Structural biology and structure–function relationships of membrane proteins

X-rays in the Cryo-Electron Microscopy Era: Structural Biology’s Dynamic Future

(2018) Susannah C. Shoemaker et al.   BIOCHEMISTRY

Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis

(2018) Kari J. Tanaka et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

ATP Binding Enables Substrate Release from Multidrug Resistance Protein 1

(2018) Zachary Lee Johnson et al.   CELL

The yin and yang of solubilization and stabilization for wild-type and full-length membrane protein

(2018) David Hardy et al.   METHODS

Unexplored therapeutic opportunities in the human genome

(2018) Tudor I. Oprea et al.   NATURE REVIEWS DRUG DISCOVERY

Structure of full-length human TRPM4

(2018) Jingjing Duan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPM channels come into focus

(2018) Chanhyung Bae et al.   SCIENCE

Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures

(2018) Chia-Hsueh Lee et al.   SCIENCE

Neural Cotransmission in Spinal Circuits Governing Locomotion

(2018) Erik Svensson et al.   TRENDS IN NEUROSCIENCES

Cryo-EM structure of 5-HT3A receptor in its resting conformation

(2018) Sandip Basak et al.   Nature Communications

The Molecular Determinants of Small-Molecule Ligand Binding at P2X Receptors

(2018) Gaia Pasqualetto et al.   Frontiers in Pharmacology

Structure of a human synaptic GABAA receptor

(2018) Shaotong Zhu et al.   NATURE

The therapeutic potential of targeting ABC transporters to combat multi-drug resistance

(2017) Piyush Bugde et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Recent Advances in Structure-Based Drug Design Targeting Class A G Protein-Coupled Receptors Utilizing Crystal Structures and Computational Simulations

(2017) Yoonji Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Electron cryo-microscopy structure of a human TRPM4 channel

(2017) Paige A. Winkler et al.   NATURE

Structure of the human multidrug transporter ABCG2

(2017) Nicholas M. I. Taylor et al.   NATURE

Trends in GPCR drug discovery: new agents, targets and indications

(2017) Alexander S. Hauser et al.   NATURE REVIEWS DRUG DISCOVERY

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and symmetry inform gating principles of ionotropic glutamate receptors

(2017) Shujia Zhu et al.   NEUROPHARMACOLOGY

Structure of the human TRPM4 ion channel in a lipid nanodisc

(2017) Henriette E. Autzen et al.   SCIENCE

Classification Systems of Secondary Active Transporters

(2017) Emelie Perland et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel

(2017) Go Kasuya et al.   Nature Communications

Structural basis for lipopolysaccharide extraction by ABC transporter LptB2FG

(2017) Qingshan Luo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quantification of Detergents Complexed with Membrane Proteins

(2017) Vincent Chaptal et al.   Scientific Reports

Insights into the channel gating of P2X receptors from structures, dynamics and small molecules

(2016) Jin Wang et al.   ACTA PHARMACOLOGICA SINICA

Transport mechanism of a glutamate transporter homologue GltPh

(2016) Y. Ji et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Current strategies for protein production and purification enabling membrane protein structural biology

(2016) Aditya Pandey et al.   Biochemistry and Cell Biology

The transport mechanism of the mitochondrial ADP/ATP carrier

(2016) Edmund R.S. Kunji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling

(2016) Alex R.B. Thomsen et al.   CELL

Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator

(2016) Zhe Zhang et al.   CELL

Structural biology of glutamate receptor ion channel complexes

(2016) Mark L Mayer   CURRENT OPINION IN STRUCTURAL BIOLOGY

Importance of ABC Transporters in Drug Development

(2016) Marcel Benadiba et al.   CURRENT PHARMACEUTICAL DESIGN

Structure of the adenosine A2A receptor bound to an engineered G protein

(2016) Byron Carpenter et al.   NATURE

Crystal structure of the human sterol transporter ABCG5/ABCG8

(2016) Jyh-Yeuan Lee et al.   NATURE

Structure of a CLC chloride ion channel by cryo-electron microscopy

(2016) Eunyong Park et al.   NATURE

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

(2016) Libin Ye et al.   NATURE

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

A mutagenesis and screening strategy to generate optimally thermostabilized membrane proteins for structural studies

(2016) Francesca Magnani et al.   Nature Protocols

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanistic diversity in ATP-binding cassette (ABC) transporters

(2016) Kaspar P Locher   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for subtype-specific inhibition of the P2X7 receptor

(2016) Akira Karasawa et al.   eLife

Membrane proteins — do we catch up with the breathless pace of soluble protein structural biology?

