Review
Cell Biology
G. Gemma Stathatos, E. M. Jessica Dunleavy, Jennifer Zenker, K. Moira O'Bryan
Summary: Delta and epsilon tubulin, lesser-known relatives of alpha and beta tubulin, likely regulate centriole function across species, with their roles in mammals still mysterious. Mutations in 6- and epsilon-tubulin cause centriole destabilization, atypical mitosis, and cell death, indicating their importance in cellular processes beyond centrioles. They also interact with KATNAL2 during spermatogenesis, suggesting novel functions beyond the centriole.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Haruki Yoshida, Shunichi Ishida, Taiki Yamamoto, Takayuki Ishikawa, Yuichi Nagata, Kazuhito Takeuchi, Hironori Ueno, Yohsuke Imai
Summary: In this study, computational fluid dynamics was used to investigate the effects of cilia-induced surface velocity on cerebrospinal fluid (CSF) flow. The results showed that ciliary motility disorder could delay CSF exchange in the lateral ventricles.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Multidisciplinary Sciences
Akshatha Ganne, Meenakshisundaram Balasubramaniam, Haarika Ayyadevara, Lily Kiaei, Robert J. Shmookler Reis, Kottayil I. Varughese, Mahmoud Kiaei
Summary: Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder with no cure. Mutations in various genes have been identified as potential targets for therapy. Molecular-dynamic modeling predicts that these mutations disrupt the stability and functions of the tubulin protein, contributing to motor neuron degeneration in ALS.
SCIENTIFIC REPORTS
(2023)
Article
Clinical Neurology
Julien F. Bally, Sarah Camargos, Camila Oliveira dos Santos, Drew S. Kern, Teresa Lee, Francisco Pereira da Silva-Junior, Renato David Puga, Francisco Cardoso, Egberto Reis Barbosa, Rachita Yadav, Laurie J. Ozelius, Patricia de Carvalho Aguiar, Anthony E. Lang
Summary: This study reported 4 novel TUBB4A gene mutations leading to laryngeal and cervical dystonia with frequent generalization. The variants segregated with the disease in 3 families and were classified as likely pathogenic. Laryngeal involvement is a hallmark feature of DYT-TUBB4A.
Article
Mechanics
T. Bultreys, S. Van Offenwert, W. Goethals, M. N. Boone, J. Aelterman, V. Cnudde
Summary: A new 3D velocimetry approach based on time-resolved x-ray micro-computed tomography (CT) is introduced to measure complex flow fields in optically opaque porous materials. The method has the potential to make breakthroughs in fluid dynamics research in various scientific and industrial fields.
Article
Multidisciplinary Sciences
Anthony D. Junker, Staffan Jacob, Herve Philippe, Delphine Legrand, Chad G. Pearson
Summary: This study found that different phenotypic dispersal strategies co-exist within a species, and multiple distinct and plastic morphological changes impact cilia-dependent motility during dispersal.
Article
Multidisciplinary Sciences
Kimberly A. S. Boster, Shengze Cai, Antonio Ladron-de-Guevara, Jiatong Sun, Xiaoning Zheng, Ting Du, John H. Thomas, Maiken Nedergaard, George Em Karniadakis, Douglas H. Kelley
Summary: This study demonstrates the use of artificial intelligence velocimetry (AIV) to quantify the flow of cerebrospinal fluid (CSF) in pial perivascular spaces (PVSs) by integrating sparse velocity measurements with physics-informed neural networks. AIV infers three-dimensional high-resolution velocity, pressure, and shear stress, and the results are validated and analyzed for sensitivity. The findings contribute to improving fluid dynamic models and potentially providing insights into how CSF flow changes in aging, Alzheimer's disease, and small vessel disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Mechanics
Pawel J. Zuk, Agnieszka M. Slowicka, Maria L. Ekiel-Jezewska, Howard A. Stone
Summary: A numerical study of an elastic fiber in a shear flow at low Reynolds number was conducted, where different theoretical schemes were applied to understand the motion of the fiber. The results showed that the bending, curling, and rotation of the fiber, depending on its length and stiffness, determined the overall motion and shape evolution. The numerical findings were further supported by an interpretation using an elastica model.
JOURNAL OF FLUID MECHANICS
(2021)
Article
Agronomy
Dandan Qin, Gang Liu, Rui Liu, Chunchao Wang, Fuchao Xu, Qing Xu, Yu Ling, Guoqing Dong, Yanchun Peng, Shuangtao Ge, Ganggang Guo, Jing Dong, Chengdao Li
Summary: This study identifies HvTUB8 as a candidate gene for barley spike and leaf development. The mutant phenotype of round lateral spikelet and dark green leaves is caused by changes in cell arrangement in the glume and enlarged chloroplasts. RNA-Seq analysis suggests that HvTUB8 may control spike morphogenesis through ethylene homeostasis and signaling, and regulate leaf color through chlorophyll metabolism. These findings provide new insights into the mechanisms of barley development.
THEORETICAL AND APPLIED GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Sonia Gomes Pereira, Ana Laura Sousa, Catarina Nabais, Tiago Paixao, Alexander J. Holmes, Martin Schorb, Gohta Goshima, Erin M. Tranfield, Jorg D. Becker, Monica Bettencourt-Dias
Summary: Centrioles in the spermatogenesis of the bryophyte Physcomitrium patens are born through an uncharacterized de novo pathway, showing twisted and asymmetric morphology. This phenomenon reveals that centriole biogenesis is more diverse than previously thought.
Article
Engineering, Electrical & Electronic
Jiaming Liang, Shengze Cai, Chao Xu, Tehuan Chen, Jian Chu
Summary: This article introduces a deep neural network called DeepPTV for efficiently and accurately learning complex fluid flow motion. It proposes a solution to the challenges of performing PTV under high flow speed and high particle density conditions. Experimental evaluations demonstrate that the framework provides high accuracy and efficiency, making it suitable for real-time estimation and flow control problems.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Neurosciences
Kaito Kawamura, Masakazu Miyajima, Madoka Nakajima, Mitsuyasu Kanai, Yumiko Motoi, Shuko Nojiri, Chihiro Akiba, Ikuko Ogino, Hanbing Xu, Chihiro Kamohara, Shinya Yamada, Kostadin Karagiozov, Takeshi Ikeuchi, Akihide Kondo, Hajime Arai
Summary: The study found that patients with iNPH have higher levels of A beta O10-20 in their CSF, and the levels decrease after CSF shunting, which is associated with improved cognitive function.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Energy & Fuels
Diana Carolina Guio-Perez, Filip Johnsson, David Pallares
Summary: This study used Magnetic Particle Tracking (MPT) to investigate solid fuel conversion in fluidized bed reactors. The results showed that increasing bed height improves solid mixing, with fluidization velocity having a higher sensitivity.
Article
Neurosciences
Simon Liden, Dan Farahmand, Katarina Laurell
Summary: This study investigated the relationship between ventricular volume and cerebrospinal fluid (CSF) biomarker levels in patients with idiopathic normal pressure hydrocephalus (iNPH). The results showed a weak negative correlation between ventricular volume and amyloid-beta 1-42 (A beta 42) levels, but no correlation with other CSF biomarkers. The findings also revealed differences between males and females, suggesting the importance of sex-based subgroup analysis in future investigations of CSF patterns in iNPH.
FLUIDS AND BARRIERS OF THE CNS
(2022)
Article
Biochemistry & Molecular Biology
Yuanwei Fan, Natasha Bilkey, Derek L. Bolhuis, Kevin C. Slep, Ram Dixit
Summary: The acentrosomal cortical microtubules of higher plants play a crucial role in determining the axis of cell expansion. The Arabidopsis SPIRAL2 protein has been shown to regulate microtubule length and array reorientation by stabilizing microtubule minus ends. This study reveals the structural determinants of SPIRAL2 and how it targets and stabilizes microtubule minus ends through its unique TOG domain architecture, basic region, and coiled-coil domain.
Article
Infectious Diseases
Mirela C. M. Prates, Edwin Tamashiro, Jose L. Proenca-Modena, Miria F. Criado, Tamara H. Saturno, Anibal S. Oliveira, Guilherme P. Buzatto, Bruna L. S. Jesus, Marcos G. Jacob, Lucas R. Carenzi, Ricardo C. Demarco, Eduardo T. Massuda, Davi Aragon, Fabiana C. P. Valera, Eurico Arruda, Wilma T. Anselmo-Lima
CANADIAN JOURNAL OF INFECTIOUS DISEASES & MEDICAL MICROBIOLOGY
(2018)
Article
Virology
Jose Luiz Proenca-Modena, Ricardo de Souza Cardoso, Miria Ferreira Criado, Guilherme Paier Milanez, William Marciel de Souza, Pierina Lorencini Parise, Jessica Wildgrube Bertol, Bruna Lais Santos de Jesus, Mirela Cristina Moreira Prates, Maria Lucia Silva, Guilherme Pietrucci Buzatto, Ricardo Cassiano Demarco, Fabiana Cardoso Pereira Valera, Edwin Tamashiro, Wilma Terezinha Anselmo-Lima, Eurico Arruda
JOURNAL OF MEDICAL VIROLOGY
(2019)
Article
Infectious Diseases
Mariana L. C. Silveira, Wilma T. Anselmo-Lima, Francesca M. Faria, Danielle L. C. Queiroz, Rodrigo L. Nogueira, Marcelo G. J. Leite, Ricardo M. Lessa, Belinda P. Simoes, Edwin Tamashiro, Fabiana C. P. Valera
BMC INFECTIOUS DISEASES
(2019)
Article
Otorhinolaryngology
Andrea A. Braga, Fabiana C. P. Valera, Francesca M. Faria, Maria Rossato, Adriana A. B. Murashima, Marina Z. Fantucci, Davi C. Aragon, Danielle L. C. Queiroz, Wilma T. Anselmo-Lima, Edwin Tamashiro
AMERICAN JOURNAL OF RHINOLOGY & ALLERGY
(2019)
Article
Allergy
Guilherme Constante Preis Sella, Edwin Tamashiro, Juliana Augusta Sella, Davi C. Aragon, Thais Nociti de Mendonca, Luisa Karla de Paula Arruda, Wilma Terezinha Anselmo Lima, Fabiana Cardoso Pereira Valera
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2020)
Article
Otorhinolaryngology
Vanessa R. Pires Dinarte, Wilson A. Silva Jr, Anemari R. D. Baccarin, Edwin Tamashiro, Fabiana C. Valera, Wilma T. Anselmo-Lima
Summary: Polymorphisms in the IL22RA1 gene are associated with chronic rhinosinusitis susceptibility or protection. Further larger-scale studies are necessary to validate this hypothesis.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2021)
Article
Virology
Italo A. Castro, Daniel M. M. Jorge, Lucas M. Ferreri, Ronaldo B. Martins, Marjorie C. Pontelli, Bruna L. S. Jesus, Ricardo S. Cardoso, Miria F. Criado, Lucas Carenzi, Fabiana C. P. Valera, Edwin Tamashiro, Wilma T. Anselmo-Lima, Daniel R. Perez, Eurico Arruda
JOURNAL OF VIROLOGY
(2020)
Article
Clinical Neurology
Marcela de Oliveira Silva, Graziella Ribeiro de Sousa, Sarah Capelupe Simoes, Patricia Nicolucci, Edwin Tamashiro, Fabiano Saggioro, Ricardo Santos de Oliveira, Maria Sol Brassesco
Summary: POH demonstrates effective anti-medulloblastoma effects in vitro and shows synergistic combinations with other conventional therapeutics; in vivo experiments confirm that POH reduces tumor volume when administered intraperitoneally, but its effect on orthotopic tumors remains unclear.
CHILDS NERVOUS SYSTEM
(2021)
Review
Otorhinolaryngology
Wilma T. Anselmo-Lima, Edwin Tamashiro, Fabrizio R. Romano, Marcel M. Miyake, Renato Roithmann, Eduardo M. Kosugi, Marcio Nakanishi, Marco A. Fornazieri, Thiago F. P. Bezerra, Joao F. Mello, Marcus M. Lessa, Richard L. Voegels, Otavio B. Piltcher, Eulalia Sakano, Fabiana C. P. Valera
Summary: This article reviews the current status of biologic treatment in chronic rhinosinusitis and highlights its effectiveness in improving patients' quality of life, but suggests the need for further research and clinical experience.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)
Article
Pharmacology & Pharmacy
Graziella Gomes Rivelli, Andre Coura Perez, Pedro Henrique Reis Silva, Elionai Cassiana de Lima Gomes, Carolina Paula de Souza Moreira, Edwin Tamashiro, Fabiana Cardoso Pereira Valera, Wilma Terezinha Anselmo-Lima, Gerson Antonio Pianetti, Armando Silva-Cunha
Summary: The study developed biodegradable polymeric nanofibers and optimized their preparation conditions using Design of Experiments and Response Surface Methodology. In vivo tests demonstrated that polymeric nanofibers containing mometasone furoate are safe for treating chronic rhinosinusitis in the sinonasal mucosa.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Otorhinolaryngology
Carolina B. de Azevedo, Fabiana C. P. Valera, Lucas R. Carenzi, Daniel S. Kupper, Joao Vitor B. Caetano, Danielle L. C. Queiroz, Wilma T. Anselmo-Lima, Edwin Tamashiro
Summary: The study findings indicate that the use of anti-inflammatory or antibiotic drugs postoperatively did not improve pain levels in children undergoing tonsillectomy. There were no significant differences in pain progression or analgesic intake among the different medication groups, and patients experienced significant pain up to day 4 after surgery.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Review
Otorhinolaryngology
Francisco Leite-Santos, Edwin Tamashiro, Adriana de Andrade Batista Murashima, Wilma T. Anselmo-Lima, Fabiana C. P. Valera
Summary: This article reviewed the murine models for Eosinophilic Chronic Rhinosinusitis (ECRS) and compared them regarding eosinophilic polypoid formation. The study found that OVA associated with SEB protocol appears to produce the most robust eosinophilic sinonasal inflammation.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Wilma T. Anselmo-Lima, Mateus R. Soares, Jefferson P. Fonseca, Denny M. Garcia, Antonio A. Velasco e Cruz, Edwin Tamashiro, Fabiana C. P. Valera
Summary: This study revisited three classification systems of orbital complications of acute rhinosinusitis (ARS) and observed which of them presented the best clinical applicability. It was found that Velasco e Cruz & Anselmo-Lima's classification system proved valid, simple, and effective for categorizing orbital complications of ARS.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2023)
Article
Immunology
Henrique Augusto Cantareira Sabino, Fabiana Cardoso Pereira Valera, Denise Vieira Santos, Marina Zilio Fantucci, Carolina Carneiro Titoneli, Roberto Martinez, Wilma T. Anselmo-Lima, Edwin Tamashiro
Summary: This study aims to explore the antibiofilm properties of bacteria in AECRS patients and finds that bacteria forming biofilms have higher resistance to antibiotics. Additionally, the antibiotic resistance observed in planktonic forms can serve as an indicator for predicting biofilm resistance.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Otorhinolaryngology
Guilherme H. M. Fenolio, Wilma T. Anselmo-Lima, Gabriela C. Tomazini, Inae M. Compagnoni, Maria S. A. do Amaral, Marina Z. Fantucci, Pedro P. L. Peixoto, Alessandro F. Guimaraes, Roberto E. S. Guimaraes, Eulalia Sakano, Fabiana C. P. Valera, Edwin Tamashiro
Summary: Olfactory changes are common and have a significant impact on quality of life. The CCCRC test is a cheap and easy-to-administer test for assessing olfactory function, but its validity for the Brazilian population has not been widely evaluated. In this study, the CCCRC test was adapted for the Brazilian population and showed good reproducibility and similar normality values compared to other countries.
BRAZILIAN JOURNAL OF OTORHINOLARYNGOLOGY
(2022)