Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Insights into the channel gating of P2X receptors from structures, dynamics and small molecules
Authors
Keywords
-
Journal
ACTA PHARMACOLOGICA SINICA
Volume 37, Issue 1, Pages 44-55
Publisher
Springer Nature
Online
2016-01-04
DOI
10.1038/aps.2015.127
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Hearing Loss Caused by a P2RX2 Mutation Identified in a MELAS Family With a Coexisting Mitochondrial 3243AG Mutation
- (2015) Hideaki Moteki et al. ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY
- Single-Particle Cryo-EM at Crystallographic Resolution
- (2015) Yifan Cheng CELL
- Key Sites for P2X Receptor Function and Multimerization: Overview of Mutagenesis Studies on a Structural Basis
- (2015) Ralf Hausmann et al. CURRENT MEDICINAL CHEMISTRY
- Editorial (Thematic Issue: Purinergic P2X Receptors: Physiological and Pathological Roles and Potential as Therapeutic Targets)
- (2015) Diego Ben et al. CURRENT MEDICINAL CHEMISTRY
- Purinergic P2X Receptors: Structural and Functional Features Depicted by X-Ray and Molecular Modelling Studies
- (2015) Leanne Grimes et al. CURRENT MEDICINAL CHEMISTRY
- Medicinal Chemistry of P2X Receptors: Allosteric Modulators
- (2015) Christa Muller CURRENT MEDICINAL CHEMISTRY
- Medicinal Chemistry of P2X Receptors: Agonists and Orthosteric Antagonists
- (2015) Catia Lambertucci et al. CURRENT MEDICINAL CHEMISTRY
- Solution structure of the rat P2X4 receptor head domain involved in inhibitory metal binding
- (2015) Tatsuhiro Igawa et al. FEBS LETTERS
- Contribution of the Juxtatransmembrane Intracellular Regions to the Time Course and Permeation of ATP-gated P2X7 Receptor Ion Channels
- (2015) Rebecca C. Allsopp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Architectural and Functional Similarities between Trimeric ATP-Gated P2X Receptors and Acid-Sensing Ion Channels
- (2015) Stephan Kellenberger et al. JOURNAL OF MOLECULAR BIOLOGY
- P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study
- (2015) Rayid Abdulqawi et al. LANCET
- Cryo-EM: A Unique Tool for the Visualization of Macromolecular Complexity
- (2015) Eva Nogales et al. MOLECULAR CELL
- Flexible subunit stoichiometry of functional human P2X2/3 heteromeric receptors
- (2015) Maria Kowalski et al. NEUROPHARMACOLOGY
- Biophysical properties of acid-sensing ion channels (ASICs)
- (2015) Stefan Gründer et al. NEUROPHARMACOLOGY
- Roles of the lateral fenestration residues of the P2X4 receptor that contribute to the channel function and the deactivation effect of ivermectin
- (2015) Chao Gao et al. Purinergic Signalling
- Involvement of Ectodomain Leu 214 in ATP Binding and Channel Desensitization of the P2X4 Receptor
- (2014) Longmei Zhang et al. BIOCHEMISTRY
- Non-Synonymous Single Nucleotide Polymorphisms in the P2X Receptor Genes: Association with Diseases, Impact on Receptor Functions and Potential Use as Diagnosis Biomarkers
- (2014) Emily Caseley et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ectodomain Movements of an ATP-gated Ion Channel (P2X2 Receptor) Probed by Disulfide Locking
- (2014) Olga Stelmashenko et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Voltage- and ATP-dependent structural rearrangements of the P2X2 receptor associated with the gating of the pore
- (2014) Batu Keceli et al. JOURNAL OF PHYSIOLOGY-LONDON
- Nucleotide signalling during inflammation
- (2014) Marco Idzko et al. NATURE
- Involvement of the left-flipper-to-dorsal-fin interface of the zebrafish P2X4 receptor in ATP binding and structural rearrangement
- (2014) Yanling Jie et al. NEUROSCIENCE LETTERS
- Inherent Dynamics of Head Domain Correlates with ATP-Recognition of P2X4 Receptors: Insights Gained from Molecular Simulations
- (2014) Li-Dong Huang et al. PLoS One
- Identification of Functionally Important Residues of the Rat P2X4 Receptor by Alanine Scanning Mutagenesis of the Dorsal Fin and Left Flipper Domains
- (2014) Vendula Tvrdonova et al. PLoS One
- Structural and functional properties of the rat P2X4 purinoreceptor extracellular vestibule during gating
- (2014) Milos B. Rokic et al. Frontiers in Cellular Neuroscience
- Principles and properties of ion flow in P2X receptors
- (2014) Damien S. K. Samways et al. Frontiers in Cellular Neuroscience
- Unanticipated parallels in architecture and mechanism between ATP-gated P2X receptors and acid sensing ion channels
- (2013) Isabelle Baconguis et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- A novel P2RX2 mutation in an Italian family affected by autosomal dominant nonsyndromic hearing loss
- (2013) Flavio Faletra et al. GENE
- Regulation of activity of P2X7 receptor by its splice variants in cultured mouse astrocytes
- (2013) Yuuka Kido et al. GLIA