(2015) Bjørn Panyella Pedersen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

A Call for Systematic Research on Solute Carriers

(2015) Adrián César-Razquin et al.   CELL

Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin Receptor

(2015) Haitao Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

(2015) Thomas J. Jentsch   JOURNAL OF PHYSIOLOGY-LONDON

Quercetin Enhances Cisplatin Sensitivity of Human Osteosarcoma Cells by Modulating microRNA-217-KRAS Axis

(2015) Xian Zhang et al.   MOLECULES AND CELLS

Cryo-electron microscopy structure of the Slo2.2 Na+-activated K+ channel

(2015) Richard K. Hite et al.   NATURE

Molecular basis of ligand recognition and transport by glucose transporters

(2015) Dong Deng et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

Two disparate ligand-binding sites in the human P2Y1 receptor

(2015) Dandan Zhang et al.   NATURE

Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

(2015) Yanyong Kang et al.   NATURE

The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides

(2015) Konstantinos D. Tsirigos et al.   NUCLEIC ACIDS RESEARCH

Crystal structure of the anion exchanger domain of human erythrocyte band 3

(2015) T. Arakawa et al.   SCIENCE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes

(2015) Phillip J. Stansfeld et al.   STRUCTURE

Diversity in ABC transporters: Type I, II and III importers

(2014) Austin J. Rice et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Structural diversity of ABC transporters

(2014) Josy ter Beek et al.   JOURNAL OF GENERAL PHYSIOLOGY

Crystal structure of the human glucose transporter GLUT1

(2014) Dong Deng et al.   NATURE

Visualization of arrestin recruitment by a G-protein-coupled receptor

(2014) Arun K. Shukla et al.   NATURE

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

NMDA receptor structures reveal subunit arrangement and pore architecture

(2014) Chia-Hsueh Lee et al.   NATURE

What do drug transporters really do?

(2014) Sanjay K. Nigam   NATURE REVIEWS DRUG DISCOVERY

The ABC-F protein EttA gates ribosome entry into the translation elongation cycle

(2014) Grégory Boël et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Excitatory amino acid transporters: Roles in glutamatergic neurotransmission

(2014) Christopher B. Divito et al.   NEUROCHEMISTRY INTERNATIONAL

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

(2014) Jennifer L. Miller-Gallacher et al.   PLoS One

Trpm4 Gene Invalidation Leads to Cardiac Hypertrophy and Electrophysiological Alterations

(2014) Marie Demion et al.   PLoS One

Structure of sugar-bound LacY

(2014) Hemant Kumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of yeast mitochondrial ADP/ATP carriers support a domain-based alternating-access transport mechanism

(2014) J. J. Ruprecht et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Crystal structure of a heterotetrameric NMDA receptor ion channel

(2014) E. Karakas et al.   SCIENCE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coupled ion binding and structural transitions along the transport cycle of glutamate transporters

(2014) Grégory Verdon et al.   eLife

Visualization of membrane protein crystals in lipid cubic phase using X-ray imaging

(2013) Anna J. Warren et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation and allosteric modulation of a muscarinic acetylcholine receptor

(2013) Andrew C. Kruse et al.   NATURE

Structure of a bacterial energy-coupling factor transporter

(2013) Tingliang Wang et al.   NATURE

Molecular signatures of G-protein-coupled receptors

(2013) A. J. Venkatakrishnan et al.   NATURE

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

(2013) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation

(2013) L. Sauguet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol-β1AR interaction versus cholesterol-β2AR interaction

(2013) Xiaohui Cang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

The Role of a Sodium Ion Binding Site in the Allosteric Modulation of the A2A Adenosine G Protein-Coupled Receptor

(2013) Hugo Gutiérrez-de-Terán et al.   STRUCTURE

Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel

(2013) Anirban Banerjee et al.   eLife

In situmacromolecular crystallography using microbeams

(2012) Danny Axford et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Conserved activation pathways in G-protein-coupled receptors

(2012) Xavier Deupi et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Structure, Function, and Modulation of GABAAReceptors

(2012) Erwin Sigel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ion Channels as Therapeutic Targets: A Drug Discovery Perspective

(2012) Sharan K. Bagal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the agonist-bound neurotensin receptor

(2012) Jim F. White et al.   NATURE

Crystal structure of a bacterial homologue of glucose transporters GLUT1–4

(2012) Linfeng Sun et al.   NATURE

Molecular mechanism of ATP binding and ion channel activation in P2X receptors

(2012) Motoyuki Hattori et al.   NATURE

Structure of a KirBac potassium channel with an open bundle crossing indicates a mechanism of channel gating

(2012) Vassiliy N Bavro et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structure of an asymmetric trimer of a bacterial glutamate transporter homolog

(2012) Grégory Verdon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and Carvedilol

(2012) Tony Warne et al.   STRUCTURE

Mutational spectrum in the Ca2+-activated cation channel gene TRPM4 in patients with cardiac conductance disturbances

(2011) Birgit Stallmeyer et al.   HUMAN MUTATION

Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel

(2011) Peng Yuan et al.   NATURE

Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

(2011) Guillaume Lebon et al.   NATURE

Crystal structure of metarhodopsin II

(2011) Hui-Woog Choe et al.   NATURE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Trends in the exploitation of novel drug targets

(2011) Mathias Rask-Andersen et al.   NATURE REVIEWS DRUG DISCOVERY

Pharmacological inhibition of TRPM4 hyperpolarizes vascular smooth muscle

(2010) Albert L. Gonzales et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

A Structural Insight into the Reorientation of Transmembrane Domains 3 and 5 during Family A G Protein-Coupled Receptor Activation

(2010) K. Sansuk et al.   MOLECULAR PHARMACOLOGY

Structure of the gating ring from the human large-conductance Ca2+-gated K+ channel

(2010) Yunkun Wu et al.   NATURE

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

Function of human Rh based on structure of RhCG at 2.1 A

(2010) F. Gruswitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 A Resolution

(2010) P. Yuan et al.   SCIENCE

The Role of Transient Receptor Potential Cation Channels in Ca2+ Signaling

(2010) M. Gees et al.   Cold Spring Harbor Perspectives in Biology

Computational analysis of membrane proteins: the largest class of drug targets

(2009) Yalini Arinaminpathy et al.   DRUG DISCOVERY TODAY

Structure and function of mitochondrial carriers - Role of the transmembrane helix P and G residues in the gating and transport mechanism

(2009) Ferdinando Palmieri et al.   FEBS LETTERS

A Conserved Aromatic Lock for the Tryptophan Rotameric Switch in TM-VI of Seven-transmembrane Receptors

(2009) Birgitte Holst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping Daunorubicin-binding Sites in the ATP-binding Cassette Transporter MsbA Using Site-specific Quenching by Spin Labels

(2009) Smriti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

(2009) Alexander I. Sobolevsky et al.   NATURE

Crystal structure of the ATP-gated P2X4 ion channel in the closed state

(2009) Toshimitsu Kawate et al.   NATURE

ABC transporters: the power to change

(2009) Douglas C. Rees et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CFTR Function and Prospects for Therapy

(2008) John R. Riordan   Annual Review of Biochemistry

The solute carrier (SLC) complement of the human genome: Phylogenetic classification reveals four major families

(2008) Robert Fredriksson et al.   FEBS LETTERS

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Mechanism for alternating access in neurotransmitter transporters

(2008) L. R. Forrest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA