Article
Neurosciences
Hayley S. Mountford, Amanda Hill, Anna L. Barnett, Dianne F. Newbury
Summary: The ability to finely control movement is crucial for educational milestones and life skills, yet our understanding of the biology behind motor coordination is lacking. Developmental Coordination Disorder (DCD) is a common but neglected neurodevelopmental disorder, with research on the genetic and environmental factors still in its early stages.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Medicine, Research & Experimental
M. A. Hamed, T. M. Akhigbe, R. E. Akhigbe, A. O. Aremu, P. A. Oyedokun, A. Gbadamos, P. E. Anifowose, M. A. Adewole, O. O. Aboyeji, H. O. Yisau, G. O. Tajudeen, M. M. Titiloye, N. F. Ayinla, A. F. Ajayi
Summary: Sleep deprivation has detrimental effects on male reproductive function, including reduced sperm quality and testicular injury. In addition, it leads to erectile dysfunction and decreased libido. Glutamine supplementation has been found to attenuate the negative effects of sleep deprivation on reproductive function.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Behavioral Sciences
Mei Elansary, Lara J. Pierce, Wendy S. Wei, Dana Charles McCoy, Barry Zuckerman, Charles A. Nelson
Summary: The study aimed to test the associations between maternal stress, mindset, and infant neurodevelopment at 12 months of age. Results did not show significant main effects of maternal stress or mindset on infant EEG outcomes, but significant positive interactions were found when looking at the interactions between maternal stress and mindset. Infants of mothers with growth mindsets may be protected against the negative effects of maternal stress on neurodevelopment.
JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS
(2022)
Article
Pediatrics
Francesca Gallini, Domenico Umberto De Rose, Maria Coppola, Maria Sofia Pelosi, Francesco Cota, Anthea Bottoni, Daniela Ricci, Domenico Marco Romeo, Teresa Spanu, Luca Maggio, Eugenio Mercuri, Giovanni Vento
Summary: This study aimed to evaluate the neurodevelopmental outcomes of preterm infants born to mothers with Ureaplasma/Mycoplasma colonization during pregnancy. The study found that infants exposed to colonization had poorer locomotor abilities compared to unexposed infants, while the incidences of cognitive and motor impairments were similar between the two groups.
FRONTIERS IN PEDIATRICS
(2022)
Article
Environmental Sciences
Lucia Iglesias-Vazquez, Anne-Claire Binter, Josefa Canals, Carmen Hernandez-Martinez, Nuria Voltas, Albert Ambros, Silvia Fernandez-Barres, Laura Perez-Crespo, Monica Guxens, Victoria Arjia
Summary: This study aimed to investigate the effects of prenatal exposure to air pollution on a child's cognitive, language, and motor functions. The results showed that all assessed air pollutants, except PM2.5 absorbance, were associated with lower motor function in children, while no association was observed between prenatal exposure to air pollution and cognitive and language functions.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Chong Liu, Carmen Messerlian, Ying-Jun Chen, Vicente Mustieles, Li-Li Huang, Yang Sun, Yan-Ling Deng, Ying-Hui Cheng, Jing Liu, A-Mei Liu, Wen-Qing Lu, Yi-Xin Wang
Summary: The study revealed that exposure to high levels of disinfection by-products during specific trimesters of pregnancy can lead to impaired neonatal neurodevelopment, especially in male infants and mothers aged 25 or older. Further research is needed to explore the underlying mechanisms.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Hsing-Kang Chen, Shu-Li Wang, Yu-Hsun Chang, Chien-Wen Sun, Ming-Tsang Wu, Mei-Lien Chen, Yu-Jie Lin, Chia -Jung Hsieh
Summary: This study examines the associations between prenatal phthalate exposure and neonatal neurobehavioral development. It found that phthalate exposure was negatively associated with neurobehaviors in female infants and positively associated with neurobehaviors in male infants. These findings highlight the gender-specific effects of maternal phthalate exposure on the neurodevelopment of newborns.
ENVIRONMENTAL POLLUTION
(2023)
Review
Neurosciences
Masa Cater, Gregor Majdic
Summary: Early life stress can have long-term effects on brain development and behavior, with adequate maternal care being crucial for normal brain development. Maternal deprivation in early life can lead to altered emotional and behavioral responses in adulthood and disrupt neuroendocrine stress mechanisms.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Obstetrics & Gynecology
Lucia Iglesias-Vazquez, Carmen Hernandez-Martinez, Nuria Voltas, Josefa Canals, Pilar Coronel, Mercedes Gimeno, Victoria Arija
Summary: In non-anaemic women in early pregnancy, there were no differences in the cognitive, language, and motor development of children at 40 days of age between the adjusted dose of iron based on initial haemoglobin levels and the dose of the control group.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Biochemistry & Molecular Biology
Ze Fan, Lirong Liang, Ruixue Ma, Rougang Xie, Youyi Zhao, Ming Zhang, Baolin Guo, Tian Zeng, Danyi He, Xianghui Zhao, Hui Zhang
Summary: Maternal exposure to sevoflurane anesthesia during pregnancy can have detrimental effects on the cognitive and motor functions of offspring, possibly due to impaired myelination.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Neurosciences
Fereshte Ebrahimian, Nazila Najdi, Forouzan Fattahi Masrour, Ali-Akbar Salari
Summary: Pregnancy is a complex and highly stressful time for women, and this study suggests that swimming exercise before and during pregnancy may affect maternal care and postpartum depression-like behavior in a strain-dependent manner.
BRAIN RESEARCH BULLETIN
(2022)
Article
Behavioral Sciences
Helen E. Vuong, Elena J. L. Coley, Maria Kazantsev, Michaela E. Cooke, Tomiko K. Rendon, Jorge Paramo, Elaine Y. Hsiao
Summary: This study demonstrates that maternal treatment with the SSRI fluoxetine can induce widespread alterations in the fetal brain transcriptome during midgestation, affecting genes related to synaptic organization, neuronal signaling, DNA replication, and mitosis. Furthermore, the maternal gut microbiome plays a significant role in modulating the fetal brain's transcriptional responses to maternal fluoxetine treatment, as shown by the elevation of certain gene expression in specific brain regions and the prevention of this effect by maternal antibiotic treatment.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yang Liu, Guohua Li, Nafei Guo, Xiaosong Liu, Shijia Huang, Qiaoling Du
Summary: The study found that maternal age, residence, parity, pre-pregnancy body mass index (BMI), and iron status were associated with the onset of isolated maternal hypothyroxinemia (IMH).
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weizeng Zheng, Guohui Yan, Ying Jiang, Zhongkun Bao, Kui Li, Meixiang Deng, Baohua Li, Yu Zou
Summary: This study aimed to evaluate the differences in diffusion-weighted imaging (DWI) of the fetal brain between normotensive pregnancies and pregnancies with preeclampsia (PE) or gestational hypertension (GH), with a focus on pregnancies with fetal growth restriction (FGR). The results showed significantly lower average apparent diffusion coefficient (ADC) values in certain brain regions of fetuses with PE/GH and FGR.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Review
Clinical Neurology
Josephine Power, Marinus van IJzendoorn, Andrew J. Lewis, Wai Chen, Megan Galbally
Summary: The systematic review and meta-analysis revealed inadequate assessment of maternal depression and unreliable measures of executive function in many studies. However, there was a small yet statistically significant relationship between perinatal depression and child executive function, supporting the hypothesis that maternal depression during the perinatal period impacts offspring's executive function. Future studies should focus on robust measurement of depression and executive function, and consider the chronicity of maternal depression and developmental context for meaningful results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
B. D. Fulop, B. Sandor, E. Szentleleky, E. Karanyicz, D. Reglodi, B. Gaszner, R. Zakany, H. Hashimoto, T. Juhasz, A. Tamas
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Article
Neurosciences
Agnes Hunyady, Zsofia Hajna, Timea Gubanyi, Balint Scheich, Agnes Kemeny, Balazs Gaszner, Eva Borbely, Zsuzsanna Helyes
BRAIN RESEARCH BULLETIN
(2019)
Article
Multidisciplinary Sciences
Daniel Balazs Fulop, Viktoria Humli, Judit Szepesy, Virag Ott, Dora Reglodi, Balazs Gaszner, Adrienn Nemeth, Agnes Szirmai, Laszlo Tamas, Hitoshi Hashimoto, Tibor Zelles, Andrea Tamas
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Timea Aczel, Angela Kecskes, Jozsef Kun, Kalman Szenthe, Ferenc Banati, Susan Szathmary, Robert Herczeg, Peter Urban, Attila Gyenesei, Balazs Gaszner, Zsuzsanna Helyes, Kata Bolcskei
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Angela Kecskes, Krisztina Pohoczky, Miklos Kecskes, Zoltan V. Varga, Viktoria Kormos, Eva Szoke, Nora Henn-Mike, Mate Feher, Jozsef Kun, Attila Gyenesei, Eva Renner, Miklos Palkovits, Peter Ferdinandy, Istvan M. Abraham, Balazs Gaszner, Zsuzsanna Helyes
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Balazs Nemes, Kata Bolcskei, Angela Kecskes, Viktoria Kormos, Balazs Gaszner, Timea Aczel, Daniel Hegedus, Erika Pinter, Zsuzsanna Helyes, Zoltan Sandor
Summary: The humanized SST4 mouse model allows researchers to study the differences in expression and function of SST4 receptors between humans and mice, as well as evaluate the effects of SST4 receptor agonist drug candidates.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Surgery
Tamas Szabo, Viktoria Kormos, Zoltan Rekasi, Balazs Gaszner
Summary: The study demonstrates the successful implementation of in vivo nerve staining technique in a rat sciatic nerve model. This method can aid in locating potentially displaced nerves, and staining nerves with methylene blue did not cause detectable negative effects on the function and morphology of the nerves.
EUROPEAN SURGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Fruzsina Kiss, Viktoria Kormos, Eva Szoke, Angela Kecskes, Norbert Toth, Anita Steib, Arpad Szallasi, Balint Scheich, Balazs Gaszner, Jozsef Kun, Gabor Fulop, Krisztina Pohoczky, Zsuzsanna Helyes
Summary: The expression of TRPA1 and TRPV1 is upregulated in oral squamous cell carcinoma (OSCC) and their activation may regulate cancer cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Peter Kiss, Eszter Banki, Balazs Gaszner, Daniel Nagy, Zsuzsanna Helyes, Endre Pal, Gyongyver Reman, Gabor Toth, Andrea Tamas, Dora Reglodi
Summary: Pituitary adenylate cyclase-activating peptide (PACAP) shows promising therapeutic effects in a rat model of streptozotocin-induced diabetic neuropathy. PACAP treatment can alleviate mechanical hyperalgesia, reduce morphological signs of neuropathy, and attenuate neuronal activation in pain processing centers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Emoke Olah, Zoltan Rumbus, Viktoria Kormos, Valeria Tekus, Eszter Pakai, Hannah V. Wilson, Kata Fekete, Margit Solymar, Leonardo Kelava, Patrik Keringer, Balazs Gaszner, Matthew Whiteman, Julie Keeble, Erika Pinter, Andras Garami
Summary: Research has shown that H2S can induce hypothermia and vasodilation in mice by activating TRPA1 channels in hypothalamic neurons.
Article
Chemistry, Medicinal
Janos Konkoly, Viktoria Kormos, Balazs Gaszner, Zoltan Sandor, Angela Kecskes, Ammar Alomari, Aliz Szilagyi, Beatrix Szilagyi, Dora Zelena, Erika Pinter
Summary: The research found that TRPA1 is expressed in the olfactory bulb and piriform cortex of mice, has different effects on cat and fox odors, may play an important role in olfactory processing pathways, and may influence the social behavior of mice.
Article
Neurosciences
Lu Xu, Nora Furedi, Christoph Lutter, Bram Geenen, Erika Petervari, Marta Balasko, Adam Denes, Krisztina J. Kovacs, Balazs Gaszner, Tamas Kozicz
Summary: This study reveals that the centrally-projecting Edinger-Westphal nucleus (EWcp) plays a role in controlling white adipose tissue (WAT) size and fat metabolism, in response to leptin signaling. The existence of a circuitry between EWcp and WAT allows the organism to recruit energy without being able to eat, in situations such as the fight-or-flight response.
Article
Biochemistry & Molecular Biology
Mate Feher, Zsombor Marton, Akos Szabo, Janos Kocsa, Viktoria Kormos, Agnes Hunyady, Laszlo Akos Kovacs, Balazs Ujvari, Gergely Berta, Jozsef Farkas, Nora Furedi, Tamas Gaszner, Bence Pytel, Dora Reglodi, Balazs Gaszner
Summary: In this study, the researchers examined the role of the PACAP/PAC1R system in neuroprotection and its involvement in the development and progression of Parkinson's disease using a rat model. The results further supported the importance of the PACAP/PAC1R system in neurodegenerative diseases such as Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Dora K. Kovacs, Szimonetta Eitmann, Gergely Berta, Viktoria Kormos, Balazs Gaszner, Erika Petervari, Marta Balasko
Summary: Middle-aged obesity and aging cachexia pose challenges to healthcare. The role of Ucn2 in middle-aged obesity and aging cachexia was studied, and it was found that age-dependent changes in Ucn2 may contribute to these conditions. Ucn2 showed potential in preventing middle-aged obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tamas Gaszner, Jozsef Farkas, Daniel Kun, Balazs Ujvari, Nora Furedi, Laszlo Akos Kovacs, Hitoshi Hashimoto, Dora Reglodi, Viktoria Kormos, Balazs Gaszner
Summary: Depression poses challenges to patients, the healthcare system, and the economy. This study used a mouse model to explore the "three-hit concept" of depression. The findings suggest that early life adversities and later life stress interact with the effect of fluoxetine therapy by modulating FOSB and H3K9ac in specific regions, supporting the reliability of the model.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)