Article
Immunology
Bohao Zheng, Jie Li, Mengdi Zhang, Pengju Zhang, Weiwei Deng, Yang Pu
Summary: This study constructed an immunotherapeutic response-related signature (IRRS) and evaluated its performance in prognosis and immunotherapeutic responsiveness of esophageal squamous cell carcinoma (ESCC) patients. The results showed that the IRRS score can serve as a biomarker for predicting immunotherapy response and prognosis of ESCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Medicine, General & Internal
Jing Wen, Shuogui Fang, Yi Hu, Mian Xi, Zelin Weng, Chuqing Pan, Kongjia Luo, Yihong Ling, Renchun Lai, Xiuying Xie, Xiaodan Lin, Ting Lin, Jiyang Chen, Qianwen Liu, Jianhua Fu, Hong Yang
Summary: This study used single-cell RNA sequencing to examine the cellular and molecular dynamics in esophageal squamous cell carcinoma (ESCC) patients before and after neoadjuvant chemoradiotherapy (neoCRT). The findings revealed that neoCRT increased the infiltration of CD8(+) T cells in the tumor microenvironment but also promoted their exhaustion. Additionally, neoCRT influenced the differentiation and abundance of other immune cell types, including Th cells, Treg cells, cDC1s, and macrophages.
Article
Oncology
Riyue Feng, Yin Yin, Yuge Wei, Yang Li, Lei Li, Rui Zhu, Xiao Yu, Yuhao Liu, Yahui Zhao, Zhihua Liu
Summary: p53 mutations predispose cancer cell development, promote their survival and metastasis. No drug that abrogates the oncogenic functions of mutant p53 has been approved for cancer treatment. Whole-genome sequencing of esophageal squamous cell carcinoma (ESCC) tumor tissues and paired normal tissues indicates a higher proportion of TP53 nonsense mutants in our cohort compared to European and American ESCC samples in the IARC database. The most frequent p53 mutations disrupt the inhibition of proliferation, migration, and invasion mediated by wild-type p53 in ESCC.
Article
Medicine, Research & Experimental
Mengnan Zhao, Tao Lu, Guoshu Bi, Zhengyang Hu, Jiaqi Liang, Yunyi Bian, Mingxiang Feng, Cheng Zhan
Summary: The study found that down-regulation of PLK1 can inhibit the pentose phosphate pathway (PPP), reduce the levels of NADPH and GSH, promote ferroptosis, and improve the sensitivity of ESCC to radiotherapy and chemotherapy. The transcription factor YY1 has a positive regulatory effect on PLK1, and their expressions are positively correlated. PLK1 may be a target for predicting and enhancing the chemoradiotherapy sensitivity of ESCC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Yongxu Jia, Baifeng Zhang, Chunyang Zhang, Dora Lai-Wan Kwong, Zhiwei Chang, Shanshan Li, Zehua Wang, Huiqiong Han, Jing Li, Yali Zhong, Xin Sui, Li Fu, Xinyuan Guan, Yanru Qin
Summary: In this study, the authors analyzed the transcriptomes of 85,263 single cells from four ESCC patients with lymph node metastasis. They identified various cells and genes that play a role in the metastatic microenvironment, including IFIT3(+) T and B cells, APOC1(+)APOE(+) macrophages, myofibroblasts, and immunoglobulin genes. They also discovered an epithelial-immune dual expression program that regulates immune processes in metastatic cells. Additionally, they found differential intercellular communications in the metastatic ESCC microenvironment, mainly involving the interaction of APOC1(+)APOE(+) macrophages with tumor and stromal cells. These findings provide insights into the molecular mechanisms underlying lymph-node metastasis and offer potential targets for inhibiting tumor growth and improving clinical outcomes.
Article
Chemistry, Physical
Yida Huang, Haijun Yang, Junkuo Li, Fuqiang Wang, Wanshan Liu, Yiwen Liu, Ruimin Wang, Lijuan Duan, Jiao Wu, Zhaowei Gao, Jing Cao, Fang Bian, Juxiang Zhang, Fang Zhao, Shouzhi Yang, Shasha Cao, Aihua Yang, Xueliang Wang, Mingfei Geng, Anlin Hao, Jian Li, Jianwei Cao, Chaowei Li, Zheyuan Zhang, Ning Zhang, Yanlin Huang, Yaowen Zhang, Kun Qian, Fuyou Zhou
Summary: In this study, ferric-particle-enhanced laser desorption/ionization mass spectrometry was used to record the serum metabolic fingerprints and build diagnostic models for ESCC. A metabolic biomarker panel was constructed with high diagnostic sensitivity for early ESCC.
