Journal
TISSUE ANTIGENS
Volume 82, Issue 3, Pages 177-185Publisher
WILEY
DOI: 10.1111/tan.12183
Keywords
Ache; Amerindians; Guarani; immune response genes; interleukins; Kaingang
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Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brazil)
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
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Native American populations generally have a higher prevalence of infectious diseases than non-Native populations and this fact can induce different pressures in their immune system. We investigated the patterns of population differentiation (F-ST) of 32 polymorphisms related to adaptive immune response in four Native American populations (Ache, Guarani-Kaiowa, Guarani-Nandeva and Kaingang), and the results were compared with the three major world population data [Yoruba of Ibadan, Nigeria (YRI), Utah residents with northern and Western Europe ancestry (CEU) and Han Chinese of Beijing, China (CHB)] available in the HapMap database. The Ache clearly differentiated from the other Amerindians, but when all Native Americans were compared with the samples of other ethnic groups the lowest difference (0.08) was found with CHB (Asians), the second lowest (0.15) with YRI (Africans) and the most marked with CEU (European-derived). The considerable intra and interethnic differences found can be explained both in terms of diverse evolutionary distances and more recent environmental pathogen exposures; and they should be appropriately considered prior to any specific public health action.
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