Diazo Compounds in Continuous-Flow Technology

Extremely Fast Gas/Liquid Reactions in Flow Microreactors: Carboxylation of Short-Lived Organolithiums

(2014) Aiichiro Nagaki et al.   CHEMISTRY-A EUROPEAN JOURNAL

Continuous flow asymmetric cyclopropanation reactions using Cu(i) complexes of Pc-L* ligands supported on silica as catalysts with carbon dioxide as a carrier

(2014) Brunilde Castano et al.   GREEN CHEMISTRY

Continuous Flow Synthesis of α-Halo Ketones: Essential Building Blocks of Antiretroviral Agents

(2014) Vagner D. Pinho et al.   JOURNAL OF ORGANIC CHEMISTRY

Safe Generation and Direct Use of Diazoesters in Flow Chemistry

(2014) Thomas Wirth et al.   SYNLETT

Novel Multicomponent Reactions via Trapping of Protic Onium Ylides with Electrophiles

(2013) Xin Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

“Batch” Kinetics in Flow: Online IR Analysis and Continuous Control

(2013) Jason S. Moore et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

(2013) Salvatore Mascia et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ethyl diazoacetate synthesis in flow

(2013) Mariëlle M E Delville et al.   Beilstein Journal of Organic Chemistry

Flow chemistry syntheses of natural products

(2013) Julio C. Pastre et al.   CHEMICAL SOCIETY REVIEWS

Catalytic X–H insertion reactions based on carbenoids

(2013) Dennis Gillingham et al.   CHEMICAL SOCIETY REVIEWS

A prototype device for evaporation in batch and flow chemical processes

(2013) Benjamin J. Deadman et al.   GREEN CHEMISTRY

Continuous flow synthesis of toxic ethyl diazoacetate for utilization in an integrated microfluidic system

(2013) Ram Awatar Maurya et al.   GREEN CHEMISTRY

Batch and Flow Photochemical Benzannulations Based on the Reaction of Ynamides and Diazo Ketones. Application to the Synthesis of Polycyclic Aromatic and Heteroaromatic Compounds

(2013) Thomas P. Willumstad et al.   JOURNAL OF ORGANIC CHEMISTRY

Continuous Flow Generation and Reactions of Anhydrous Diazomethane Using a Teflon AF-2400 Tube-in-Tube Reactor

(2013) Federica Mastronardi et al.   ORGANIC LETTERS

Continuous-flow generation of diazoesters and their direct use in S–H and P–H insertion reactions: synthesis of α-sulfanyl, α-sulfonyl, and α-phosphono carboxylates

(2013) Hannah E. Bartrum et al.   TETRAHEDRON

Intramolecular generation and rearrangement of oxonium ylides: methodology studies and their application in synthesis

(2013) Graham K. Murphy et al.   TETRAHEDRON

Flow photochemistry: Old light through new windows

(2012) Jonathan P Knowles et al.   Beilstein Journal of Organic Chemistry

On Being Green: Can Flow Chemistry Help?

(2012) Steven V. Ley   CHEMICAL RECORD

Continuous Hydrolysis and Liquid–Liquid Phase Separation of an Active Pharmaceutical Ingredient Intermediate Using a Miniscale Hydrophobic Membrane Separator

(2012) Albert E. Cervera-Padrell et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Two-Step Flow Synthesis of Biarylmethanes by Reductive Arylation of Tosylhydrazones

(2012) Lukas Kupracz et al.   Journal of Flow Chemistry

Continuous In Situ Generation, Separation, and Reaction of Diazomethane in a Dual-Channel Microreactor

(2011) Ram Awatar Maurya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ten key issues in modern flow chemistry

(2011) Jens Wegner et al.   CHEMICAL COMMUNICATIONS

Guiding principles for site selective and stereoselective intermolecular C–H functionalization by donor/acceptor rhodium carbenes

(2011) Huw M. L. Davies et al.   CHEMICAL SOCIETY REVIEWS

Continuous Flow System with a Polymer-Supported Dirhodium(II) Catalyst: Application to Enantioselective Carbonyl Ylide Cycloaddition Reactions

(2011) Koji Takeda et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rapid Access to α-Alkoxy and α-Amino Acid Derivatives through Safe Continuous-Flow Generation of Diazoesters

(2011) Hannah E. Bartrum et al.   CHEMISTRY-A EUROPEAN JOURNAL

The Oxygen-Mediated Synthesis of 1,3-Butadiynes in Continuous Flow: Using Teflon AF-2400 to Effect Gas/Liquid Contact

(2011) Trine P. Petersen et al.   ChemSusChem

Efficient enhancement of copper-pyridineoxazoline catalysts through immobilization and process design

(2011) C. Aranda et al.   GREEN CHEMISTRY

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Key Green Engineering Research Areas for Sustainable Manufacturing: A Perspective from Pharmaceutical and Fine Chemicals Manufacturers

(2011) Concepción Jiménez-González et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Continuous Preparation of Arylmagnesium Reagents in Flow with Inline IR Monitoring

(2011) Tobias Brodmann et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

(2011) Emiliano Rossi et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Buchner and Beyond: Arene Cyclopropanation as Applied to Natural Product Total Synthesis

(2011) Sarah Reisman et al.   SYNLETT

A flow-microreactor approach to protecting-group-free synthesis using organolithium compounds

(2011) Heejin Kim et al.   Nature Communications

The Continuous-Flow Synthesis of Carboxylic Acids using CO2 in a Tube-In-Tube Gas Permeable Membrane Reactor

(2010) Anastasios Polyzos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of β-Keto Esters In-Flow and Rapid Access to Substituted Pyrimidines

(2010) Hannah E. Bartrum et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantiomerically Puretrans-β-Lactams from α-Amino Acids via Compact Fluorescent Light (CFL) Continuous-Flow Photolysis

(2010) Yvette S. Mimieux Vaske et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Flow Ozonolysis Using a Semipermeable Teflon AF-2400 Membrane To Effect Gas−Liquid Contact

(2010) Matthew O’Brien et al.   ORGANIC LETTERS

Safe and Reliable Synthesis of Diazoketones and Quinoxalines in a Continuous Flow Reactor

(2010) Laetitia J. Martin et al.   ORGANIC LETTERS

Catalytic Carbene Insertion into C−H Bonds

(2009) Michael P. Doyle et al.   CHEMICAL REVIEWS

Production of (S)-1-Benzyl-3-diazo-2-oxopropylcarbamic Acidtert-Butyl Ester, a Diazoketone Pharmaceutical Intermediate, Employing a Small Scale Continuous Reactor

(2009) Pamela Pollet et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

Metal-free carbon–carbon bond-forming reductive coupling between boronic acids and tosylhydrazones

(2009) José Barluenga et al.   Nature Chemistry

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Making diazomethane accessible for R&D and industry: generation and direct conversion in a continuous micro-reactor set-up

(2007) Michael Struempel et al.   GREEN CHEMISTRY