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Rong Li, Xing-Feng Pang, Zhi-Guang Huang, Li-Hua Yang, Zhi-Gang Peng, Jie Ma, Rong-Quan He
Summary: This study revealed that UBE2C mRNA and protein levels were highly expressed in ESCC and may play different roles in different stages of the disease. UBE2C mainly influences the biological function of esophageal cancer through synergistic effects with genes such as CDK1, PTTG1, and SKP2. Additionally, a potential UBE2C-related ceRNA network (HCP5/has-miR-139-5p/UBE2C) was constructed for ESCC.
Article
Biophysics
Qingfu Zhu, Hao Xu, Liu Huang, Jiaxin Luo, Hengrui Li, Rui Yang, Xiaoling Liu, Fei Liu
Summary: This study investigates the potential of extracellular vesicles (EVs) as biomarkers for esophageal cancer diagnosis. The researchers successfully isolated and identified differentially expressed proteins in EVs from esophageal cancer patients using the EXODUS and ELISA techniques. They found that EV-CD14 could be a potential diagnostic biomarker for esophageal cancer. The application of ELISA for the detection and screening of esophageal cancer based on circulating EV-CD14 showed high accuracy and sensitivity.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Medicine, General & Internal
Long Wang, Yi-Meng Jia, Jing Zuo, Yu-Dong Wang, Zhi-Song Fan, Li Feng, Xue Zhang, Jing Han, Wen-Jing Lyu, Zhi-Yu Ni
Summary: ESCC is a highly aggressive cancer with limited therapeutic options. Through next-generation sequencing, common mutations in genes like TP53, NOTCH1, EP300, and KMT2C were identified. The study also revealed genetic variants associated with crucial signaling pathways. PD-L1 expression was significantly associated with tumor mutation burden but not with gene mutations.
CHINESE MEDICAL JOURNAL
(2021)
Article
Genetics & Heredity
Adam N. Bennett, Rui Xuan Huang, Qian He, Nikki P. Lee, Wing-Kin Sung, Kei Hang Katie Chan
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma, is a significant challenge globally, with high incidence and mortality rates. The limited number of effective therapeutic options contributes to the high mortality rate. Repurposing existing drugs approved for other diseases through drug repositioning is a more time and cost-effective strategy. This study identified potential therapeutic drugs for esophageal cancer patients through gene expression analysis and network analysis, including both known drugs like Doxorubicin and potential psychiatric drugs like Venlafaxine.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Katsunori Matsueda, Ryu Ishihara
Summary: Endoscopic resection is the main treatment for superficial esophageal squamous cell carcinoma due to its minimal invasiveness and favorable outcomes. Accurate assessment of tumor depth and extent is crucial in determining the suitability for endoscopic resection, with different types of esophageal cancers requiring specific treatment approaches.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Genetics & Heredity
Shang-Wei Chen, Hua-Fu Zhou, Han-Jie Zhang, Rong-Quan He, Zhi-Guang Huang, Yi-Wu Dang, Xia Yang, Jun Liu, Zong-Wang Fu, Jun-Xian Mo, Zhong-Qing Tang, Chang-Bo Li, Rong Li, Li-Hua Yang, Jie Ma, Lin-Jie Yang, Gang Chen
Summary: Esophageal squamous cell carcinoma (ESCC) is the major histological type of esophageal cancers. The transcription factor PTTG1 was found to be highly expressed in ESCC tissues and may interact with target genes through chemokines and cytokine signaling pathways, particularly SLC25A17 and ERH. This suggests that PTTG1 may play a crucial role in the formation of ESCC by regulating downstream target genes.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Article
Endocrinology & Metabolism
Yuanliu Nie, Guangyue Yao, Xiaoying Xu, Yi Liu, Ke Yin, Jingjiang Lai, Qiang Li, Fengge Zhou, Zhe Yang
Summary: This study investigated the role of m6A modification in esophageal cancer development and its impact on immune infiltration and treatment sensitivity. A risk model was constructed based on m6A-related differential genes, and it was found to have significant value in prognostic stratification and immune infiltration analysis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Xi Chen, Hongjin Wu, Jia Feng, Ying Li, Jiao Lv, Weikai Shi, Weiwei Fan, Li Xiao, Danmeng Sun, Mingfeng Jiang, Ming Shi
Summary: The study showed that the expression of GAP43 in colorectal cancer is influenced by DNA methylation, and overexpression of GAP43 significantly affects the expression of genes in multiple signaling pathways. The findings reveal the important role of GAP43 in the development of human colorectal cancer.
Article
Biotechnology & Applied Microbiology
Qiang Hou, Zhenzhen Jiang, Ziwei Li, Mingfeng Jiang
Summary: A study identified three candidate genes related to radioresistance in ESCC: AHNAK2, EVPL, and LAMA5. Knockdown of AHNAK2 and EVPL genes increased radioresistance in ESCC cell lines and affected the expression of interleukins, interleukin receptors, and chemokines by inhibiting NF-kappa B and TNF signaling pathways, suppressing immune response in radioresistant ESCC cells.
ONCOTARGETS AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Fangyoumin Feng, Bihan Shen, Xiaoqin Mou, Yixue Li, Hong Li
Summary: The response rate of most anti-cancer drugs is limited due to cancer heterogeneity and complex drug mechanisms. Personalized treatment using molecular biomarkers shows promise. Advances in pharmacogenomics, especially computational methods in drug response prediction, have been successful and increasingly utilized in personalized cancer medicine.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Multidisciplinary Sciences
Fengrong Chen, Lei Zou, Yicong Dai, Jiaxue Sun, Cheng Chen, Yongjin Zhang, Qingyan Peng, Zunyue Zhang, Zhenrong Xie, Hongjin Wu, Weiwei Tian, Xu Yu, Juehua Yu, Kunhua Wang
Summary: This study explored the associations between exosomal miRNAs and anxiety and depression in SUD patients, finding significant negative correlations between specific miRNAs and anxiety scores, but less correlation with depression scores. The target genes of these miRNAs are mainly enriched in synapse, cell adhesion, and MHC class II protein complex.
SCIENTIFIC REPORTS
(2021)
Review
Immunology
Ying Li, Jiao Lv, Weikai Shi, Jia Feng, Mingxi Liu, Shenao Gan, Hongjin Wu, Weiwei Fan, Ming Shi
Summary: Inflammasomes are innate immune mechanisms associated with tumorigenesis and prognosis of cancers. They drive the production of inflammatory cytokines and recruit immune cells to tumor sites.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zunyue Zhang, Hongjin Wu, Qingyan Peng, Zhenrong Xie, Fengrong Chen, Yuru Ma, Yizhi Zhang, Yong Zhou, Jiqing Yang, Cheng Chen, Shaoyou Li, Yongjin Zhang, Weiwei Tian, Yuan Wang, Yu Xu, Huayou Luo, Mei Zhu, Yi-Qun Kuang, Juehua Yu, Kunhua Wang
Summary: This study investigated the molecular inflammatory interactome in heroin addicts undergoing withdrawal, identifying disturbed cytokine balances and dysregulated exosomal lncRNA/mRNA profiles. These findings contribute to a better understanding of the pathogenic mechanisms of withdrawal symptoms in heroin addicts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Yunqin Chen, Zhen Wang, Hong Li, Yixue Li
Summary: This study identified a 6-miRNA prognostic signature in nasopharyngeal carcinoma, which showed good prediction capability in terms of overall survival, disease-free survival, and metastasis-free survival. The 6-miRNA risk score may be useful for clinicians in treatment strategies and predicting patient outcomes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuru Ma, Hongjin Wu, Huawei Wang, Fengrong Chen, Zhenrong Xie, Zunyue Zhang, Qingyan Peng, Jiqing Yang, Yong Zhou, Cheng Chen, Minghui Chen, Yongjin Zhang, Juehua Yu, Kunhua Wang
Summary: This study found that the concentration of bile acids in the plasma of patients with methamphetamine use disorders (MUDs) is lower during withdrawal and is associated with liver injury and psychiatric symptoms. Specific bile acids may be associated with disease progression through the liver-brain axis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Jiqing Yang, Zunyue Zhang, Zhenrong Xie, Ling Bai, Pu Xiong, Fengrong Chen, Tailin Zhu, Qingyan Peng, Hongjin Wu, Yong Zhou, Yuru Ma, Yongjin Zhang, Minghui Chen, Jianyuan Gao, Weiwei Tian, Kai Shi, Yan Du, Yong Duan, Huawei Wang, Yu Xu, Yi-Qun Kuang, Mei Zhu, Juehua Yu, Kunhua Wang
Summary: This study demonstrates that anxiety and depression-like behaviors induced by METH withdrawal can be transmitted via gut microbiota in a mouse model. The therapeutic effects of metformin on psychiatric manifestations are associated with microbiota-derived metabolites. This highlights the role of gut microbiota in substance use disorders and withdrawal symptom pathophysiology.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Fengrong Chen, Jiaxue Sun, Cheng Chen, Yongjin Zhang, Lei Zou, Zunyue Zhang, Minghui Chen, Hongjin Wu, Weiwei Tian, Yu Liu, Yu Xu, Huayou Luo, Mei Zhu, Juehua Yu, Qian Wang, Kunhua Wang
Summary: This study found that methamphetamine abuse can result in neurotoxic outcomes such as anxiety and depression. The researchers developed a mouse model of anxiety-like behavior induced by methamphetamine and identified mitochondria as a potential mechanism involved. They used quercetin, a mitochondrial protector, and found that it alleviated anxiety-like behavior and improved mitochondrial impairment. In vitro experiments also showed that quercetin could alleviate mitochondrial dysfunction induced by methamphetamine.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Fengrong Chen, Yu Xu, Kai Shi, Zunyue Zhang, Zhenrong Xie, Hongjin Wu, Yuru Ma, Yong Zhou, Cheng Chen, Jiqing Yang, Yuan Wang, Trevor W. Robbins, Kunhua Wang, Juehua Yu
Summary: This study characterized the changes in neurotransmitter and exosomal miRNA profiles during heroin and methamphetamine withdrawal. It identified a series of miRNAs associated with anxiety, depression, and the concentrations of GABA, choline, and serotonin. Bioinformatics analyses revealed their association with developmental and intellectual abnormalities. Dysregulated miRNA signatures, including hsa-miR-451a and hsa-miR-21a, showed high accuracy in predicting patients with substance use disorders. Furthermore, hsa-miR-744a-5p was correlated with serotonin and has an important role in neuronal development and function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Hongjin Wu, Zunyue Zhang, Yuru Ma, Fengrong Chen, Pu Xiong, Zhenrong Xie, Guo Ding, Juehua Yu, Kunhua Wang
Summary: This study investigated the peripheral cytokines and exosomal transcriptome regulatory networks in patients with METH use disorders (MUDs) undergoing withdrawal. Abnormal levels of cytokines were observed during acute withdrawal, but mostly restored to baseline in protracted withdrawal. However, certain cytokines remained increased even after one year of withdrawal. Additionally, T cell numbers were decreased during acute withdrawal, but restored to normal levels during protracted withdrawal.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biochemical Research Methods
Bihan Shen, Fangyoumin Feng, Kunshi Li, Ping Lin, Liangxiao Ma, Hong Li
Summary: Drug response prediction is an important issue in personalized cancer therapy, and deep learning methods have shown significant improvement in prediction performance. However, there is a lack of systematic comparisons of deep learning methods, especially regarding the transferability from preclinical models to clinical cohorts. To address this, six representative deep learning methods were benchmarked for drug response prediction in various scenarios, using nine evaluation metrics. TGSA showed promising performance with lower time cost, and CRDNN also maintained certain ability to distinguish clinical response on some drugs. This provides guidance for researchers in choosing appropriate methods and insights for future development in clinical scenarios.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Cell Biology
Ying Li, O. D. A. Harunori, Shihu Fu, Fuyuan Xing, Huawan Wu, Juan Wang, Aihua Chen, Xinhua Ren, Dawei Peng, Xia Ling, Ming Shi, Hongjin Wu
Summary: Immune normalization, a new paradigm in immunotherapy, can be used in cancer patients and sub-healthy individuals for cancer prevention. In vitro cultured mixed natural killer (NKM) cells show high cytotoxicity, positively correlated with NK cell proportion. Sub-healthy individuals and cancer patients treated with NKM-cell therapy demonstrated reduced T cell percentage and good tolerance.
Article
Biotechnology & Applied Microbiology
Jianyu Yang, Ping Lin, Minwei Yang, Wei Liu, Xueliang Fu, Dejun Liu, Lingye Tao, Yanmiao Huo, Junfeng Zhang, Rong Hua, Zhigang Zhang, Yixue Li, Liwei Wang, Jing Xue, Hong Li, Yongwei Sun
Summary: This study conducted exome sequencing and RNA sequencing for synchronous resected primary tumors and paired hepatic metastases from 17 hepatic oligometastatic pancreatic ductal adenocarcinoma cases and found high similarity between the two, as well as unique characteristics in the hepatic metastases such as 3p21.1 loss, enhanced proliferation abilities, downregulation of epithelial to mesenchymal transition activity, and metabolic rewiring. Altered tumor microenvironments were also observed in hepatic metastases, including a higher proportion of tumor infiltrating M2 macrophages and upregulation of complement cascade. Further experiments demonstrated the role of C1q in promoting migration and invasion of PDAC cells.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
