20 YEARS OF LEPTIN: Connecting leptin signaling to biological function

Leptin Acts Independently of Food Intake to Modulate Gut Microbial Composition in Male Mice

(2014) Michael W. Rajala et al.   ENDOCRINOLOGY

Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor

(2014) Ryan C. Tsou et al.   Molecular Metabolism

Neither Signal Transducer and Activator of Transcription 3 (STAT3) or STAT5 Signaling Pathways Are Required for Leptin's Effects on Fertility in Mice

(2013) Amritha V. Singireddy et al.   ENDOCRINOLOGY

Modulation of AgRP-neuronal function by SOCS3 as an initiating event in diet-induced hypothalamic leptin resistance

(2013) L. E. Olofsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiomyocyte-specific deletion of leptin receptors causes lethal heart failure in Cre-recombinase-mediated cardiotoxicity

(2012) Michael E. Hall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

IRS2 Signaling in LepR-b Neurons Suppresses FoxO1 to Control Energy Balance Independently of Leptin Action

(2012) Marianna Sadagurski et al.   Cell Metabolism

Deficiency of PTP1B in Leptin Receptor-Expressing Neurons Leads to Decreased Body Weight and Adiposity in Mice

(2012) Ryan C. Tsou et al.   ENDOCRINOLOGY

Shp2 Controls Female Body Weight and Energy Balance by Integrating Leptin and Estrogen Signals

(2012) Z. He et al.   MOLECULAR AND CELLULAR BIOLOGY

Leptin action via LepR-b Tyr1077 contributes to the control of energy balance and female reproduction

(2012) Christa M. Patterson et al.   Molecular Metabolism

Systolic dysfunction in cardiac-specific ligand-inducible MerCreMer transgenic mice

(2011) Michael E. Hall et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Molecular mapping of mouse brain regions innervated by leptin receptor-expressing cells

(2011) Christa M. Patterson et al.   BRAIN RESEARCH

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

Selective deletion of the leptin receptor in dopamine neurons produces anxiogenic-like behavior and increases dopaminergic activity in amygdala

(2011) J Liu et al.   MOLECULAR PSYCHIATRY

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

The Hypothalamus and  -Cell Connection in the Gene-Targeting Era

(2010) M. W. Schwartz et al.   DIABETES

Insufficiency of Janus Kinase 2-Autonomous Leptin Receptor Signals for Most Physiologic Leptin Actions

(2010) S. Robertson et al.   DIABETES

Disruption of Hepatic Leptin Signaling Protects Mice From Age- and Diet-Related Glucose Intolerance

(2010) F. K. Huynh et al.   DIABETES

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Functional Role of Suppressor of Cytokine Signaling 3 Upregulation in Hypothalamic Leptin Resistance and Long-Term Energy Homeostasis

(2010) A. S. Reed et al.   DIABETES

Critical Role of the Src Homology 2 (SH2) Domain of Neuronal SH2B1 in the Regulation of Body Weight and Glucose Homeostasis in Mice

(2010) David L. Morris et al.   ENDOCRINOLOGY

Development and Characterization of High Affinity Leptins and Leptin Antagonists

(2010) Michal Shpilman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disruption of hypothalamic leptin signaling in mice leads to early-onset obesity, but physiological adaptations in mature animals stabilize adiposity levels

(2010) Laurence E. Ring et al.   JOURNAL OF CLINICAL INVESTIGATION

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Segregation of Acute Leptin and Insulin Effects in Distinct Populations of Arcuate Proopiomelanocortin Neurons

(2010) K. W. Williams et al.   JOURNAL OF NEUROSCIENCE

The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo

(2009) Jiejin Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Geometry of Leptin Action in the Brain: More Complicated Than a Simple ARC

(2009) Martin G. Myers et al.   Cell Metabolism

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Leptin targets in the mouse brain

(2009) Michael M. Scott et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

(2009) Jing Liu et al.   PSYCHOPHARMACOLOGY

Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity

(2008) Andrea Mesaros et al.   Cell Metabolism

Signal Transducer and Activator of Transcription-3 Is Required in Hypothalamic Agouti-Related Protein/Neuropeptide Y Neurons for Normal Energy Homeostasis

(2008) Lijie Gong et al.   ENDOCRINOLOGY

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Cytokine-STAT5 Signaling in the CNS and Pituitary Gland Alters Energy Balance and Leads to Obesity

(2008) Ji-Yeon Lee et al.   PLoS One

Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis

(2008) L. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA