LncRNAs regulating stemness in aging

Long Noncoding RNA uc.173 Promotes Renewal of the Intestinal Mucosa by Inducing Degradation of MicroRNA 195

(2018) Lan Xiao et al.   GASTROENTEROLOGY

Cellular and epigenetic drivers of stem cell ageing

(2018) Maria Ermolaeva et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Silencing of the lncRNA Zeb2-NAT facilitates reprogramming of aged fibroblasts and safeguards stem cell pluripotency

(2018) Bruno Bernardes de Jesus et al.   Nature Communications

The Long Non-coding RNA lnc-31 Interacts with Rock1 mRNA and Mediates Its YB-1-Dependent Translation

(2018) Dacia Dimartino et al.   Cell Reports

Adult Sox2+ stem cell exhaustion in mice results in cellular senescence and premature aging

(2018) Jéssica M. Vilas et al.   AGING CELL

lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy

(2017) Ronald L Neppl et al.   JOURNAL OF CELL BIOLOGY

Lnc-mg is a long non-coding RNA that promotes myogenesis

(2017) Mu Zhu et al.   Nature Communications

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD

(2017) Xiaohua Yu et al.   Nature Communications

An emerging function of circRNA-miRNAs-mRNA axis in human diseases

(2017) Dawei Rong et al.   Oncotarget

Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity

(2017) Xiaona Chen et al.   Cell Discovery

Angelman syndrome: Current and emerging therapies in 2016

(2016) Wen-Hann Tan et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Regulation of crucial lncRNAs in differentiation of chicken embryonic stem cells to spermatogonia stem cells

(2016) D. Li et al.   ANIMAL GENETICS

Niche heterogeneity in the bone marrow

(2016) Alexander Birbrair et al.   Annals of the New York Academy of Sciences

Divergent lncRNAs Regulate Gene Expression and Lineage Differentiation in Pluripotent Cells

(2016) Sai Luo et al.   Cell Stem Cell

Rapid evolutionary turnover underlies conserved lncRNA–genome interactions

(2016) Jeffrey J. Quinn et al.   GENES & DEVELOPMENT

H19Long Noncoding RNA Regulates Intestinal Epithelial Barrier Function via MicroRNA 675 by Interacting with RNA-Binding Protein HuR

(2016) Tongtong Zou et al.   MOLECULAR AND CELLULAR BIOLOGY

Long noncoding RNA SPRY4-IT1 regulates intestinal epithelial barrier function by modulating the expression levels of tight junction proteins

(2016) Lan Xiao et al.   MOLECULAR BIOLOGY OF THE CELL

Out with the old

(2016) Jesús Gil et al.   NATURE

Melanoma addiction to the long non-coding RNA SAMMSON

(2016) Eleonora Leucci et al.   NATURE

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Influence of donor age on induced pluripotent stem cells

(2016) Valentina Lo Sardo et al.   NATURE BIOTECHNOLOGY

Transcript-level expression analysis of RNA-seq experiments with HISAT, StringTie and Ballgown

(2016) Mihaela Pertea et al.   Nature Protocols

Non-coding RNAs as drug targets

(2016) Masayuki Matsui et al.   NATURE REVIEWS DRUG DISCOVERY

Natural antisense RNA promotes 3′ end processing and maturation of MALAT1 lncRNA

(2016) Xinying Zong et al.   NUCLEIC ACIDS RESEARCH

The emerging landscape of circular RNA in life processes

(2016) Shibin Qu et al.   RNA Biology

Anti-Aging Strategies Based on Cellular Reprogramming

(2016) Alejandro Ocampo et al.   TRENDS IN MOLECULAR MEDICINE

iPSCs: On the Road to Reprogramming Aging

(2016) Clara Soria-Valles et al.   TRENDS IN MOLECULAR MEDICINE

Telomeric RNAs are essential to maintain telomeres

(2016) Juan José Montero et al.   Nature Communications

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate

(2016) Antonis Giakountis et al.   Cell Reports

Posttranscriptional regulation of intestinal epithelial integrity by noncoding RNAs

(2016) Jun-Yao Wang et al.   Wiley Interdisciplinary Reviews-RNA

Role of lncRNAs in Cellular Aging

(2016) Ufuk Degirmenci et al.   Frontiers in Endocrinology

Long noncoding RNAs (lncRNAs) and the molecular hallmarks of aging

(2016) Ioannis Grammatikakis et al.   Aging-US

Adult stem cells: hopes and hypes of regenerative medicine

(2015) Józef Dulak et al.   ACTA BIOCHIMICA POLONICA

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing

(2015) Takayuki Nojima et al.   CELL

Long Non-Coding RNAs Control Hematopoietic Stem Cell Function

(2015) Min Luo et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Antisense Approach to Inflammatory Bowel Disease: Prospects and Challenges

