Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT

Sotrastaurin, a Novel Small Molecule Inhibiting Protein-Kinase C: Randomized Phase II Study in Renal Transplant Recipients

(2011) S. Friman et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

PTPN22 1858C>T Polymorphism Distribution in Europe and Association with Rheumatoid Arthritis: Case-Control Study and Meta-Analysis

(2011) Michele Ciro Totaro et al.   PLoS One

ORAL PROTEIN KINASE C β INHIBITION USING RUBOXISTAURIN

(2011) Lloyd Paul Aiello et al.   RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES

The lymph node microenvironment promotes B-cell receptor signaling, NF- B activation, and tumor proliferation in chronic lymphocytic leukemia

(2010) Y. Herishanu et al.   BLOOD

Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin

(2010) C. C. Chu et al.   BLOOD

Protein tyrosine phosphatases as drug targets: strategies and challenges of inhibitor development

(2010) Alastair J Barr   Future Medicinal Chemistry

Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells

(2010) M Suljagic et al.   LEUKEMIA

Lyn, PKC- , SHIP-1 interactions regulate GPVI-mediated platelet-dense granule secretion

(2009) R. Chari et al.   BLOOD

Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia

(2009) J. W. Friedberg et al.   BLOOD

PTPN22 Deficiency Cooperates with the CD45 E613R Allele to Break Tolerance on a Non-Autoimmune Background

(2009) J. Zikherman et al.   JOURNAL OF IMMUNOLOGY

Protein Tyrosine Phosphatases in Autoimmunity

(2008) Torkel Vang et al.   Annual Review of Immunology

A new perspective: molecular motifs on oxidized LDL, apoptotic cells, and bacteria are targets for chronic lymphocytic leukemia antibodies

(2008) A. Lanemo Myhrinder et al.   BLOOD

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

(2008) V. Orru et al.   HUMAN MOLECULAR GENETICS

ER stress is involved in B cell antigen receptor ligation-induced apoptosis

(2007) Bin-Cheng Yan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells

(2007) P. G. Longo et al.   BLOOD