Journal
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
Volume 759, Issue -, Pages 1-13Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mrrev.2013.09.001
Keywords
Mitochondria; DNA deletions; Mutation; Ageing; Neurodegenerative diseases
Funding
- Preventative-Health flagship of CSIRO
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Mitochondria are essential for mammalian and human cell function as they generate ATP via aerobic respiration. The proteins required in the electron transport chain are mainly encoded by the circular mitochondrial genome but other essential mitochondrial proteins such as DNA repair genes, are coded in the nuclear genome and require transport into the mitochondria. In this review we summarize current knowledge on the association of point mutations and deletions in the mitochondrial genome that are detrimental to mitochondrial function and are associated with accelerated ageing and neurological disorders including Alzheimer's, Parkinson's, Huntington's and Amyotrophic lateral sclerosis (ALS). Mutations in the nuclear encoded gerfes that disrupt mitochondrial functions are also discussed. It is evident that a greater understanding of the causes of mutations that adversely affect mitochondrial metabolism is required to develop preventive measures against accelerated ageing and neurological disorders caused by mitochondrial dysfunction. (C) 2013 Elsevier B.V. All rights reserved.
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