- Direct Gating of ATP-activated Ion Channels (P2X2 Receptors) by Lipophilic Attachment at the Outer End of the Second Transmembrane Domain
- (2013) Simon W. Rothwell et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Acid-sensing ion channels in pain and disease
- (2013) John A. Wemmie et al. NATURE REVIEWS NEUROSCIENCE
- Multiple Roles of the Extracellular Vestibule Amino Acid Residues in the Function of the Rat P2X4 Receptor
- (2013) Milos B. Rokic et al. PLoS One
- Optical control of trimeric P2X receptors and acid-sensing ion channels
- (2013) L. E. Browne et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutation of the ATP-gated P2X2 receptor leads to progressive hearing loss and increased susceptibility to noise
- (2013) D. Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Optical control of an ion channel gate
- (2013) D. Lemoine et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Inter- and intrasubunit interactions between transmembrane helices in the open state of P2X receptor channels
- (2013) G. Heymann et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Tryptophan 46 is a site for ethanol and ivermectin action in P2X4 receptors
- (2013) Maya Popova et al. Purinergic Signalling
- Heteromeric assembly of P2X subunits
- (2013) Anika Saul et al. Frontiers in Cellular Neuroscience
- Exploring the ATP-binding site of P2X receptors
- (2013) Thierry Chataigneau et al. Frontiers in Cellular Neuroscience
- Introduction and perspective, historical note
- (2013) Geoffrey Burnstock Frontiers in Cellular Neuroscience
- Post-translational regulation of P2X receptor channels: modulation by phospholipids
- (2013) Louis-Philippe Bernier et al. Frontiers in Cellular Neuroscience
- Clinical evaluation of the efficacy of the P2X7purinergic receptor antagonist AZD9056 on the signs and symptoms of rheumatoid arthritis in patients with active disease despite treatment with methotrexate or sulphasalazine
- (2012) Edward C Keystone et al. ANNALS OF THE RHEUMATIC DISEASES
- Ligand-Gated Ion Channels: New Insights into Neurological Disorders and Ligand Recognition
- (2012) Damien Lemoine et al. CHEMICAL REVIEWS
- Tightening of the ATP-binding sites induces the opening of P2X receptor channels
- (2012) Ruotian Jiang et al. EMBO JOURNAL
- Allosteric Modulation of Ca2+flux in Ligand-gated Cation Channel (P2X4) by Actions on Lateral Portals
- (2012) Damien S. K. Samways et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Gating properties of the P2X2a and P2X2b receptor channels: Experiments and mathematical modeling
- (2012) Anmar Khadra et al. JOURNAL OF GENERAL PHYSIOLOGY
- Differential Expression and Pharmacology of Native P2X Receptors in Rat and Primate Sensory Neurons
- (2012) A. Serrano et al. JOURNAL OF NEUROSCIENCE
- Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexes
- (2012) Isabelle Baconguis et al. NATURE
- Molecular mechanism of ATP binding and ion channel activation in P2X receptors
- (2012) Motoyuki Hattori et al. NATURE
- Black mamba venom peptides target acid-sensing ion channels to abolish pain
- (2012) Sylvie Diochot et al. NATURE
- Neuromodulation by Extracellular ATP and P2X Receptors in the CNS
- (2012) Baljit S. Khakh et al. NEURON
- Covalent Modification of Mutant Rat P2X2 Receptors with a Thiol-Reactive Fluorophore Allows Channel Activation by Zinc or Acidic pH without ATP
- (2012) Shlomo S. Dellal et al. PLoS One
- Gating mechanism of a P2X4 receptor developed from normal mode analysis and molecular dynamics simulations
- (2012) J. Du et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor
- (2012) E. Lorinczi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Agonist binding evokes extensive conformational changes in the extracellular domain of the ATP-gated human P2X1 receptor ion channel
- (2012) J. A. Roberts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Moving through the gate in ATP-activated P2X receptors
- (2012) Ruotian Jiang et al. TRENDS IN BIOCHEMICAL SCIENCES
- Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1
- (2012) Roger J.P. Dawson et al. Nature Communications
- Role of the Ectodomain Serine 275 in Shaping the Binding Pocket of the ATP-Gated P2X3 Receptor
- (2011) Nataliia Petrenko et al. BIOCHEMISTRY
- Molecular basis of selective antagonism of the P2X1 receptor for ATP by NF449 and suramin: contribution of basic amino acids in the cysteine-rich loop
- (2011) S El-Ajouz et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Loss-of-Function Polymorphism in the Human P2X4 Receptor Is Associated With Increased Pulse Pressure
- (2011) Leanne Stokes et al. HYPERTENSION
- Cysteine Scanning Mutagenesis (Residues Glu52–Gly96) of the Human P2X1 Receptor for ATP
- (2011) Rebecca C. Allsopp et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ion access pathway to the transmembrane pore in P2X receptor channels
