Applications and Challenges for Use of Cell-Penetrating Peptides as Delivery Vectors for Peptide and Protein Cargos

Penetratin-Mediated Transepithelial Insulin Permeation: Importance of Cationic Residues and pH for Complexation and Permeation

(2015) Mie Kristensen et al.   AAPS Journal

Conjugation of Cell-Penetrating Peptides to Parathyroid Hormone Affects Its Structure, Potency, and Transepithelial Permeation

(2015) Mie Kristensen et al.   BIOCONJUGATE CHEMISTRY

Monitoring the cytosolic entry of cell-penetrating peptides using a pH-sensitive fluorophore

(2015) Ziqing Qian et al.   CHEMICAL COMMUNICATIONS

Selenium as an alternative peptide label – comparison to fluorophore-labelled penetratin

(2015) Laura Hyrup Møller et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Effect of different intestinal conditions on the intermolecular interaction between insulin and cell-penetrating peptide penetratin and on its contribution to stimulation of permeation through intestinal epithelium

(2015) Noriyasu Kamei et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation

(2015) Alistair Taverner et al.   JOURNAL OF CONTROLLED RELEASE

Peptide-enhanced oral delivery of therapeutic peptides and proteins

(2015) M. Kristensen et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Early Endosomal Escape of a Cyclic Cell-Penetrating Peptide Allows Effective Cytosolic Cargo Delivery

(2014) Ziqing Qian et al.   BIOCHEMISTRY

In vivo proof of concept of oral insulin delivery based on a co-administration strategy with the cell-penetrating peptide penetratin

(2014) Ebbe Juel Bech Nielsen et al.   JOURNAL OF CONTROLLED RELEASE

β- and γ-Amino Acids at α-Helical Interfaces: Toward the Formation of Highly Stable Foldameric Coiled Coils

(2014) Elisabeth K. Nyakatura et al.   ACS Medicinal Chemistry Letters

A pH-responsive α-helical cell penetrating peptide-mediated liposomal delivery system

(2013) Qianyu Zhang et al.   BIOMATERIALS

One single method to produce native and Tat-fused recombinant human α-synuclein in Escherichia coli

(2013) Laura Caldinelli et al.   BMC BIOTECHNOLOGY

The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures

(2013) Bruno P. Meloni et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Cell-Penetrating Peptide-Mediated Therapeutic Molecule Delivery into the Central Nervous System

(2013) Li-Li Zou et al.   Current Neuropharmacology

Visualization and targeted disruption of protein interactions in living cells

(2013) Henry D. Herce et al.   Nature Communications

Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs

(2012) Ziqing Qian et al.   ACS Chemical Biology

Oral biodrug delivery using cell-penetrating peptide

(2012) El-Sayed Khafagy et al.   ADVANCED DRUG DELIVERY REVIEWS

Membrane interaction and secondary structure of de novo designed arginine-and tryptophan peptides with dual function

(2012) Hanna A. Rydberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Tryptophan Content and Backbone Spacing on the Uptake Efficiency of Cell-Penetrating Peptides

(2012) Hanna A. Rydberg et al.   BIOCHEMISTRY

Membrane adsorption and binding, cellular uptake and cytotoxicity of cell-penetrating peptidomimetics with α-peptide/β-peptoid backbone: Effects of hydrogen bonding and α-chirality in the β-peptoid residues

(2012) Xiaona Jing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Tryptophan within basic peptide sequences triggers glycosaminoglycan-dependent endocytosis

(2012) Chérine Bechara et al.   FASEB JOURNAL

Human Protein 53-Derived Cell-Penetrating Peptides

(2012) Julia Suhorutsenko et al.   International Journal of Peptide Research and Therapeutics

siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat

(2012) M. Al Soraj et al.   JOURNAL OF CONTROLLED RELEASE

Cell entry of cell penetrating peptides: tales of tails wagging dogs

(2012) Arwyn T. Jones et al.   JOURNAL OF CONTROLLED RELEASE

Determination of the Optimal Cell-Penetrating Peptide Sequence for Intestinal Insulin Delivery Based on Molecular Orbital Analysis with Self-Organizing Maps

(2012) Noriyasu Kamei et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Interaction of Peptidomimetics with Bilayer Membranes: Biophysical Characterization and Cellular Uptake

(2012) Xiaona Jing et al.   LANGMUIR

Cell-penetrating Peptides as Versatile Vehicles for Oligonucleotide Delivery

(2012) Helerin Margus et al.   MOLECULAR THERAPY

Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

(2012) Hisaaki Hirose et al.   MOLECULAR THERAPY

Enterohemorrhagic Escherichia coli infection stimulates Shiga toxin 1 macropinocytosis and transcytosis across intestinal epithelial cells

(2011) Valeriy Lukyanenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Fate of polymeric nanocarriers for oral drug delivery

(2011) Laurence Plapied et al.   CURRENT OPINION IN COLLOID & INTERFACE SCIENCE

PepFect 14, a novel cell-penetrating peptide for oligonucleotide delivery in solution and as solid formulation

(2011) Kariem Ezzat et al.   NUCLEIC ACIDS RESEARCH

Relationships between Membrane Binding, Affinity and Cell Internalization Efficacy of a Cell-Penetrating Peptide: Penetratin as a Case Study

(2011) Isabel D. Alves et al.   PLoS One

Cell-penetrating peptide exploited syndecans

(2010) Tamás Letoha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Generation of Endosomolytic Reagents by Branching of Cell-Penetrating Peptides: Tools for the Delivery of Bioactive Compounds to Live Cells in Cis or Trans

(2010) Alfredo M. Angeles-Boza et al.   BIOCONJUGATE CHEMISTRY

Structural requirements of penetratin absorption enhancement efficiency for insulin delivery

(2010) El-Sayed Khafagy et al.   JOURNAL OF CONTROLLED RELEASE

Molecular imaging analysis of intestinal insulin absorption boosted by cell-penetrating peptides by using positron emission tomography

(2010) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

Lipid reorganization induced by membrane-active peptides probed using differential scanning calorimetry

(2009) Pierre Joanne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Specific labeling with potent radiolabels alters the uptake of cell-penetrating peptides

(2009) Cornelia Walther et al.   BIOPOLYMERS

Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins

(2009) Dohoon Kim et al.   Cell Stem Cell

Efficiency of cell-penetrating peptides on the nasal and intestinal absorption of therapeutic peptides and proteins

(2009) El-Sayed Khafagy et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Translocation and Endocytosis for Cell-penetrating Peptide Internalization

(2009) Chen-Yu Jiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protein absorption using cell-penetrating peptides

(2009) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

Conjugation with Cationic Cell-Penetrating Peptide Increases Pulmonary Absorption of Insulin

(2009) Leena N. Patel et al.   MOLECULAR PHARMACEUTICS

Cell-penetrating d-Isomer Peptides of p53 C-terminus: Long-term Inhibitory Effect on the Growth of Bladder Cancer

(2009) Daiji Araki et al.   UROLOGY

Metabolic Cleavage and Translocation Efficiency of Selected Cell Penetrating Peptides: A Comparative Study with Epithelial Cell Cultures

(2008) Christina Foerg et al.   AAPS Journal

Foldamers with Heterogeneous Backbones

(2008) W. Seth Horne et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stimulated endocytosis in penetratin uptake: Effect of arginine and lysine

(2008) Helene L. Åmand et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Membrane interaction and perturbation mechanisms induced by two cationic cell penetrating peptides with distinct charge distribution

(2008) I ALVES et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Distinct Uptake Routes of Cell-Penetrating Peptide Conjugates

(2008) Per Lundin et al.   BIOCONJUGATE CHEMISTRY

Direct Peptide Interaction with Surface Glycosaminoglycans Contributes to the Cell Penetration of Maurocalcine

(2008) Narendra Ram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Usefulness of cell-penetrating peptides to improve intestinal insulin absorption

(2008) Noriyasu Kamei et al.   JOURNAL OF CONTROLLED RELEASE

Binding and Clustering of Glycosaminoglycans: A Common Property of Mono- and Multivalent Cell-Penetrating Compounds

(2007) André Ziegler et al.   BIOPHYSICAL JOURNAL

Live-cell analysis of cell penetration ability and toxicity of oligo-arginines

(2007) Gisela Tünnemann et al.   JOURNAL OF PEPTIDE SCIENCE