Chemical structure modifications and nano-technology applications for improving ADME-Tox properties, a review

What Contributes to Serotonin–Norepinephrine Reuptake Inhibitors’ Dual-Targeting Mechanism? The Key Role of Transmembrane Domain 6 in Human Serotonin and Norepinephrine Transporters Revealed by Molecular Dynamics Simulation

(2018) Weiwei Xue et al.   ACS Chemical Neuroscience

Practical guidelines for the characterization and quality control of pure drug nanoparticles and nano-cocrystals in the pharmaceutical industry

(2018) Leena Peltonen   ADVANCED DRUG DELIVERY REVIEWS

Antibody–Drug Conjugates for Cancer Treatment

(2018) John M. Lambert et al.   Annual Review of Medicine

N -methylation in amino acids and peptides: Scope and limitations

(2018) Anamika Sharma et al.   BIOPOLYMERS

Medicinal chemistry in drug discovery in big pharma: past, present and future

(2018) Ian B. Campbell et al.   DRUG DISCOVERY TODAY

2017 in review: FDA approvals of new molecular entities

(2018) Michael S. Kinch et al.   DRUG DISCOVERY TODAY

Antibody-drug conjugates: Promising and efficient tools for targeted cancer therapy

(2018) Hadi Nasiri et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Computational identification of the binding mechanism of a triple reuptake inhibitor amitifadine for the treatment of major depressive disorder

(2018) Weiwei Xue et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Physical characterization and in vivo organ distribution of coated iron oxide nanoparticles

(2018) Anirudh Sharma et al.   Scientific Reports

The BET inhibitor I-BET762 inhibits pancreatic ductal adenocarcinoma cell proliferation and enhances the therapeutic effect of gemcitabine

(2018) Fang Xie et al.   Scientific Reports

Enhancing the therapeutic potential of peptide toxins

(2017) Raymond S. Norton   Expert Opinion on Drug Discovery

Fabrication of a Soybean Bowman–Birk Inhibitor (BBI) Nanodelivery Carrier To Improve Bioavailability of Curcumin

(2017) Chun Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Fulvestrant-loaded polymer-based nanoparticles for local drug delivery: Preparation and in vitro characterization

(2017) C. Hascicek et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Non-invasive approaches for drug delivery to the brain based on the receptor mediated transport

(2017) Fei Fang et al.   Materials Science & Engineering C-Materials for Biological Applications

Preclinical Evaluation of MEDI0641, a Pyrrolobenzodiazepine-Conjugated Antibody–Drug Conjugate Targeting 5T4

(2017) Jay Harper et al.   MOLECULAR CANCER THERAPEUTICS

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

(2017) Thomas H. Pillow et al.   MOLECULAR CANCER THERAPEUTICS

Lipid–Drug Conjugate for Enhancing Drug Delivery

(2017) Danielle Irby et al.   MOLECULAR PHARMACEUTICS

Improving gold nanorod delivery to the central nervous system by conjugation to the shuttle Angiopep-2

(2017) Carolina Velasco-Aguirre et al.   Nanomedicine

Selenium nanoparticles as versatile carriers for oral delivery of insulin: Insight into the synergic antidiabetic effect and mechanism

(2017) Wenji Deng et al.   Nanomedicine-Nanotechnology Biology and Medicine

Strategies and challenges for the next generation of antibody–drug conjugates

(2017) Alain Beck et al.   NATURE REVIEWS DRUG DISCOVERY

Cell-Penetrating Peptides: From Basic Research to Clinics

(2017) Giulia Guidotti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The modification of natural products for medical use

(2017) Zongru Guo   Acta Pharmaceutica Sinica B

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Molecular inflation, attrition and the rule of five

(2016) Paul D. Leeson   ADVANCED DRUG DELIVERY REVIEWS

Oral Administration of Peptide-Based Drugs: Beyond Lipinski's Rule

(2016) Gabriela B. Santos et al.   ChemMedChem

Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport

(2016) E Cocucci et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Targeting protein–protein interactions, a wide open field for drug design

(2016) May Bakail et al.   COMPTES RENDUS CHIMIE

Drug discovery beyond the rule of 5 - Opportunities and challenges

(2016) Bradley C. Doak et al.   Expert Opinion on Drug Discovery

Chemical modification of curcumin: Solubility and antioxidant capacity

(2016) Saleh A. Mohamed et al.   INTERNATIONAL JOURNAL OF FOOD PROPERTIES

Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

(2016) Mie Kristensen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

No Denying It: Medicinal Chemistry Training Is in Big Trouble

(2016) Michael F. Rafferty   JOURNAL OF MEDICINAL CHEMISTRY

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD)

