Flow chemistry as a versatile tool for the synthesis of triazoles

Supported Catalysis in Continuous-Flow Microreactors

(2015) Rajesh Munirathinam et al.   ADVANCED SYNTHESIS & CATALYSIS

Organic Synthesis: March of the Machines

(2015) Steven V. Ley et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

(2015) Bernhard Gutmann et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A layered double hydroxide, a synthetically useful heterogeneous catalyst for azide−alkyne cycloadditions in a continuous-flow reactor

(2015) Sándor B. Ötvös et al.   APPLIED CATALYSIS A-GENERAL

Continuous metal scavenging and coupling to one-pot copper-catalyzed azide-alkyne cycloaddition click reaction in flow

(2015) Iris Vural Gürsel et al.   CHEMICAL ENGINEERING JOURNAL

Organocatalysis on Tap: Enantioselective Continuous Flow Processes Mediated by Solid-Supported Chiral Organocatalysts

(2015) Carles Rodríguez-Escrich et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aminopropyl-silica-supported Cu nanoparticles: An efficient catalyst for continuous-flow Huisgen azide-alkyne cycloaddition (CuAAC)

(2015) Ravindra P. Jumde et al.   JOURNAL OF CATALYSIS

A Sequential Ugi Multicomponent/Cu-Catalyzed Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

(2015) Carlos Eduardo M. Salvador et al.   JOURNAL OF ORGANIC CHEMISTRY

Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines

(2015) Marcus Baumann et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a microfluidic “click chip” incorporating an immobilized Cu(i) catalyst

(2015) Hairong Li et al.   RSC Advances

Tandem Click-Suzuki reactions in a novel flow reactor incorporating immobilized and exchangeable reagents

(2015) Noah P. Tu et al.   RSC Advances

Strategic Application of Residence-Time Control in Continuous-Flow Reactors

(2015) István M. Mándity et al.   ChemistryOpen

Iridium-Catalyzed Intermolecular Azide-Alkyne Cycloaddition of Internal Thioalkynes under Mild Conditions

(2014) Shengtao Ding et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Monitoring Dynamic Glycosylation in Vivo Using Supersensitive Click Chemistry

(2014) Hao Jiang et al.   BIOCONJUGATE CHEMISTRY

Anthropogenic reaction parameters – the missing link between chemical intuition and the available chemical space

(2014) György M. Keserű et al.   CHEMICAL SOCIETY REVIEWS

Multistep Flow Synthesis of 5-Amino-2-aryl-2H-[1,2,3]-triazole-4-carbonitriles

(2014) Jérôme Jacq et al.   CHEMISTRY-A EUROPEAN JOURNAL

Taming Hazardous Chemistry in Flow: The Continuous Processing of Diazo and Diazonium Compounds

(2014) Benjamin J. Deadman et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pressure-Accelerated Azide-Alkyne Cycloaddition: Micro Capillary versus Autoclave Reactor Performance

(2014) Svetlana Borukhova et al.   ChemSusChem

Diazo Compounds in Continuous-Flow Technology

(2014) Simon T. R. Müller et al.   ChemSusChem

Flow approaches towards sustainability

(2014) Luigi Vaccaro et al.   GREEN CHEMISTRY

Direct Observation of Reduction of Cu(II) to Cu(I) by Terminal Alkynes

(2014) Guanghui Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advanced Strategies for Efficient Macrocyclic Cu(I)-Catalyzed Cycloaddition of Azides

(2014) Anne-Catherine Bédard et al.   ORGANIC LETTERS

Continuous Flow Total Synthesis of Rufinamide

(2014) Ping Zhang et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

“Copper-in-Charcoal” Revisited: Delineating the Nature of the Copper Species and Its Role in Catalysis

(2014) Benjamin R. Buckley et al.   ACS Catalysis

Continuous-flow azide–alkyne cycloadditions with an effective bimetallic catalyst and a simple scavenger system

(2014) Sándor B. Ötvös et al.   RSC Advances

A Facile Route to Triazolopyrimidines Using a [3+2] Cycloaddition and Continuous-Flow Chemistry

(2014) Sara Sadler et al.   Journal of Flow Chemistry

Continuous-Flow Synthesis of 1-Substituted Benzotriazoles from Chloronitrobenzenes and Amines in a CN Bond Formation/Hydrogenation/Diazotization/Cyclization Sequence

(2013) Mao Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

[3 + 2]-Cycloadditions of nitrile ylides after photoactivion of vinyl azides under flow conditions

(2013) Stephan Cludius-Brandt et al.   Beilstein Journal of Organic Chemistry

Advancements in the mechanistic understanding of the copper-catalyzed azide–alkyne cycloaddition

(2013) Regina Berg et al.   Beilstein Journal of Organic Chemistry

Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production

(2013) Sándor B Ötvös et al.   Beilstein Journal of Organic Chemistry

Flash chemistry: flow chemistry that cannot be done in batch

(2013) Jun-ichi Yoshida et al.   CHEMICAL COMMUNICATIONS

Synthesis of Carbocyclic and Heterocyclic β-Aminocarboxylic Acids

(2013) Loránd Kiss et al.   CHEMICAL REVIEWS

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Alkyne-Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives

(2013) Sándor B. Ötvös et al.   Chemistry-An Asian Journal

Solvent- and Catalyst-Free Huisgen Cycloaddition to Rufinamide in Flow with a Greener, Less Expensive Dipolarophile

(2013) Svetlana Borukhova et al.   ChemSusChem

Novel Process Windows for Enabling, Accelerating, and Uplifting Flow Chemistry

(2013) Volker Hessel et al.   ChemSusChem

The role of flow in green chemistry and engineering

(2013) Stephen G. Newman et al.   GREEN CHEMISTRY

Continuous process technology: a tool for sustainable production

(2013) Charlotte Wiles et al.   GREEN CHEMISTRY

Parallel Stranded DNA Stabilized with Internal Sugar Cross-Links: Synthesis and Click Ligation of Oligonucleotides Containing 2′-Propargylated Isoguanosine

(2013) Suresh S. Pujari et al.   JOURNAL OF ORGANIC CHEMISTRY

Applying Flow Chemistry: Methods, Materials, and Multistep Synthesis

(2013) D. Tyler McQuade et al.   JOURNAL OF ORGANIC CHEMISTRY

Stepwise Click Functionalization of DNA through a Bifunctional Azide with a Chelating and a Nonchelating Azido Group

(2013) Sachin A. Ingale et al.   JOURNAL OF ORGANIC CHEMISTRY

Click Chemistry in Peptide-Based Drug Design

(2013) Huiyuan Li et al.   MOLECULES

Continuous process for click reactions using glass micro-reactor functionalized with β-cyclodextrin

(2013) Muhammad Nazir Tahir et al.   TETRAHEDRON LETTERS

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Fast, Cell-Compatible Click Chemistry with Copper-Chelating Azides for Biomolecular Labeling

(2012) Chayasith Uttamapinant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ultrasound and Microstructures-A Promising Combination?

(2012) S. Hübner et al.   ChemSusChem

Copper(I)-Catalyzed Azide-Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit

(2012) Alvaro Carlos Varas et al.   ChemSusChem

Reactivity of Biarylazacyclooctynones in Copper-Free Click Chemistry

(2012) Chelsea G. Gordon et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

[3 + 2]-Dipolar Cycloaddition Reactions of an N-Heterocyclic Carbene Boryl Azide

(2012) Everett Merling et al.   ORGANIC LETTERS

Chemoselective Sequential “Click” Ligation Using Unsymmetrical Bisazides

(2012) Zhao Yuan et al.   ORGANIC LETTERS

Continuous Processing in the Manufacture of Active Pharmaceutical Ingredients and Finished Dosage Forms: An Industry Perspective

(2012) Peter Poechlauer et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multistep flow synthesis of vinyl azides and their use in the copper-catalyzed Huisgen-type cycloaddition under inductive-heating conditions

(2011) Lukas Kupracz et al.   Beilstein Journal of Organic Chemistry

An overview of the key routes to the best selling 5-membered ring heterocyclic pharmaceuticals

(2011) Marcus Baumann et al.   Beilstein Journal of Organic Chemistry

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

“Clicking” on/with polymers: a rapidly expanding field for the straightforward preparation of novel macromolecular architectures

(2011) Kristian Kempe et al.   CHEMICAL SOCIETY REVIEWS

Inductive Heating with Magnetic Materials inside Flow Reactors

(2011) Sascha Ceylan et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Microwave-to-Flow Paradigm: Translating High-Temperature Batch Microwave Chemistry to Scalable Continuous-Flow Processes

(2011) Toma N. Glasnov et al.   CHEMISTRY-A EUROPEAN JOURNAL

Reactions under the Click Chemistry Philosophy Employed in Supramolecular and Mechanostereochemical Systems

(2011) Albert C. Fahrenbach et al.   Chemistry-An Asian Journal

Click to Join Peptides/Proteins Together

(2011) Xuechen Li   Chemistry-An Asian Journal

Click Chemistry-Based Functionalization on Non-Oxidized Silicon Substrates

(2011) Yan Li et al.   Chemistry-An Asian Journal

Click Chemistry: 1,2,3-Triazoles as Pharmacophores

(2011) Sandip G. Agalave et al.   Chemistry-An Asian Journal

1,2,3-Triazoles in Peptidomimetic Chemistry

(2011) Daniel Sejer Pedersen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Phase Separation As a Strategy Toward Controlling Dilution Effects in Macrocyclic Glaser-Hay Couplings

(2011) Anne-Catherine Bédard et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Strained Cyclophane Macrocycles: Impact of Progressive Ring Size Reduction on Synthesis and Structure

(2011) Andrew R. Bogdan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ultrasound-assisted click chemistry in continuous flow

(2011) Noah P. Tu et al.   MOLECULAR DIVERSITY

Flow synthesis of organic azides and the multistep synthesis of imines and amines using a new monolithic triphenylphosphine reagent

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Quick and highly efficient copper-catalyzed cycloaddition of organic azides with terminal alkynes

(2011) Dong Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Free Intramolecular Alkyne–Azide Cycloadditions Leading to Seven-Membered Heterocycles

(2011) Míriam Sau et al.   ORGANIC LETTERS

Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor Technology

(2011) Andrew R. Bogdan et al.   ORGANIC LETTERS

Selective syntheses of novel highly functionalized β-aminocyclohexanecarboxylic acids

(2011) Loránd Kiss et al.   TETRAHEDRON

Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions

(2010) Michael Fuchs et al.   ADVANCED SYNTHESIS & CATALYSIS

Novel process windows – Concept, proposition and evaluation methodology, and intensified superheated processing

(2010) Volker Hessel et al.   CHEMICAL ENGINEERING SCIENCE

In situ click chemistry: probing the binding landscapes of biological molecules

(2010) Sreeman K. Mamidyala et al.   CHEMICAL SOCIETY REVIEWS

Efficient Access to New Chemical Space Through Flow-Construction of Druglike Macrocycles Through Copper-Surface-Catalyzed Azide-Alkyne Cycloaddition Reactions

(2010) Andrew R. Bogdan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Green and Sustainable Chemical Synthesis Using Flow Microreactors

(2010) Jun-ichi Yoshida et al.   ChemSusChem

Pharmacological significance of triazole scaffold

(2010) Rajeev Kharb et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Carbocycles Related to Oseltamivir as Influenza Virus Group-1-Specific Neuraminidase Inhibitors. Binding to N1 Enzymes in the Context of Virus-like Particles

(2010) Sankar Mohan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Automated Synthesis of a 96 Product-Sized Library of Triazole Derivatives Using a Solid Phase Supported Copper Catalyst

(2010) Ibtissem Jlalia et al.   MOLECULES

An efficient synthesis of rufinamide, an antiepileptic drug

(2010) Whitney H. Mudd et al.   TETRAHEDRON LETTERS

Highly efficient and safe procedure for the synthesis of aryl 1,2,3-triazoles from aromatic amine in a continuous flow reactor

(2010) Federica Stazi et al.   TETRAHEDRON LETTERS

Continuous flow multi-step organic synthesis

(2010) Damien Webb et al.   Chemical Science

The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

(2009) Andrew R. Bogdan et al.   ADVANCED SYNTHESIS & CATALYSIS

Copper(I)-Catalyzed Cycloaddition of Organic Azides and 1-Iodoalkynes

(2009) Jason E. Hein et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multistep Synthesis Using Modular Flow Reactors: Bestmann-Ohira Reagent for the Formation of Alkynes and Triazoles

(2009) Ian R. Baxendale et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu(I)-Catalyzed Huisgen Azide−Alkyne 1,3-Dipolar Cycloaddition Reaction in Nucleoside, Nucleotide, and Oligonucleotide Chemistry

(2009) Franck Amblard et al.   CHEMICAL REVIEWS

‘Click labelling’ in PET radiochemistry

(2009) Matthias Glaser et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

A Convenient and Stable Synthon for Ethyl Azide and Its Evaluation in a [3 + 2]-Cycloaddition Reaction under Continuous-Flow Conditions

(2009) Rob Tinder et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Industrial Oxidations with Organocatalyst TEMPO and Its Derivatives

(2009) Rosaria Ciriminna et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Inductive Heating for Organic Synthesis by Using Functionalized Magnetic Nanoparticles Inside Microreactors

(2008) Sascha Ceylan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Click Chemistry and Medicinal Chemistry: A Case of “Cyclo-Addiction”

(2008) A. D. Moorhouse et al.   ChemMedChem

Ruthenium-Catalyzed Azide−Alkyne Cycloaddition: Scope and Mechanism

(2008) Brant C. Boren et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

(2007) Gian Cesare Tron et al.   MEDICINAL RESEARCH REVIEWS