Antibodies to watch in 2017

The making of bispecific antibodies

(2017) Ulrich Brinkmann et al.   mAbs

Efficacy and safety of sarilumab monotherapy versus adalimumab monotherapy for the treatment of patients with active rheumatoid arthritis (MONARCH): a randomised, double-blind, parallel-group phase III trial

(2016) Gerd R Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study

(2016) David Planchard et al.   Clinical Lung Cancer

PK/PD analysis of a novel pH-dependent antigen-binding antibody using a dynamic antibody–antigen binding model

(2016) Kenta Haraya et al.   Drug Metabolism and Pharmacokinetics

Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial

(2016) Eugene R Bleecker et al.   LANCET

Benralizumab, an anti-interleukin-5 receptor α monoclonal antibody, as add-on treatment for patients with severe, uncontrolled, eosinophilic asthma (CALIMA): a randomised, double-blind, placebo-controlled phase 3 trial

(2016) J Mark FitzGerald et al.   LANCET

Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial

(2016) Howard L Kaufman et al.   LANCET ONCOLOGY

TEV-48125 for the preventive treatment of chronic migraine

(2016) Marcelo E. Bigal et al.   NEUROLOGY

Factor VIII–Mimetic Function of Humanized Bispecific Antibody in Hemophilia A

(2016) Midori Shima et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caplacizumab for Acquired Thrombotic Thrombocytopenic Purpura

(2016) Flora Peyvandi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

(2016) Felicia Cosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis

(2016) Eric L. Simpson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inotuzumab Ozogamicin versus Standard Therapy for Acute Lymphoblastic Leukemia

(2016) Hagop M. Kantarjian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tildrakizumab (MK-3222), an anti-interleukin-23p19 monoclonal antibody, improves psoriasis in a phase IIb randomized placebo-controlled trial

(2015) K. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Identification and Characterization of MEDI4736, an Antagonistic Anti-PD-L1 Monoclonal Antibody

(2015) R. Stewart et al.   Cancer Immunology Research

Efficacy and safety of tralokinumab in patients with severe uncontrolled asthma: a randomised, double-blind, placebo-controlled, phase 2b trial

(2015) Christopher E Brightling et al.   Lancet Respiratory Medicine

A phase 1 study investigating DX-2930 in healthy subjects

(2014) Yung Chyung et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Safety and efficacy of LY2951742, a monoclonal antibody to calcitonin gene-related peptide, for the prevention of migraine: a phase 2, randomised, double-blind, placebo-controlled study

(2014) David W Dodick et al.   LANCET NEUROLOGY

Targeting of acute myeloid leukemia in vitro and in vivo with an anti-CD123 mAb engineered for optimal ADCC

(2014) S J Busfield et al.   LEUKEMIA

Non–antigen-contacting region of an asymmetric bispecific antibody to factors IXa/X significantly affects factor VIII-mimetic activity

(2014) Zenjiro Sampei et al.   mAbs

Antibodies to watch in 2014

(2014) Janice M Reichert   mAbs

Antibodies to watch in 2015

(2014) Janice M Reichert   mAbs

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

(2014) Sophie E. Broughton et al.   Cell Reports

Antibodies to watch in 2014

(2013) Janice M Reichert   mAbs

Which are the antibodies to watch in 2013?

(2013) Janice M. Reichert   mAbs

Antibodies to watch in 2013

(2013) Janice M Reichert   mAbs

Which are the antibodies to watch in 2012?

(2012) Janice M. Reichert   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Pharmacokinetics and safety of roledumab, a novel human recombinant monoclonal anti-RhD antibody with an optimized Fc for improved engagement of FCγRIII, in healthy volunteers

(2012) A. Yver et al.   VOX SANGUINIS

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Antibodies to watch in 2010

(2010) Janice M. Reichert   mAbs