(2015) Irene Marafini et al.   DRUGS

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

(2015) Hoon Kim et al.   GENOME RESEARCH

Cellular localization of long non-coding RNAs affects silencing by RNAi more than by antisense oligonucleotides

(2015) Kim A. Lennox et al.   NUCLEIC ACIDS RESEARCH

Stem cells and healthy aging

(2015) M. A. Goodell et al.   SCIENCE

Loss of non-coding RNA expression from the DLK1-DIO3 imprinted locus correlates with reduced neural differentiation potential in human embryonic stem cell lines

(2015) Chu-Fan Mo et al.   Stem Cell Research & Therapy

Similarities in Gene Expression Profiles duringIn VitroAging of Primary Human Embryonic Lung and Foreskin Fibroblasts

(2015) Shiva Marthandan et al.   Biomed Research International

The ins and outs of muscle stem cell aging

(2015) Andrew S. Brack et al.   Skeletal Muscle

The role of long non-coding RNAs in genome formatting and expression

(2015) Pierre-Olivier Angrand et al.   Frontiers in Genetics

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

Identification, stability and expression of Sirt1 antisense long non-coding RNA

(2014) Yu Wang et al.   GENE

The H19 long noncoding RNA gives rise to microRNAs miR-675-3p and miR-675-5p to promote skeletal muscle differentiation and regeneration

(2014) B. K. Dey et al.   GENES & DEVELOPMENT

Nascent RNA interaction keeps PRC2 activity poised and in check

(2014) Syuzo Kaneko et al.   GENES & DEVELOPMENT

Genome-wide identification of long noncoding natural antisense transcripts and their responses to light in Arabidopsis

(2014) H. Wang et al.   GENOME RESEARCH

MUNC, a Long Noncoding RNA That Facilitates the Function of MyoD in Skeletal Myogenesis

(2014) Adam C. Mueller et al.   MOLECULAR AND CELLULAR BIOLOGY

Towards a therapy for Angelman syndrome by targeting a long non-coding RNA

(2014) Linyan Meng et al.   NATURE

Abnormalities in human pluripotent cells due to reprogramming mechanisms

(2014) Hong Ma et al.   NATURE

PVT1 dependence in cancer with MYC copy-number increase

(2014) Yuen-Yi Tseng et al.   NATURE

The STAT3-Binding Long Noncoding RNA lnc-DC Controls Human Dendritic Cell Differentiation

(2014) P. Wang et al.   SCIENCE

Physiological roles of long noncoding RNAs: insight from knockout mice

(2014) Lingjie Li et al.   TRENDS IN CELL BIOLOGY

Long non-coding RNAs and control of gene expression in the immune system

(2014) Maninjay K. Atianand et al.   TRENDS IN MOLECULAR MEDICINE

Genomic Imprinting in Mammals

(2014) D. P. Barlow et al.   Cold Spring Harbor Perspectives in Biology

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

(2014) Pavan Kumar Puvvula et al.   Nature Communications

Genome-wide Analysis of Drosophila Circular RNAs Reveals Their Structural and Sequence Properties and Age-Dependent Neural Accumulation

(2014) Jakub O. Westholm et al.   Cell Reports

Telomeric noncoding RNA: telomeric repeat-containing RNA in telomere biology

(2014) Emilio Cusanelli et al.   Wiley Interdisciplinary Reviews-RNA

Aging of blood can be tracked by DNA methylation changes at just three CpG sites

(2014) Carola Weidner et al.   GENOME BIOLOGY

Senescence-associated lncRNAs: senescence-associated long noncoding RNAs

(2013) Kotb Abdelmohsen et al.   AGING CELL

Finding the active genes in deep RNA-seq gene expression studies

(2013) Traver Hart et al.   BMC GENOMICS

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

X-Inactivation, Imprinting, and Long Noncoding RNAs in Health and Disease

(2013) Jeannie T. Lee et al.   CELL

Signaling and Mechanical Roles of E-cadherin

(2013) Tanay Bhatt et al.   CELL COMMUNICATION AND ADHESION

Negative regulation of lncRNA GAS5 by miR-21

(2013) Z Zhang et al.   CELL DEATH AND DIFFERENTIATION

Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo

(2013) Alexander D. Ramos et al.   Cell Stem Cell

Endogenous miRNA Sponge lincRNA-RoR Regulates Oct4, Nanog, and Sox2 in Human Embryonic Stem Cell Self-Renewal

(2013) Yue Wang et al.   DEVELOPMENTAL CELL

Caloric restriction and aging stem cells: The stick and the carrot?