- (2011) Toshimitsu Kawate et al. JOURNAL OF GENERAL PHYSIOLOGY
- Calcium-dependent block of P2X7 receptor channel function is allosteric
- (2011) Zonghe Yan et al. JOURNAL OF GENERAL PHYSIOLOGY
- A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
- (2011) Christopher J. Bohlen et al. NATURE
- Activation and Regulation of Purinergic P2X Receptor Channels
- (2011) C. Coddou et al. PHARMACOLOGICAL REVIEWS
- Agonist trapped in ATP-binding sites of the P2X2 receptor
- (2011) R. Jiang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preferential use of unobstructed lateral portals as the access route to the pore of human ATP-gated ion channels (P2X receptors)
- (2011) D. S. K. Samways et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutation of Putative N-Linked Glycosylation Sites on the Human Nucleotide Receptor P2X7Reveals a Key Residue Important for Receptor Function
- (2010) Lisa Y. Lenertz et al. BIOCHEMISTRY
- Structural interpretation of P2X receptor mutagenesis studies on drug action
- (2010) Richard J Evans BRITISH JOURNAL OF PHARMACOLOGY
- N-Glycans mutations rule oligomeric assembly and functional expression of P2X3 receptor for extracellular ATP
- (2010) F. Vacca et al. GLYCOBIOLOGY
- Gated Access to the Pore of a P2X Receptor
- (2010) Sebastian Kracun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Putative Extracellular Salt Bridge at the Subunit Interface Contributes to the Ion Channel Function of the ATP-gated P2X2 Receptor
- (2010) Ruotian Jiang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating
- (2010) Z. Yan et al. JOURNAL OF NEUROSCIENCE
- Molecular Determinants of Potent P2X2 Antagonism Identified by Functional Analysis, Mutagenesis, and Homology Docking
- (2010) C. Wolf et al. MOLECULAR PHARMACOLOGY
- P2X receptor channels show threefold symmetry in ionic charge selectivity and unitary conductance
- (2010) Liam E Browne et al. NATURE NEUROSCIENCE
- A Nonproton Ligand Sensor in the Acid-Sensing Ion Channel
- (2010) Ye Yu et al. NEURON
- Identification of the amino acid residues in the extracellular domain of rat P2X7receptor involved in functional inhibition by acidic pH
- (2009) X Liu et al. BRITISH JOURNAL OF PHARMACOLOGY
- Contribution of the region Glu181 to Val200 of the extracellular loop of the human P2X1 receptor to agonist binding and gating revealed using cysteine scanning mutagenesis1
- (2009) Jonathan A. Roberts et al. JOURNAL OF NEUROCHEMISTRY
- Polar Residues in the Second Transmembrane Domain of the Rat P2X2 Receptor That Affect Spontaneous Gating, Unitary Conductance, and Rectification
- (2009) L. Cao et al. JOURNAL OF NEUROSCIENCE
- Functional and structural identification of amino acid residues of the P2X2receptor channel critical for the voltage- and [ATP]-dependent gating
- (2009) Batu Keceli et al. JOURNAL OF PHYSIOLOGY-LONDON
- Pore architecture and ion sites in acid-sensing ion channels and P2X receptors
- (2009) Eric B. Gonzales et al. NATURE
- Crystal structure of the ATP-gated P2X4 ion channel in the closed state
- (2009) Toshimitsu Kawate et al. NATURE
- P2X receptors: dawn of the post-structure era
- (2009) Mark T. Young TRENDS IN BIOCHEMICAL SCIENCES
- Direct Observation of ATP-Induced Conformational Changes in Single P2X4 Receptors
- (2009) Youichi Shinozaki et al. PLOS BIOLOGY
- Signaling at Purinergic P2X Receptors
- (2008) Annmarie Surprenant et al. Annual Review of Physiology
- Role of the domain encompassing Arg304–Ile328in rat P2X2receptor conformation revealed by alterations in complex glycosylation at Asn298
- (2008) Mark T. Young et al. BIOCHEMICAL JOURNAL
- Identification of regions of the P2X7 receptor that contribute to human and rat species differences in antagonist effects
- (2008) A D Michel et al. BRITISH JOURNAL OF PHARMACOLOGY
- Ectodomain Lysines and Suramin Block of P2X1Receptors
- (2008) Joan A. Sim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The P2X7Receptor Channel Pore Dilates under Physiological Ion Conditions
- (2008) Zonghe Yan et al. JOURNAL OF GENERAL PHYSIOLOGY
- Voltage- and [ATP]-dependent Gating of the P2X2ATP Receptor Channel
- (2008) Yuichiro Fujiwara et al. JOURNAL OF GENERAL PHYSIOLOGY
- Gating the pore of P2X receptor channels
- (2008) Mufeng Li et al. NATURE NEUROSCIENCE
- Patch-clamp coordinated spectroscopy shows P2X2 receptor permeability dynamics require cytosolic domain rearrangements but not Panx-1 channels
- (2008) S. Chaumont et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ADP-ribosylation at R125 gates the P2X7 ion channel by presenting a covalent ligand to its nucleotide binding site
- (2007) Sahil Adriouch et al. FASEB JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started