AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver

The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation

(2012) Mitchell R. McGill et al.   JOURNAL OF CLINICAL INVESTIGATION

1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N-Acetyltransferase

(2011) Q. Sun et al.   DRUG METABOLISM AND DISPOSITION

Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes

(2011) M.G.L. Elferink et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On-line HPLC Analysis System for Metabolism and Inhibition Studies in Precision-Cut Liver Slices

(2010) Paul M. van Midwoud et al.   ANALYTICAL CHEMISTRY

Role of Human GlutathioneS-Transferases in the Inactivation of Reactive Metabolites of Clozapine

(2010) Sanja Dragovic et al.   CHEMICAL RESEARCH IN TOXICOLOGY

HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity

(2010) Mitchell R. McGill et al.   HEPATOLOGY

Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies

(2010) Inge A M de Graaf et al.   Nature Protocols

Differential Regulation of Mitogen-Activated Protein Kinase Pathways by Acetaminophen and Its Nonhepatotoxic Regioisomer 3′-Hydroxyacetanilide in TAMH Cells

(2010) Brendan D. Stamper et al.   TOXICOLOGICAL SCIENCES

Acetaminophen Overdose with Altered Acetaminophen Pharmacokinetics and Hepatotoxicity Associated with Premature Cessation of Intravenous N-Acetylcysteine Therapy

(2008) Silas W Smith et al.   ANNALS OF PHARMACOTHERAPY

Mechanistic Investigation of the Noncytochrome P450-Mediated Metabolism of Triadimefon to Triadimenol in Hepatic Microsomes

(2008) John F. Kenneke et al.   CHEMICAL RESEARCH IN TOXICOLOGY

The hepatotoxic metabolite of acetaminophen directly activates the Keap1-Nrf2 cell defense system

(2008) Ian M. Copple et al.   HEPATOLOGY

Microarray analysis in rat liver slices correctly predicts in vivo hepatotoxicity

(2008) M ELFERINK et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Interspecies differences in acetaminophen sensitivity of human, rat, and mouse primary hepatocytes

(2008) Katalin Jemnitz et al.   TOXICOLOGY IN VITRO