In Silico Prediction of Diffusion Interaction Parameter (kD), a Key Indicator of Antibody Solution Behaviors

Biopharmaceutical Informatics: supporting biologic drug development via molecular modelling and informatics

(2017) Sandeep Kumar et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Quantifying the Risks of Asparagine Deamidation and Aspartate Isomerization in Biopharmaceuticals by Computing Reaction Free-Energy Surfaces

(2017) Nikolay V. Plotnikov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions

(2017) Dheeraj S. Tomar et al.   mAbs

Charge Shielding Prevents Aggregation of Supercharged GFP Variants at High Protein Concentration

(2017) Joshua R. Laber et al.   MOLECULAR PHARMACEUTICS

Biophysical properties of the clinical-stage antibody landscape

(2017) Tushar Jain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Both Reversible Self-Association and Structural Changes Underpin Molecular Viscoelasticity of mAb Solutions

(2016) Prasad S. Sarangapani et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibodies to watch in 2017

(2016) Janice M. Reichert   mAbs

Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering

(2016) James C. Geoghegan et al.   mAbs

Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development

(2016) Dheeraj S. Tomar et al.   mAbs

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo

(2016) Claire L. Dobson et al.   Scientific Reports

Critical Examination of the Colloidal Particle Model of Globular Proteins

(2015) Prasad S. Sarangapani et al.   BIOPHYSICAL JOURNAL

Computational tool for the early screening of monoclonal antibodies for their viscosities

(2015) Neeraj J Agrawal et al.   mAbs

Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobicversuselectrostatic inter-molecular interactions

(2015) Pilarin Nichols et al.   mAbs

Solubility Challenges in High Concentration Monoclonal Antibody Formulations: Relationship with Amino Acid Sequence and Intermolecular Interactions

(2015) Mariya Pindrus et al.   MOLECULAR PHARMACEUTICS

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Intermolecular Interactions and the Viscosity of Highly Concentrated Monoclonal Antibody Solutions

(2015) Elaheh Binabaji et al.   PHARMACEUTICAL RESEARCH

Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab

(2015) Giovanna Scapin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy

(2014) Jayapriya Jayaraman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Targeted purification development enabled by computational biophysical modeling

(2014) Francis K. Insaidoo et al.   BIOTECHNOLOGY PROGRESS

Anisotropic Contributions to Protein–Protein Interactions

(2014) Leigh J. Quang et al.   Journal of Chemical Theory and Computation

Gauging Colloidal and Thermal Stability in Human IgG1–Sugar Solutions through Diffusivity Measurements

(2014) Jonathan Rubin et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Role of Anisotropic Interactions for Proteins and Patchy Nanoparticles

(2014) Christopher J. Roberts et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Highly Viscous Antibody Solutions Are a Consequence of Network Formation Caused by Domain–Domain Electrostatic Complementarities: Insights from Coarse-Grained Simulations

(2014) Patrick M. Buck et al.   MOLECULAR PHARMACEUTICS

Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration

(2014) Shubhadra N. Singh et al.   PHARMACEUTICAL RESEARCH

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability

(2014) Vikas K. Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

(2013) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

(2013) Wayne G. Lilyestrom et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Developability studies before initiation of process development

(2013) Xiaoyu Yang et al.   mAbs

Application of a PEG precipitation method for solubility screening: A tool for developing high protein concentration formulations

(2013) Li Li et al.   PROTEIN SCIENCE

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Toward a Molecular Understanding of Protein Solubility: Increased Negative Surface Charge Correlates with Increased Solubility

(2012) Ryan M. Kramer et al.   BIOPHYSICAL JOURNAL

Proximity energies: a framework for understanding concentrated solutions

(2012) Tom Laue   JOURNAL OF MOLECULAR RECOGNITION

Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies

(2012) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

(2012) Sandeep Yadav et al.   MOLECULAR PHARMACEUTICS

Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics

(2012) P. M. Buck et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Development of high concentration protein biopharmaceuticals: The use of platform approaches in formulation development

(2011) Nicholas W. Warne   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

(2011) Neeraj J. Agrawal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects

(2011) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

(2010) Atul Saluja et al.   BIOPHYSICAL JOURNAL

Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies

(2010) Veysel Kayser et al.   Biotechnology Journal

Prediction of Aggregation Prone Regions of Therapeutic Proteins

(2010) Naresh Chennamsetty et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Folding and binding cascades: Dynamic landscapes and population shifts

(2010) Sandeep Kumar et al.   PROTEIN SCIENCE

Intrinsic amino acid side-chain hydrophilicity/hydrophobicity coefficients determined by reversed-phase high-performance liquid chromatography of model peptides: Comparison with other hydrophilicity/hydrophobicity scales

(2009) Colin T. Mant et al.   BIOPOLYMERS

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA