Antisense Approach to Inflammatory Bowel Disease: Prospects and Challenges

An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease

(2015) Zhen Huang et al.   BIOMATERIALS

Mongersen, an Oral SMAD7 Antisense Oligonucleotide, and Crohn’s Disease

(2015) Giovanni Monteleone et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Integrins and Adhesion Molecules to Combat Inflammatory Bowel Disease

(2014) Irene Marafini et al.   INFLAMMATORY BOWEL DISEASES

Meta-analysis using individual patient data: efficacy and durability of topical alicaforsen for the treatment of active ulcerative colitis

(2013) S. Vegter et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

New targets for mucosal healing and therapy in inflammatory bowel diseases

(2013) M F Neurath   Mucosal Immunology

Molecular function of macrophage migration inhibitory factor and a novel therapy for inflammatory bowel disease

(2012) Jun Nishihira   Annals of the New York Academy of Sciences

Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia

(2012) B. Yu et al.   BLOOD

Reprogramming the Immune System in IBD

(2012) Thomas T. MacDonald et al.   DIGESTIVE DISEASES

Treatment of experimental murine colitis with CD40 antisense oligonucleotides delivered in amphoteric liposomes

(2012) A. Arranz et al.   JOURNAL OF CONTROLLED RELEASE

Phase I Clinical Trial of Smad7 Knockdown Using Antisense Oligonucleotide in Patients With Active Crohn's Disease

(2012) Giovanni Monteleone et al.   MOLECULAR THERAPY

A New Therapeutic Approach Using a Schizophyllan-based Drug Delivery System for Inflammatory Bowel Disease

(2012) Hidetoshi Takedatsu et al.   MOLECULAR THERAPY

An Overview of Sugar-Modified Oligonucleotides for Antisense Therapeutics

(2011) Thazha P. Prakash   CHEMISTRY & BIODIVERSITY

Regulation of Homeostasis and Inflammation in the Intestine

(2011) Thomas T. MacDonald et al.   GASTROENTEROLOGY

Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases

(2011) Warren Strober et al.   GASTROENTEROLOGY

Intestinal homeostasis and its breakdown in inflammatory bowel disease

(2011) Kevin J. Maloy et al.   NATURE

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes

(2011) Erich Koller et al.   NUCLEIC ACIDS RESEARCH

Oral nuclear factor-κB decoy oligonucleotides delivery system with chitosan modified poly(d,l-lactide-co-glycolide) nanospheres for inflammatory bowel disease

(2010) Kohei Tahara et al.   BIOMATERIALS

Antisense Treatment in Human Prostate Cancer and Melanoma

(2010) C. Di Cresce et al.   CURRENT CANCER DRUG TARGETS

Homing of immune cells: Role in homeostasis and intestinal inflammation

(2010) Ailsa L. Hart et al.   INFLAMMATORY BOWEL DISEASES

Long-term complications, extraintestinal manifestations, and mortality in adult Crohnʼs disease in population-based cohorts

(2010) Laurent Peyrin-Biroulet et al.   INFLAMMATORY BOWEL DISEASES

G3139, an Anti-Bcl-2 Antisense Oligomer That Binds Heparin-Binding Growth Factors and Collagen I, Alters In vitro Endothelial Cell Growth and Tubular Morphogenesis

(2009) C.A. Stein et al.   CLINICAL CANCER RESEARCH

Targeting delivery of anti-TNF  oligonucleotide into activated colonic macrophages protects against experimental colitis

(2009) L. Zuo et al.   GUT

Inflammatory Bowel Disease

(2009) Clara Abraham et al.   NEW ENGLAND JOURNAL OF MEDICINE