Diagnostic and prognostic value of circulating tumor-related DNA in cancer patients

Genome-wide DNA Methylation Profiling of Cell-Free Serum DNA in Esophageal Adenocarcinoma and Barrett Esophagus

(2015) Rihong Zhai et al.   NEOPLASIA

Cancer heterogeneity: implications for targeted therapeutics

(2013) R Fisher et al.   BRITISH JOURNAL OF CANCER

Assessment of SOX17 DNA methylation in cell free DNA from patients with operable gastric cancer. Association with prognostic variables and survival

(2013) Ioanna Balgkouranidou et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Maternal Plasma Cell-Free Fetal and Maternal DNA at 11-13 Weeks' Gestation: Relation to Fetal and Maternal Characteristics and Pregnancy Outcomes

(2013) L.C.Y. Poon et al.   FETAL DIAGNOSIS AND THERAPY

A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA

(2013) Qing Zhang et al.   GYNECOLOGIC ONCOLOGY

Establishment of tumor-specific copy number alterations from plasma DNA of patients with cancer

(2013) Ellen Heitzer et al.   INTERNATIONAL JOURNAL OF CANCER

Methylated Tissue Factor Pathway Inhibitor 2 (TFPI2) DNA in Serum Is a Biomarker of Metastatic Melanoma

(2013) Cristiana Lo Nigro et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Methylation and Immunoexpression ofp16INK4aTumor Suppressor Gene in Primary Breast Cancer Tissue and Their Quantitativep16INK4aHypermethylation in Plasma by Real-Time PCR

(2013) Jae Jun Lee et al.   Korean Journal of Pathology

Non-invasive analysis of acquired resistance to cancer therapy by sequencing of plasma DNA

(2013) Muhammed Murtaza et al.   NATURE

Analysis of Circulating Tumor DNA to Monitor Metastatic Breast Cancer

(2013) Sarah-Jane Dawson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple Marker Detection in Peripheral Blood for NSCLC Diagnosis

(2013) Paola Ulivi et al.   PLoS One

Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer

(2013) Hakan Akca et al.   Cancer Genetics

Tumor-associated copy number changes in the circulation of patients with prostate cancer identified through whole-genome sequencing

(2013) Ellen Heitzer et al.   Genome Medicine

Genomic Analysis of Fetal Nucleic Acids in Maternal Blood

(2012) Yuk Ming Dennis Lo et al.   Annual Review of Genomics and Human Genetics

LOH at 6q and 10q in fractionated circulating DNA of ovarian cancer patients is predictive for tumor cell spread and overall survival

(2012) Jan Dominik Kuhlmann et al.   BMC CANCER

Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study

(2012) Anneke Q. van Hoesel et al.   BREAST CANCER RESEARCH AND TREATMENT

Role of early cell-free DNA levels decrease as a predictive marker of fatal outcome after severe traumatic brain injury

(2012) Hada Macher et al.   CLINICA CHIMICA ACTA

CST6 promoter methylation in circulating cell-free DNA of breast cancer patients

(2012) Maria Chimonidou et al.   CLINICAL BIOCHEMISTRY

Loss of Heterozygosity at Tumor Suppressor Genes Detectable on Fractionated Circulating Cell-Free Tumor DNA as Indicator of Breast Cancer Progression

(2012) H. Schwarzenbach et al.   CLINICAL CANCER RESEARCH

Quantitative Cell-Free DNA, KRAS, and BRAF Mutations in Plasma from Patients with Metastatic Colorectal Cancer during Treatment with Cetuximab and Irinotecan

(2012) K.-L. G. Spindler et al.   CLINICAL CANCER RESEARCH

Detection of Tumor PIK3CA Status in Metastatic Breast Cancer Using Peripheral Blood

(2012) M. J. Higgins et al.   CLINICAL CANCER RESEARCH

SOX17 Promoter Methylation in Circulating Tumor Cells and Matched Cell-Free DNA Isolated from Plasma of Patients with Breast Cancer

