Why is PTPN22 a good candidate susceptibility gene for autoimmune disease?

Identification of a variant form of tyrosine phosphatase LYP

(2010) Shaofeng Wang et al.   BMC MOLECULAR BIOLOGY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Autoimmune-associated PTPN22 R620W Variation Reduces Phosphorylation of Lymphoid Phosphatase on an Inhibitory Tyrosine Residue

(2010) Edoardo Fiorillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update

(2010) WW Lea et al.   LUPUS

Comprehensive Expression Profiles of Genes for Protein Tyrosine Phosphatases in Immune Cells

(2010) Y. Arimura et al.   Science Signaling

PTPN22 gene regulates natural killer cell proliferation during in vitro expansion

(2010) K. Douroudis et al.   TISSUE ANTIGENS

Deep resequencing reveals excess rare recent variants consistent with explosive population growth

(2010) Alex Coventry et al.   Nature Communications

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Crystal Structure of the Human Lymphoid Tyrosine Phosphatase Catalytic Domain: Insights into Redox Regulation,

(2009) Sophia J. Tsai et al.   BIOCHEMISTRY

Regulation of Lymphoid Tyrosine Phosphatase Activity: Inhibition of the Catalytic Domain by the Proximal Interdomain

(2009) Yingge Liu et al.   BIOCHEMISTRY

Natural killer cells in human autoimmunity

(2009) Malin Flodström-Tullberg et al.   CURRENT OPINION IN IMMUNOLOGY

Genetically Encoded Forster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase Lck

(2009) W. Paster et al.   JOURNAL OF IMMUNOLOGY

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

The Tyrosine Kinase Csk Dimerizes through Its SH3 Domain

(2009) Nicholas M. Levinson et al.   PLoS One

PTPN22C1858T polymorphism and human brucellosis

(2009) Maria Jose Bravo et al.   SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES

Association ofPTPN22gene functional variants with development of pulmonary tuberculosis in Moroccan population

(2009) H. Lamsyah et al.   TISSUE ANTIGENS

Recent Advances in the Genetics of Autoimmune Disease

(2008) Peter K. Gregersen et al.   Annual Review of Immunology

Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease

(2008) Beate Skinningsrud et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

(2008) V. Orru et al.   HUMAN MOLECULAR GENETICS

Reduced CD4+T cell activation in children with type 1 diabetes carrying the PTPN22/Lyp 620Trp variant

(2008) Johanna Aarnisalo et al.   JOURNAL OF AUTOIMMUNITY

PTPN22 R620W promotes production of anti-AChR autoantibodies and IL-2 in myasthenia gravis

(2008) Ann Kari Lefvert et al.   JOURNAL OF NEUROIMMUNOLOGY

The PTPN22-1858C>T (R620W) functional polymorphism is associated with generalized vitiligo in the Romanian population

(2008) Greggory S. LaBerge et al.   Pigment Cell & Melanoma Research

Protein tyrosine phosphatase non-receptor type 22 gene variants at position 1858 are associated with type 1 and type 2 diabetes in Estonian population

(2008) K. Douroudis et al.   TISSUE ANTIGENS

PTPN22 C1858T Polymorphism and the Outcome of Hepatitis C Virus Infection

(2008) M.A. Montes-Cano et al.   VIRAL IMMUNOLOGY

Association of PTPN22 1858C/T polymorphism with vitiligo susceptibility in Gujarat population

(2007) Naresh C. Laddha et al.   JOURNAL OF DERMATOLOGICAL SCIENCE