(2013) Gianluigi Mazzoccoli et al.   EXPERIMENTAL GERONTOLOGY

Functional dysregulation of stem cells during aging: a focus on skeletal muscle stem cells

(2013) Laura García-Prat et al.   FEBS Journal

Clinical Trials Using Antisense Oligonucleotides in Duchenne Muscular Dystrophy

(2013) Taeyoung Koo et al.   HUMAN GENE THERAPY

Life without A tail: New formats of long noncoding RNAs

(2013) Yang Zhang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia

(2013) Peter P. Toth   Journal of Clinical Lipidology

Age-Associated Remodeling of the Intestinal Epithelial Barrier

(2013) L. Tran et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Stem cells: Surf the waves of reprogramming

(2013) Ignacio Sancho-Martinez et al.   NATURE

Gene regulation by antisense transcription

(2013) Vicent Pelechano et al.   NATURE REVIEWS GENETICS

Structure and function of long noncoding RNAs in epigenetic regulation

(2013) Tim R Mercer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation

(2013) G. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple knockout mouse models reveal lincRNAs are required for life and brain development

(2013) Martin Sauvageau et al.   eLife

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2

(2013) Oskar Marín-Béjar et al.   GENOME BIOLOGY

Mitochondrial DNA polymerase editing mutation, PolgD257A, disturbs stem-progenitor cell cycling in the small intestine and restricts excess fat absorption

(2012) Raymond G. Fox et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Genome Regulation by Long Noncoding RNAs

(2012) John L. Rinn et al.   Annual Review of Biochemistry

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Recurrent Variations in DNA Methylation in Human Pluripotent Stem Cells and Their Differentiated Derivatives

(2012) Kristopher L. Nazor et al.   Cell Stem Cell

Antagonism of microRNA Function in Zebrafish Embryos by Using Locked Nucleic Acid Enzymes (LNAzymes)

(2012) Hemant Suryawanshi et al.   CHEMBIOCHEM

Assessing Cell and Organ Senescence Biomarkers

(2012) Bruno Bernardes de Jesus et al.   CIRCULATION RESEARCH

Aging and reprogramming: a two-way street

(2012) Salah Mahmoudi et al.   CURRENT OPINION IN CELL BIOLOGY

Conceptual approaches for lncRNA drug discovery and future strategies

(2012) Deeksha Bhartiya et al.   Expert Opinion on Drug Discovery

The Retinoblastoma Protein Selectively Represses E2F1 Targets via a TAAC DNA Element during Cellular Senescence

(2012) Tianda Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Airn Transcriptional Overlap, But Not Its lncRNA Products, Induces Imprinted Igf2r Silencing

(2012) P. A. Latos et al.   SCIENCE

Epigenetic Regulation by Long Noncoding RNAs

(2012) J. T. Lee   SCIENCE

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells

(2011) Taotao Chen et al.   AGING CELL

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

(2011) F. Aguilo et al.   CANCER RESEARCH

The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion

(2011) D. Khaitan et al.   CANCER RESEARCH

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

Telomeres: The silence is broken

(2011) Claus M. Azzalin et al.   CELL CYCLE

Human iPS cell-based therapy: Considerations before clinical applications

(2011) Ning Sun et al.   CELL CYCLE

Reprogramming Factor Stoichiometry Influences the Epigenetic State and Biological Properties of Induced Pluripotent Stem Cells

(2011) Bryce W. Carey et al.   Cell Stem Cell

The Efficiency of Cell Fusion-Based Reprogramming Is Affected by the Somatic Cell Type and the In Vitro Age of Somatic Cells

(2011) Pollyanna Agnes Tat et al.   Cellular Reprogramming

E-cadherin is crucial for embryonic stem cell pluripotency and can replace OCT4 during somatic cell reprogramming

(2011) Torben Redmer et al.   EMBO REPORTS

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses

(2011) M. N. Cabili et al.   GENES & DEVELOPMENT

E-Cadherin/β-Catenin Complex and the Epithelial Barrier

(2011) Xinrui Tian et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Manifestations and mechanisms of stem cell aging

