Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations

Characterizing Intermolecular Interactions That Initiate Native-Like Protein Aggregation

(2012) Francesco Bemporad et al.   BIOPHYSICAL JOURNAL

N-glycosylation of enhanced aromatic sequons to increase glycoprotein stability

(2012) Joshua L. Price et al.   BIOPOLYMERS

Relationship Between Potential Aggregation-Prone Regions and HLA-DR-Binding T-Cell Immune Epitopes: Implications for Rational Design of Novel and Follow-on Therapeutic Antibodies

(2012) Sandeep Kumar et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The impact of glycosylation on monoclonal antibody conformation and stability

(2012) Kai Zheng et al.   mAbs

Marketing approval of mogamulizumab

(2012) Alain Beck et al.   mAbs

Intrinsic disorder modulates protein self-assembly and aggregation

(2012) A. De Simone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of an Intermediate State in Protein Folding and Aggregation

(2012) P. Neudecker et al.   SCIENCE

Coarse-grained models for protein aggregation

(2011) Chun Wu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Introduction to current and future protein therapeutics: A protein engineering perspective

(2011) Paul J. Carter   EXPERIMENTAL CELL RESEARCH

Shortened Engineered Human Antibody CH2 Domains

(2011) Rui Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

(2011) Ramil F. Latypov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions

(2011) Neeraj J. Agrawal et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Evaluation of a Non-Arrhenius Model for Therapeutic Monoclonal Antibody Aggregation

(2011) Veysel Kayser et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nonnative Aggregation of an IgG1 Antibody in Acidic Conditions, Part 2: Nucleation and Growth Kinetics with Competing Growth Mechanisms

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Predicting accelerated aggregation rates for monoclonal antibody formulations, and challenges for low-temperature predictions

(2011) Rebecca K. Brummitt et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Structural and Thermodynamic Investigations on the Aggregation and Folding of Acylphosphatase by Molecular Dynamics Simulations and Solvation Free Energy Analysis

(2011) Song-Ho Chong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic

(2011) Adam W Barb et al.   Nature Chemical Biology

Disulfide Scrambling in IgG2 Monoclonal Antibodies: Insights from Molecular Dynamics Simulations

(2011) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Oxidized and Aggregated Recombinant Human Interferon Beta is Immunogenic in Human Interferon Beta Transgenic Mice

(2011) Miranda M. C. van Beers et al.   PHARMACEUTICAL RESEARCH

Large Proteins Have a Great Tendency to Aggregate but a Low Propensity to Form Amyloid Fibrils

(2011) Hassan Ramshini et al.   PLoS One

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

(2011) A. De Simone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationalization of poor solubility of TGF-β3 using MD simulation

(2010) Shahid M. Nayeem et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Construction, MD Simulation, and Hydrodynamic Validation of an All-Atom Model of a Monoclonal IgG Antibody

(2010) J. Paul Brandt et al.   BIOPHYSICAL JOURNAL

Impact of Product-Related Factors on Immunogenicity of Biotherapeutics

(2010) Satish Kumar Singh   JOURNAL OF PHARMACEUTICAL SCIENCES

Potential aggregation prone regions in biotherapeutics

(2010) Xiaoling Wang et al.   mAbs

Exploring the sequence determinants of amyloid structure using position-specific scoring matrices

(2010) Sebastian Maurer-Stroh et al.   NATURE METHODS

Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis

(2010) Xiaoling Wang et al.   PHARMACEUTICAL RESEARCH

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Physiological responses to protein aggregates: Fibrinolysis, coagulation and inflammation (new roles for old factors)

(2009) Martijn F.B.G. Gebbink et al.   FEBS LETTERS

Protein sequences encode safeguards against aggregation

(2009) Joke Reumers et al.   HUMAN MUTATION

Engineered Human Antibody Constant Domains with Increased Stability

(2009) Rui Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aggregation-Prone Motifs in Human Immunoglobulin G

(2009) Naresh Chennamsetty et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic Fluctuations of Protein-Carbohydrate Interactions Promote Protein Aggregation

(2009) Vladimir Voynov et al.   PLoS One

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations

(2009) J. Rui Rodrigues et al.   PROTEIN SCIENCE

When binding is enough: nonactivating antibody formats

(2008) Aran F Labrijn et al.   CURRENT OPINION IN IMMUNOLOGY

The Degree of Structural Protection at the Edge β-Strands Determines the Pathway of Amyloid Formation in Globular Proteins

(2008) Gemma Soldi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bacterial Inclusion Bodies Contain Amyloid-Like Structure

(2008) Lei Wang et al.   PLOS BIOLOGY

β Edge strands in protein structure prediction and aggregation

(2003) Jennifer A. Siepen et al.   PROTEIN SCIENCE