(2012) M. Chimonidou et al.   CLINICAL CHEMISTRY

Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing

(2012) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Detection of TFPI2 Methylation in the Serum of Hepatocellular Carcinoma Patients

(2012) Feng-Kai Sun et al.   DIGESTIVE DISEASES AND SCIENCES

Detection of promoter methylation of tumor suppressor genes in serum DNA of breast cancer cases and benign breast disease controls

(2012) Susan R. Sturgeon et al.   Epigenetics

Circulating cell-free DNA is associated with mortality and inflammatory markers in nonagenarians: The Vitality 90+ Study

(2012) Juulia Jylhävä et al.   EXPERIMENTAL GERONTOLOGY

Prognostic role of methylated free circulating DNA in colorectal cancer

(2012) Alexander B. Philipp et al.   INTERNATIONAL JOURNAL OF CANCER

Clinical Relevance of CDH1 and CDH13 DNA-Methylation in Serum of Cervical Cancer Patients

(2012) Abida Abudukadeer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impact of non-tumor-derived circulating nucleic acids implicates the prognosis of non-small cell lung cancer

(2012) Chanida Vinayanuwattikun et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Free Circulating Tumor DNA as a Diagnostic Marker for Breast Cancer

(2012) D. Hashad et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Association Between Circulating Tumor Cells and Prognosis in Patients With Stage III Melanoma With Sentinel Lymph Node Metastasis in a Phase III International Multicenter Trial

(2012) Sojun Hoshimoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Pretreatment Epidermal Growth Factor Receptor (EGFR) T790M Mutation Predicts Shorter EGFR Tyrosine Kinase Inhibitor Response Duration in Patients With Non–Small-Cell Lung Cancer

(2012) Kang-Yi Su et al.   JOURNAL OF CLINICAL ONCOLOGY

DNA Methylation in Peripheral Blood: A Potential Biomarker for Cancer Molecular Epidemiology

(2012) Lian Li et al.   JOURNAL OF EPIDEMIOLOGY

AIM1 and LINE-1 Epigenetic Aberrations in Tumor and Serum Relate to Melanoma Progression and Disease Outcome

(2012) Sojun Hoshimoto et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Clinical evaluations of cell-free fetal DNA quantities in pre-eclamptic pregnancies

(2012) Yosun Görkem Zeybek et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

The prognostic value of KRAS mutated plasma DNA in advanced non-small cell lung cancer

(2012) Anneli Dowler Nygaard et al.   LUNG CANCER

Methylation of TMEFF2 gene in tissue and serum DNA from patients with non-small cell lung cancer

(2012) Su Man Lee et al.   MOLECULES AND CELLS

Non-invasive prenatal measurement of the fetal genome

(2012) H. Christina Fan et al.   NATURE

Clonal selection drives genetic divergence of metastatic medulloblastoma

(2012) Xiaochong Wu et al.   NATURE

DNA methylation profiling in the clinic: applications and challenges

(2012) Holger Heyn et al.   NATURE REVIEWS GENETICS

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methylated DNA and Total DNA in Serum Detected by One-Step Methylation-Specific PCR Is Predictive of Poor Prognosis for Breast Cancer Patients

(2012) Noriko Fujita et al.   ONCOLOGY

Total serum DNA and DNA integrity: diagnostic value in patients with hepatitis B virus-related hepatocellular carcinoma

(2012) Hui Chen et al.   PATHOLOGY

A Genome-Wide Association Study Identifies UGT1A1 as a Regulator of Serum Cell-Free DNA in Young Adults: The Cardiovascular Risk in Young Finns Study

(2012) Juulia Jylhävä et al.   PLoS One

Multiparametric Analysis of Cell-Free DNA in Melanoma Patients

(2012) Francesca Salvianti et al.   PLoS One

Multi-Purpose Utility of Circulating Plasma DNA Testing in Patients with Advanced Cancers

(2012) Geraldine Perkins et al.   PLoS One

Genome-Scale Discovery of DNA-Methylation Biomarkers for Blood-Based Detection of Colorectal Cancer

