Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation

Metabolite Profiling of Triterpene Saponins inMedicago truncatulaHairy Roots by Liquid Chromatography Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

(2011) Jacob Pollier et al.   JOURNAL OF NATURAL PRODUCTS

The saponins – polar isoprenoids with important and diverse biological activities

(2011) Anne Osbourn et al.   NATURAL PRODUCT REPORTS

Isolation and analysis of ginseng: advances and challenges

(2011) Lian-Wen Qi et al.   NATURAL PRODUCT REPORTS

Molecular activities, biosynthesis and evolution of triterpenoid saponins

(2011) Jörg M. Augustin et al.   PHYTOCHEMISTRY

Metabolic Engineering inNicotiana benthamianaReveals Key Enzyme Functions inArabidopsisIndole Glucosinolate Modification

(2011) Marina Pfalz et al.   PLANT CELL

Towards the development of better crops by genetic transformation using engineered plant chromosomes

(2011) Manoj K. Dhar et al.   PLANT CELL REPORTS

Plastid Biotechnology: Food, Fuel, and Medicine for the 21st Century

(2011) P. Maliga et al.   PLANT PHYSIOLOGY

Jasmonate signaling involves the abscisic acid receptor PYL4 to regulate metabolic reprogramming in Arabidopsis and tobacco

(2011) P. Lackman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycosylation of capsaicinoids withPanax ginsengstimulated by salicylic acid

(2010) H. Katsuragi et al.   ACTA BIOLOGICA HUNGARICA

American ginseng: Potential structure–function relationship in cancer chemoprevention

(2010) Lian-Wen Qi et al.   BIOCHEMICAL PHARMACOLOGY

Biotransformation of Cinnamic Acid,p-Coumaric Acid, Caffeic Acid, and Ferulic Acid by Plant Cell Cultures ofEucalyptus perriniana

(2010) Hisashi KATSURAGI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Use of cyclodextrins in biotransformation reactions with cell cultures ofMorus nigra: biosynthesis of prenylated chalcone isocordoin

(2010) Adriana Bolasco et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Hybrid floral scent novelty drives pollinator shift in sexually deceptive orchids

(2010) Nicolas J Vereecken et al.   BMC EVOLUTIONARY BIOLOGY

Anti-inflammatory Triterpenoid Blocks Immune Suppressive Function of MDSCs and Improves Immune Response in Cancer

(2010) S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Engineered Minichromosomes in Plants

(2010) James A. Birchler et al.   CRITICAL REVIEWS IN PLANT SCIENCES

Privileged scaffolds for library design and drug discovery

(2010) Matthew E Welsch et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms

(2010) Yi-Ming Chiang et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Production of the Cancer-Preventive Glucoraphanin in Tobacco

(2010) Michael Dalgaard Mikkelsen et al.   Molecular Plant

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis

(2010) Carlos Olano et al.   NATURAL PRODUCT REPORTS

Methods and options for the heterologous production of complex natural products

(2010) Haoran Zhang et al.   NATURAL PRODUCT REPORTS

Integrating carbon–halogen bond formation into medicinal plant metabolism

(2010) Weerawat Runguphan et al.   NATURE

Synthetic biology: applications come of age

(2010) Ahmad S. Khalil et al.   NATURE REVIEWS GENETICS

Application of two bicistronic systems involving 2A and IRES sequences to the biosynthesis of carotenoids in rice endosperm

(2010) Sun-Hwa Ha et al.   PLANT BIOTECHNOLOGY JOURNAL

The production of artemisinin precursors in tobacco

(2010) Yansheng Zhang et al.   PLANT BIOTECHNOLOGY JOURNAL

Genomic and Coexpression Analyses Predict Multiple Genes Involved in Triterpene Saponin Biosynthesis in Medicago truncatula

(2010) M. A. Naoumkina et al.   PLANT CELL

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

(2010) Teun W. J. M. van Herpen et al.   PLoS One

Novel biotransformation processes of dihydroartemisinic acid and artemisinic acid to their hydroxylated derivatives by two plant cell culture systems

