Niche heterogeneity in the bone marrow

Osteoblast ablation reduces normal long-term hematopoietic stem cell self-renewal but accelerates leukemia development

(2015) M. Bowers et al.   BLOOD

Making sense of hematopoietic stem cell niches

(2015) P. E. Boulais et al.   BLOOD

Hematopoietic stem cells: concepts, definitions, and the new reality

(2015) C. J. Eaves   BLOOD

Pericytes at the intersection between tissue regeneration and pathology: Figure 1

(2015) Alexander Birbrair et al.   CLINICAL SCIENCE

Bone Marrow Macrophages Contribute to Diabetic Stem Cell Mobilopathy by Producing Oncostatin M

(2015) Mattia Albiero et al.   DIABETES

Neuropeptide Y regulates the hematopoietic stem cell microenvironment and prevents nerve injury in the bone marrow

(2015) M. H. Park et al.   EMBO JOURNAL

Macrophages retain hematopoietic stem cells in the spleen via VCAM-1

(2015) Partha Dutta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

(2015) Melih Acar et al.   NATURE

Neural Regulation of Hematopoiesis, Inflammation, and Cancer

(2015) Maher Hanoun et al.   NEURON

Fetal liver hematopoietic stem cell niches associate with portal vessels

(2015) J. A. Khan et al.   SCIENCE

Pericytes are Essential for Skeletal Muscle Formation

(2015) Alexander Birbrair et al.   Stem Cell Reviews and Reports

Pericytes are Essential for Skeletal Muscle Formation

(2015) Alexander Birbrair et al.   Stem Cell Reviews and Reports

Type-2 pericytes participate in normal and tumoral angiogenesis

(2014) Alexander Birbrair et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Megakaryocytes are essential for HSC quiescence through the production of thrombopoietin

(2014) Ayako Nakamura-Ishizu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In vivo time-lapse imaging shows diverse niche engagement by quiescent and naturally activated hematopoietic stem cells

(2014) N. M. Rashidi et al.   BLOOD

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

Osterix Marks Distinct Waves of Primitive and Definitive Stromal Progenitors during Bone Marrow Development

(2014) Toshihide Mizoguchi et al.   DEVELOPMENTAL CELL

Pro-inflammatory cytokines: Emerging players regulating HSC function in normal and diseased hematopoiesis

(2014) Cristina Mirantes et al.   EXPERIMENTAL CELL RESEARCH

Neurotrophic factor expression in denervated motor and sensory Schwann cells: Relevance to specificity of peripheral nerve regeneration

(2014) Tessa Gordon   EXPERIMENTAL NEUROLOGY

Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo

(2014) M. K. Chang et al.   JOURNAL OF IMMUNOLOGY

The bone marrow niche for haematopoietic stem cells

(2014) Sean J. Morrison et al.   NATURE

Foxc1 is a critical regulator of haematopoietic stem/progenitor cell niche formation

(2014) Yoshiki Omatsu et al.   NATURE

Megakaryocytes maintain homeostatic quiescence and promote post-injury regeneration of hematopoietic stem cells

(2014) Meng Zhao et al.   NATURE MEDICINE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion

(2014) Ingmar Bruns et al.   NATURE MEDICINE

Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner

(2014) Alexander Birbrair et al.   Stem Cell Research & Therapy

Pericytes: multitasking cells in the regeneration of injured, diseased, and aged skeletal muscle

(2014) Alexander Birbrair et al.   Frontiers in Aging Neuroscience

Type-1 pericytes participate in fibrous tissue deposition in aged skeletal muscle

(2013) Alexander Birbrair et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age

(2013) C. Gekas et al.   BLOOD

Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning

(2013) T. S. Olson et al.   BLOOD

Clonal Analysis Unveils Self-Renewing Lineage-Restricted Progenitors Generated Directly from Hematopoietic Stem Cells

(2013) Ryo Yamamoto et al.   CELL

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs

(2013) Borhane Guezguez et al.   Cell Stem Cell

SLAM Family Markers Resolve Functionally Distinct Subpopulations of Hematopoietic Stem Cells and Multipotent Progenitors

(2013) Hideyuki Oguro et al.   Cell Stem Cell

Molecular and functional characterization of human bone marrow adipocytes

(2013) Antonella Poloni et al.   EXPERIMENTAL HEMATOLOGY

Heterogeneity and hierarchy of hematopoietic stem cells

(2013) Hideo Ema et al.   EXPERIMENTAL HEMATOLOGY

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

PDGFRα and CD51 mark human Nestin+sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion

(2013) Sandra Pinho et al.   JOURNAL OF EXPERIMENTAL MEDICINE

New insights into osteoporosis: the bone-fat connection

(2013) M. Kawai et al.   JOURNAL OF INTERNAL MEDICINE

CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance

(2013) Adam Greenbaum et al.   NATURE

Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

(2013) Lei Ding et al.   NATURE

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

Arteriolar niches maintain haematopoietic stem cell quiescence

(2013) Yuya Kunisaki et al.   NATURE

Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment

(2013) César Nombela-Arrieta et al.   NATURE CELL BIOLOGY

GATA-3 regulates the self-renewal of long-term hematopoietic stem cells

(2013) Catherine Frelin et al.   NATURE IMMUNOLOGY

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

(2013) Phuong L Doan et al.   NATURE MEDICINE

Exploring the erythroblastic island

(2013) Merav Socolovsky   NATURE MEDICINE

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

(2013) Pedro Ramos et al.   NATURE MEDICINE

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration

(2013) Daniel Lucas et al.   NATURE MEDICINE

CD169+ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

(2013) Andrew Chow et al.   NATURE MEDICINE

Megakaryocytes co-localise with hemopoietic stem cells and release cytokines that up-regulate stem cell proliferation

(2013) Shen Y. Heazlewood et al.   Stem Cell Research

Role of Pericytes in Skeletal Muscle Regeneration and Fat Accumulation

(2013) Alexander Birbrair et al.   STEM CELLS AND DEVELOPMENT

Adipocytic Cells Augment the Support of Primitive Hematopoietic Cells In Vitro But Have No Effect in the Bone Marrow Niche Under Homeostatic Conditions

(2013) Tassja J. Spindler et al.   STEM CELLS AND DEVELOPMENT

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

Molecular and functional characterization of early human hematopoiesis

(2012) Elisa Laurenti et al.   Annals of the New York Academy of Sciences

Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells

(2012) L. M. Calvi et al.   BLOOD

Stem cell heterogeneity: implications for aging and regenerative medicine

(2012) C. E. Muller-Sieburg et al.   BLOOD

Signaling from the Sympathetic Nervous System Regulates Hematopoietic Stem Cell Emergence during Embryogenesis

(2012) Simon R. Fitch et al.   Cell Stem Cell

Hematopoietic Stem Cell Heterogeneity Takes Center Stage

(2012) Michael R. Copley et al.   Cell Stem Cell

Hematopoietic Stem Cell Subtypes Expand Differentially during Development and Display Distinct Lymphopoietic Programs

(2012) Claudia Benz et al.   Cell Stem Cell

The relationship between adipose tissue and bone metabolism

(2012) Jeffrey M. Gimble et al.   CLINICAL BIOCHEMISTRY

Marrow Fat and the Bone Microenvironment: Developmental, Functional, and Pathological Implications

(2012) Clifford J. Rosen et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Adrenergic Nerves Govern Circadian Leukocyte Recruitment to Tissues

(2012) Christoph Scheiermann et al.   IMMUNITY

Hematopoietic recovery following chemotherapy is improved by BADGE-induced inhibition of adipogenesis

(2012) Rong-Jia Zhu et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Increased Marrow Adiposity in Premenopausal Women with Idiopathic Osteoporosis

(2012) Adi Cohen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow

(2012) Anna Mansour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow fat content in the elderly: A reversal of sex difference seen in younger subjects

(2012) James F. Griffith et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cells

(2012) P Singh et al.   LEUKEMIA

Myocardial infarction accelerates atherosclerosis

(2012) Partha Dutta et al.   NATURE

Endothelial and perivascular cells maintain haematopoietic stem cells

(2012) Lei Ding et al.   NATURE

Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow

(2012) Aya Ludin et al.   NATURE IMMUNOLOGY

Enhancement of hematopoiesis and lymphopoiesis in diet-induced obese mice

(2012) M. D. Trottier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Skeletal muscle pericyte subtypes differ in their differentiation potential

(2012) Alexander Birbrair et al.   Stem Cell Research

Wall structures of myocardial precapillary arterioles and postcapillary venules reexamined and reconstructed in vitro for studies on barrier functions

(2011) Stephan Nees et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The relationship between bone, hemopoietic stem cells, and vasculature

(2011) S. L. Ellis et al.   BLOOD

Characterization of age-related gene expression profiling in bone marrow and epididymal adipocytes

(2011) Li-Fen Liu et al.   BMC GENOMICS

Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

(2011) A. Krings et al.   BONE

Marrow fat metabolism is linked to the systemic energy metabolism

(2011) Beata Lecka-Czernik   BONE

Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche

(2011) Satoshi Yamazaki et al.   CELL

Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model

(2011) Kylie A Alexander et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Expression of the G-CSF receptor in monocytic cells is sufficient to mediate hematopoietic progenitor mobilization by G-CSF in mice

(2011) Matthew J. Christopher et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow CD169+macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

(2011) Andrew Chow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche

(2011) Joji Fujisaki et al.   NATURE

The majority of myelinated and unmyelinated sensory nerve fibers that innervate bone express the tropomyosin receptor kinase A

(2011) G. Castañeda-Corral et al.   NEUROSCIENCE

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diet-induced obesity alters bone remodeling leading to decreased femoral trabecular bone mass in mice

(2010) Jay J. Cao et al.   Annals of the New York Academy of Sciences

Hematopoietic progenitor cell regulation by CD4+CD25+ T cells

(2010) M. Urbieta et al.   BLOOD

Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo

(2010) S. Lymperi et al.   BLOOD

Impact of interactions of cellular components of the bone marrow microenvironment on hematopoietic stem and progenitor cell function

(2010) B. R. Chitteti et al.   BLOOD

Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs

(2010) I. G. Winkler et al.   BLOOD

Skeletal aging and the adipocyte program

(2010) Beata Lecka-Czernik et al.   CELL CYCLE

Intermediate-Term Hematopoietic Stem Cells with Extended but Time-Limited Reconstitution Potential

(2010) Patricia Benveniste et al.   Cell Stem Cell

Distinct Hematopoietic Stem Cell Subtypes Are Differentially Regulated by TGF-β1

(2010) Grant A. Challen et al.   Cell Stem Cell

Endothelial Cells Are Essential for the Self-Renewal and Repopulation of Notch-Dependent Hematopoietic Stem Cells

(2010) Jason M. Butler et al.   Cell Stem Cell

Obesity-mediated inflammatory microenvironment stimulates osteoclastogenesis and bone loss in mice

(2010) Ganesh V. Halade et al.   EXPERIMENTAL GERONTOLOGY

The Essential Functions of Adipo-osteogenic Progenitors as the Hematopoietic Stem and Progenitor Cell Niche

(2010) Yoshiki Omatsu et al.   IMMUNITY

Caloric restriction leads to high marrow adiposity and low bone mass in growing mice

(2010) Maureen J Devlin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

High fat diet-induced animal model of age-associated obesity and osteoporosis

(2010) Ganesh V. Halade et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

(2010) Simón Méndez-Ferrer et al.   NATURE

Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

(2010) Hideki Kobayashi et al.   NATURE CELL BIOLOGY

Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells

(2010) Heather A Himburg et al.   NATURE MEDICINE

Neutrophil kinetics in health and disease

(2010) Charlotte Summers et al.   TRENDS IN IMMUNOLOGY

Hematopoietic stem cell: self-renewal versus differentiation

(2010) Jun Seita et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Complex and Context Dependent Regulation of Hematopoiesis by TGF-β Superfamily Signaling

(2009) Sofie Singbrant Söderberg et al.   Annals of the New York Academy of Sciences

Development of mesenchymal stem cells partially originate from the neural crest

(2009) Satoru Morikawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prostaglandin E2 enhances hematopoietic stem cell homing, survival, and proliferation

(2009) J. Hoggatt et al.   BLOOD

Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential

(2009) D. G. Kent et al.   BLOOD

Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo

(2009) A. B. Salter et al.   BLOOD

Altered cellular dynamics and endosteal location of aged early hematopoietic progenitor cells revealed by time-lapse intravital imaging in long bones

(2009) A. Kohler et al.   BLOOD

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Blood-forming stem cells are nervous: Direct and indirect regulation of immature human CD34+ cells by the nervous system

(2009) Alexander Kalinkovich et al.   BRAIN BEHAVIOR AND IMMUNITY

Engraftment and Reconstitution of Hematopoiesis Is Dependent on VEGFR2-Mediated Regeneration of Sinusoidal Endothelial Cells

(2009) Andrea T. Hooper et al.   Cell Stem Cell

Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow

(2009) Satoru Morikawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

NPY regulation of bone remodelling

(2009) Nicola J. Lee et al.   NEUROPEPTIDES

Expression of cytokines and cytokine receptors in human Schwann cells

(2009) Akihiko Ozaki et al.   NEUROREPORT

Endothelial cells mediate the regeneration of hematopoietic stem cells

(2009) Bei Li et al.   Stem Cell Research

Osteal macrophages: A new twist on coupling during bone dynamics

(2008) Allison R. Pettit et al.   BONE

Hematopoiesis: An Evolving Paradigm for Stem Cell Biology

(2008) Stuart H. Orkin et al.   CELL

The Emergence of Hematopoietic Stem Cells Is Initiated in the Placental Vasculature in the Absence of Circulation

(2008) Katrin E. Rhodes et al.   Cell Stem Cell

Mobilized Hematopoietic Stem Cell Yield Depends on Species-Specific Circadian Timing

(2008) Daniel Lucas et al.   Cell Stem Cell

Neutrophil mobilization and clearance in the bone marrow

(2008) Rebecca C. Furze et al.   IMMUNOLOGY

Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal

(2008) Leonard I. Zon   NATURE

Haematopoietic stem cell release is regulated by circadian oscillations

(2008) Simón Méndez-Ferrer et al.   NATURE

A role for leptin in sustaining lymphopoiesis and myelopoiesis

(2008) K. Claycombe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Stem Cells and the Aging Hematopoietic System

(2008) Roi Gazit et al.   SEMINARS IN HEMATOLOGY

Human Bone Marrow Adipocytes Block Granulopoiesis Through Neuropilin-1-Induced Granulocyte Colony-Stimulating Factor Inhibition

(2008) Zakia Belaid-Choucair et al.   STEM CELLS

Lipocalin 2-mediated growth suppression is evident in human erythroid and monocyte/macrophage lineage cells

(2007) Kenichi Miharada et al.   JOURNAL OF CELLULAR PHYSIOLOGY