Conceptual approaches for lncRNA drug discovery and future strategies

Antagonism of microRNA Function in Zebrafish Embryos by Using Locked Nucleic Acid Enzymes (LNAzymes)

(2012) Hemant Suryawanshi et al.   CHEMBIOCHEM

Suppression of progenitor differentiation requires the long noncoding RNA ANCR

(2012) M. Kretz et al.   GENES & DEVELOPMENT

miR-31 and its host gene lncRNA LOC554202 are regulated by promoter hypermethylation in triple-negative breast cancer

(2012) Katarzyna Augoff et al.   Molecular Cancer

The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR-21 Function by Directly Targeting Its Precursor

(2011) Debojit Bose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Overexpression of Long Non-coding RNA HOTAIR Predicts Tumor Recurrence in Hepatocellular Carcinoma Patients Following Liver Transplantation

(2011) Zhe Yang et al.   ANNALS OF SURGICAL ONCOLOGY

Identification of novel transcripts in annotated genomes using RNA-Seq

(2011) A. Roberts et al.   BIOINFORMATICS

Long Noncoding RNA, Polycomb, and the Ghosts Haunting INK4b-ARF-INK4a Expression

(2011) F. Aguilo et al.   CANCER RESEARCH

The Melanoma-Upregulated Long Noncoding RNA SPRY4-IT1 Modulates Apoptosis and Invasion

(2011) D. Khaitan et al.   CANCER RESEARCH

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

A Long Noncoding RNA Controls Muscle Differentiation by Functioning as a Competing Endogenous RNA

(2011) Marcella Cesana et al.   CELL

A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

(2011) Leonardo Salmena et al.   CELL

Additive Effect of ANRIL and BRAP Polymorphisms on Ankle-Brachial Index in a Taiwanese Population

(2011) Pei-Chien Tsai et al.   CIRCULATION JOURNAL

Advances and Perspectives in Cell-Specific Aptamers

(2011) Wei Sun et al.   CURRENT PHARMACEUTICAL DESIGN

The central role of RNA in human development and cognition

(2011) John S. Mattick   FEBS LETTERS

Xist regulation and function eXplored

(2011) Daphne B. Pontier et al.   HUMAN GENETICS

The KCNQ1OT1 imprinting control region and non-coding RNA: new properties derived from the study of Beckwith–Wiedemann syndrome and Silver–Russell syndrome cases

(2011) Nicoletta Chiesa et al.   HUMAN MOLECULAR GENETICS

MEG3 imprinted gene contribution in tumorigenesis

(2011) Leonidas Benetatos et al.   INTERNATIONAL JOURNAL OF CANCER

Acquisition of neuron-like electrophysiological properties in neuroblastoma cells by controlled expression of NDM29 ncRNA

(2011) Paola Gavazzo et al.   JOURNAL OF NEUROCHEMISTRY

Gene Expression Profiling Reveals Upregulated UCA1 and BMF in Gallbladder Epithelia of Children With Pancreaticobiliary Maljunction

(2011) Kenitiro Kaneko et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Role of Noncoding RNA ANRIL in Genesis of Plexiform Neurofibromas in Neurofibromatosis Type 1

(2011) Eric Pasmant et al.   JNCI-Journal of the National Cancer Institute

A possible role for long non-coding RNA in modulating signaling pathways

(2011) Barak Rotblat et al.   MEDICAL HYPOTHESES

The functional role of long non-coding RNA in human carcinomas

(2011) Ewan A Gibb et al.   Molecular Cancer

Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly

(2011) Yingrui Li et al.   NATURE BIOTECHNOLOGY

Selective 2′-hydroxyl acylation analyzed by protection from exoribonuclease (RNase-detected SHAPE) for direct analysis of covalent adducts and of nucleotide flexibility in RNA

(2011) Kady-Ann Steen et al.   Nature Protocols

Gene silencing in X-chromosome inactivation: advances in understanding facultative heterochromatin formation

(2011) Anton Wutz   NATURE REVIEWS GENETICS

Long non-coding RNAs in Huntington's disease neurodegeneration

(2011) Rory Johnson   NEUROBIOLOGY OF DISEASE

Long-range chromatin interactions at the mouse Igf2/H19 locus reveal a novel paternally expressed long non-coding RNA

(2011) Franck Court et al.   NUCLEIC ACIDS RESEARCH

Large-scale prediction of long non-coding RNA functions in a coding–non-coding gene co-expression network

(2011) Qi Liao et al.   NUCLEIC ACIDS RESEARCH

MicroRNAs in Development and Disease

(2011) Danish Sayed et al.   PHYSIOLOGICAL REVIEWS

Human Cancer Long Non-Coding RNA Transcriptomes

(2011) Ewan A. Gibb et al.   PLoS One

Long noncoding RNA in genome regulation

(2011) Tiffany Hung et al.   RNA Biology

LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation

(2011) Jessica M. Silva et al.   RNA Biology

Pseudogenes: Pseudo-functional or key regulators in health and disease?

(2011) R. C. Pink et al.   RNA

Exploring long non-coding RNAs through sequencing

(2011) Sophie R. Atkinson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Potential Applications of MicroRNAs in Cancer Diagnosis, Prognosis, and Treatment

(2011) Sukhinder Sandhu et al.   SEMINARS IN ONCOLOGY

Long Noncoding RNAs, Chromatin, and Development

(2011) Daniel P. Caley et al.   TheScientificWorldJOURNAL

Long noncoding RNAs and human disease

(2011) Orly Wapinski et al.   TRENDS IN CELL BIOLOGY

Genome-wide transcription factor binding: beyond direct target regulation

(2011) Kyle L. MacQuarrie et al.   TRENDS IN GENETICS

The Emergence of lncRNAs in Cancer Biology

(2011) J. R. Prensner et al.   Cancer Discovery

The Reality of Pervasive Transcription

(2011) Michael B. Clark et al.   PLOS BIOLOGY

From RNA-seq reads to differential expression results

(2011) Alicia Oshlack et al.   GENOME BIOLOGY

MacroRNA underdogs in a microRNA world: Evolutionary, regulatory, and biomedical significance of mammalian long non-protein-coding RNA

(2010) Leonard Lipovich et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Long non-coding RNAs in nervous system function and disease

(2010) Irfan A. Qureshi et al.   BRAIN RESEARCH

Recurrent Focal Copy-Number Changes and Loss of Heterozygosity Implicate Two Noncoding RNAs and One Tumor Suppressor Gene at Chromosome 3q13.31 in Osteosarcoma

(2010) I. Pasic et al.   CANCER RESEARCH

Association of a novel long non-coding RNA in 8q24 with prostate cancer susceptibility

(2010) Suyoun Chung et al.   CANCER SCIENCE

A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response

(2010) Maite Huarte et al.   CELL

HOTAIR: Flight of noncoding RNAs in cancer metastasis

(2010) Yue Wan et al.   CELL CYCLE

The anti-apoptotic protein G1P3 is overexpressed in psoriasis and regulated by the non-coding RNA, PRINS

(2010) Krisztina Szegedi et al.   EXPERIMENTAL DERMATOLOGY

An Alu-like RNA promotes cell differentiation and reduces malignancy of human neuroblastoma cells

(2010) Manuele Castelnuovo et al.   FASEB JOURNAL

ANRIL, a long, noncoding RNA, is an unexpected major hotspot in GWAS

(2010) Eric Pasmant et al.   FASEB JOURNAL

Identification of protein interaction regions of VINC/NEAT1/Men epsilon RNA

(2010) U.M. Sreenivasa Murthy et al.   FEBS LETTERS

Transcribed dark matter: meaning or myth?

(2010) C. P. Ponting et al.   HUMAN MOLECULAR GENETICS

Deletion of the NoncodingGNASAntisense Transcript Causes Pseudohypoparathyroidism Type Ib and Biparental Defects ofGNASMethylationin cis

(2010) Smitha Chillambhi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

(2010) Rajnish A. Gupta et al.   NATURE

A map of human genome variation from population-scale sequencing

(2010) Richard M. Durbin et al.   NATURE

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

(2010) Jiayi Wang et al.   NUCLEIC ACIDS RESEARCH

Cell-Specific Aptamer-Mediated Targeted Drug Delivery

(2010) Jiehua Zhou et al.   OLIGONUCLEOTIDES

Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15 INK4B tumor suppressor gene

(2010) Y Kotake et al.   ONCOGENE

Expression and functional role of a transcribed noncoding RNA with an ultraconserved element in hepatocellular carcinoma

(2010) C. Braconi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE

(2010) et al.   SCIENCE

Antagomirzymes: Oligonucleotide Enzymes That Specifically Silence MicroRNA Function

(2009) Vaibhav M. Jadhav et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly upregulated in liver cancer noncoding RNA is overexpressed in hepatic colorectal metastasis

(2009) Imad J. Matouk et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Strategies for the design of RNA-binding small molecules

(2009) Fareed Aboul-ela   Future Medicinal Chemistry

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation

(2008) Shiro Tochitani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

(2008) Fan Wang et al.   FEBS LETTERS

The diploid genome sequence of an Asian individual

(2008) Jun Wang et al.   NATURE

GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer

(2008) M Mourtada-Maarabouni et al.   ONCOGENE

Novel noncoding antisense RNA transcribed from human anti-NOS2A locus is differentially regulated during neuronal differentiation of embryonic stem cells

(2008) S. A. Korneev et al.   RNA