Foldamer-mediated manipulation of a pre-amyloid toxin

Structure-Based Small Molecule Modulation of a Pre-Amyloid State: Pharmacological Enhancement of IAPP Membrane-Binding and Toxicity

(2015) Abhinav Nath et al.   BIOCHEMISTRY

Islet Amyloid-Induced Cell Death and Bilayer Integrity Loss Share a Molecular Origin Targetable with Oligopyridylamide-Based α-Helical Mimetics

(2015) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

Functional advantages of dynamic protein disorder

(2015) Rebecca B. Berlow et al.   FEBS LETTERS

Characterization of Phospholipids in Insulin Secretory Granules and Mitochondria in Pancreatic Beta Cells and Their Changes with Glucose Stimulation

(2015) Michael J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose

(2015) Nagula Chandramouli et al.   Nature Chemistry

Using ancient protein kinases to unravel a modern cancer drug's mechanism

(2015) C. Wilson et al.   SCIENCE

Mechanism Matters: A Taxonomy of Cell Penetrating Peptides

(2015) W. Berkeley Kauffman et al.   TRENDS IN BIOCHEMICAL SCIENCES

Type 2 diabetes as a protein misfolding disease

(2015) Abhisek Mukherjee et al.   TRENDS IN MOLECULAR MEDICINE

Fiber-Dependent and -Independent Toxicity of Islet Amyloid Polypeptide

(2014) Diana E. Schlamadinger et al.   BIOPHYSICAL JOURNAL

Folded Small Molecule Manipulation of Islet Amyloid Polypeptide

(2014) Sunil Kumar et al.   CHEMISTRY & BIOLOGY

Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch

(2014) Alaji Bah et al.   NATURE

Microarrays for identifying binding sites and probing structure of RNAs

(2014) Ryszard Kierzek et al.   NUCLEIC ACIDS RESEARCH

Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein by Small Molecules as a Potential Therapeutic Strategy for Parkinson’s Disease

(2014) Gergely Tóth et al.   PLoS One

Small molecule screening in context: Lipid-catalyzed amyloid formation

(2014) James A. Hebda et al.   PROTEIN SCIENCE

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

A foldamer approach to targeting membrane bound helical states of islet amyloid polypeptide

(2013) Sunil Kumar et al.   CHEMICAL COMMUNICATIONS

Identification of small-molecule binding pockets in the soluble monomeric form of the Aβ42 peptide

(2013) Maximillian Zhu et al.   JOURNAL OF CHEMICAL PHYSICS

A β-Peptide Agonist of the GLP-1 Receptor, a Class B GPCR

(2013) Elizabeth V. Denton et al.   ORGANIC LETTERS

Common mechanism unites membrane poration by amyloid and antimicrobial peptides

(2013) N. B. Last et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles

(2012) Erdinc Sezgin et al.   Nature Protocols

Concentration-dependent transitions govern the subcellular localization of islet amyloid polypeptide

(2011) Mazin Magzoub et al.   FASEB JOURNAL

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

The Flavanol (−)-Epigallocatechin 3-Gallate Inhibits Amyloid Formation by Islet Amyloid Polypeptide, Disaggregates Amyloid Fibrils, and Protects Cultured Cells against IAPP-Induced Toxicity

(2010) Fanling Meng et al.   BIOCHEMISTRY

Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

(2010) Elizabeth R. Middleton et al.   BIOPHYSICAL JOURNAL

Cellular Internalization of Water-Soluble Helical Aromatic Amide Foldamers

(2010) Jone Iriondo-Alberdi et al.   CHEMBIOCHEM

Intrinsically disordered proteins are potential drug targets

(2010) Steven J Metallo   CURRENT OPINION IN CHEMICAL BIOLOGY

The Sulfated Triphenyl Methane Derivative Acid Fuchsin Is a Potent Inhibitor of Amyloid Formation by Human Islet Amyloid Polypeptide and Protects against the Toxic Effects of Amyloid Formation

(2010) Fanling Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Absolute Control of Helical Handedness in Quinoline Oligoamides

(2010) Amol M. Kendhale et al.   JOURNAL OF ORGANIC CHEMISTRY

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

(2010) Seth L Masters et al.   NATURE IMMUNOLOGY

Inhibiting Islet Amyloid Polypeptide Fibril Formation by the Red Wine Compound Resveratrol

(2009) Rajesh Mishra et al.   CHEMBIOCHEM

A Peptidomimetic Approach to Targeting Pre-amyloidogenic States in Type II Diabetes

(2009) James A. Hebda et al.   CHEMISTRY & BIOLOGY

The Role of Prefibrillar Structures in the Assembly of a Peptide Amyloid

(2009) Amy M. Ruschak et al.   JOURNAL OF MOLECULAR BIOLOGY

Helix Stabilization Precedes Aqueous and Bilayer-Catalyzed Fiber Formation in Islet Amyloid Polypeptide

(2009) Jessica A. Williamson et al.   JOURNAL OF MOLECULAR BIOLOGY

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

De novo design and in vivo activity of conformationally restrained antimicrobial arylamide foldamers

(2009) S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biological mimicry of protein surface recognition by  / -peptide foldamers

(2009) W. S. Horne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetics of Helix-Handedness Inversion: Folding and Unfolding in Aromatic Amide Oligomers

(2008) Nicolas Delsuc et al.   CHEMPHYSCHEM

Structure of α-Helical Membrane-bound Human Islet Amyloid Polypeptide and Its Implications for Membrane-mediated Misfolding

(2008) Melania Apostolidou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity

(2008) D. Gomika Udugamasooriya et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY