Journal
TISSUE ANTIGENS
Volume 76, Issue 4, Pages 297-300Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1399-0039.2010.01521.x
Keywords
polymorphism; PTPN22; rheumatoid arthritis
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Funding
- National Science Technology Pillar Program [2008BAI59B01, 2008BAI59B02, 2008BAI59B03]
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This study aimed at examining the association of the single nucleotide polymorphism (SNP) in the protein tyrosine phosphatase gene (PTPN22) with the risk of rheumatoid arthritis (RA) in a Chinese population. A total of 200 RA patients and age and gender-matched healthy controls were recruited. Their genotypes and allelic frequency were determined by the TaqMan-MGB probe-based polymerase chain reaction (PCR). The frequencies of the CC genotype and C allele in RA patient group were significantly higher than that of controls (P < 0.01 or P < 0.05) with an odds ratio of 1.67, respectively. These data suggest, the CC genotype and C allele of the -1123G > C in the PTPN22 gene are associated with an increased risk for RA in Chinese population. Therefore, the CC genotype and C allele of the -1123G > C in the PTPN22 gene may be used as a genetic marker for the predisposition of RA in Chinese.
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