(2010) Jian-Hua Zhu et al.   PROCESS BIOCHEMISTRY

Biotransformation of Paeonol and Emodin by Transgenic Crown Galls of Panax quinquefolium

(2009) W. L. Ma et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Biosynthesis and biotechnological production of flavanones: current state and perspectives

(2009) Zachary L. Fowler et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts

(2009) Remco Muntendam et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Betulin Elicits Anti-Cancer Effects in Tumour Primary Cultures and Cell LinesIn Vitro

(2009) Wojciech Rzeski et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Biotransformation of ingenol-3-angelate in four plant cell suspension cultures

(2009) Rong-Wei Teng et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Adzuki bean: A new resource of biocatalyst for asymmetric reduction of aromatic ketones with high stereoselectivity and substrate tolerance

(2009) Yan Xie et al.   BIORESOURCE TECHNOLOGY

Tobacco, a highly efficient green bioreactor for production of therapeutic proteins

(2009) Reynald Tremblay et al.   BIOTECHNOLOGY ADVANCES

Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis

(2009) Holger Schäfer et al.   Biotechnology Journal

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Impact of Natural Products on Developing New Anti-Cancer Agents†

(2009) Gordon M. Cragg et al.   CHEMICAL REVIEWS

Homochiral Drugs: A Demanding Tendency of the Pharmaceutical Industry

(2009) Maria Nunez et al.   CURRENT MEDICINAL CHEMISTRY

Opportunities for enzyme engineering in natural product biosynthesis

(2009) Peter Bernhardt et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Indolocarbazole antitumour compounds by combinatorial biosynthesis

(2009) José A Salas et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Ginseng Compounds: An Update on their Molecular Mechanisms and Medical Applications

(2009) Jian-Ming Lu et al.   Current Vascular Pharmacology

Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

(2009) Hong-Fang Ji et al.   EMBO REPORTS

Robustness of QTLs across germplasm pools using a model quantitative trait

(2009) E. A. Lee et al.   GENOME

Glycosylation of Fluorophenols by Plant Cell Cultures

(2009) Kei Shimoda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enantioselective reduction of fluorenones in surfactant-aqueous solution by fruits and vegetables

(2009) Bo Xie et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Epigenome manipulation as a pathway to new natural product scaffolds and their congeners

(2009) Robert H. Cichewicz   NATURAL PRODUCT REPORTS

Synthesis at the molecular frontier

(2009) Paul A. Wender et al.   NATURE

Metabolic reprogramming of periwinkle plant culture

(2009) Weerawat Runguphan et al.   Nature Chemical Biology

Glucosinolate engineering identifies a γ-glutamyl peptidase

(2009) Fernando Geu-Flores et al.   Nature Chemical Biology

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

The second wave of synthetic biology: from modules to systems

(2009) Priscilla E. M. Purnick et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Daucus carotaMediated-Reduction of Cyclic 3-Oxo-amines

(2009) Romain Lacheretz et al.   ORGANIC LETTERS

Glycosylation of sesamol by cultured plant cells

(2009) Kei Shimoda et al.   PHYTOCHEMISTRY

Biotransformation of naringin and naringenin by cultured Eucalyptus perriniana cells

(2009) Kei Shimoda et al.   PHYTOCHEMISTRY

Production and characterisation of the intergeneric hybrids between Dendranthema morifolium and Artemisia vulgaris exhibiting enhanced resistance to chrysanthemum aphid (Macrosiphoniella sanbourni)

(2009) Yanming Deng et al.   PLANTA

Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy

(2009) Melanie Laszczyk   PLANTA MEDICA

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

(2009) W. Runguphan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vacuolar transport of nicotine is mediated by a multidrug and toxic compound extrusion (MATE) transporter in Nicotiana tabacum

(2009) M. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Antibiotics for Emerging Pathogens

(2009) M. A. Fischbach et al.   SCIENCE

Jasmonate-inducible gene: what does it mean?

