Monitoring Melanoma Using Circulating Free DNA

Evaluation of a Rapid, Fully Automated Platform for Detection of BRAF and NRAS Mutations in Melanoma

(2018) F Barel et al.   ACTA DERMATO-VENEREOLOGICA

Fe-Au Nanoparticle-Coupling for Ultrasensitive Detections of Circulating Tumor DNA

(2018) Ping Hu et al.   ADVANCED MATERIALS

Circulating tumoral DNA: Preanalytical validation and quality control in a diagnostic laboratory

(2018) Sergey Nikolaev et al.   ANALYTICAL BIOCHEMISTRY

Circulating Tumor DNA: Measurement and Clinical Utility

(2018) Joshua Donaldson et al.   Annual Review of Medicine

Correlation between circulating tumour DNA and metabolic tumour burden in metastatic melanoma patients

(2018) Ashleigh C. McEvoy et al.   BMC CANCER

The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues

(2018) Nong Yang et al.   BMC CANCER

Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA

(2018) Neeraj Agarwal et al.   CANCER

Liquid Biopsies and Cancer Immunotherapy

(2018) Jonathan R. Thompson et al.   CANCER JOURNAL

Melanoma circulating tumor cells: Benefits and challenges required for clinical application

(2018) G. Marsavela et al.   CANCER LETTERS

The role of circulating tumour cells and nucleic acids in blood for the detection of bladder cancer: A systematic review

(2018) Pramit Khetrapal et al.   CANCER TREATMENT REVIEWS

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients

(2018) Oliver A. Zill et al.   CLINICAL CANCER RESEARCH

Clinical Utility of Cell-Free DNA for the Detection ofALKFusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non–Small Cell Lung Cancer

(2018) Caroline E. McCoach et al.   CLINICAL CANCER RESEARCH

The identification and isolation of CTCs: A biological Rubik’s cube

(2018) Cristina Mansilla et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Plasma total cell-free DNA (cfDNA) is a surrogate biomarker for tumour burden and a prognostic biomarker for survival in metastatic melanoma patients

(2018) S. Valpione et al.   EUROPEAN JOURNAL OF CANCER

Circulating cell-free nucleic acids: characteristics and applications

(2018) Ondrej Pös et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Circulating tumor DNA in blood: Future genomic biomarkers for cancer detection

(2018) Sumbal Sumbal et al.   EXPERIMENTAL HEMATOLOGY

Molecular classification and subtype-specific characterization of skin cutaneous melanoma by aggregating multiple genomic platform data

(2018) Xiaofan Lu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A review on the Idylla platform: towards the assessment of actionable genomic alterations in one day

(2018) Arnaud Uguen et al.   JOURNAL OF CLINICAL PATHOLOGY

Genetic profiling of cancer with circulating tumor DNA analysis

(2018) Ling Lu et al.   Journal of Genetics and Genomics

Analytical Validation of a Hybrid Capture–Based Next-Generation Sequencing Clinical Assay for Genomic Profiling of Cell-Free Circulating Tumor DNA

(2018) Travis A. Clark et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Evaluating Circulating Tumor DNA From the Cerebrospinal Fluid of Patients With Melanoma and Leptomeningeal Disease

(2018) Leomar Y Ballester et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Encorafenib plus binimetinib versus vemurafenib or encorafenib in patients with BRAF -mutant melanoma (COLUMBUS): a multicentre, open-label, randomised phase 3 trial

(2018) Reinhard Dummer et al.   LANCET ONCOLOGY

Illustrative cases for monitoring by quantitative analysis of BRAF/NRAS ctDNA mutations in liquid biopsies of metastatic melanoma patients who gained clinical benefits from anti-PD1 antibody therapy

(2018) Teofila Seremet et al.   MELANOMA RESEARCH

Liquid biomarkers in melanoma: detection and discovery

(2018) Su Yin Lim et al.   Molecular Cancer

Cell-Free eccDNAs: A New Type of Nucleic Acid Component for Liquid Biopsy?

(2018) Jing Zhu et al.   Molecular Diagnosis & Therapy

Implementation of next generation sequencing technology for somatic mutation detection in routine laboratory practice

(2018) Tindaro Giardina et al.   PATHOLOGY

Molecular signatures of circulating melanoma cells for monitoring early response to immune checkpoint therapy

(2018) Xin Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Next-Generation Sequencing in Men with Metastatic Prostate Cancer: a Pilot Study

(2018) Pedro C. Barata et al.   Targeted Oncology

Comparison of targeted next generation sequencing (NGS) versus isolated BRAF V600E analysis in patients with metastatic melanoma

(2018) Meng-Lei Zhu et al.   VIRCHOWS ARCHIV

Whole-exome sequencing of cell-free DNA and circulating tumor cells in multiple myeloma

(2018) S. Manier et al.   Nature Communications

Circulating Tumor DNA Genomics Correlate with Resistance to Abiraterone and Enzalutamide in Prostate Cancer

(2018) Matti Annala et al.   Cancer Discovery

Comparison of 4 commercial kits for the extraction of circulating DNA from plasma

(2018) Kristina Warton et al.   Cancer Genetics

Quantitative monitoring of circulating tumor DNA predicts response of cutaneous metastatic melanoma to anti-PD1 immunotherapy

(2018) Guillaume Herbreteau et al.   Oncotarget

Evaluation of pre-analytical factors affecting plasma DNA analysis

(2018) Havell Markus et al.   Scientific Reports

Liquid biopsy by NGS: differential presence of exons (DPE) in cell-free DNA reveals different patterns in metastatic and nonmetastatic colorectal cancer

(2018) Susana Olmedillas-López et al.   Cancer Medicine

Biomarkers for Clinical Benefit of Immune Checkpoint Inhibitor Treatment—A Review From the Melanoma Perspective and Beyond

(2018) Kristina Buder-Bakhaya et al.   Frontiers in Immunology

Association Between Circulating Tumor DNA and Pseudoprogression in Patients With Metastatic Melanoma Treated With Anti–Programmed Cell Death 1 Antibodies

(2018) Jenny H. Lee et al.   JAMA Oncology

Melanoma Immunotherapy: Next-Generation Biomarkers

(2018) Sabrina A. Hogan et al.   Frontiers in Oncology

Personalized Medicine in Malignant Melanoma: Towards Patient Tailored Treatment

(2018) Hildur Helgadottir et al.   Frontiers in Oncology

Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab

(2018) David R. Gandara et al.   NATURE MEDICINE

Clinical potential of circulating tumour DNA in patients receiving anticancer immunotherapy

(2018) Luc Cabel et al.   Nature Reviews Clinical Oncology

Extracellular vesicles and their nucleic acids for biomarker discovery

(2018) Fatemeh Momen-Heravi et al.   PHARMACOLOGY & THERAPEUTICS

Evaluation of commercial kits for purification of circulating free DNA

(2018) Russell J. Diefenbach et al.   Cancer Genetics

Latest development of liquid biopsy

(2018) Alvin Ho-Kwan Cheung et al.   Journal of Thoracic Disease

Somatic mutation analysis in melanoma using targeted next generation sequencing

(2017) Allen P. Miraflor et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Droplet-based digital PCR and next generation sequencing for monitoring circulating tumor DNA: a cancer diagnostic perspective

(2017) Mathilde Postel et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification

(2017) Rick Kamps et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Circulating mutational portrait of cancer: manifestation of aggressive clonal events in both early and late stages

(2017) Meng Yang et al.   Journal of Hematology & Oncology

Comparison of Blood Collection Tubes from Three Different Manufacturers for the Collection of Cell-Free DNA for Liquid Biopsy Mutation Testing

(2017) Christina Alidousty et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

A Comparison of Cell-Free DNA Isolation Kits

(2017) Laure Sorber et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer

(2017) Young Kwang Chae et al.   MOLECULAR CANCER THERAPEUTICS

Evaluation of Streck BCT and PAXgene Stabilised Blood Collection Tubes for Cell-Free Circulating DNA Studies in Plasma

(2017) Kristina Warton et al.   Molecular Diagnosis & Therapy

Application of circulating tumor DNA in prospective clinical oncology trials - standardization of preanalytical conditions

(2017) Lisanne F. van Dessel et al.   Molecular Oncology

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution

(2017) Christopher Abbosh et al.   NATURE

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Targeted agents and immunotherapies: optimizing outcomes in melanoma

(2017) Jason J. Luke et al.   Nature Reviews Clinical Oncology

Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma

(2017) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Feasibility of monitoring advanced melanoma patients using cell-free DNA from plasma

(2017) Tara C. Gangadhar et al.   Pigment Cell & Melanoma Research

The Role of Next-Generation Sequencing in Sarcomas: Evolution From Light Microscope to Molecular Microscope

(2017) Roman Groisberg et al.   Current Oncology Reports

Sensitive droplet digital PCR method for detection of TERT promoter mutations in cell free DNA from patients with metastatic melanoma

(2017) Ashleigh C. McEvoy et al.   Oncotarget

Liquid biopsy in colon cancer: comparison of different circulating DNA extraction systems following absolute quantification of KRAS mutations using Intplex allele-specific PCR

(2017) Vera Kloten et al.   Oncotarget

Plasma Circulating Tumor DNA Levels for the Monitoring of Melanoma Patients: Landscape of Available Technologies and Clinical Applications

(2017) Benoit Busser et al.   Biomed Research International

Liquid Biopsy: Current Status and Future Perspectives

(2017) Sonja Mader et al.   Oncology Research and Treatment

Application of liquid biopsy in precision medicine: opportunities and challenges

(2017) Junyun Wang et al.   Frontiers of Medicine

Comparison of 2 Commercially Available Next-Generation Sequencing Platforms in Oncology

(2017) Nicole M. Kuderer et al.   JAMA Oncology

Characterisation of the changing genomic landscape of metastatic melanoma using cell free DNA

(2017) Anthony Cutts et al.   npj Genomic Medicine

Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients

(2017) Florence Koeppel et al.   PLoS One

Towards Personalized Medicine in Melanoma: Implementation of a Clinical Next-Generation Sequencing Panel

(2017) Blanca de Unamuno Bustos et al.   Scientific Reports

Detection of ubiquitous and heterogeneous mutations in cell-free DNA from patients with early-stage non-small-cell lung cancer

(2016) M. Jamal-Hanjani et al.   ANNALS OF ONCOLOGY

Noninvasive diagnosis and monitoring of mutations by deep sequencing of circulating tumor DNA in esophageal squamous cell carcinoma

(2016) Honglei Luo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Next generation predictive biomarkers for immune checkpoint inhibition

(2016) Yulian Khagi et al.   CANCER AND METASTASIS REVIEWS

Origins, structures, and functions of circulating DNA in oncology

(2016) A. R. Thierry et al.   CANCER AND METASTASIS REVIEWS

Detection of Therapeutically Targetable Driver and Resistance Mutations in Lung Cancer Patients by Next-Generation Sequencing of Cell-Free Circulating Tumor DNA

(2016) J. C. Thompson et al.   CLINICAL CANCER RESEARCH

The Effect of Preservative and Temperature on the Analysis of Circulating Tumor DNA

(2016) Sonya Parpart-Li et al.   CLINICAL CANCER RESEARCH

Cobimetinib combined with vemurafenib in advanced BRAFV600-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

(2016) Paolo A Ascierto et al.   LANCET ONCOLOGY

The genomic landscape of cutaneous melanoma

(2016) Tongwu Zhang et al.   Pigment Cell & Melanoma Research

Next-generation sequencing: advances and applications in cancer diagnosis

(2016) Simona Serratì et al.   OncoTargets and Therapy

Quantification of tumor-derived cell free DNA(cfDNA) by digital PCR (DigPCR) in cerebrospinal fluid of patients with BRAFV600 mutated malignancies

(2016) Parisa Momtaz et al.   Oncotarget

Simple, Sensitive and Accurate Multiplex Detection of Clinically Important Melanoma DNA Mutations in Circulating Tumour DNA with SERS Nanotags

(2016) Eugene J.H. Wee et al.   Theranostics

Fragment Length of Circulating Tumor DNA

(2016) Hunter R. Underhill et al.   PLoS Genetics

Detection of BRAF Mutations Using a Fully Automated Platform and Comparison with High Resolution Melting, Real-Time Allele Specific Amplification, Immunohistochemistry and Next Generation Sequencing Assays, for Patients with Metastatic Melanoma

(2016) Alexandre Harlé et al.   PLoS One

Targeted Next-Generation Sequencing of Plasma DNA from Cancer Patients: Factors Influencing Consistency with Tumour DNA and Prospective Investigation of Its Utility for Diagnosis

(2016) Pamela J. Kaisaki et al.   PLoS One

Low Input Whole-Exome Sequencing to Determine the Representation of the Tumor Exome in Circulating DNA of Non-Small Cell Lung Cancer Patients

(2016) Steffen Dietz et al.   PLoS One

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR

(2015) Anna L. Reid et al.   CLINICAL BIOCHEMISTRY

Targeting oncogenic BRAF and aberrant MAPK activation in the treatment of cutaneous melanoma

(2015) Matteo S. Carlino et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Beyond BRAF V600 : Clinical Mutation Panel Testing by Next-Generation Sequencing in Advanced Melanoma

(2015) Alan E. Siroy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Evolving treatment options for melanoma brain metastases

(2015) Thankamma Ajithkumar et al.   LANCET ONCOLOGY

Sensitivity of plasma BRAFmutant and NRASmutant cell-free DNA assays to detect metastatic melanoma in patients with low RECIST scores and non-RECIST disease progression

(2015) Gregory A. Chang et al.   Molecular Oncology

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Clonal and Subclonal Copy-Number Variants in Cell-Free DNA from Patients with Breast Cancer Using a Massively Multiplexed PCR Methodology

(2015) Eser Kirkizlar et al.   Translational Oncology

Application of Sequencing, Liquid Biopsies, and Patient-Derived Xenografts for Personalized Medicine in Melanoma

(2015) M. R. Girotti et al.   Cancer Discovery

Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma

(2015) Jian Guan et al.   Scientific Reports

Monitoring response to therapy in melanoma by quantifying circulating tumour DNA with droplet digital PCR for BRAF and NRAS mutations

(2015) Simon Chang-Hao Tsao et al.   Scientific Reports

Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA

(2015) Richard B. Lanman et al.   PLoS One

Towards standardisation of cell-free DNA measurement in plasma: controls for extraction efficiency, fragment size bias and quantification

(2014) Alison S. Devonshire et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Noninvasive Detection of Response and Resistance in EGFR-Mutant Lung Cancer Using Quantitative Next-Generation Genotyping of Cell-Free Plasma DNA

(2014) G. R. Oxnard et al.   CLINICAL CANCER RESEARCH

Quantitative Cell-Free Circulating BRAFV600E Mutation Analysis by Use of Droplet Digital PCR in the Follow-up of Patients with Melanoma Being Treated with BRAF Inhibitors

(2014) M. F. Sanmamed et al.   CLINICAL CHEMISTRY

A Meta-analysis of Somatic Mutations from Next Generation Sequencing of 241 Melanomas: A Road Map for the Study of Genes with Potential Clinical Relevance

(2014) J. Xia et al.   MOLECULAR CANCER THERAPEUTICS

An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage

(2014) Aaron M Newman et al.   NATURE MEDICINE

Evaluation of Exome Sequencing to Estimate Tumor Burden in Plasma

(2014) Daniel Klevebring et al.   PLoS One

Circulating cell free DNA: Preanalytical considerations

(2013) Safia El Messaoudi et al.   CLINICA CHIMICA ACTA

Optimizing blood collection, transport and storage conditions for cell free DNA increases access to prenatal testing

(2013) David Wong et al.   CLINICAL BIOCHEMISTRY

Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

(2013) Diego M Marzese et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy

(2013) H. Shi et al.   Cancer Discovery

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Origin and quantification of circulating DNA in mice with human colorectal cancer xenografts

(2010) Alain R. Thierry et al.   NUCLEIC ACIDS RESEARCH

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE