Extended Combined Neonatal Treatment With Erythropoietin Plus Melatonin Prevents Posthemorrhagic Hydrocephalus of Prematurity in Rats

A mutation in Ccdc39 causes neonatal hydrocephalus with abnormal motile cilia development in mice

(2018) Zakia Abdelhamed et al.   DEVELOPMENT

Ante-, peri- and postnatal factors associated with intraventricular hemorrhage in very premature infants

(2018) Martin Poryo et al.   EARLY HUMAN DEVELOPMENT

Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury

(2018) Shenandoah Robinson et al.   EXPERIMENTAL NEUROLOGY

A sustained systemic inflammatory response syndrome is associated with shunt-dependent hydrocephalus after aneurysmal subarachnoid hemorrhage

(2018) Aaron P. Wessell et al.   JOURNAL OF NEUROSURGERY

Endoscopic third ventriculostomy and choroid plexus cauterization in infant hydrocephalus: a prospective study by the Hydrocephalus Clinical Research Network

(2018) Abhaya V. Kulkarni et al.   Journal of Neurosurgery-Pediatrics

High-Dose Erythropoietin for Asphyxia and Encephalopathy (HEAL): A Randomized Controlled Trial – Background, Aims, and Study Protocol

(2018) Sandra E. Juul et al.   Neonatology

Preterm birth leads to hyper-reactive cognitive control processing and poor white matter organization in adulthood

(2018) Alexander Olsen et al.   NEUROIMAGE

Posthemorrhagic ventricular dilatation in preterm infants

(2018) Lara M. Leijser et al.   NEUROLOGY

Hydrocephalus in Pediatric Traumatic Brain Injury: National Incidence, Risk Factors, and Outcomes in 124,444 Hospitalized Patients

(2018) Kavelin Rumalla et al.   PEDIATRIC NEUROLOGY

Conditional ablation of the RFX4 isoform 1 transcription factor: Allele dosage effects on brain phenotype

(2018) Ping Xu et al.   PLoS One

Ependymal cilia beating induces an actin network to protect centrioles against shear stress

(2018) Alexia Mahuzier et al.   Nature Communications

ZMYND10 stabilizes intermediate chain proteins in the cytoplasmic pre-assembly of dynein arms

(2018) Kyeong Jee Cho et al.   PLoS Genetics

Neurodevelopmental and Behavioral Outcomes in Extremely Premature Neonates With Ventriculomegaly in the Absence of Periventricular-Intraventricular Hemorrhage

(2018) Athina Pappas et al.   JAMA Pediatrics

White matter alterations and their associations with motor function in young adults born preterm with very low birth weight

(2018) Ingrid Marie Husby Hollund et al.   NeuroImage-Clinical

Predictors Associated With Post-Traumatic Hydrocephalus in Patients With Head Injury Undergoing Unilateral Decompressive Craniectomy

(2018) Qianxin Hu et al.   Frontiers in Neurology

Repetitive Neonatal Erythropoietin and Melatonin Combinatorial Treatment Provides Sustained Repair of Functional Deficits in a Rat Model of Cerebral Palsy

(2018) Lauren L. Jantzie et al.   Frontiers in Neurology

Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway

(2017) Shanwu Wei et al.   EXPERIMENTAL CELL RESEARCH

Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation

(2017) Zheng Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Magnesium sulfate for neuroprotection in the setting of chorioamnionitis

(2017) James M. Edwards et al.   Journal of Maternal-Fetal & Neonatal Medicine

Ventricular Zone Disruption in Human Neonates With Intraventricular Hemorrhage

(2017) James P. McAllister et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Infant hydrocephalus in sub-Saharan Africa: the reality on the Tanzanian side of the lake

(2017) Maria M. Santos et al.   Journal of Neurosurgery-Pediatrics

Melatonin enhances neural stem cell differentiation and engraftment by increasing mitochondrial function

(2017) Miguel Mendivil-Perez et al.   JOURNAL OF PINEAL RESEARCH

Maternal administration of melatonin exerts short- and long-term neuroprotective effects on the offspring from lipopolysaccharide-treated mice

(2017) Ana Paula Domínguez Rubio et al.   JOURNAL OF PINEAL RESEARCH

Erythropoietin signaling increases neurogenesis and oligodendrogenesis of endogenous neural stem cells following spinal cord injury both in�vivo and in�vitro

(2017) Hui Zhang et al.   Molecular Medicine Reports

Melatonin Pharmacokinetics Following Oral Administration in Preterm Neonates

(2017) Silvia Carloni et al.   MOLECULES

Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

(2017) Alan T. Tang et al.   NATURE

Inflammation-dependent cerebrospinal fluid hypersecretion by the choroid plexus epithelium in posthemorrhagic hydrocephalus

(2017) Jason K Karimy et al.   NATURE MEDICINE

Intravenous injection of umbilical cord-derived mesenchymal stromal cells attenuates reactive gliosis and hypomyelination in a neonatal intraventricular hemorrhage model

(2017) Takeo Mukai et al.   NEUROSCIENCE

Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2

(2017) Nicole D. Osier et al.   NEUROSCIENCE LETTERS

Both antenatal and postnatal inflammation contribute information about the risk of brain damage in extremely preterm newborns

(2017) Diana Yanni et al.   PEDIATRIC RESEARCH

Cerebral microbleeds in a neonatal rat model

(2017) Brianna Carusillo Theriault et al.   PLoS One

Erythropoietin Protects Against Lipopolysaccharide-Induced Microgliosis and Abnormal Granule Cell Development in the Ovine Fetal Cerebellum

(2017) Annie R. A. McDougall et al.   Frontiers in Cellular Neuroscience

Melatonin attenuated the brain damage and cognitive impairment partially through MT2 melatonin receptor in mice with chronic cerebral hypoperfusion

(2017) Tzu-Hsien Tsai et al.   Oncotarget

Constitutive Cyclin O deficiency results in penetrant hydrocephalus, impaired growth and infertility

(2017) Marc Núnez-Ollé et al.   Oncotarget

Daple Coordinates Planar Polarized Microtubule Dynamics in Ependymal Cells and Contributes to Hydrocephalus

(2017) Maki Takagishi et al.   Cell Reports

Erythropoietin regulates immune/inflammatory reaction and improves neurological function outcomes in traumatic brain injury

(2017) Zi-wei Zhou et al.   Brain and Behavior

Melatonin Mediates Protective Effects against Kainic Acid-Induced Neuronal Death through Safeguarding ER Stress and Mitochondrial Disturbance

(2017) Feixiao Xue et al.   Frontiers in Molecular Neuroscience

Correlation between white matter microstructure and executive functions suggests early developmental influence on long fibre tracts in preterm born adolescents

(2017) Brigitte Vollmer et al.   PLoS One

The mouse Jhy gene regulates ependymal cell differentiation and ciliogenesis

(2017) Hilmarie Muniz-Talavera et al.   PLoS One

Snapshot: implications for melatonin in endoplasmic reticulum homeostasis

(2016) Wei Hu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional outcome at school age of neonatal post-hemorrhagic ventricular dilatation

(2016) Janyte C. Holwerda et al.   EARLY HUMAN DEVELOPMENT

Risk factors for shunt malfunction in pediatric hydrocephalus: a multicenter prospective cohort study

(2016) Jay Riva-Cambrin et al.   Journal of Neurosurgery-Pediatrics

Imaging and serum biomarkers reflecting the functional efficacy of extended erythropoietin treatment in rats following infantile traumatic brain injury

(2016) Shenandoah Robinson et al.   Journal of Neurosurgery-Pediatrics

Diffusion tensor imaging study of pediatric patients with congenital hydrocephalus: 1-year postsurgical outcomes

(2016) Francesco T. Mangano et al.   Journal of Neurosurgery-Pediatrics

Melatonin modulates neonatal brain inflammation through endoplasmic reticulum stress, autophagy, and miR-34a/silent information regulator 1 pathway

(2016) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Risk Factors for Intraventricular Hemorrhage in Preterm Infants Born at 34 Weeks of Gestation or Less Following Preterm Premature Rupture of Membranes

(2016) Hongyan Lu et al.   Journal of Stroke & Cerebrovascular Diseases

Diffusion tensor imaging detects early brain microstructure changes before and after ventriculoperitoneal shunt in children with high intracranial pressure hydrocephalus

(2016) Cailei Zhao et al.   MEDICINE

Global surgery for pediatric hydrocephalus in the developing world: a review of the history, challenges, and future directions

(2016) Ryan T. Muir et al.   Neurosurgical Focus

High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial

(2016) Y. W. Wu et al.   PEDIATRICS

Preschool Assessment of Preterm Infants Treated With Darbepoetin and Erythropoietin

(2016) Robin K. Ohls et al.   PEDIATRICS

Cilia-based flow network in the brain ventricles

(2016) R. Faubel et al.   SCIENCE

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus

(2016) Raehee Park et al.   Nature Communications

Risk Factors for Intraventricular Hemorrhage in Preterm Infants Born at 34 Weeks of Gestation or Less Following Preterm Premature Rupture of Membranes

(2016) Hongyan Lu et al.   Journal of Stroke & Cerebrovascular Diseases

Intrauterine inflammation, cerebral oxygen consumption and susceptibility to early brain injury in very preterm newborns

(2015) Michael J Stark et al.   Archives of Disease in Childhood-Fetal and Neonatal Edition

Expansion of the lateral ventricles and ependymal deficits underlie the hydrocephalus evident in mice lacking the transcription factor NFIX

(2015) Diana Vidovic et al.   BRAIN RESEARCH

YAP Is a Critical Inducer of SOCS3, Preventing Reactive Astrogliosis

(2015) Zhihui Huang et al.   CEREBRAL CORTEX

Mcidas and GemC1 are key regulators for the generation of multiciliated ependymal cells in the adult neurogenic niche

(2015) C. Kyrousi et al.   DEVELOPMENT

Erythropoietin Modulates Cerebral and Serum Degradation Products from Excess Calpain Activation following Prenatal Hypoxia-Ischemia

(2015) Lauren L. Jantzie et al.   DEVELOPMENTAL NEUROSCIENCE

Preclinical Models of Encephalopathy of Prematurity

(2015) Lauren L. Jantzie et al.   DEVELOPMENTAL NEUROSCIENCE

Methemoglobin Is an Endogenous Toll-Like Receptor 4 Ligand—Relevance to Subarachnoid Hemorrhage

(2015) Min Kwon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM

(2015) JoonHo Lee et al.   Journal of Maternal-Fetal & Neonatal Medicine

Erythropoietin Delivered via Intra-Arterial Infusion Reduces Endoplasmic Reticulum Stress in Brain Microvessels of Rats Following Cerebral Ischemia and Reperfusion

(2015) Haiping Zhao et al.   Journal of Neuroimmune Pharmacology

An update on research priorities in hydrocephalus: overview of the third National Institutes of Health-sponsored symposium “Opportunities for Hydrocephalus Research: Pathways to Better Outcomes”

(2015) James P. McAllister et al.   JOURNAL OF NEUROSURGERY

Outcomes of intraventricular hemorrhage and posthemorrhagic hydrocephalus in a population-based cohort of very preterm infants born to residents of Nova Scotia from 1993 to 2010

(2015) Julia A. E. Radic et al.   Journal of Neurosurgery-Pediatrics

Safety of Early High-Dose Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants

(2015) Jean-Claude Fauchère et al.   JOURNAL OF PEDIATRICS

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

(2015) Anna Fernández et al.   JOURNAL OF PINEAL RESEARCH

Impaired cognitive performance in premature newborns with two or more surgeries prior to term-equivalent age

(2015) Dawn Gano et al.   PEDIATRIC RESEARCH

Combined in utero hypoxia-ischemia and lipopolysaccharide administration in rats induces chorioamnionitis and a fetal inflammatory response syndrome

(2015) Jessie R. Maxwell et al.   PLACENTA

Intracerebral Hematoma Contributes to Hydrocephalus After Intraventricular Hemorrhage via Aggravating Iron Accumulation

(2015) Qianwei Chen et al.   STROKE

Melatonin Modulates Endoplasmic Reticulum Stress and Akt/GSK3-Beta Signaling Pathway in a Rat Model of Renal Warm Ischemia Reperfusion

(2015) Kaouther Hadj Ayed Tka et al.   Analytical Cellular Pathology

Prenatal Hypoxia–Ischemia Induces Abnormalities in CA3 Microstructure, Potassium Chloride Co-Transporter 2 Expression and Inhibitory Tone

(2015) Lauren L. Jantzie et al.   Frontiers in Cellular Neuroscience

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

(2015) Lauren L. Jantzie et al.   Jove-Journal of Visualized Experiments

Pediatric hydrocephalus: systematic literature review and evidence-based guidelines. Part 2: Management of posthemorrhagic hydrocephalus in premature infants

(2015) Catherine A. Mazzola et al.   Journal of Neurosurgery-Pediatrics

Association Between Early Administration of High-Dose Erythropoietin in Preterm Infants and Brain MRI Abnormality at Term-Equivalent Age

(2014) Russia Ha-Vinh Leuchter et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Role of Red Blood Cell Lysis and Iron in Hydrocephalus after Intraventricular Hemorrhage

(2014) Chao Gao et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Complex pattern of interaction between in utero hypoxia-ischemia and intra-amniotic inflammation disrupts brain development and motor function

(2014) Lauren L Jantzie et al.   Journal of Neuroinflammation

Traumatic Brain Injury-Induced Ependymal Ciliary Loss Decreases Cerebral Spinal Fluid Flow

(2014) Guoxiang Xiong et al.   JOURNAL OF NEUROTRAUMA

Maternal Race, Demography, and Health Care Disparities Impact Risk for Intraventricular Hemorrhage in Preterm Neonates

(2014) Seetha Shankaran et al.   JOURNAL OF PEDIATRICS

Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia

(2014) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH

Erythropoietin attenuates loss of potassium chloride co-transporters following prenatal brain injury

(2014) L.L. Jantzie et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cognitive Outcomes of Preterm Infants Randomized to Darbepoetin, Erythropoietin, or Placebo

(2014) R. K. Ohls et al.   PEDIATRICS

Intracerebroventricular Viral Injection of the Neonatal Mouse Brain for Persistent and Widespread Neuronal Transduction

(2014) Ji-Yoen Kim et al.   Jove-Journal of Visualized Experiments

The effect of histological chorioamnionitis on the short-term outcome of preterm infants ≤32 weeks: a single-center study

(2013) Sema Arayici et al.   Journal of Maternal-Fetal & Neonatal Medicine

Histological Characteristics of the Fetal Inflammatory Response Associated with Neurodevelopmental Impairment and Death in Extremely Preterm Infants

(2013) Ariel A. Salas et al.   JOURNAL OF PEDIATRICS

Erythropoietin signaling promotes oligodendrocyte development following prenatal systemic hypoxic–ischemic brain injury

(2013) Lauren L. Jantzie et al.   PEDIATRIC RESEARCH

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Toll-Like Receptor 4 Antagonist Attenuates Intracerebral Hemorrhage–Induced Brain Injury

(2013) Yan-Chun Wang et al.   STROKE

Mesenchymal Stem Cells Prevent Hydrocephalus After Severe Intraventricular Hemorrhage

(2013) So Yoon Ahn et al.   STROKE

Ependymal Ciliary Dysfunction and Reactive Astrocytosis in a Reorganized Subventricular Zone after Stroke

(2012) Christopher C. Young et al.   CEREBRAL CORTEX

Nuclear Factor  B Activation Impairs Ependymal Ciliogenesis and Links Neuroinflammation to Hydrocephalus Formation

(2012) M. Lattke et al.   JOURNAL OF NEUROSCIENCE

Reduced ventricular shunt rate in very preterm infants with severe intraventricular hemorrhage: an institutional experience

(2012) Nima Alan et al.   Journal of Neurosurgery-Pediatrics

Which Neuroprotective Agents are Ready for Bench to Bedside Translation in the Newborn Infant?

(2012) Nicola J. Robertson et al.   JOURNAL OF PEDIATRICS

Overexpression of melatonin membrane receptors increases calcium-binding proteins and protects VSC4.1 motoneurons from glutamate toxicity through multiple mechanisms

(2012) Arabinda Das et al.   JOURNAL OF PINEAL RESEARCH

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications

(2012) Hannah Blencowe et al.   LANCET

Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice

(2012) Xu Peng et al.   Protein & Cell

Mechanisms of Hydrocephalus After Neonatal and Adult Intraventricular Hemorrhage

(2012) Jennifer Strahle et al.   Translational Stroke Research

Treatment advances in neonatal neuroprotection and neurointensive care

(2011) Michael V Johnston et al.   LANCET NEUROLOGY

Protective effects of erythropoietin in experimental spinal cord injury by reducing the C/EBP-homologous protein expression

(2011) Zhenghua Hong et al.   NEUROLOGICAL RESEARCH

Lysophosphatidic Acid Signaling May Initiate Fetal Hydrocephalus

(2011) Y. C. Yung et al.   Science Translational Medicine

Correlation between placental histopathology and fetal/neonatal outcome: chorioamnionitis and funisitis are associated to intraventricular haemorrage and retinopathy of prematurity in preterm newborns

(2010) Francesca Moscuzza et al.   GYNECOLOGICAL ENDOCRINOLOGY

Cilia Organize Ependymal Planar Polarity

(2010) Z. Mirzadeh et al.   JOURNAL OF NEUROSCIENCE

Postnatal erythropoietin treatment mitigates neural cell loss after systemic prenatal hypoxic-ischemic injury

(2010) Marcus Mazur et al.   Journal of Neurosurgery-Pediatrics

Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia

(2010) Boris Guirao et al.   NATURE CELL BIOLOGY

Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus

(2010) Fadel Tissir et al.   NATURE NEUROSCIENCE

Risk Factors for Conversion to Permanent Ventricular Shunt in Patients Receiving Therapeutic Ventriculostomy for Traumatic Brain Injury

(2010) David F. Bauer et al.   NEUROSURGERY

Neonatal Behavioral Changes in Rats With Gestational Exposure to Lipopolysaccharide: A Prenatal Infection Model for Developmental Neuropsychiatric Disorders

(2010) M. Baharnoori et al.   SCHIZOPHRENIA BULLETIN

Enhanced Oligodendrogenesis and Recovery of Neurological Function by Erythropoietin After Neonatal Hypoxic/Ischemic Brain Injury

(2010) Masanori Iwai et al.   STROKE

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Effects of maternal separation on the neurobehavioral development of newborn Wistar rats

(2009) Jozsef Farkas et al.   BRAIN RESEARCH BULLETIN

Hospital care for children with hydrocephalus in the United States: utilization, charges, comorbidities, and deaths

(2008) Tamara D. Simon et al.   Journal of Neurosurgery-Pediatrics

Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats

(2008) Supriti Samantaray et al.   JOURNAL OF PINEAL RESEARCH

Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances

(2008) Joseph J Volpe   LANCET NEUROLOGY

A Phase I/II Trial of High-Dose Erythropoietin in Extremely Low Birth Weight Infants: Pharmacokinetics and Safety

(2008) S. E. Juul et al.   PEDIATRICS

Neurodevelopmental Outcome of Extremely Low Birth Weight Infants With Posthemorrhagic Hydrocephalus Requiring Shunt Insertion

(2008) I. Adams-Chapman et al.   PEDIATRICS

Therapeutics for neonatal brain injury

(2008) Fernando F. Gonzalez et al.   PHARMACOLOGY & THERAPEUTICS

Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats

(2007) Silvia Carloni et al.   JOURNAL OF PINEAL RESEARCH