Alkyne-Azide Cycloadditions with Copper Powder in a High-Pressure Continuous-Flow Reactor: High-Temperature Conditions versus the Role of Additives

Flow Chemistry - A Key Enabling Technology for (Multistep) Organic Synthesis

(2012) Jens Wegner et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly Efficient 1,4-Addition of Aldehydes to Nitroolefins: Organocatalysis in Continuous Flow by Solid-Supported Peptidic Catalysts

(2012) Sándor B. Ötvös et al.   ChemSusChem

Copper(I)-Catalyzed Azide-Alkyne Cycloadditions in Microflow: Catalyst Activity, High-T Operation, and an Integrated Continuous Copper Scavenging Unit

(2012) Alvaro Carlos Varas et al.   ChemSusChem

When Cyclodextrins Meet Click Chemistry

(2012) Pierre-Antoine Faugeras et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The impact of click chemistry in medicinal chemistry

(2012) Jingli Hou et al.   Expert Opinion on Drug Discovery

Asymmetric aldol reaction in a continuous-flow reactor catalyzed by a highly reusable heterogeneous peptide

(2012) Sándor B. Ötvös et al.   JOURNAL OF CATALYSIS

Multikilogram Synthesis of 4-d-Erythronolactone via Batch and Continuous Processing

(2012) Loretta L. Wong et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Mixing and Dispersion in Small-Scale Flow Systems

(2012) Kevin D. Nagy et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Copper on Iron: Catalyst and Scavenger for Azide–Alkyne Cycloaddition

(2012) Zoltán Novák et al.   SYNTHESIS-STUTTGART

Self-Optimizing Continuous Reactions in Supercritical Carbon Dioxide

(2011) Andrew J. Parrott et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Deciding Whether To Go with the Flow: Evaluating the Merits of Flow Reactors for Synthesis

(2011) Ryan L. Hartman et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient synthesis and in vitro antitubercular activity of 1,2,3-triazoles as inhibitors of Mycobacterium tuberculosis

(2011) Poovan Shanmugavelan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Recent advances in micro reaction technology

(2011) Charlotte Wiles et al.   CHEMICAL COMMUNICATIONS

Syntheses and transformations of α-azido ketones and related derivatives

(2011) Tamás Patonay et al.   CHEMICAL SOCIETY REVIEWS

“Clicking” on/with polymers: a rapidly expanding field for the straightforward preparation of novel macromolecular architectures

(2011) Kristian Kempe et al.   CHEMICAL SOCIETY REVIEWS

10 Years of Click Chemistry: Synthesis and Applications of Ferrocene-Derived Triazoles

(2011) Venkataraman Ganesh et al.   Chemistry-An Asian Journal

Reactions under the Click Chemistry Philosophy Employed in Supramolecular and Mechanostereochemical Systems

(2011) Albert C. Fahrenbach et al.   Chemistry-An Asian Journal

Click to Join Peptides/Proteins Together

(2011) Xuechen Li   Chemistry-An Asian Journal

Click Chemistry: 1,2,3-Triazoles as Pharmacophores

(2011) Sandip G. Agalave et al.   Chemistry-An Asian Journal

1,2,3-Triazoles in Peptidomimetic Chemistry

(2011) Daniel Sejer Pedersen et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Continuous flow reactors: a perspective

(2011) Charlotte Wiles et al.   GREEN CHEMISTRY

Acid–Base Jointly Promoted Copper(I)-Catalyzed Azide–Alkyne Cycloaddition

(2011) Changwei Shao et al.   JOURNAL OF ORGANIC CHEMISTRY

Exhaustive glycosylation, pegylation, and glutathionylation of a [G4]-ene48 dendrimer via photoinduced thiol-ene coupling

(2011) Mauro Lo Conte et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

A fully automated, multistep flow synthesis of 5-amino-4-cyano-1,2,3-triazoles

(2011) Catherine J. Smith et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of 5-Iodo-1,2,3-triazole-Containing Macrocycles Using Copper Flow Reactor Technology

(2011) Andrew R. Bogdan et al.   ORGANIC LETTERS

Fast Scale-Up Using Microreactors: Pyrrole Synthesis from Micro to Production Scale

(2011) Pieter J. Nieuwland et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Covalently immobilized tris(triazolyl)methanol–Cu(i) complexes: highly active and recyclable catalysts for CuAAC reactions

(2011) Erhan Ozkal et al.   Catalysis Science & Technology

Copper(I) Acetate: A Structurally Simple but Highly Efficient Dinuclear Catalyst for Copper-Catalyzed Azide-Alkyne Cycloaddition

(2010) Changwei Shao et al.   ADVANCED SYNTHESIS & CATALYSIS

Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions

(2010) Michael Fuchs et al.   ADVANCED SYNTHESIS & CATALYSIS

Intelligent Microflow: Development of Self-Optimizing Reaction Systems

(2010) Munawwer Rasheed et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A comparison of five bioconjugatable ferrocenes for labeling of biomolecules

(2010) Dongbiao Ge et al.   CHEMICAL COMMUNICATIONS

Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and esters

(2010) Ina Wilkening et al.   CHEMICAL COMMUNICATIONS

Scale-up concept of single-channel microreactors from process development to industrial production

(2010) Norbert Kockmann et al.   CHEMICAL ENGINEERING JOURNAL

Flash chemistry: flow microreactor synthesis based on high-resolution reaction time control

(2010) Jun-Ichi Yoshida   CHEMICAL RECORD

Click chemistry generates privileged CH hydrogen-bonding triazoles: the latest addition to anion supramolecular chemistry

(2010) Yuran Hua et al.   CHEMICAL SOCIETY REVIEWS

Click polymerization

(2010) Anjun Qin et al.   CHEMICAL SOCIETY REVIEWS

Click chemistry with DNA

(2010) Afaf H. El-Sagheer et al.   CHEMICAL SOCIETY REVIEWS

Efficient Access to New Chemical Space Through Flow-Construction of Druglike Macrocycles Through Copper-Surface-Catalyzed Azide-Alkyne Cycloaddition Reactions

(2010) Andrew R. Bogdan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Green and Sustainable Chemical Synthesis Using Flow Microreactors

(2010) Jun-ichi Yoshida et al.   ChemSusChem

Carboxylic Acid-Promoted Copper(I)-Catalyzed Azide−Alkyne Cycloaddition

(2010) Changwei Shao et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach

(2010) Sándor B. Ötvös et al.   MOLECULAR DIVERSITY

Synthesis of conformationally restricted 1,2,3-triazole-substituted ethyl β- and γ-aminocyclopentanecarboxylate stereoisomers. Multifunctionalized alicyclic amino esters

(2010) Loránd Kiss et al.   TETRAHEDRON

Towards Continuous Flow, Highly Enantioselective Allylic Amination: Ligand Design, Optimization and Supporting

(2009) Dana Popa et al.   ADVANCED SYNTHESIS & CATALYSIS

The Use of Copper Flow Reactor Technology for the Continuous Synthesis of 1,4-Disubstituted 1,2,3-Triazoles

(2009) Andrew R. Bogdan et al.   ADVANCED SYNTHESIS & CATALYSIS

A Gold-Immobilized Microchannel Flow Reactor for Oxidation of Alcohols with Molecular Oxygen

(2009) Naiwei Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of click reaction for the synthesis of modified nucleosides as chitin synthase inhibitors

(2009) Preeti M. Chaudhary et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel Process Windows - Gate to Maximizing Process Intensification via Flow Chemistry

(2009) V. Hessel   CHEMICAL ENGINEERING & TECHNOLOGY

Applications of Orthogonal “Click” Chemistries in the Synthesis of Functional Soft Materials

(2009) Rhiannon K. Iha et al.   CHEMICAL REVIEWS

A Highly Active Catalyst for Huisgen 1,3-Dipolar Cycloadditions Based on the Tris(triazolyl)methanol−Cu(I) Structure

(2009) Salih Özçubukçu et al.   ORGANIC LETTERS

Novel functionalized cispentacin derivatives. Synthesis of 1,2,3-triazole-substituted 2-aminocyclopentanecarboxylate stereoisomers

(2009) Loránd Kiss et al.   TETRAHEDRON-ASYMMETRY

Development of microchannel reactors using polysilane-supported palladium catalytic systems in capillaries

(2008) Masaharu Ueno et al.   CHEMICAL COMMUNICATIONS

Cu-Catalyzed Azide−Alkyne Cycloaddition

(2008) Morten Meldal et al.   CHEMICAL REVIEWS

Flash Chemistry: Fast Chemical Synthesis by Using Microreactors

(2008) Jun-ichi Yoshida et al.   CHEMISTRY-A EUROPEAN JOURNAL

Click Chemistry and Medicinal Chemistry: A Case of “Cyclo-Addiction”

(2008) A. D. Moorhouse et al.   ChemMedChem

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

(2008) Christopher D. Hein et al.   PHARMACEUTICAL RESEARCH

Electrochemical detection of kinase-catalyzed phosphorylation using ferrocene-conjugated ATP

(2007) Haifeng Song et al.   CHEMICAL COMMUNICATIONS