(2016) Jiawang Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Identification of Novel Ligands Targeting Multiple Sites within a Chemokine–G-Protein-Coupled-Receptor Interface

(2016) Emmanuel W. Smith et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation

(2016) Zeljko M. Prijovich et al.   MOLECULAR PHARMACEUTICS

Recent advances in the construction of antibody–drug conjugates

(2016) Vijay Chudasama et al.   Nature Chemistry

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Cyclic Dipeptide Shuttles as a Novel Skin Penetration Enhancement Approach: Preliminary Evaluation with Diclofenac

(2016) Yousuf Mohammed et al.   PLoS One

Systematic Analysis of Drug Targets Confirms Expression in Disease-Relevant Tissues

(2016) Vinod Kumar et al.   Scientific Reports

Supramolecular Crafting of Self-Assembling Camptothecin Prodrugs with Enhanced Efficacy against Primary Cancer Cells

(2016) Hao Su et al.   Theranostics

A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria

(2016) Margaret A. Phillips et al.   ACS Infectious Diseases

How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies

(2016) Liang Shen et al.   Scientific Reports

Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors

(2016) Mélaine A. Kuenemann et al.   Scientific Reports

The vascular disrupting activity of OXi8006 in endothelial cells and its phosphate prodrug OXi8007 in breast tumor xenografts

(2015) Tracy E. Strecker et al.   CANCER LETTERS

Preparation and evaluation of Baicalin-loaded cationic solid lipid nanoparticles conjugated with OX26 for improved delivery across the BBB

(2015) Zhidong Liu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Peptide therapeutics: current status and future directions

(2015) Keld Fosgerau et al.   DRUG DISCOVERY TODAY

Stabilization of Exosome-targeting Peptides via Engineered Glycosylation

(2015) Michelle E. Hung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Percutaneous delivery of α-melanocyte-stimulating hormone for the treatment of imiquimod-induced psoriasis

(2015) Punit P. Shah et al.   JOURNAL OF DRUG TARGETING

ABT-199 (venetoclax) and BCL-2 inhibitors in clinical development

(2015) Shundong Cang et al.   Journal of Hematology & Oncology

Permeability of the Blood–Brain Barrier: Molecular Mechanism of Transport of Drugs and Physiologically Important Compounds

(2015) Clifford W. Fong   JOURNAL OF MEMBRANE BIOLOGY

Lipid Bilayer Crossing—The Gate of Symmetry. Water-Soluble Phenylproline-Based Blood-Brain Barrier Shuttles

(2015) Pol Arranz-Gibert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Predicting drug metabolism: experiment and/or computation?

(2015) Johannes Kirchmair et al.   NATURE REVIEWS DRUG DISCOVERY

Principles in the design of ligand-targeted cancer therapeutics and imaging agents

(2015) Madduri Srinivasarao et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Property Design: Does Everyone Get It?

(2015) Paul D. Leeson et al.   ACS Medicinal Chemistry Letters

Designed BH3 Peptides with High Affinity and Specificity for Targeting Mcl-1 in Cells

(2014) Glenna Wink Foight et al.   ACS Chemical Biology

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

(2014) Wenxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

(2014) Bradley Croy Doak et al.   CHEMISTRY & BIOLOGY

ANG4043, a Novel Brain-Penetrant Peptide-mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice

(2014) A. Regina et al.   MOLECULAR CANCER THERAPEUTICS

Redox Potential Ultrasensitive Nanoparticle for the Targeted Delivery of Camptothecin to HER2-Positive Cancer Cells

(2014) Remant Bahadur K.C. et al.   MOLECULAR PHARMACEUTICS

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

(2014) Lee D. Fader et al.   ACS Medicinal Chemistry Letters

Current prodrug strategies for improving oral absorption of nucleoside analogues

(2014) Youxi Zhang et al.   Asian Journal of Pharmaceutical Sciences

Systemic delivery of gemcitabine triphosphate via LCP nanoparticles for NSCLC and pancreatic cancer therapy

(2013) Yuan Zhang et al.   BIOMATERIALS

New phenstatin–fatty acid conjugates: Synthesis and evaluation

(2013) Jinhui Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Distribution of the anticancer drugs doxorubicin, mitoxantrone and topotecan in tumors and normal tissues

(2013) Krupa J. Patel et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Design, optimization and evaluation of poly-ɛ-caprolactone (PCL) based polymeric nanoparticles for oral delivery of lopinavir

(2013) Punna Rao Ravi et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Thermodynamic modeling for solubility prediction of indomethacin in self-nanoemulsifying drug delivery system (SNEDDS) and its individual components

(2013) Faiyaz Shakeel et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Basic Concepts in Medicinal Chemistry

(2013) Marc W. Harrold et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Combining two technologies: Multifunctional polymers and self-nanoemulsifying drug delivery system (SNEDDS) for oral insulin administration

(2013) Duangkamon Sakloetsakun et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

PRECEDENT: A Randomized Phase II Trial Comparing Vintafolide (EC145) and Pegylated Liposomal Doxorubicin (PLD) in Combination Versus PLD Alone in Patients With Platinum-Resistant Ovarian Cancer

(2013) R. Wendel Naumann et al.   JOURNAL OF CLINICAL ONCOLOGY

Prodrugs for masking bitter taste of antibacterial drugs—a computational approach

(2013) Rafik Karaman   JOURNAL OF MOLECULAR MODELING

The MIntAct project—IntAct as a common curation platform for 11 molecular interaction databases

(2013) Sandra Orchard et al.   NUCLEIC ACIDS RESEARCH

Bioreductive prodrugs as cancer therapeutics: targeting tumor hypoxia

(2013) Christopher P. Guise et al.   Chinese Journal of Cancer

Challenges in Development of Nanoparticle-Based Therapeutics

(2012) Neil Desai   AAPS Journal

Small-molecule inhibitor starting points learned from protein–protein interaction inhibitor structure

(2012) David Ryan Koes et al.   BIOINFORMATICS

HINT: High-quality protein interactomes and their applications in understanding human disease

(2012) Jishnu Das et al.   BMC Systems Biology

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Relationship between Hot Spot Residues and Ligand Binding Hot Spots in Protein–Protein Interfaces

(2012) Brandon S. Zerbe et al.   Journal of Chemical Information and Modeling

Synthesis and Biological Characterization of Protease-Activated Prodrugs of Doxazolidine

(2012) Benjamin L. Barthel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Oxaliplatin: a review in the era of molecularly targeted therapy

(2011) T. Alcindor et al.   Current Oncology

Enhanced bioavailability of nano-sized chitosan–atorvastatin conjugate after oral administration to rats

(2011) Mohammed Anwar et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ibulocydine Is a Novel Prodrug Cdk Inhibitor That Effectively Induces Apoptosis in Hepatocellular Carcinoma Cells

(2011) Seung-Ju Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved proteolytic stability of chicken cathelicidin-2 derived peptides by d-amino acid substitutions and cyclization

(2011) E. Margo Molhoek et al.   PEPTIDES

N-Methyl Phenylalanine-Rich Peptides as Highly Versatile Blood−Brain Barrier Shuttles

(2010) Morteza Malakoutikhah et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solid lipid nanoparticles for transdermal delivery of diclofenac sodium: preparation, characterization andin vitrostudies

(2010) Dongfei Liu et al.   JOURNAL OF MICROENCAPSULATION

Effects of nanomaterial physicochemical properties on in vivo toxicity

(2009) Kristin L. Aillon et al.   ADVANCED DRUG DELIVERY REVIEWS

Arabinogalactan−Folic Acid−Drug Conjugate for Targeted Delivery and Target-Activated Release of Anticancer Drugs to Folate Receptor-Overexpressing Cells

(2009) Roy I. Pinhassi et al.   BIOMACROMOLECULES

Natural product inhibitors of protein–protein interactions mediated by Src-family SH2 domains

(2009) Bianca Sperl et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Characteristics of compounds that cross the blood-brain barrier

(2009) William A Banks   BMC Neurology

The Design and Development of Fesoterodine as a Prodrug of 5- Hydroxymethyl Tolterodine (5-HMT), the Active Metabolite of Tolterodine

(2009) B. Malhotra et al.   CURRENT MEDICINAL CHEMISTRY

Conjugation with Cationic Cell-Penetrating Peptide Increases Pulmonary Absorption of Insulin

(2009) Leena N. Patel et al.   MOLECULAR PHARMACEUTICS

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Increasing Solubility of Proteins and Peptides by Site-Specific Modification with Betaine

(2008) Junpeng Xiao et al.   BIOCONJUGATE CHEMISTRY

Nanotechnology in ocular drug delivery

(2008) S SAHOO et al.   DRUG DISCOVERY TODAY

Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state

(2008) Flemming Seier Nielsen et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Thermodynamic and Structure Guided Design of Statin Based Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase

(2008) Ronald W. Sarver et al.   JOURNAL OF MEDICINAL CHEMISTRY

Backbone Cyclic Peptidomimetic Melanocortin-4 Receptor Agonist as a Novel Orally Administrated Drug Lead for Treating Obesity

(2008) Shmuel Hess et al.   JOURNAL OF MEDICINAL CHEMISTRY