(2011) Ling Liu et al.   JOURNAL OF CELL BIOLOGY

Cell cycle regulation in hematopoietic stem cells

(2011) Eric M. Pietras et al.   JOURNAL OF CELL BIOLOGY

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

lincRNAs act in the circuitry controlling pluripotency and differentiation

(2011) Mitchell Guttman et al.   NATURE

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Dnmt3a is essential for hematopoietic stem cell differentiation

(2011) Grant A Challen et al.   NATURE GENETICS

Status of Genomic Imprinting in Epigenetically Distinct Pluripotent Stem Cells

(2011) Bowen Sun et al.   STEM CELLS

Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues

(2010) Jacob H. Hanna et al.   CELL

A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts

(2010) Ronghui Li et al.   Cell Stem Cell

Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming

(2010) Payman Samavarchi-Tehrani et al.   Cell Stem Cell

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Linc-ing Long Noncoding RNAs and Enhancer Function

(2010) John S. Mattick   DEVELOPMENTAL CELL

The role of telomeres and telomerase in stem cell aging

(2010) Ignacio Flores et al.   FEBS LETTERS

The essence of senescence

(2010) T. Kuilman et al.   GENES & DEVELOPMENT

Activation of the ImprintedDlk1-Dio3Region Correlates with Pluripotency Levels of Mouse Stem Cells

(2010) Lei Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells

(2010) Matthias Stadtfeld et al.   NATURE

Large intergenic non-coding RNA-RoR modulates reprogramming of human induced pluripotent stem cells

(2010) Sabine Loewer et al.   NATURE GENETICS

What do natural antisense transcripts regulate?

(2010) Andreas Werner et al.   RNA Biology

Expression of Linear and Novel Circular Forms of an INK4/ARF-Associated Non-Coding RNA Correlates with Atherosclerosis Risk

(2010) Christin E. Burd et al.   PLoS Genetics

Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function

(2009) Vaibhav M. Jadhav et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Fresh Look at iPS Cells

(2009) Shinya Yamanaka   CELL

Epigenetic reprogramming and induced pluripotency

(2009) K. Hochedlinger et al.   DEVELOPMENT

A ‘higher order’ of telomere regulation: telomere heterochromatin and telomeric RNAs

(2009) Stefan Schoeftner et al.   EMBO JOURNAL

Senescence impairs successful reprogramming to pluripotent stem cells

(2009) A. Banito et al.   GENES & DEVELOPMENT

Linking the p53 tumour suppressor pathway to somatic cell reprogramming

(2009) Teruhisa Kawamura et al.   NATURE

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

(2009) Rosa M. Marión et al.   NATURE

Direct cell reprogramming is a stochastic process amenable to acceleration

(2009) Jacob Hanna et al.   NATURE

Suppression of induced pluripotent stem cell generation by the p53–p21 pathway

(2009) Hyenjong Hong et al.   NATURE

Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

(2009) Jochen Utikal et al.   NATURE

The Ink4/Arf locus is a barrier for iPS cell reprogramming

(2009) Han Li et al.   NATURE

Embryonic stem cell–specific microRNAs promote induced pluripotency

(2009) Robert L Judson et al.   NATURE BIOTECHNOLOGY

Long non-coding RNAs: insights into functions

(2009) Tim R. Mercer et al.   NATURE REVIEWS GENETICS

Relationship between CAD Risk Genotype in the Chromosome 9p21 Locus and Gene Expression. Identification of Eight New ANRIL Splice Variants

(2009) Lasse Folkersen et al.   PLoS One

Conserved long noncoding RNAs transcriptionally regulated by Oct4 and Nanog modulate pluripotency in mouse embryonic stem cells

(2009) J. Sheik Mohamed et al.   RNA

Dicer independent small RNAs associate with telomeric heterochromatin

(2009) F. Cao et al.   RNA

Chromatin regulation and non-coding RNAs at mammalian telomeres

(2009) Stefan Schoeftner et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Aging and Cancer-Related Loss of Insulin-like Growth Factor 2 Imprinting in the Mouse and Human Prostate

(2008) V. X. Fu et al.   CANCER RESEARCH

Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

(2008) Yang Zhao et al.   Cell Stem Cell

Polycomb Group Proteins Ezh2 and Rnf2 Direct Genomic Contraction and Imprinted Repression in Early Mouse Embryos

(2008) Rémi Terranova et al.   DEVELOPMENTAL CELL

A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition

(2008) M. Beltran et al.   GENES & DEVELOPMENT

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

(2008) M Mourtada-Maarabouni et al.   ONCOGENE

The Air Noncoding RNA Epigenetically Silences Transcription by Targeting G9a to Chromatin

(2008) T. Nagano et al.   SCIENCE

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE