Rational design of viscosity reducing mutants of a monoclonal antibody: Hydrophobicversuselectrostatic inter-molecular interactions

Plasmonic measurements of monoclonal antibody self-association using self-interaction nanoparticle spectroscopy

(2014) Jayapriya Jayaraman et al.   BIOTECHNOLOGY AND BIOENGINEERING

Dipole-Dipole Interaction in Antibody Solutions: Correlation with Viscosity Behavior at High Concentration

(2014) Shubhadra N. Singh et al.   PHARMACEUTICAL RESEARCH

Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties

(2014) Li Li et al.   PHARMACEUTICAL RESEARCH

Energetic and Dynamic Aspects of the Affinity Maturation Process: Characterizing Improved Variants from the Bevacizumab Antibody with Molecular Simulations

(2013) Dario Corrada et al.   Journal of Chemical Information and Modeling

Polar Solvents Decrease the Viscosity of High Concentration IgG1 Solutions Through Hydrophobic Solvation and Interaction: Formulation and Biocompatibility Considerations

(2013) Tim J. Kamerzell et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High Shear Rheology and Anisotropy in Concentrated Solutions of Monoclonal Antibodies

(2013) Isidro E. Zarraga et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling

(2013) Anuj Chaudhri et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations

(2013) Wayne G. Lilyestrom et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Consequences of glycan truncation on Fc structural integrity

(2013) Patrick M Buck et al.   mAbs

Characterization and Suitability of Therapeutic Antibody Dense Phases for Subcutaneous Delivery

(2013) Harvey R. Johnson et al.   MOLECULAR PHARMACEUTICS

Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions

(2013) Charudharshini Srinivasan et al.   PHARMACEUTICAL RESEARCH

Application of a PEG precipitation method for solubility screening: A tool for developing high protein concentration formulations

(2013) Li Li et al.   PROTEIN SCIENCE

Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

(2013) Xiaoling Wang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses

(2013) Patrick M. Buck et al.   PLoS Computational Biology

Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter

(2012) Brian D. Connolly et al.   BIOPHYSICAL JOURNAL

Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells

(2012) Amelie Croset et al.   JOURNAL OF BIOTECHNOLOGY

Proximity energies: a framework for understanding concentrated solutions

(2012) Tom Laue   JOURNAL OF MOLECULAR RECOGNITION

Investigating Allostery in Molecular Recognition: Insights from a Computational Study of Multiple Antibody–Antigen Complexes

(2012) Dario Corrada et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Generation and Comparative Characterization of Glycosylated and Aglycosylated Human IgG1 Antibodies

(2012) Dmitrij Hristodorov et al.   MOLECULAR BIOTECHNOLOGY

The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions

(2012) Sandeep Yadav et al.   MOLECULAR PHARMACEUTICS

Glycan variability on a recombinant IgG antibody transiently produced in HEK-293E cells

(2012) Sophie Nallet et al.   New Biotechnology

Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies

(2012) Zheng Guo et al.   PHARMACEUTICAL RESEARCH

Viscosity of concentrated therapeutic protein compositions

(2011) Jan Jezek et al.   ADVANCED DRUG DELIVERY REVIEWS

Development of high concentration protein biopharmaceuticals: The use of platform approaches in formulation development

(2011) Nicholas W. Warne   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Viscosity Behavior of High-Concentration Protein Mixtures

(2011) William J. Galush et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

(2011) Sandeep Yadav et al.   PHARMACEUTICAL RESEARCH

Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B 2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations

(2011) Shuntaro Saito et al.   PHARMACEUTICAL RESEARCH

Use of dynamic light scattering to determine second virial coefficient in a semidilute concentration regime

(2010) Sandeep Yadav et al.   ANALYTICAL BIOCHEMISTRY

Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation

(2010) Atul Saluja et al.   BIOPHYSICAL JOURNAL

Effect of protein and solution properties on the donnan effect during the ultrafiltration of proteins

(2010) Glen R. Bolton et al.   BIOTECHNOLOGY PROGRESS

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Specific interactions in high concentration antibody solutions resulting in high viscosity

(2009) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Physicochemical principles that regulate the competition between functional and dysfunctional association of proteins

(2009) S. Pechmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prediction of Aggregation-Prone Regions in Structured Proteins

(2008) Gian Gaetano Tartaglia et al.   JOURNAL OF MOLECULAR BIOLOGY

Effect of Ions on Agitation- and Temperature-Induced Aggregation Reactions of Antibodies

(2008) R. Matthew Fesinmeyer et al.   PHARMACEUTICAL RESEARCH