THERAPY

Phase I Trial of Interleukin-12 Plasmid Electroporation in Patients With Metastatic Melanoma

(2008) Adil I. Daud et al.   JOURNAL OF CLINICAL ONCOLOGY

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

(2008) C. Zuber et al.   JOURNAL OF GENERAL VIROLOGY

CNS Delivery of Vectored Prion-specific Single-chain Antibodies Delays Disease Onset

(2008) Charles A Wuertzer et al.   MOLECULAR THERAPY

Gene transfer: the challenge of regulated gene expression

(2008) Z. Sheng Guo et al.   TRENDS IN MOLECULAR MEDICINE

Genetic delivery of an anti-RSV antibody to protect against pulmonary infection with RSV

(2008) Davor Skaricic et al.   VIROLOGY

Genetically delivered antibody protects against West Nile virus

(2007) Alexander Pereboev et al.   ANTIVIRAL RESEARCH

Rapid/Sustained Anti-anthrax Passive Immunity Mediated by Co-administration of Ad/AAV

(2007) Bishnu P De et al.   MOLECULAR THERAPY

Intramuscular delivery of a single chain antibody gene reduces brain Aβ burden in a mouse model of Alzheimer's disease

(2007) Yan-Jiang Wang et al.   NEUROBIOLOGY OF AGING