Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
出版年份 2013 全文链接
标题
Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis
作者
关键词
acetaminophen, drug metabolism, drug transporters, hepatotoxicity, nuclear receptors
出版物
PHARMACEUTICAL RESEARCH
Volume 30, Issue 9, Pages 2174-2187
出版商
Springer Nature
发表日期
2013-03-06
DOI
10.1007/s11095-013-1007-6
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Models of drug-induced liver injury for evaluation of phytotherapeutics and other natural products
- (2013) Hartmut Jaeschke et al. FOOD AND CHEMICAL TOXICOLOGY
- AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver
- (2012) Mackenzie Hadi et al. ARCHIVES OF TOXICOLOGY
- Primary hepatocyte cultures for pharmaco-toxicological studies: at the busy crossroad of various anti-dedifferentiation strategies
- (2012) J. Fraczek et al. ARCHIVES OF TOXICOLOGY
- Vα14iNKT cell deficiency prevents acetaminophen-induced acute liver failure by enhancing hepatic glutathione and altering APAP metabolism
- (2012) Isaac Downs et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity
- (2012) Hartmut Jaeschke et al. DRUG METABOLISM REVIEWS
- Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
- (2012) Laura P. James et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Increased susceptibility of natural killer T-cell-deficient mice to acetaminophen-induced liver injury
- (2012) Brittany V. Martin-Murphy et al. HEPATOLOGY
- The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
- (2012) Mitchell R. McGill et al. JOURNAL OF CLINICAL INVESTIGATION
- Molecular forms of HMGB1 and keratin-18 as mechanistic biomarkers for mode of cell death and prognosis during clinical acetaminophen hepatotoxicity
- (2012) Daniel J. Antoine et al. JOURNAL OF HEPATOLOGY
- Resistance to acetaminophen-induced hepatotoxicity in glutathione S-transferase Mu 1-null mice
- (2012) Shingo Arakawa et al. JOURNAL OF TOXICOLOGICAL SCIENCES
- Effect of Therapeutic Doses of Acetaminophen (up to 4 g/day) on Serum Alanine Aminotransferase Levels in Subjects Consuming Ethanol: Systematic Review and Meta-analysis of Randomized Controlled Trials
- (2012) Barry Rumack et al. PHARMACOTHERAPY
- Purinergic Receptor Antagonist A438079 Protects Against Acetaminophen-Induced Liver Injury by Inhibiting P450 Isoenzymes, Not by Inflammasome Activation
- (2012) Yuchao Xie et al. TOXICOLOGICAL SCIENCES
- Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity
- (2012) Mitchell R. McGill et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Optimization of the HepaRG cell model for drug metabolism and toxicity studies
- (2012) Sébastien Anthérieu et al. TOXICOLOGY IN VITRO
- Caveats of using acetaminophen hepatotoxicity models for natural product testing
- (2012) Hartmut Jaeschke et al. TOXICOLOGY LETTERS
- Emergency Department Visits for Overdoses of Acetaminophen-Containing Products
- (2011) Daniel S. Budnitz et al. AMERICAN JOURNAL OF PREVENTIVE MEDICINE
- Acetaminophen-cysteine adducts during therapeutic dosing and following overdose
- (2011) Kennon J Heard et al. BMC GASTROENTEROLOGY
- Inhibition of paracetamol glucuronidation by tyrosine kinase inhibitors
- (2011) Yong Liu et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- The role of the glutathione S-transferase genes GSTT1, GSTM1, and GSTP1 in acetaminophen-poisoned patients
- (2011) Anders Buchard et al. CLINICAL TOXICOLOGY
- UGT1A6 and UGT2B15 Polymorphisms and Acetaminophen Conjugation in Response to a Randomized, Controlled Diet of Select Fruits and Vegetables
- (2011) S. L. Navarro et al. DRUG METABOLISM AND DISPOSITION
- SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity
- (2011) Zhongping Lu et al. EMBO REPORTS
- Activation of liver X receptor increases acetaminophen clearance and prevents its toxicity in mice
- (2011) Simrat P.S. Saini et al. HEPATOLOGY
- c-Jun N-terminal Kinase (JNK)-dependent Acute Liver Injury from Acetaminophen or Tumor Necrosis Factor (TNF) Requires Mitochondrial Sab Protein Expression in Mice
- (2011) Sanda Win et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products
- (2011) Hartmut Jaeschke et al. LIFE SCIENCES
- Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity
- (2011) Hartmut Jaeschke et al. LIVER INTERNATIONAL
- Exacerbation of Acetaminophen Hepatotoxicity by the Anthelmentic Drug Fenbendazole
- (2011) Carol R. Gardner et al. TOXICOLOGICAL SCIENCES
- Apoptosis-Inducing Factor Modulates Mitochondrial Oxidant Stress in Acetaminophen Hepatotoxicity
- (2011) Mary Lynn Bajt et al. TOXICOLOGICAL SCIENCES
- The effects of paracetamol (acetaminophen) on hepatic tests in patients who chronically abuse alcohol - a randomized study
- (2010) R. C. Dart et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Regulation of hepatic ABCC transporters by xenobiotics and in disease states
- (2010) Xinsheng Gu et al. DRUG METABOLISM REVIEWS
- Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury
- (2010) Anup Ramachandran et al. FREE RADICAL RESEARCH
- HepaRG cells: A human model to study mechanisms of acetaminophen hepatotoxicity
- (2010) Mitchell R. McGill et al. HEPATOLOGY
- Acetaminophen-Induced Hepatotoxicity in Mice Occurs with Inhibition of Activity and Nitration of Mitochondrial Manganese Superoxide Dismutase
- (2010) R. Agarwal et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Activation of the Farnesoid X Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity
- (2010) Florence Ying Lee et al. MOLECULAR ENDOCRINOLOGY
- The Oxygen Tension Modulates Acetaminophen-Induced Mitochondrial Oxidant Stress and Cell Injury in Cultured Hepatocytes
- (2010) Hui-Min Yan et al. TOXICOLOGICAL SCIENCES
- c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity
- (2010) Chieko Saito et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Mitochondrial CYP2E1 is sufficient to mediate oxidative stress and cytotoxicity induced by ethanol and acetaminophen
- (2010) Laetitia Knockaert et al. TOXICOLOGY IN VITRO
- Herbal extracts as hepatoprotectants against acetaminophen hepatotoxicity
- (2010) Hartmut Jaeschke WORLD JOURNAL OF GASTROENTEROLOGY
- The FDA Acetaminophen Advisory Committee Meeting – what is the future of acetaminophen in the United States? The perspective of a committee member
- (2009) Edward P. Krenzelok CLINICAL TOXICOLOGY
- Sex-Dependent Disposition of Acetaminophen Sulfate and Glucuronide in the in Situ Perfused Mouse Liver
- (2009) J. K. Lee et al. DRUG METABOLISM AND DISPOSITION
- Stable Expression, Activity, and Inducibility of Cytochromes P450 in Differentiated HepaRG Cells
- (2009) S. Antherieu et al. DRUG METABOLISM AND DISPOSITION
- Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
- (2009) L. P. James et al. DRUG METABOLISM AND DISPOSITION
- Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity
- (2009) J. Cheng et al. DRUG METABOLISM AND DISPOSITION
- Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression
- (2009) Claire Legendre et al. EUROPEAN JOURNAL OF CANCER
- Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-acetylcysteine
- (2009) Chieko Saito et al. HEPATOLOGY
- The utilization of liver transplantation in the management of acute liver failure: Comparison between acetaminophen and non-acetaminophen etiologies
- (2009) Kenneth J. Simpson et al. LIVER TRANSPLANTATION
- Acute Liver Failure in a Metropolitan Area in Germany: a Retrospective Study (2002 – 2008)
- (2009) A. Canbay et al. ZEITSCHRIFT FUR GASTROENTEROLOGIE
- Acute Ethanol Coingestion Confers a Lower Risk of Hepatotoxicity after Deliberate Acetaminophen Overdose
- (2008) W. Stephen Waring et al. ACADEMIC EMERGENCY MEDICINE
- Hepatic Mrp4 induction following acetaminophen exposure is dependent on Kupffer cell function
- (2008) Sarah N. Campion et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Interindividual variability in acetaminophen sulfation by human fetal liver: Implications for pharmacogenetic investigations of drug-induced birth defects
- (2008) Araba A. Adjei et al. BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
- Structure, Function and Polymorphism of Human Cytosolic Sulfotransferases
- (2008) Yong Li et al. CURRENT DRUG METABOLISM
- Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation
- (2008) Hayato Nakagawa et al. GASTROENTEROLOGY
- GlutathioneS-transferase m1 and t1 null genotypes increase susceptibility to idiosyncratic drug-induced liver injury
- (2008) M. Isabel Lucena et al. HEPATOLOGY
- Role of JNK Translocation to Mitochondria Leading to Inhibition of Mitochondria Bioenergetics in Acetaminophen-induced Liver Injury
- (2008) Naoko Hanawa et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial protein thiol modifications in acetaminophen hepatotoxicity: Effect on HMG-CoA synthase
- (2008) Kelly K. Andringa et al. TOXICOLOGY LETTERS
- Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2
- (2007) Lauren M. Aleksunes et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Genomics and proteomics analysis of cultured primary rat hepatocytes
- (2007) Juergen Beigel et al. TOXICOLOGY IN VITRO
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