(2009) Laurens Pauwels et al.   TRENDS IN PLANT SCIENCE

When more is better: multigene engineering in plants

(2009) Shaista Naqvi et al.   TRENDS IN PLANT SCIENCE

Adjuvant activities of saponins from traditional Chinese medicinal herbs

(2009) Xiaoming Song et al.   VACCINE

Amplified immune response by ginsenoside-based nanoparticles (ginsomes)

(2009) Xiaoming Song et al.   VACCINE

Advances in saponin-based adjuvants

(2009) Hong-Xiang Sun et al.   VACCINE

ISCOMs and ISCOMATRIX™

(2009) Hong-Xiang Sun et al.   VACCINE

Synthetic Biology for Synthetic Chemistry

(2008) Jay D. Keasling   ACS Chemical Biology

High production of β-thujaplicin glycosides by immobilized plant cells ofNicotiana tabacum

(2008) S. Kwon et al.   ACTA BIOLOGICA HUNGARICA

Glycoconjugates in Cancer Therapy

(2008) Laura Cipolla et al.   Anti-Cancer Agents in Medicinal Chemistry

Biotransformation of Valdecoxib by Plant Cell Cultures

(2008) V. Molmoori et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Reduction and cyclization in biotransformation of carbonyl compounds by cultured cells ofTaxusspecies

(2008) Consuelo Sandoval et al.   BIOCATALYSIS AND BIOTRANSFORMATION

Biotransformation of zerumbone by Caragana chamlagu

(2008) Hiroshi Sakamaki et al.   BIOTECHNOLOGY LETTERS

Engineering of Plant Polyketide Biosynthesis

(2008) Ikuro Abe   CHEMICAL & PHARMACEUTICAL BULLETIN

Synthesis of Unnatural Mono- and Oligosaccharides of Farnesol, Geraniol, and (S)-Perillyl Alcohol by Biocatalytic Glycosylations

(2008) Kei Shimoda et al.   CHEMISTRY LETTERS

Synthesis of Oligosaccharides of Genistein and Quercetin as Potential Anti-inflammatory Agents

(2008) Kei Shimoda et al.   CHEMISTRY LETTERS

Asymmetric bioreduction of substituted acenaphthenequinones using plant enzymatic systems: A novel strategy for the preparation of (+)- and (−)-mono hydroxyacenaphthenones

(2008) Lian Peng Tong et al.   CHINESE CHEMICAL LETTERS

Engineering natural products using combinatorial biosynthesis and biocatalysis

(2008) Hui Zhou et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering for plant natural product biosynthesis in microbes

(2008) Joseph A Chemler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering of natural products in plants; tools of the trade and challenges for the future

(2008) Shuiqin Wu et al.   CURRENT OPINION IN BIOTECHNOLOGY

Natural products in drug discovery

(2008) A HARVEY   DRUG DISCOVERY TODAY

Biotransformation of cholesterol to diosgenin by freely suspended and immobilised cells ofDioscorea bulbiferaL.

(2008) G. Jyothishwaran et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asymmetric reduction of prochiral ketones to chiral alcohols catalyzed by plants tissue

(2008) Zhong-Hua Yang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Sugar cane juice for the bioreduction of carbonyl compounds

(2008) João Carlos C. Assunção et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Biotransformation of p-, m-, and o-hydroxybenzoic acids by Panax ginseng hairy root cultures

(2008) Xin Chen et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Biotransformation and tumor multidrug resistance reversal potency of polyoxygenated taxadienes

(2008) Jian-Hua Zou et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Coconut water (Cocos nucifera L.)—A new biocatalyst system for organic synthesis

(2008) Aluísio M. Fonseca et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Metagenomics for Mining New Genetic Resources of Microbial Communities

(2008) Manuel Ferrer et al.   JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY

Reduction of Carbonylic and Carboxylic Groups by Plant Cell Cultures

(2008) Raffaella Villa et al.   JOURNAL OF NATURAL PRODUCTS

Maternal and child undernutrition: global and regional exposures and health consequences

(2008) Robert E Black et al.   LANCET

Betulinic acid: A natural product with anticancer activity

(2008) Simone Fulda   MOLECULAR NUTRITION & FOOD RESEARCH

Natural products to drugs: natural product-derived compounds in clinical trials

(2008) Mark S. Butler   NATURAL PRODUCT REPORTS

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY

Glycosylation of hesperetin by plant cell cultures

(2008) Kei Shimoda et al.   PHYTOCHEMISTRY

Glycosylation of daidzein by the Eucalyptus cell cultures

(2008) Kei Shimoda et al.   PHYTOCHEMISTRY

A straightforward procedure to biosynthesise melatonin using freshly chopped Achillea millefolium L. as reagent

(2008) Franco Marioni et al.   Phytochemistry Letters

Progress in understanding of ginsenoside biosynthesis

(2008) Y. Liang et al.   PLANT BIOLOGY

The Leaf Epidermome of Catharanthus roseus Reveals Its Biochemical Specialization

(2008) J. Murata et al.   PLANT CELL

Opium poppy and Madagascar periwinkle: model non-model systems to investigate alkaloid biosynthesis in plants

(2008) Peter J. Facchini et al.   PLANT JOURNAL

Ectopic Expression of VvMybPA2 Promotes Proanthocyanidin Biosynthesis in Grapevine and Suggests Additional Targets in the Pathway

(2008) N. Terrier et al.   PLANT PHYSIOLOGY

Phytochemical diversity: The sounds of silent metabolism

(2008) Efraim Lewinsohn et al.   PLANT SCIENCE

Towards engineering glucosinolates into non-cruciferous plants

(2008) Fernando Geu-Flores et al.   PLANTA

Anti-Cancer Effect of Betulin on a Human Lung Cancer Cell Line: A Pharmacoproteomic Approach Using 2 D SDS PAGE Coupled with Nano-HPLC Tandem Mass Spectrometry

(2008) Jae Pyo et al.   PLANTA MEDICA

Bioreduction of substituted a-tetralones promoted by Daucus carota root

(2008) Helena M. C. Ferraz et al.   QUIMICA NOVA

Metabolic Diversification--Independent Assembly of Operon-Like Gene Clusters in Different Plants

(2008) B. Field et al.   SCIENCE

Single-Molecule DNA Sequencing of a Viral Genome

(2008) T. D. Harris et al.   SCIENCE

Real-Time DNA Sequencing from Single Polymerase Molecules

(2008) J. Eid et al.   SCIENCE

Structural diversification of taxanes by whole-cell biotransformation

(2008) Jungui Dai et al.   TETRAHEDRON

Enantioselective reduction of 2-substituted tetrahydropyran-4-ones using Daucus carota plant cells

(2008) J.S. Yadav et al.   TETRAHEDRON LETTERS

(3R,9R,10R)-Panaxytriol: a molecular-based nutraceutical with possible application to cancer prevention and treatment

(2008) Fay Ng et al.   TETRAHEDRON LETTERS

Asymmetric reduction of ketones with a germinated plant

(2008) Kiyoko Matsuo et al.   TETRAHEDRON-ASYMMETRY

Immobilized Manihot esculenta preparation as a novel biocatalyst in the enantioselective acetylation of racemic alcohols

(2008) Luciana L. Machado et al.   TETRAHEDRON-ASYMMETRY

Comparative study in the asymmetric bioreduction of ketones by plant organs and undifferentiated cells

(2007) Alejandro A. Orden et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Bioreduction of aromatic aldehydes and ketones by fruits’ barks of Passiflora edulis

(2007) Luciana L. Machado et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC

Stereoinversion of 1-arylethanols by Cyanidioschyzon merolae NEIS-1332

(2007) Takamitsu Utsukihara et al.   JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC