PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models

(2013) Xuezhi Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways

(2013) John C. Cambier   JOURNAL OF CLINICAL INVESTIGATION

Variation in theICAM1–ICAM4–ICAM5locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries

(2012) Kwangwoo Kim et al.   ANNALS OF THE RHEUMATIC DISEASES

CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation

(2012) Nataly Manjarrez-Orduño et al.   NATURE GENETICS

Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

(2012) R. J. Brownlie et al.   Science Signaling

Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study

(2011) Elena Sánchez et al.   ARTHRITIS AND RHEUMATISM

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans

(2011) Laurence Menard et al.   JOURNAL OF CLINICAL INVESTIGATION

Lyp breakdown and autoimmunity

(2011) Timothy W Behrens   NATURE GENETICS

The autoimmune disease–associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness

(2011) Jinyi Zhang et al.   NATURE GENETICS

PTPN22 1858C>T Polymorphism Distribution in Europe and Association with Rheumatoid Arthritis: Case-Control Study and Meta-Analysis

(2011) Michele Ciro Totaro et al.   PLoS One

Identification of a Systemic Lupus Erythematosus Susceptibility Locus at 11p13 between PDHX and CD44 in a Multiethnic Study

(2010) Christopher J. Lessard et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis

(2010) L. Diaz-Gallo et al.   ANNALS OF THE RHEUMATIC DISEASES

The PTPN22 R263Q polymorphism is a risk factor for rheumatoid arthritis in Caucasian case-control samples

(2010) Luis Rodríguez-Rodríguez et al.   ARTHRITIS AND RHEUMATISM

PTPN22 gene polymorphisms in autoimmune diseases with special reference to systemic lupus erythematosus disease susceptibility

(2010) V Pradhan et al.   Journal of Postgraduate Medicine

The association between the PTPN22 C1858T polymorphism and systemic lupus erythematosus: a meta-analysis update

(2010) WW Lea et al.   LUPUS

Genetics and Beyond – The Transcriptome of Human Monocytes and Disease Susceptibility

(2010) Tanja Zeller et al.   PLoS One

CTLA-4 CT60 Polymorphism in Thyroid and Polyglandular Autoimmunity

(2009) G. Dultz et al.   HORMONE AND METABOLIC RESEARCH

Cutting Edge: The PTPN22 Allelic Variant Associated with Autoimmunity Impairs B Cell Signaling

(2009) A. F. Arechiga et al.   JOURNAL OF IMMUNOLOGY

PTPN22/LYP 1858C>T gene polymorphism and susceptibility to endometriosis in a Polish population

(2009) Rafał Płoski et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms in the PTPN22 region are associated with psoriasis of early onset

(2008) Rh.Ll. Smith et al.   BRITISH JOURNAL OF DERMATOLOGY

Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease

(2008) Beate Skinningsrud et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus

(2008) V. Orru et al.   HUMAN MOLECULAR GENETICS

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS