The genomic landscape of cutaneous melanoma

An interaction proteomics survey of transcription factor binding at recurrent TERT promoter mutations

(2016) Matthew M. Makowski et al.   PROTEOMICS

Inherited Genetic Variants Associated with Occurrence of Multiple Primary Melanoma

(2015) D. C. Gibbs et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Genomic Classification of Cutaneous Melanoma

(2015) Rehan Akbani et al.   CELL

Germline TERT promoter mutations are rare in familial melanoma

(2015) Mark Harland et al.   Familial Cancer

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

The Genomic Landscape of Childhood and Adolescent Melanoma

(2015) Charles Lu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome

(2015) R. C. Poulos et al.   MOLECULAR CANCER RESEARCH

Alternative transcription initiation leads to expression of a novel ALK isoform in cancer

(2015) Thomas Wiesner et al.   NATURE

Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas

(2015) Michael Krauthammer et al.   NATURE GENETICS

Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway

(2015) A Hunter Shain et al.   NATURE GENETICS

Recurrent inactivating RASA2 mutations in melanoma

(2015) Rand Arafeh et al.   NATURE GENETICS

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma

(2015) Matthew H Law et al.   NATURE GENETICS

CTCF/cohesin-binding sites are frequently mutated in cancer

(2015) Riku Katainen et al.   NATURE GENETICS

The Genetic Evolution of Melanoma from Precursor Lesions

(2015) A. Hunter Shain et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical activity of the MEK inhibitor trametinib in metastatic melanoma containingBRAFkinase fusion

(2015) Alexander M. Menzies et al.   Pigment Cell & Melanoma Research

The functional relevance of somatic synonymous mutations in melanoma and other cancers

(2015) Valer Gotea et al.   Pigment Cell & Melanoma Research

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

(2015) R. J. A. Bell et al.   SCIENCE

Activating MET kinase rearrangements in melanoma and Spitz tumours

(2015) Iwei Yeh et al.   Nature Communications

Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma

(2015) Jian Guan et al.   Scientific Reports

Whole exome sequencing identifies a recurrent RQCD1 P131L mutation in cutaneous melanoma

(2015) Stephen Q. Wong et al.   Oncotarget

A highly recurrent RPS27 5’UTR mutation in melanoma

(2015) Ken Dutton-Regester et al.   Oncotarget

The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF

(2014) Ian R. Watson et al.   CANCER RESEARCH

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers

(2014) Fran Supek et al.   CELL

Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions

(2014) Jennifer H. Barrett et al.   INTERNATIONAL JOURNAL OF CANCER

FBXW7 Mutations in Melanoma and a New Therapeutic Paradigm

(2014) Iraz T. Aydin et al.   JNCI-Journal of the National Cancer Institute

Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma

(2014) Lauren G. Aoude et al.   JNCI-Journal of the National Cancer Institute

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

(2014) Paul A. Northcott et al.   NATURE

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

Genome-wide analysis of noncoding regulatory mutations in cancer

(2014) Nils Weinhold et al.   NATURE GENETICS

POT1 loss-of-function variants predispose to familial melanoma

(2014) Carla Daniela Robles-Espinoza et al.   NATURE GENETICS

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types

(2014) Nils J Fredriksson et al.   NATURE GENETICS

Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma

(2014) Jianxin Shi et al.   NATURE GENETICS

Genetic Basis for Clinical Response to CTLA-4 Blockade in Melanoma

(2014) Alexandra Snyder et al.   NEW ENGLAND JOURNAL OF MEDICINE

UV Signature Mutations

(2014) Douglas E. Brash   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Clinical and pathological associations of the activatingRAC1P29S mutation in primary cutaneous melanoma

(2014) Victoria J. Mar et al.   Pigment Cell & Melanoma Research

Clonal Architectures and Driver Mutations in Metastatic Melanomas

(2014) Li Ding et al.   PLoS One

The landscape of kinase fusions in cancer

(2014) Nicolas Stransky et al.   Nature Communications

Kinase fusions are frequent in Spitz tumours and spitzoid melanomas

(2014) Thomas Wiesner et al.   Nature Communications

miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

(2014) Matteo Forloni et al.   eLife

BRAF/NRAS Wild-Type Melanomas Have a High Mutation Load Correlating with Histologic and Molecular Signatures of UV Damage

(2013) V. J. Mar et al.   CLINICAL CANCER RESEARCH

BRAF Fusions Define a Distinct Molecular Subset of Melanomas with Potential Sensitivity to MEK Inhibition

(2013) K. E. Hutchinson et al.   CLINICAL CANCER RESEARCH

Genome sequencing of mucosal melanomas reveals that they are driven by distinct mechanisms from cutaneous melanoma

(2013) Simon J Furney et al.   JOURNAL OF PATHOLOGY

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3

(2013) Marcel Martin et al.   NATURE GENETICS

Emerging patterns of somatic mutations in cancer

(2013) Ian R. Watson et al.   NATURE REVIEWS GENETICS

Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy

(2013) Thomas Botton et al.   Pigment Cell & Melanoma Research

Whole-genome sequencing identifies a recurrent functional synonymous mutation in melanoma

(2013) J. J. Gartner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

SF3B1 Mutations Are Associated with Alternative Splicing in Uveal Melanoma

(2013) S. J. Furney et al.   Cancer Discovery

A Landscape of Driver Mutations in Melanoma

(2012) Eran Hodis et al.   CELL

Distinguishing Clinicopathologic Features of Patients with V600E and V600K BRAF-Mutant Metastatic Melanoma

(2012) A. M. Menzies et al.   CLINICAL CANCER RESEARCH

Lifetime Cancer Risks in Individuals with Germline PTEN Mutations

(2012) M.-H. Tan et al.   CLINICAL CANCER RESEARCH

Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

(2012) Michael Krauthammer et al.   NATURE GENETICS

Effect of a natural mutation in the 5′ untranslated region on the translational control of p53 mRNA

(2012) D Khan et al.   ONCOGENE

Genomic characterisation of acral melanoma cell lines

(2012) Simon J. Furney et al.   Pigment Cell & Melanoma Research

Novel Somatic Mutations to PI3K Pathway Genes in Metastatic Melanoma

(2012) Austin Y. Shull et al.   PLoS One

Whole genome sequencing of matched primary and metastatic acral melanomas

(2011) S. Turajlic et al.   GENOME RESEARCH

Genome-wide association study identifies novel loci predisposing to cutaneous melanoma†

(2011) Christopher I. Amos et al.   HUMAN MOLECULAR GENETICS

Meta-Analysis Combining New and Existing Data Sets Confirms that the TERT–CLPTM1L Locus Influences Melanoma Risk

(2011) Matthew H. Law et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

(2011) Satoru Yokoyama et al.   NATURE

A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma

(2011) Corine Bertolotto et al.   NATURE

Genome-wide association study identifies three new melanoma susceptibility loci

(2011) Jennifer H Barrett et al.   NATURE GENETICS

Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing

(2011) Mitchell S Stark et al.   NATURE GENETICS

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma

(2011) Sergey I Nikolaev et al.   NATURE GENETICS

Exome sequencing identifies GRIN2A as frequently mutated in melanoma

(2011) Xiaomu Wei et al.   NATURE GENETICS

Personalized Oncology Through Integrative High-Throughput Sequencing: A Pilot Study

(2011) S. Roychowdhury et al.   Science Translational Medicine

Integrative analysis of the melanoma transcriptome

(2010) M. F. Berger et al.   GENOME RESEARCH

Genetic variants in telomere-maintaining genes and skin cancer risk

(2010) Hongmei Nan et al.   HUMAN GENETICS

Functional analysis of CDKN2A/p16INK4a 5′-UTR variants predisposing to melanoma

(2010) Alessandra Bisio et al.   HUMAN MOLECULAR GENETICS

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma

(2010) Nallasivam Palanisamy et al.   NATURE MEDICINE

Frequent Mutation of BAP1 in Metastasizing Uveal Melanomas

(2010) J. W. Harbour et al.   SCIENCE

The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation

(2009) William E Tidyman et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

A comprehensive catalogue of somatic mutations from a human cancer genome

(2009) Erin D. Pleasance et al.   NATURE

New common variants affecting susceptibility to basal cell carcinoma

(2009) Simon N Stacey et al.   NATURE GENETICS

Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi

(2009) Mario Falchi et al.   NATURE GENETICS

Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4

(2009) Todd D Prickett et al.   NATURE GENETICS

Genome-wide association study identifies three loci associated with melanoma risk

(2009) D Timothy Bishop et al.   NATURE GENETICS

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

(2009) Thorunn Rafnar et al.   NATURE GENETICS

Frequent mutations in the MITF pathway in melanoma

(2009) Julia C. Cronin et al.   Pigment Cell & Melanoma Research

A novel AKT3 mutation in melanoma tumours and cell lines

(2008) M A Davies et al.   BRITISH JOURNAL OF CANCER

Modeling Genomic Diversity and Tumor Dependency in Malignant Melanoma

(2008) W. M. Lin et al.   CANCER RESEARCH

MC1R variants, melanoma and red hair color phenotype: A meta-analysis

(2008) Sara Raimondi et al.   INTERNATIONAL JOURNAL OF CANCER

Common sequence variants on 20q11.22 confer melanoma susceptibility

(2008) Kevin M Brown et al.   NATURE GENETICS

ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma

(2008) Daniel F Gudbjartsson et al.   NATURE GENETICS