G-quadruplex interacting small molecules and drugs: from bench toward bedside

Efficacy of Multiple Low-dose Photodynamic TMPYP4 Therapy on Cervical Cancer Tumour Growth in Nude Mice

(2014) Ai-Hong Liu et al.   Asian Pacific Journal of Cancer Prevention

Chromatin dynamics: Interplay between remodeling enzymes and histone modifications

(2014) Sarah G. Swygert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Existence and consequences of G-quadruplex structures in DNA

(2014) Pierre Murat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

c-Myc Quadruplex-forming Sequence Pu-27 Induces Extensive Damage in Both Telomeric and Nontelomeric Regions of DNA

(2014) Md Ashraful Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSC746364, a G-Quadruplex-Stabilizing Agent, Suppresses Cell Growth of A549 Human Lung Cancer Cells Through Activation of the ATR/Chk1-Dependent Pathway

(2014) Yun-Lung Chung et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Reprogramming the Mechanism of Action of Chlorambucil by Coupling to a G-Quadruplex Ligand

(2014) Marco Di Antonio et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anticancer activity of cationic porphyrins in melanoma tumour-bearing mice and mechanistic in vitro studies

(2014) Valentina Rapozzi et al.   Molecular Cancer

G-quadruplexes regulate Epstein-Barr virus–encoded nuclear antigen 1 mRNA translation

(2014) Pierre Murat et al.   Nature Chemical Biology

G quadruplexes are genomewide targets of transcriptional helicases XPB and XPD

(2014) Lucas T Gray et al.   Nature Chemical Biology

RHPS4 G-Quadruplex Ligand Induces Anti-Proliferative Effects in Brain Tumor Cells

(2014) Sunil Lagah et al.   PLoS One

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

(2014) S. Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

Solution Structure of a G-quadruplex Bound to the Bisquinolinium Compound Phen-DC3

(2013) Wan Jun Chung et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A network of players in H3 histone variant deposition and maintenance at centromeres

(2013) Sebastian Müller et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DNA2, a new player in telomere maintenance and tumor suppression

(2013) Weihang Chai et al.   CELL CYCLE

Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

(2013) Weiqiang Lin et al.   EMBO JOURNAL

Binding of G-quadruplexes to the N-terminal Recognition Domain of the RNA Helicase Associated with AU-rich Element (RHAU)

(2013) Markus Meier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specialization among Iron-Sulfur Cluster Helicases to Resolve G-quadruplex DNA Structures That Threaten Genomic Stability

(2013) Sanjay Kumar Bharti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TMPyP4 Porphyrin Distorts RNA G-quadruplex Structures of the Disease-associated r(GGGGCC)nRepeat of theC9orf72Gene and Blocks Interaction of RNA-binding Proteins

(2013) Bita Zamiri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FANCJ couples replication past natural fork barriers with maintenance of chromatin structure

(2013) Rebekka A. Schwab et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of a Promoter Sequence in the B-raf Gene Reveals an Intertwined Dimer Quadruplex

(2013) Dengguo Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging trends in G-quadruplex biology – role in epigenetic and evolutionary events

(2013) Aradhita Baral et al.   Molecular BioSystems

G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors

(2013) Tarek Shalaby et al.   MOLECULES

Pif1 family helicases suppress genome instability at G-quadruplex motifs

(2013) Katrin Paeschke et al.   NATURE

Visualization and selective chemical targeting of RNA G-quadruplex structures in the cytoplasm of human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Quantitative visualization of DNA G-quadruplex structures in human cells

(2013) Giulia Biffi et al.   Nature Chemistry

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

Human Rev1 polymerase disrupts G-quadruplex DNA

(2013) S. Eddy et al.   NUCLEIC ACIDS RESEARCH

Detection of G-quadruplex DNA in mammalian cells

(2013) A. Henderson et al.   NUCLEIC ACIDS RESEARCH

DNA damage signaling induced by the G-quadruplex ligand 12459 is modulated by PPM1D/WIP1 phosphatase

(2013) Céline Douarre et al.   NUCLEIC ACIDS RESEARCH

The G-quadruplex ligand, SYUIQ-FM05, targets proto-oncogene c-kittranscription and induces apoptosis in K562 cells

(2013) Fei-Hai Shen et al.   PHARMACEUTICAL BIOLOGY

New Approaches of PARP-1 Inhibitors in Human Lung Cancer Cells and Cancer Stem-Like Cells by Some Selected Anthraquinone-Derived Small Molecules

(2013) Yu-Ru Lee et al.   PLoS One

RTEL1 Is a Replisome-Associated Helicase That Promotes Telomere and Genome-Wide Replication

(2013) J.-B. Vannier et al.   SCIENCE

G-quadruplex structures are stable and detectable in human genomic DNA

(2013) Enid Yi Ni Lam et al.   Nature Communications

V-Shaped Dinuclear Pt(II) Complexes: Selective Interaction with Human Telomeric G-quadruplex and Significant Inhibition towards Telomerase

(2013) Cui-Xia Xu et al.   Scientific Reports

The G4 Genome

(2013) Nancy Maizels et al.   PLoS Genetics

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

(2012) Rama Rao Damerla et al.   CELL CYCLE

Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene,c-Myb

(2012) Takeshi Miyazaki et al.   CLINICAL CANCER RESEARCH

Shooting for Selective Druglike G-Quadruplex Binders: Evidence for Telomeric DNA Damage and Tumor Cell Death

(2012) Sandro Cosconati et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anticancer Activity and Cellular Repression of c-MYC by the G-Quadruplex-Stabilizing 11-Piperazinylquindoline Is Not Dependent on Direct Targeting of the G-Quadruplex in the c-MYC Promoter

(2012) Peda V. L. Boddupally et al.   JOURNAL OF MEDICINAL CHEMISTRY

Small-molecule–induced DNA damage identifies alternative DNA structures in human genes

(2012) Raphaël Rodriguez et al.   Nature Chemical Biology

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Chromatin and the genome integrity network

(2012) Manolis Papamichos-Chronakis et al.   NATURE REVIEWS GENETICS

Crystal structure of a c-kit promoter quadruplex reveals the structural role of metal ions and water molecules in maintaining loop conformation

(2012) D. Wei et al.   NUCLEIC ACIDS RESEARCH

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

(2012) Sebastian Müller et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Stimulation of Gross Chromosomal Rearrangements by the Human CEB1 and CEB25 Minisatellites in Saccharomyces cerevisiae Depends on G-Quadruplexes or Cdc13

(2012) Aurèle Piazza et al.   PLoS Genetics

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

G-quadruplex-induced instability during leading-strand replication

(2011) Judith Lopes et al.   EMBO JOURNAL

Chromatin: constructing the big picture

(2011) Bas van Steensel   EMBO JOURNAL

Inhibition of Cell Proliferation by Quindoline Derivative (SYUIQ-05) through its Preferential Interaction withc-mycPromoter G-Quadruplex

(2011) Tian-Miao Ou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antitumor effects of telomerase inhibitor TMPyP4 in osteosarcoma cell lines

(2011) Jun Fujimori et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

G-Quadruplex-Binding Benzo[a]phenoxazines Down-Regulatec-KITExpression in Human Gastric Carcinoma Cells

(2011) Keith I. E. McLuckie et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genomic c-Myc Quadruplex DNA Selectively Kills Leukemia

(2011) K. C. Sedoris et al.   MOLECULAR CANCER THERAPEUTICS

Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?

(2011) Shankar Balasubramanian et al.   NATURE REVIEWS DRUG DISCOVERY

Rudimentary G-quadruplex–based telomere capping in Saccharomyces cerevisiae

(2011) Jasmine S Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Solution structure of all parallel G-quadruplex formed by the oncogene RET promoter sequence

(2011) Xiaotian Tong et al.   NUCLEIC ACIDS RESEARCH

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

(2011) Peter Sarkies et al.   NUCLEIC ACIDS RESEARCH

G4 Resolvase 1 tightly binds and unwinds unimolecular G4-DNA

(2011) Banabihari Giri et al.   NUCLEIC ACIDS RESEARCH

The DEAH-box RNA helicase RHAU binds an intramolecular RNA G‐quadruplex in TERC and associates with telomerase holoenzyme

(2011) Simon Lattmann et al.   NUCLEIC ACIDS RESEARCH

A non-canonical DNA structure is a binding motif for the transcription factor SP1 in vitro

(2011) Eun-Ang Raiber et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: selective DNA targeting for cancer therapeutics?

(2011) Kyle M Miller et al.   Expert Review of Clinical Pharmacology

ATR-X Syndrome Protein Targets Tandem Repeats and Influences Allele-Specific Expression in a Size-Dependent Manner

(2010) Martin J. Law et al.   CELL

Unwinding the functions of the Pif1 family helicases

(2010) Matthew L. Bochman et al.   DNA REPAIR

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

Telomestatin: Formal Total Synthesis and Cation-Mediated Interaction of Itsseco-Derivatives with G-Quadruplexes

(2010) Jörg Linder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Disabling c-Myc in Childhood Medulloblastoma and Atypical Teratoid/Rhabdoid Tumor Cells by the Potent G-Quadruplex Interactive Agent S2T1-6OTD

(2010) T. Shalaby et al.   MOLECULAR CANCER THERAPEUTICS

Epigenetic Instability due to Defective Replication of Structured DNA

(2010) Peter Sarkies et al.   MOLECULAR CELL

Small-molecule-mediated G-quadruplex isolation from human cells

(2010) Sebastian Müller et al.   Nature Chemistry

Quadruplex structures of muscle gene promoter sequences enhance in vivo MyoD-dependent gene expression

(2010) Jeny Shklover et al.   NUCLEIC ACIDS RESEARCH

Genetic instability triggered by G-quadruplex interacting Phen-DC compounds in Saccharomyces cerevisiae

(2010) Aurèle Piazza et al.   NUCLEIC ACIDS RESEARCH

A G-quadruplex structure within the 5′-UTR of TRF2 mRNA represses translation in human cells

(2010) Dennis Gomez et al.   NUCLEIC ACIDS RESEARCH

PARP1 is activated at telomeres upon G4 stabilization: possible target for telomere-based therapy

(2010) E Salvati et al.   ONCOGENE

Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex

(2010) Anthony Bugaut et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Targeting the c-Kit Promoter G-quadruplexes with 6-Substituted Indenoisoquinolines

(2010) Mallesham Bejugam et al.   ACS Medicinal Chemistry Letters

Engineering Bisquinolinium/Thiazole Orange Conjugates for Fluorescent Sensing of G-Quadruplex DNA

(2009) Peng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Novel Molecular Mechanism for Actinomycin D Activity as an Oncogenic Promoter G-Quadruplex Binder

(2009) Hyun-Jin Kang et al.   BIOCHEMISTRY

Histone modification patterns and epigenetic codes

(2009) Andreas Lennartsson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis

(2009) D. Drygin et al.   CANCER RESEARCH

Non-B DNA structure-induced genetic instability and evolution

(2009) Junhua Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

G-quadruplex recognition by macrocyclic hexaoxazole (6OTD) dimer: greater selectivity than monomer

(2009) Keisuke Iida et al.   CHEMICAL COMMUNICATIONS

G-quadruplex nucleic acids as therapeutic targets

(2009) Shankar Balasubramanian et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The structures of quadruplex nucleic acids and their drug complexes

(2009) Stephen Neidle   CURRENT OPINION IN STRUCTURAL BIOLOGY

Antitumor activity of TMPyP4 interacting G-quadruplex in retinoblastoma cell lines

(2009) Yoko Mikami-Terao et al.   EXPERIMENTAL EYE RESEARCH

Human telomeric G-quadruplex: The current status of telomeric G-quadruplexes as therapeutic targets in human cancer

(2009) Stephen Neidle   FEBS Journal

Identification and Characterization of Nucleolin as a c-mycG-quadruplex-binding Protein

(2009) Verónica González et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Human Gastrointestinal Stromal Tumor Cells with a Quadruplex-Binding Small Molecule

(2009) Mekala Gunaratnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

NM23-H2 may play an indirect role in transcriptional activation of c-myc gene expression but does not cleave the nuclease hypersensitive element III1

(2009) T. S. Dexheimer et al.   MOLECULAR CANCER THERAPEUTICS

Structure of a two-G-tetrad intramolecular G-quadruplex formed by a variant human telomeric sequence in K+ solution: insights into the interconversion of human telomeric G-quadruplex structures

(2009) Zhenjiang Zhang et al.   NUCLEIC ACIDS RESEARCH

Synthesis and evaluation of fused bispyrimidinoacridines as novel pentacyclic analogues of quadruplex-binder BRACO-19

(2009) Julien Debray et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

(2009) Nassima Temime-Smaali et al.   PLoS One

An Alternative DNA Structure Is Necessary for Pilin Antigenic Variation in Neisseria gonorrhoeae

(2009) L. A. Cahoon et al.   SCIENCE

G-quadruplex structures: in vivo evidence and function

(2009) Hans J. Lipps et al.   TRENDS IN CELL BIOLOGY

The Yeast Pif1 Helicase Prevents Genomic Instability Caused by G-Quadruplex-Forming CEB1 Sequences In Vivo

(2009) Cyril Ribeyre et al.   PLoS Genetics

Welcome the Family of FANCJ-like Helicases to the Block of Genome Stability Maintenance Proteins

(2008) Y. Wu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Controlled-folding of a small molecule modulates DNA G-quadruplex recognition

(2008) Sebastian Müller et al.   CHEMICAL COMMUNICATIONS

Mutagenic Capacity of Endogenous G4 DNA Underlies Genome Instability in FANCJ-Defective C. elegans

(2008) Evelien Kruisselbrink et al.   CURRENT BIOLOGY

Decomposition of the Telomere-Targeting agent BRACO19 in physiological media results in products with decreased inhibitory potential

(2008) S. Taetz et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G4 Resolvase 1 Binds Both DNA and RNA Tetramolecular Quadruplex with High Affinity and Is the Major Source of Tetramolecular Quadruplex G4-DNA and G4-RNA Resolving Activity in HeLa Cell Lysates

(2008) Steven D. Creacy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Small Molecule That Alters Shelterin Integrity and Triggers a DNA-Damage Response at Telomeres

(2008) Raphaël Rodriguez et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FANCJ Helicase Defective in Fanconia Anemia and Breast Cancer Unwinds G-Quadruplex DNA To Defend Genomic Stability

(2008) Y. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY

Metastases suppressor NM23-H2 interaction with G-quadruplex DNA within c-MYC promoter nuclease hypersensitive element induces c-MYC expression

(2008) Ram Krishna Thakur et al.   NUCLEIC ACIDS RESEARCH

Role of ATM in the telomere response to the G-quadruplex ligand 360A

(2008) Gaëlle Pennarun et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes: the beginning and end of UTRs

(2008) Julian Leon Huppert et al.   NUCLEIC ACIDS RESEARCH

Inhibition of translation in living eukaryotic cells by an RNA G-quadruplex motif

(2008) A. Arora et al.   RNA

Antitumor activity of G-quadruplex–interactive agent TMPyP4 in K562 leukemic cells

(2007) Yoko Mikami-Terao et al.   CANCER LETTERS

A hitchhiker's guide to G-quadruplex ligands

(2007) David Monchaud et al.   ORGANIC & BIOMOLECULAR CHEMISTRY