(2012) Christopher P. E. Lange et al.   PLoS One

Noninvasive prenatal diagnosis empowered by high-throughput sequencing

(2012) Rossa W. K. Chiu et al.   PRENATAL DIAGNOSIS

Noninvasive Whole-Genome Sequencing of a Human Fetus

(2012) J. O. Kitzman et al.   Science Translational Medicine

Noninvasive Identification and Monitoring of Cancer Mutations by Targeted Deep Sequencing of Plasma DNA

(2012) T. Forshew et al.   Science Translational Medicine

Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing

(2012) R. J. Leary et al.   Science Translational Medicine

Characterization of cell-free circulating DNA in plasma in patients with prostate cancer

(2012) Pâmela Oliveira Delgado et al.   TUMOR BIOLOGY

Assessment of Prognostic Circulating Tumor Cells in a Phase III Trial of Adjuvant Immunotherapy After Complete Resection of Stage IV Melanoma

(2011) Sojun Hoshimoto et al.   ANNALS OF SURGERY

Circulating Cell-Free DNA: A Promising Marker of Pathologic Tumor Response in Rectal Cancer Patients Receiving Preoperative Chemoradiotherapy

(2011) Marco Agostini et al.   ANNALS OF SURGICAL ONCOLOGY

Circulating Tumor Cells and Circulating Tumor DNA

(2011) Catherine Alix-Panabières et al.   Annual Review of Medicine

Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression

(2011) Carina Roth et al.   BMC CANCER

Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer

(2011) Anneke Q. van Hoesel et al.   BREAST CANCER RESEARCH AND TREATMENT

Prognostic significance of methylated RASSF1A and PITX2 genes in blood- and bone marrow plasma of breast cancer patients

(2011) Georg Göbel et al.   BREAST CANCER RESEARCH AND TREATMENT

Detection of aberrant promoter methylation of GSTP1, RASSF1A, and RARβ2 in serum DNA of patients with breast cancer by a newly established one-step methylation-specific PCR assay

(2011) Noriaki Yamamoto et al.   BREAST CANCER RESEARCH AND TREATMENT

Circulating tumour markers can define patients with normal colons, benign polyps and cancers

(2011) R Mead et al.   BRITISH JOURNAL OF CANCER

Detection of HER2 amplification in circulating free DNA in patients with breast cancer

(2011) K Page et al.   BRITISH JOURNAL OF CANCER

Serum cell-free DNA in renal cell carcinoma

(2011) Michela de Martino et al.   CANCER

Circulating cell-free DNA in plasma of melanoma patients: Qualitative and quantitative considerations

(2011) Pamela Pinzani et al.   CLINICA CHIMICA ACTA

A sensitive method to quantify human cell-free circulating DNA in blood: Relevance to myocardial infarction screening

(2011) Rong-Rong Jing et al.   CLINICAL BIOCHEMISTRY

Genomic analysis of circulating cell-free DNA infers breast cancer dormancy

(2011) J. A. Shaw et al.   GENOME RESEARCH

Quantitative detection of RASSF1A DNA promoter methylation in tumors and serum of patients with serous epithelial ovarian cancer

(2011) Amy E. BonDurant et al.   GYNECOLOGIC ONCOLOGY

Prognostic Value of Free DNA Quantification in Serum and Cerebrospinal Fluid in Glioma Patients

(2011) Wei Shi et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Epidermal Growth Factor Receptor Mutation Status in Circulating Free DNA in Serum: From IPASS, a Phase III Study of Gefitinib or Carboplatin/Paclitaxel in Non-small Cell Lung Cancer

(2011) Koichi Goto et al.   Journal of Thoracic Oncology

Tumour evolution inferred by single-cell sequencing

(2011) Nicholas Navin et al.   NATURE

Increased methylation variation in epigenetic domains across cancer types

(2011) Kasper Daniel Hansen et al.   NATURE GENETICS

Mitotic catastrophe: a mechanism for avoiding genomic instability

(2011) Ilio Vitale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Serum DNA can define tumor-specific genetic and epigenetic markers in gliomas of various grades

