Article
Cell Biology
Min S. Kwon, Hee K. Chung, Lan Xiao, Ting-Xi Yu, Shelley R. Wang, Jun-Jie Piao, Jaladanki N. Rao, Myriam Gorospe, Jian-Ying Wang
Summary: In this study, it was found that miR-195 regulates the function of Tuft and Paneth cells in the small intestinal epithelium posttranscriptionally, impacting the mucosal immune response in the gut. Overexpression of miR-195 led to a reduction in the numbers of Tuft and Paneth cells and increased vulnerability of the gut barrier to lipopolysaccharide.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaojiao Zhao, Hongliang Zeng, Li Lei, Xiaoliang Tong, Lun Yang, Yan Yang, Si Li, Ying Zhou, Liping Luo, Jinhua Huang, Rong Xiao, Jing Chen, Qinghai Zeng
Summary: Tight junction (TJ) is a zipping up junction structure located at the uppermost portion of adjacent epithelial/endothelial cells in organs and tissues, maintaining the stability of intracellular substances and functions. TJs are widely present in various organs and tissues, dysfunction of which can lead to various diseases, and they are also regulated by non-coding RNAs.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hsiao-Fan Chen, Chia-Ting Chang, Kai-Wen Hsu, Pei-Hua Peng, Joseph Chieh-Yu Lai, Mien-Chie Hung, Kou-Juey Wu
Summary: This study identifies the epigenetic regulatory mechanisms, including BRD4 and lncRNA LIBR, that control asymmetric cell division (ACD). The findings suggest limitations in using BRD4 inhibitors for cancer treatment due to their potential to promote symmetric cell division.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Cell Biology
Hee K. Chung, Lan Xiao, Krishna C. Jaladanki, Jian-Ying Wang
Summary: Paneth cells are specialized intestinal epithelial cells located at the base of small intestinal crypts, playing a crucial role in maintaining gut epithelium homeostasis. Post-transcriptional regulation of Paneth cells by RNA-binding proteins (RBPs) and noncoding RNAs (ncRNAs) is essential in gut mucosal diseases where Paneth cell dysfunction is a key factor.
Article
Multidisciplinary Sciences
Yongsuk Ku, Joo-Hwan Park, Ryeongeun Cho, Yongki Lee, Hyoung-Min Park, MinA Kim, Kyunghoon Hur, Soo Young Byun, Jun Liu, Young-Suk Lee, David Shum, Dong-Yeop Shin, Youngil Koh, Je-Yoel Cho, Sung-Soo Yoon, Junshik Hong, Yoosik Kim
Summary: This study uncovers the mechanism of viral mimicry and cell death triggered by decitabine through the activation of endogenous retroviruses (ERVs), highlighting the essential role of the double-stranded RNA-binding protein Staufen1 (Stau1) and providing a novel target for predicting the efficacy of DNMTis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell Biology
Wentao Ma, Weihong Zhang, Bing Cui, Jing Gao, Qiuhong Liu, Mengying Yao, Hanbing Ning, Lihua Xing
Summary: This study reveals that EPCs derived EVs transmit TUG1 to alleviate sepsis by promoting macrophage M2 polarization. Additionally, TUG1 can competitively bind to miR-9-5p to upregulate SIRT1 expression, leading to the inhibition of miR-9-5p-mediated SIRT1 inhibition, which contributes to a more comprehensive understanding of the pathogenesis of sepsis.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Paola Briata, Luca Mastracci, Ettore Zapparoli, Luca Caputo, Elisa Ferracci, Alessandra Silvestri, Anna Garuti, Meriem Hadjer Hamadou, Alberto Inga, Elisa Marcaccini, Federica Grillo, Gabriele Bucci, Pier Lorenzo Puri, Galina Beznoussenko, Alexander Mironov, Fulvio Chiacchiera, Roberto Gherzi
Summary: The long non-coding RNA EPR regulates various biological activities in mouse mammary gland cells and is highly expressed in the intestine. The specific deletion of EPR in the colon of mice results in hyperproliferation of epithelial cells, impaired mucus production and secretion, inflammatory infiltration, and increased vulnerability to colitis and tumor formation. EPR interacts with genes involved in mucus metabolism and its deletion causes changes in chromatin organization.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Artem Smirnov, Anna Maria Lena, Giulia Tosetti, Xue Yang, Angela Cappello, Manuela Helmer Citterich, Gerry Melino, Eleonora Candi
Summary: This study describes a skin-specific non-coding RNA XP33 as a novel target of p63, and its transcription is epigenetically regulated by CTCF and p63.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Sihui Li, Shizhen Shen, Wanzhong Ge, Yixuan Cen, Songfa Zhang, Xiaodong Cheng, Xinyu Wang, Xing Xie, Weiguo Lu
Summary: This study found that the long non-coding RNA SLC25A21-AS1 is downregulated in ovarian cancer tissues compared to normal ovarian tissues. Upregulation of SLC25A21-AS1 significantly inhibits the proliferation and metastasis of EOC cells, while downregulation has the opposite effect. SLC25A21-AS1 functions by promoting the degradation of PTBP3 protein stability, thereby suppressing EOC cell proliferation and metastasis. This research reveals the impact of SLC25A21-AS1 on EOC development and suggests it as a prognostic target to improve patient survival by promoting PTBP3 degradation.
BIOMARKER RESEARCH
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Microbiology
Brice Felden, Yoann Augagneur
Summary: Bacterial gene expression is controlled by a complex system of molecules, with small regulatory RNAs (sRNAs) emerging as key players alongside transcription factors. sRNAs influence various biological processes and can act intracellularly or even in extracellular vesicles, impacting host cell interactions. Studies suggest that sRNA-mediated mechanisms are more diverse than previously thought, beyond traditional classifications.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Swati Mohapatra, Carlotta Pioppini, Bulent Ozpolat, George A. Calin
Summary: Noncoding RNA transcripts, as important regulators in the tumor microenvironment, play crucial roles in modulating macrophage polarization and influencing tumor progression and clinical outcomes. More research is needed to further understand the mechanisms underlying these processes and the potential therapeutic implications.
Article
Biochemistry & Molecular Biology
Zhenjun Yu, Yuhan Li, Shuai Shao, Beichen Guo, Mengxia Zhang, Lina Zheng, Kun Zhang, Feng Zhou, Li Zhang, Chiyi Chen, Wentao Jiang, Wei Hong, Tao Han
Summary: Chinese researchers have discovered that a long non-coding RNA called Mir122hg plays a protective role in promoting the growth of new healthy cells after liver injury. By activating signaling pathways and promoting gene transcription, Mir122hg encourages hepatocyte proliferation, suggesting its potential use in new therapies.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Jihae Shin, Qingbao Ding, Luyang Wang, Yange Cui, Erdene Baljinnyam, Aysegul Guvenek, Bin Tian
Summary: APA is an important aspect of gene expression program critical for defining cell identity. A method named CRISPRpas, which enhances proximal PAS usage, is developed to alter APA isoform abundance. The efficiency of CRISPRpas is influenced by various factors. The study demonstrates the modulation of APA for multiple endogenous genes and highlights the impact of CRISPRpas on gene expression.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Medicine, Research & Experimental
Baiyin Zhong, Qicheng Liao, Xin Wang, Xiaonong Wang, Jianhong Zhang
Summary: Cholangiocarcinoma (CCA) is a malignant tumor of bile duct epithelial cells with aggressiveness, difficult diagnosis, and poor prognosis. Genetic and epigenetic alterations, including histone modification, DNA methylation, and noncoding RNA modulation, play a role in the development of CCA. Alterations in epigenetic regulation can be potential therapeutic targets and diagnostic biomarkers for CCA.
BIOMEDICINE & PHARMACOTHERAPY
(2023)