Neuroprotective Properties of the Marine Carotenoid Astaxanthin and Omega-3 Fatty Acids, and Perspectives for the Natural Combination of Both in Krill Oil

Alzheimer's Disease: Cerebrovascular Dysfunction, Oxidative stress, and Advanced Clinical Therapies

(2017) Michael W. Marlatt et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β, Tau Protein, and Oxidative Changes as a Physiological Compensatory Mechanism to Maintain CNS Plasticity under Alzheimer's Disease and Other Neurodegenerative Conditions

(2017) Alexei Koudinov et al.   JOURNAL OF ALZHEIMERS DISEASE

Early Onset Alzheimer’s Disease and Oxidative Stress

(2014) Marco Antonio Meraz-Ríos et al.   Oxidative Medicine and Cellular Longevity

Inflammatory responses in hypoxic ischemic encephalopathy

(2013) Fudong Liu et al.   ACTA PHARMACOLOGICA SINICA

Update on marine omega-3 fatty acids: Management of dyslipidemia and current omega-3 treatment options

(2013) Howard Weintraub   ATHEROSCLEROSIS

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MitoQ, a mitochondria-targeted antioxidant, delays disease progression and alleviates pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis

(2013) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astaxanthin ameliorates heat stress-induced impairment of blastocyst development In Vitro: –astaxanthin colocalization with and action on mitochondria–

(2013) T. Kuroki et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Enhanced cognitive function and antidepressant-like effects after krill oil supplementation in rats

(2013) Karin Wibrand et al.   Lipids in Health and Disease

Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress

(2013) Ling-Yan Dong et al.   Marine Drugs

Mutations that affect mitochondrial functions and their association with neurodegenerative diseases

(2013) Varinderpal S. Dhillon et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Oxidative stress, DNA damage, and the telomeric complex as therapeutic targets in acute neurodegeneration

(2013) Joshua A. Smith et al.   NEUROCHEMISTRY INTERNATIONAL

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

(2013) Amanda Sierra et al.   Frontiers in Cellular Neuroscience

Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms

(2013) Balaraman Kalyanaraman   Redox Biology

Functional Consequences of Age-Dependent Changes in Glutathione Status in the Brain

(2012) Antonio Currais et al.   ANTIOXIDANTS & REDOX SIGNALING

Severe Life Stress and Oxidative Stress in the Brain: From Animal Models to Human Pathology

(2012) Stefania Schiavone et al.   ANTIOXIDANTS & REDOX SIGNALING

Oxidative stress underlying axonal degeneration in adrenoleukodystrophy: A paradigm for multifactorial neurodegenerative diseases?

(2012) Elena Galea et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astaxanthin protects against MPP+-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis

(2012) Qinyong Ye et al.   BMC NEUROSCIENCE

Dysregulated relationship of inflammation and oxidative stress in major depression

(2012) B.J. Rawdin et al.   BRAIN BEHAVIOR AND IMMUNITY

Supra-physiological doses of testosterone affect membrane oxidation of human neutrophils monitored by the fluorescent probe C11-BODIPY581/591

(2012) Tácito Pessoa de Souza-Junior et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Krill oil versus fish oil in modulation of inflammation and lipid metabolism in mice transgenic for TNF-α

(2012) Natalya Filipchuk Vigerust et al.   EUROPEAN JOURNAL OF NUTRITION

Oxidative stress-related biomarkers in autism: Systematic review and meta-analyses

(2012) Alessandra Frustaci et al.   FREE RADICAL BIOLOGY AND MEDICINE

Recent Advances on the Neuroprotective Potential of Antioxidants in Experimental Models of Parkinson’s Disease

(2012) Sushruta Koppula et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Astaxanthin modulates age-associated mitochondrial dysfunction in healthy dogs1

(2012) J. S. Park et al.   JOURNAL OF ANIMAL SCIENCE

Shrimp Waste Extract and Astaxanthin: Rat Alveolar Macrophage, Oxidative Stress and Inflammation

(2012) Suzan D. Santos et al.   JOURNAL OF FOOD SCIENCE

Low vitamin and carotenoid levels are related to cerebral white matter lesions

(2012) Y. Ohshima et al.   Journal of Nutrition Health & Aging

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS

(2012) Derek A. Drechsel et al.   NEUROTOXICITY RESEARCH

Schizophrenia is primed for an increased expression of depression through activation of immuno-inflammatory, oxidative and nitrosative stress, and tryptophan catabolite pathways

(2012) George Anderson et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Antioxidant therapies in traumatic brain and spinal cord injury

(2011) Mona Bains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Astaxanthin Induces Mitochondria-Mediated Apoptosis in Rat Hepatocellular Carcinoma CBRH-7919 Cells

(2011) Xiao-dong Song et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Omega-3 Polyunsaturated Fatty Acids in Alzheimers Disease: Key Questions and Partial Answers

(2011) F. Calon   Current Alzheimer Research

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

(2011) P. H. Reddy et al.   Current Alzheimer Research

Combined fish oil and astaxanthin supplementation modulates rat lymphocyte function

(2011) Rosemari Otton et al.   EUROPEAN JOURNAL OF NUTRITION

Different sources of omega-3 polyunsaturated fatty acids affects apparent digestibility, tissue deposition, and tissue oxidative stability in growing female rats

(2011) Janet C Tou et al.   Lipids in Health and Disease

Dietary lipids and their oxidized products in Alzheimer's disease

(2011) Laura Corsinovi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons

(2011) Yuki Kambe et al.   NEUROCHEMISTRY INTERNATIONAL

Role of oxidative stress in epileptic seizures

(2011) Eun-Joo Shin et al.   NEUROCHEMISTRY INTERNATIONAL

Astaxanthin limits fish oil-related oxidative insult in the anterior forebrain of Wistar rats: Putative anxiolytic effects?

(2011) Rita Mattei et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Putative benefits of microalgal astaxanthin on exercise and human health

(2011) Marcelo P. Barros et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

(2010) Vittorio Calabrese et al.   ANTIOXIDANTS & REDOX SIGNALING

Antioxidants: Molecules, medicines, and myths

(2010) John M.C. Gutteridge et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Neuroprotective effect of astaxanthin on H 2 O 2 -induced neurotoxicity in vitro and on focal cerebral ischemia in vivo

(2010) Ya-Peng Lu et al.   BRAIN RESEARCH

Astaxanthin upregulates heme oxygenase-1 expression through ERK1/2 pathway and its protective effect against beta-amyloid-induced cytotoxicity in SH-SY5Y cells

(2010) Hong-Quan Wang et al.   BRAIN RESEARCH

Pharmacokinetics and first-pass metabolism of astaxanthin in rats

(2010) Hye Duck Choi et al.   BRITISH JOURNAL OF NUTRITION

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes

(2010) Anaysa P. Bolin et al.   CELL BIOLOGY AND TOXICOLOGY

Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats

(2010) Rosemari Otton et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Astaxanthin protects against MPTP/MPP+-induced mitochondrial dysfunction and ROS production in vivo and in vitro

(2010) Dae-Hee Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Extraction and characterisation of lipids from Antarctic krill (Euphausia superba)

(2010) Joseph C. Gigliotti et al.   FOOD CHEMISTRY

Down-regulation of IL-6 production by astaxanthin via ERK-, MSK-, and NF-κB-mediated signals in activated microglia

(2010) Yeon Hyang Kim et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

ROS production in neutrophils from alloxan-induced diabetic rats treated in vivo with astaxanthin

(2010) Douglas Popp Marin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quantitative analysis, in vitro assessment of bioavailability and antioxidant activity of food carotenoids—A review

(2010) Delia B. Rodriguez-Amaya   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Metabolic Effects of Krill Oil are Essentially Similar to Those of Fish Oil but at Lower Dose of EPA and DHA, in Healthy Volunteers

(2010) Stine M. Ulven et al.   LIPIDS

γ-Glutamylcysteine ameliorates oxidative injury in neurons and astrocytes in vitro and increases brain glutathione in vivo

(2010) Truc M. Le et al.   NEUROTOXICOLOGY

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

(2010) Jean Park et al.   Nutrition & Metabolism

Prooxidant Actions of Carotenoids in Biologic Systems

(2010) Paola Palozza   NUTRITION REVIEWS

Krill phosphatidylserine improves learning and memory in Morris water maze in aged rats

(2010) Bombi Lee et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Oxygen toxicity: chemistry and biology of reactive oxygen species

(2010) Giuseppe Buonocore et al.   Seminars in Fetal & Neonatal Medicine

Interplay of Oxidants and Antioxidants During Exercise: Implications for Muscle Health

(2010) Maria-Carmen Gomez-Cabrera et al.   PHYSICIAN AND SPORTSMEDICINE

Omega-3 fatty acids: potential role in the management of early Alzheimer’s disease

(2010) Greg Jicha   Clinical Interventions in Aging

The inhibition of TNF-α-induced NF-κB activation by marine natural products

(2009) Florence Folmer et al.   BIOCHEMICAL PHARMACOLOGY

Mitochondrial structural and functional dynamics in Huntington's disease

(2009) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary krill oil increases docosahexaenoic acid and reduces 2-arachidonoylglycerol but not N-acylethanolamine levels in the brain of obese Zucker rats

(2009) Vincenzo Di Marzo et al.   INTERNATIONAL DAIRY JOURNAL

Astaxanthin inhibits tumor invasion by decreasing extracellular matrix production and induces apoptosis in experimental rat colon carcinogenesis by modulating the expressions of ERK-2, NFkB and COX-2

(2009) Ponnuraj Nagendraprabhu et al.   INVESTIGATIONAL NEW DRUGS

Antioxidative and Anti-Inflammatory Neuroprotective Effects of Astaxanthin and Canthaxanthin in Nerve Growth Factor Differentiated PC12 Cells

(2009) Kung-chi Chan et al.   JOURNAL OF FOOD SCIENCE

Astaxanthin protects mitochondrial redox state and functional integrity against oxidative stress

(2009) Alexander M. Wolf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women

(2009) Kevin C. Maki et al.   NUTRITION RESEARCH

Comparative effects of DHA and EPA on cell function

(2009) Renata Gorjão et al.   PHARMACOLOGY & THERAPEUTICS

Fish, docosahexaenoic acid and Alzheimer’s disease

(2009) S.C. Cunnane et al.   PROGRESS IN LIPID RESEARCH

Nrf2-induced antioxidant protection: A promising target to counteract ROS-mediated damage in neurodegenerative disease?

(2008) Helga E. de Vries et al.   FREE RADICAL BIOLOGY AND MEDICINE

Depression in Parkinson's disease: A double-blind, randomized, placebo-controlled pilot study of omega-3 fatty-acid supplementation

(2008) Ticyana Moralez da Silva et al.   JOURNAL OF AFFECTIVE DISORDERS

Docosahexaenoic Acid and the Aging Brain

(2008) Walter J. Lukiw et al.   JOURNAL OF NUTRITION

Krill for Human Consumption: Nutritional Value and Potential Health Benefits

(2008) Janet C. Tou et al.   NUTRITION REVIEWS

No clear evidence of an association between plasma concentrations of n-3 long-chain polyunsaturated fatty acids and depressed mood in a non-clinical population

(2008) K.M. Appleton et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY

Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson’s disease

(2007) M. Bousquet et al.   FASEB JOURNAL