(2011) I. Lavon et al.   NEURO-ONCOLOGY

Hypermethylation of Tumor Suppressor Genes Involved in Critical Regulatory Pathways for Developing a Blood-Based Test in Breast Cancer

(2011) Ramin Radpour et al.   PLoS One

LINE-1 Hypomethylation During Primary Colon Cancer Progression

(2011) Eiji Sunami et al.   PLoS One

Development of Sporadic Microsatellite Instability in Colorectal Tumors Involves Hypermethylation at Methylated-In-Tumor Loci in Adenoma

(2010) Michiel F.G. de Maat et al.   AMERICAN JOURNAL OF PATHOLOGY

Circulating free DNA and p53 antibodies in plasma of patients with ovarian epithelial cancers

(2010) B. Dobrzycka et al.   ANNALS OF ONCOLOGY

Plasma cell-free DNA in ovarian cancer

(2010) Aparna A. Kamat et al.   CANCER

The virtosome-a novel cytosolic informative entity and intercellular messenger

(2010) Peter B. Gahan et al.   CELL BIOCHEMISTRY AND FUNCTION

Time of sampling is crucial for measurement of cell-free plasma DNA following acute aseptic inflammation induced by exercise

(2010) Ioannis G. Fatouros et al.   CLINICAL BIOCHEMISTRY

Serial Monitoring of Circulating Tumor Cells Predicts Outcome of Induction Biochemotherapy plus Maintenance Biotherapy for Metastatic Melanoma

(2010) K. Koyanagi et al.   CLINICAL CANCER RESEARCH

Potential Clinical Significance of a Plasma-Based KRAS Mutation Analysis in Patients with Advanced Non-Small Cell Lung Cancer

(2010) S. Wang et al.   CLINICAL CANCER RESEARCH

Direct Serum Assay for MicroRNA-21 Concentrations in Early and Advanced Breast Cancer

(2010) S. Asaga et al.   CLINICAL CHEMISTRY

Real-time polymerase chain reaction quantification of free DNA in serum of patients with polyps and colorectal cancers

(2010) Elisa Danese et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Association of KRAS p.G13D Mutation With Outcome in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer Treated With Cetuximab

(2010) Wendy De Roock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients

(2010) Heidi Schwarzenbach et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Prediction of epidermal growth factor receptor mutations in the plasma/pleural effusion to efficacy of gefitinib treatment in advanced non-small cell lung cancer

(2010) Guo Jian et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients

(2010) Gayatri Sharma et al.   LIFE SCIENCES

Aging is associated with quantitative and qualitative changes in circulating cell-free DNA: The Vitality 90+ study

(2010) Juulia Jylhävä et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

(2010) Peter J. Campbell et al.   NATURE

Levels of Circulating Cell-Free Nuclear and Mitochondrial DNA in Benign and Malignant Ovarian Tumors

(2010) Rebecca R. Zachariah et al.   OBSTETRICS AND GYNECOLOGY

Circulating mitochondrial DNA in serum: A universal diagnostic biomarker for patients with urological malignancies

(2010) Jörg Ellinger et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

A Prospective Diagnostic Accuracy Study of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, Multidetector Row Computed Tomography, and Magnetic Resonance Imaging in Primary Diagnosis and Staging of Pancreatic Cancer

(2009) Saila P. Kauhanen et al.   ANNALS OF SURGERY

Quantification of LINE1 in Circulating DNA as a Molecular Biomarker of Breast Cancer

(2009) Eiji Sunami et al.   Annals of the New York Academy of Sciences

The Origin of Elevated Levels of Circulating DNA in Blood Plasma of Premature Neonates

(2009) N. O. Tuaeva et al.   Annals of the New York Academy of Sciences

Circulating Nucleic Acids in Plasma and Serum

(2009) Peter B. Gahan et al.   Annals of the New York Academy of Sciences

Detection and Monitoring of Cell-Free DNA in Blood of Patients with Colorectal Cancer

(2009) Heidi Schwarzenbach et al.   Annals of the New York Academy of Sciences

Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study

(2009) R E Board et al.   BRITISH JOURNAL OF CANCER

The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients

(2009) I Van der Auwera et al.   BRITISH JOURNAL OF CANCER

CpG hypomethylation of MDR1 gene in tumor and serum of invasive ductal breast carcinoma patients

(2009) Gayatri Sharma et al.   CLINICAL BIOCHEMISTRY

Clinical significance of Stratifin, ERα and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients

(2009) Sameer Mirza et al.   CLINICAL BIOCHEMISTRY

Cell-free Tumor DNA in Blood Plasma As a Marker for Circulating Tumor Cells in Prostate Cancer

(2009) H. Schwarzenbach et al.   CLINICAL CANCER RESEARCH

Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients

(2009) E. Sunami et al.   CLINICAL CHEMISTRY

Circulating Methylated SEPT9 DNA in Plasma Is a Biomarker for Colorectal Cancer

(2009) T. deVos et al.   CLINICAL CHEMISTRY

PCR-Based Methods for Detecting Single-Locus DNA Methylation Biomarkers in Cancer Diagnostics, Prognostics, and Response to Treatment

(2009) L. S. Kristensen et al.   CLINICAL CHEMISTRY

Inferring tumor progression from genomic heterogeneity

(2009) N. Navin et al.   GENOME RESEARCH

Circulating free DNA, p53 antibody and mutations of KRAS gene in endometrial cancer

(2009) Bozena Dobrzycka et al.   INTERNATIONAL JOURNAL OF CANCER

Comparison of Circulating Plasma DNA Levels between Lung Cancer Patients and Healthy Controls

(2009) Kyong-Ah Yoon et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Noninvasive Prenatal Diagnosis: Past, Present, and Future

(2009) Christian Litton et al.   MOUNT SINAI JOURNAL OF MEDICINE

Sensitive digital quantification of DNA methylation in clinical samples

(2009) Meng Li et al.   NATURE BIOTECHNOLOGY

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

(2009) Rafael Rosell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prediction of Clear Cell Renal Cell Carcinoma by Integrity of Cell-free DNA in Serum

(2009) Feng Gang et al.   UROLOGY

Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer

(2008) Heidi Schwarzenbach et al.   BJU INTERNATIONAL

Apoptotic DNA fragments in serum of patients with muscle invasive bladder cancer: A prognostic entity

(2008) Jörg Ellinger et al.   CANCER LETTERS

Persistent Aberrations in Circulating DNA Integrity after Radiotherapy Are Associated with Poor Prognosis in Nasopharyngeal Carcinoma Patients

(2008) K.C. A. Chan et al.   CLINICAL CANCER RESEARCH

Prognostic Relevance of Occult Nodal Micrometastases and Circulating Tumor Cells in Colorectal Cancer in a Prospective Multicenter Trial

(2008) K. Koyanagi et al.   CLINICAL CANCER RESEARCH

Quantitative Analysis of Circulating Methylated DNA as a Biomarker for Hepatocellular Carcinoma

(2008) K. C. A. Chan et al.   CLINICAL CHEMISTRY

Quantification of Free Circulating Tumor DNA as a Diagnostic Marker for Breast Cancer

(2008) Raquel Catarino et al.   DNA AND CELL BIOLOGY

Needle track seeding following biopsy of liver lesions in the diagnosis of hepatocellular cancer: a systematic review and meta-analysis

(2008) M A Silva et al.   GUT

Cell-Free Circulating DNA: Diagnostic Value in Patients With Testicular Germ Cell Cancer

(2008) Jörg Ellinger et al.   JOURNAL OF UROLOGY

Circulating plasma DNA as diagnostic biomarker in non-small cell lung cancer

(2008) Massimiliano Paci et al.   LUNG CANCER

Sensitive Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay

(2008) Robert Grützmann et al.   PLoS One

Noncancerous PTGS2 DNA fragments of apoptotic origin in sera of prostate cancer patients qualify as diagnostic and prognostic indicators

(2007) Jörg Ellinger et al.   INTERNATIONAL JOURNAL OF CANCER